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Conserved domains on  [gi|2462564619|ref|XP_054176608|]
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MEF2-activating motif and SAP domain-containing transcriptional regulator isoform X4 [Homo sapiens]

Protein Classification

SAP domain-containing protein( domain architecture ID 10488483)

SAP (SAF-A/B, Acinus and PIAS) domain-containing protein may bind DNA or RNA and act as a transcriptional regulator.

Gene Ontology:  GO:0003712|GO:0005634
PubMed:  10694879

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 235-264 6.39e-08

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


:

Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 48.55  E-value: 6.39e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462564619 235 LEELTVSELRQQLRLRGLPVSGTKSMLLER 264
Cdd:pfam02037   1 LSKLTVAELKEELRKRGLPTSGKKAELIER 30
 
Name Accession Description Interval E-value
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 235-264 6.39e-08

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 48.55  E-value: 6.39e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462564619 235 LEELTVSELRQQLRLRGLPVSGTKSMLLER 264
Cdd:pfam02037   1 LSKLTVAELKEELRKRGLPTSGKKAELIER 30
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
235-264 9.16e-07

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 45.17  E-value: 9.16e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462564619  235 LEELTVSELRQQLRLRGLPVSGTKSMLLER 264
Cdd:smart00513   1 LAKLKVSELKDELKKRGLSTSGTKAELVDR 30
 
Name Accession Description Interval E-value
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 235-264 6.39e-08

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 48.55  E-value: 6.39e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462564619 235 LEELTVSELRQQLRLRGLPVSGTKSMLLER 264
Cdd:pfam02037   1 LSKLTVAELKEELRKRGLPTSGKKAELIER 30
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
235-264 9.16e-07

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 45.17  E-value: 9.16e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462564619  235 LEELTVSELRQQLRLRGLPVSGTKSMLLER 264
Cdd:smart00513   1 LAKLKVSELKDELKKRGLSTSGTKAELVDR 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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