NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462566984|ref|XP_054177767|]
View 

excitatory amino acid transporter 4 isoform X1 [Homo sapiens]

Protein Classification

dicarboxylate/amino acid:cation symporter( domain architecture ID 10003465)

dicarboxylate/amino acid:cation symporter facilitates H+ or Na+ symport with C4-dicarboxylates, dicarboxylic amino acids (aspartate, glutamate) or other amino acids; belongs to the sodium:dicarboxylate symporter family

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
54-533 4.79e-121

Na+/H+-dicarboxylate symporter [Energy production and conversion];


:

Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 362.89  E-value: 4.79e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984  54 RRNAFILLTVSAVVIGVSLAFALRPYQLTYrqikyFSFPGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAA 132
Cdd:COG1301     1 FKLSLTLQILIALVLGILLGLLLPELVAAV-----LKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 133 VYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETiPTADAFMDLIRNMFPPNLVEAcfkqfktqystrvvtrtmv 212
Cdd:COG1301    76 LYFLVTTTIALVIGLVVANLFQPGAGLNLDLADAAAAEA-AEAPSLLDFLLNIIPSNIFEA------------------- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 213 rtengsepgasmpppfsvengtsFLENvtralgtlqemlsfeetvpvpgsangiNALGLVVFSVAFGLVIGGMKHKGRVL 292
Cdd:COG1301   136 -----------------------FAEG---------------------------NMLQIIFFAILFGIALAALGEKGKPL 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 293 RDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMeDMAVLGgQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFP 372
Cdd:COG1301   166 LDFFESLSEVMFKIVGWVMKLAPIGVFALIAATVAKY-GLDALG-SLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLK 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 373 FIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQIT 452
Cdd:COG1301   244 FLRAIRPALLLAFSTSSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQL 323

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 453 TISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHlSQRELELQEA 532
Cdd:COG1301   324 TIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK-WEGELDREKL 402


                  .
gi 2462566984 533 E 533
Cdd:COG1301   403 N 403
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
54-533 4.79e-121

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 362.89  E-value: 4.79e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984  54 RRNAFILLTVSAVVIGVSLAFALRPYQLTYrqikyFSFPGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAA 132
Cdd:COG1301     1 FKLSLTLQILIALVLGILLGLLLPELVAAV-----LKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 133 VYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETiPTADAFMDLIRNMFPPNLVEAcfkqfktqystrvvtrtmv 212
Cdd:COG1301    76 LYFLVTTTIALVIGLVVANLFQPGAGLNLDLADAAAAEA-AEAPSLLDFLLNIIPSNIFEA------------------- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 213 rtengsepgasmpppfsvengtsFLENvtralgtlqemlsfeetvpvpgsangiNALGLVVFSVAFGLVIGGMKHKGRVL 292
Cdd:COG1301   136 -----------------------FAEG---------------------------NMLQIIFFAILFGIALAALGEKGKPL 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 293 RDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMeDMAVLGgQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFP 372
Cdd:COG1301   166 LDFFESLSEVMFKIVGWVMKLAPIGVFALIAATVAKY-GLDALG-SLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLK 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 373 FIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQIT 452
Cdd:COG1301   244 FLRAIRPALLLAFSTSSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQL 323

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 453 TISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHlSQRELELQEA 532
Cdd:COG1301   324 TIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK-WEGELDREKL 402


                  .
gi 2462566984 533 E 533
Cdd:COG1301   403 N 403
SDF pfam00375
Sodium:dicarboxylate symporter family;
58-522 9.85e-114

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 343.35  E-value: 9.85e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984  58 FILLTVSAVVIGVSLAFALRPYqltyrqIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAAVYYM 136
Cdd:pfam00375   1 LLLQILIALVLGILIGLFFPEL------AAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYFL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 137 VTTIIAVFIGILMVTIIHPGKGSKeGLHREGRIETIPTADAFMDLIRNMFPPNLVEACFKQfktqystrvvtrtmvrten 216
Cdd:pfam00375  75 VTTAIAALIGLLVANVFQPGSGLA-LIAASLKEAKAAEAPSLLDFILNIIPSNIFEALAEG------------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 217 gsepgasmpppfsvengtsflenvtralgtlqemlsfeetvpvpgsangiNALGLVVFSVAFGLVIGGMKHKGRVLRDFF 296
Cdd:pfam00375 135 --------------------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFI 164

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 297 DSLNEAIMRLVGIIIWYAPVGILFLIAGKILEmEDMAVLGgQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFPFIGG 376
Cdd:pfam00375 165 ESLQEVMMKVIGWVMKLAPIGVFALIANTVGT-YGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKK 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 377 MLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISI 456
Cdd:pfam00375 243 MLPALLTAFSTASSAATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVL 322

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462566984 457 TATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHL 522
Cdd:pfam00375 323 TATLASIGAAGVPGGGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
PRK13027 PRK13027
C4-dicarboxylate transporter DctA; Reviewed
 63-519 3.41e-40

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 183850 [Multi-domain]  Cd Length: 421  Bit Score: 150.97  E-value: 3.41e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984  63 VSAVVIGVSLAFALRPYQLTYRQIkyfsfpGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAAVYYMVTTII 141
Cdd:PRK13027   13 VIALVLGVALGAFFPHFAESLKPL------GDGFIKLIKMLIGPIVFCVVVSGIAGAgDLKKVGRVGLKAVIYFEVMTTI 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 142 AVFIGILMVTIIHPGKGSKEGLHregrieTIPTADAfmdlirnmfppnlveacfkqfktqystrvvtrtmvrtengsepg 221
Cdd:PRK13027   87 ALVIGLVLAYLTGPGVGMNIDLR------SLDAASL-------------------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 222 asmpppfsvengTSFLENVTRALGTLQEMLSFEETVPVPGSANGiNALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNE 301
Cdd:PRK13027  117 ------------AGYAKNAQSLKGTAGFLLKLIPTTAVDAFAKG-DILQVLLFSVLFGSALSLLGERAKRVNRLIDELSH 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 302 AIMRLVGIIIWYAPVGILFLIA---GKiLEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFLVthrnpFPFIGGML 378
Cdd:PRK13027  184 VLFRIMGFIIKLAPLGVLGAIAfttGK-YGVGSLKQLGMLVAVFYLTCFVFVVVVLGAVMRLAGFSV-----FKLIRYLR 257

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 379 QALITAMGTSSSSATLPITFRCLEEgLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITA 458
Cdd:PRK13027  258 EELLIVLGTASSDAVLPQVMRKLEH-MGIKDSTVGLVIPTGYSFNLDGFSIYLTLAAVFIAQATNTPLSMHDLITILLVS 336

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462566984 459 TAASVGAAGIPQAGLVTMVIVLTSVG-LPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVI 519
Cdd:PRK13027  337 LVTSKGAHGIPGSAIVILAATLSAIPaIPVLGLVLILPVDWFMGIARALTNLIGNCVATVVV 398
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
54-533 4.79e-121

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 362.89  E-value: 4.79e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984  54 RRNAFILLTVSAVVIGVSLAFALRPYQLTYrqikyFSFPGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAA 132
Cdd:COG1301     1 FKLSLTLQILIALVLGILLGLLLPELVAAV-----LKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 133 VYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETiPTADAFMDLIRNMFPPNLVEAcfkqfktqystrvvtrtmv 212
Cdd:COG1301    76 LYFLVTTTIALVIGLVVANLFQPGAGLNLDLADAAAAEA-AEAPSLLDFLLNIIPSNIFEA------------------- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 213 rtengsepgasmpppfsvengtsFLENvtralgtlqemlsfeetvpvpgsangiNALGLVVFSVAFGLVIGGMKHKGRVL 292
Cdd:COG1301   136 -----------------------FAEG---------------------------NMLQIIFFAILFGIALAALGEKGKPL 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 293 RDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMeDMAVLGgQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFP 372
Cdd:COG1301   166 LDFFESLSEVMFKIVGWVMKLAPIGVFALIAATVAKY-GLDALG-SLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLK 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 373 FIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQIT 452
Cdd:COG1301   244 FLRAIRPALLLAFSTSSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQL 323

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 453 TISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHlSQRELELQEA 532
Cdd:COG1301   324 TIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK-WEGELDREKL 402


                  .
gi 2462566984 533 E 533
Cdd:COG1301   403 N 403
SDF pfam00375
Sodium:dicarboxylate symporter family;
58-522 9.85e-114

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 343.35  E-value: 9.85e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984  58 FILLTVSAVVIGVSLAFALRPYqltyrqIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAAVYYM 136
Cdd:pfam00375   1 LLLQILIALVLGILIGLFFPEL------AAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYFL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 137 VTTIIAVFIGILMVTIIHPGKGSKeGLHREGRIETIPTADAFMDLIRNMFPPNLVEACFKQfktqystrvvtrtmvrten 216
Cdd:pfam00375  75 VTTAIAALIGLLVANVFQPGSGLA-LIAASLKEAKAAEAPSLLDFILNIIPSNIFEALAEG------------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 217 gsepgasmpppfsvengtsflenvtralgtlqemlsfeetvpvpgsangiNALGLVVFSVAFGLVIGGMKHKGRVLRDFF 296
Cdd:pfam00375 135 --------------------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFI 164

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 297 DSLNEAIMRLVGIIIWYAPVGILFLIAGKILEmEDMAVLGgQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFPFIGG 376
Cdd:pfam00375 165 ESLQEVMMKVIGWVMKLAPIGVFALIANTVGT-YGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKK 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 377 MLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISI 456
Cdd:pfam00375 243 MLPALLTAFSTASSAATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVL 322

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462566984 457 TATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHL 522
Cdd:pfam00375 323 TATLASIGAAGVPGGGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
PRK13027 PRK13027
C4-dicarboxylate transporter DctA; Reviewed
 63-519 3.41e-40

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 183850 [Multi-domain]  Cd Length: 421  Bit Score: 150.97  E-value: 3.41e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984  63 VSAVVIGVSLAFALRPYQLTYRQIkyfsfpGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAAVYYMVTTII 141
Cdd:PRK13027   13 VIALVLGVALGAFFPHFAESLKPL------GDGFIKLIKMLIGPIVFCVVVSGIAGAgDLKKVGRVGLKAVIYFEVMTTI 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 142 AVFIGILMVTIIHPGKGSKEGLHregrieTIPTADAfmdlirnmfppnlveacfkqfktqystrvvtrtmvrtengsepg 221
Cdd:PRK13027   87 ALVIGLVLAYLTGPGVGMNIDLR------SLDAASL-------------------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 222 asmpppfsvengTSFLENVTRALGTLQEMLSFEETVPVPGSANGiNALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNE 301
Cdd:PRK13027  117 ------------AGYAKNAQSLKGTAGFLLKLIPTTAVDAFAKG-DILQVLLFSVLFGSALSLLGERAKRVNRLIDELSH 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 302 AIMRLVGIIIWYAPVGILFLIA---GKiLEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFLVthrnpFPFIGGML 378
Cdd:PRK13027  184 VLFRIMGFIIKLAPLGVLGAIAfttGK-YGVGSLKQLGMLVAVFYLTCFVFVVVVLGAVMRLAGFSV-----FKLIRYLR 257

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 379 QALITAMGTSSSSATLPITFRCLEEgLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITA 458
Cdd:PRK13027  258 EELLIVLGTASSDAVLPQVMRKLEH-MGIKDSTVGLVIPTGYSFNLDGFSIYLTLAAVFIAQATNTPLSMHDLITILLVS 336

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462566984 459 TAASVGAAGIPQAGLVTMVIVLTSVG-LPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVI 519
Cdd:PRK13027  337 LVTSKGAHGIPGSAIVILAATLSAIPaIPVLGLVLILPVDWFMGIARALTNLIGNCVATVVV 398
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 65-519 6.65e-39

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 147.99  E-value: 6.65e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984  65 AVVIGVSLAFALRpYQLTYRQ---IKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAAVYYMVTTI 140
Cdd:PRK11283   15 ALVLGILLGAYLH-YHSDSRDwlvSNLLSPAGDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIGAKTIIYFEVITT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 141 IAVFIGILMVTIIHPGKGSKEGL--------HREGRIETIPTADAFMDLIRNMFPPNLVeacfkqfktqystrvvtrtmv 212
Cdd:PRK11283   94 VAIILGITLANVFQPGAGIDMSQlatvdiskYQSTTEEVQSHSHGLMGTILSLIPTNIF--------------------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 213 rtengsepgASMpppfsvengtsflenvtrALGtlqEMLsfeetvPVpgsanginalglVVFSVAFGLVIGGMKHKGRV- 291
Cdd:PRK11283  153 ---------ASM------------------AKG---EML------PI------------IFFSVLFGLGLSSLPATHREp 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 292 LRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLggQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRnPF 371
Cdd:PRK11283  185 LVTVFRSVSETMFKVTHMVMRYAPVGVFALIAVTVANFGFASLW--PLAKLVLLVYFAILFFALVVLGIVARLCGLS-IW 261

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 372 PFIGGMLQALITAMGTSSSSATLPitfRCLE--EGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLG 449
Cdd:PRK11283  262 ILIRILKDELILAYSTASSETVLP---RIIEkmEAYGAPKSITSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIW 338

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 450 QITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVI 519
Cdd:PRK11283  339 QEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVI 408
PRK01663 PRK01663
C4-dicarboxylate transporter DctA; Reviewed
 63-535 3.00e-38

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 234968 [Multi-domain]  Cd Length: 428  Bit Score: 145.82  E-value: 3.00e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984  63 VSAVVIGVSLAFAlrpYQLTYRQIKYFsfpGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAAVYYMVTTII 141
Cdd:PRK01663   14 LVAIIIGILLGHF---YPELGAQMKPL---GDGFIKLIKMIIAPIIFCTVVTGIAGMgDMKKVGRVGGKALLYFEIVSTI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 142 AVFIGILMVTIIHPGKGskeglhregrietiptadafmdliRNMFPPNLVEACFKQFktqystrvvtrtmvrTENGSEPG 221
Cdd:PRK01663   88 ALIIGLIVVNVVQPGAG------------------------MNIDPATLDAKAVAQY---------------AAQAHEQG 128

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 222 AsmpppfsvengTSFLENVtralgtlqemlsfeetvpVPGS-----ANGiNALGLVVFSVAFGLVIGGMKHKGRVLRDFF 296
Cdd:PRK01663  129 T-----------VDFLMDI------------------IPTTvvgafASG-DILQVLLFAVLFGFALARLGEKGKPVFDFI 178

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 297 DSLNEAIMRLVGIIIWYAPVGILFLIAGKI--LEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFlvthrNPFPFI 374
Cdd:PRK01663  179 ESLSHVLFGIVNMIMKLAPIGAFGAMAFTIgkYGVGSLVQLGQLIGCFYITCILFVFVVLGAIARLTGF-----SIFKFI 253

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 375 GGMLQALITAMGTSSSSATLPITFRCLEEgLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTI 454
Cdd:PRK01663  254 RYIKEELLIVLGTSSSESALPRMMEKMEK-LGCKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNTPLSIGHQITL 332

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 455 SITATAASVGAAGIPQAGLVTMVIVLTSVG-LPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIehlSQRELELQEAE 533
Cdd:PRK01663  333 LAVLLLTSKGAAGVTGSGFIVLAATLSAVPhIPVAGLALILGIDRFMSEARALTNLIGNGVATVVV---AKWEKELDREK 409


                  ..
gi 2462566984 534 LT 535
Cdd:PRK01663  410 LD 411
TcyP COG1823
L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and ...
 64-519 1.67e-18

L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and metabolism];


Pssm-ID: 441428  Cd Length: 463  Bit Score: 88.34  E-value: 1.67e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984  64 SAVVIGVSLAFALrpyQLTY--------RQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLDN-KATGRMGMRAAVY 134
Cdd:COG1823    36 TGLGLGILFGLIL---QLIYgagspvikQSIDWFNIVGNGYVRLLQMIVMPLVFVSILSAITKLKNaSSLGKISGLIIGI 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 135 YMVTTIIAVFIGILMVTIIHPgkgSKEGLHrEGRIEtiptadafmdlirnmfppnlveacfkqfktqystrvvtrtmvrT 214
Cdd:COG1823   113 LLGTTAIAALVGILVALLFGL---TAEGLT-QGAAE-------------------------------------------T 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 215 ENGSEpgasmpppfsVENGTSFLENVTRAlgtlQEMLSFEETVP---VPGsANGINALGLVVFSVAFGLVIGGMKHK--- 288
Cdd:COG1823   146 ARGEA----------LEERLGEVEDLSLP----QQILSFIPTNPfadLTG-ARPTSTIAVVIFAAFLGIAALGLRRKkpe 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 289 -GRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAgKIL---EMEDMAVLGGQLGMYTLTVIVGLFLHagivlpLIYFL 364
Cdd:COG1823   211 qAETFLKGIDALQAIVMRLVRLVLRLTPYGVLALMT-KVVatsDFADILNLGKFVVASYVALIIMFIVH------LLLLA 283

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 365 VTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTA-LYEALAAIFIA-QVN 442
Cdd:COG1823   284 LAGLNPLTYFKKVWPVLTFAFTSRSSAGTIPLNIETQTKRLGVPEGIANFAASFGATIGQNGCAgIYPAMLAVMIApTVG 363

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462566984 443 NYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVlGDSIGAAVI 519
Cdd:COG1823   364 INPLDPSFILTLIAVVTISSFGVAGVGGGATFAALIVLSAMGLPVALAGLLISIEPLIDMGRTALNV-SGSMTAGTV 439
PRK13628 PRK13628
serine/threonine transporter SstT; Provisional
 263-468 9.83e-18

serine/threonine transporter SstT; Provisional


Pssm-ID: 184190 [Multi-domain]  Cd Length: 402  Bit Score: 85.30  E-value: 9.83e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 263 ANGINAL------GLVVFSVAFGLvigGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLG 336
Cdd:PRK13628  136 DNPINALlnanyiGILAWAIGLGL---ALRHASDTTKNVVNDLSEAVSQIVKWVIRFAPIGIFGLVASTLAETGFSALAG 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 337 -GQLgmytLTVIVG-LFLHAGIVLPLIYFLVTHRNPFPFIggmLQAL----ITAMGTSSSSATLPITFRcLEEGLGVDRR 410
Cdd:PRK13628  213 yAQL----LAVLVGcMLFVALVVNPLIVFWKIRRNPYPLV---FTCLresgVTAFFTRSSAANIPVNMA-LCEKLGLDED 284

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462566984 411 ITRFVLPVGATVNMDGtalyealAAIFI-----AQVN--NYELNLGQITTISITATAASVGAAGI 468
Cdd:PRK13628  285 TYSVSIPLGATINMAG-------AAITItvltlAAVHtlGIPVDLPTALLLSVVAAISACGASGV 342
SstT COG3633
Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];
263-469 1.46e-17

Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];


Pssm-ID: 442850  Cd Length: 406  Bit Score: 84.84  E-value: 1.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 263 ANGINAL------GLVVFSVAFGLvigGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLG 336
Cdd:COG3633   135 DNPVNALananyiGILAWAIGLGL---ALRHASDTTKTVLSDLSDAVSKIVRWVIRFAPLGIFGLVASTVATTGFSALLG 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 337 -GQLgmytLTVIVG-LFLHAGIVLPLIYFLVTHRNPFPFIggmLQAL----ITAMGTSSSSATLPITFRcLEEGLGVDRR 410
Cdd:COG3633   212 yAHL----LAVLVGcMLFVALVVNPLIVFLKIRRNPYPLV---FTCLresgITAFFTRSSAANIPVNMA-LCEKLGLDED 283

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462566984 411 ITRFVLPVGATVNMDGtalyealAAIFI-----AQVN--NYELNLGQITTISITATAASVGAAGIP 469
Cdd:COG3633   284 TYSVSIPLGATINMAG-------AAITItvltlAAVHtlGIEVDLPTALLLSVVAAVSACGASGVA 342
PRK14695 PRK14695
serine/threonine transporter SstT; Provisional
 267-526 7.96e-13

serine/threonine transporter SstT; Provisional


Pssm-ID: 173158  Cd Length: 319  Bit Score: 69.69  E-value: 7.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 267 NALGLVVFSVAFGLvigGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVlgGQLGMYTLTV 346
Cdd:PRK14695   60 NYIGILSWAVIFGI---AMREASKNSKELLKTIADVTSKIVEWIINLAPFGILGLVFKTISDKGVGSL--ANYGILLVLL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 347 IVGLFLHAGIVLPLIYFLVTHRNPFPFIGGMLQ-ALITAMGTSSSSATLPITFRCLEEgLGVDRRITRFVLPVGATVNMD 425
Cdd:PRK14695  135 VTTMLFVAPVVNPLIAFFFMRRNPYPLVWNCLRvSGVTAFFTRSSATNIPVNMKLCHD-LGLNPDTYSVSIPLGSTINMA 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566984 426 GTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFL----D 501
Cdd:PRK14695  214 GVAITINLLTLVTVNTLGIPVDFATAFVLSVVAAISACGASGIAGGSLLLIPVACSLFGISNDIAIQIVGVGFVIgviqD 293

                         250       260
                  ....*....|....*....|....*
gi 2462566984 502 RLRTMTNVLGDSIGAAVIEHLSQRE 526
Cdd:PRK14695  294 SCETALNSSTDVLFTAVAEYAATRK 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH