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Conserved domains on  [gi|2462553490|ref|XP_054171222|]
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ankyrin repeat and fibronectin type-III domain-containing protein 1 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 265-358 1.19e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 1.19e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553490  265 PEMPTNVCLMVTSSTSLTVSFQEPLSVNAAVvTRYKVEWSmsEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAY 344
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPI-TGYVVEYR--EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....
gi 2462553490  345 NMKGWGPAQTTTPA 358
Cdd:cd00063     78 NGGGESPPSESVTV 91
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
128-192 4.90e-07

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.65  E-value: 4.90e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462553490  128 NFQGNEAMFEAVEQQDMDAVQILLYQYTpeelDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGA 192
Cdd:COG0666    150 DNDGNTPLHLAAANGNLEIVKLLLEAGA----DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 265-358 1.19e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 1.19e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553490  265 PEMPTNVCLMVTSSTSLTVSFQEPLSVNAAVvTRYKVEWSmsEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAY 344
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPI-TGYVVEYR--EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....
gi 2462553490  345 NMKGWGPAQTTTPA 358
Cdd:cd00063     78 NGGGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
268-351 1.96e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 1.96e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553490  268 PTNVCLMVTSSTSLTVSFQEPLSVNAaVVTRYKVEWSMSEDFSPLAgEIIMDNlQTLRCTITGLTMGQQYFVQVSAYNMK 347
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNG-PITGYEVEYRPKNSGEPWN-EITVPG-TTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 2462553490  348 GWGP 351
Cdd:pfam00041   80 GEGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 265-350 1.57e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.39  E-value: 1.57e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553490   265 PEMPTNVCLMVTSSTSLTVSFQEPLSvnaAVVTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAY 344
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPD---DGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 2462553490   345 NMKGWG 350
Cdd:smart00060   78 NGAGEG 83
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
128-192 4.90e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.65  E-value: 4.90e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462553490  128 NFQGNEAMFEAVEQQDMDAVQILLYQYTpeelDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGA 192
Cdd:COG0666    150 DNDGNTPLHLAAANGNLEIVKLLLEAGA----DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210
Ank_2 pfam12796
Ankyrin repeats (3 copies);
131-192 3.36e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.57  E-value: 3.36e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462553490  131 GNEAMFEAVEQQDMDAVQILLyqytpEELDLNtPNSEGLTPLDIAIMTNNVPIARILLRTGA 192
Cdd:pfam12796   30 GRTALHLAAKNGHLEIVKLLL-----EHADVN-LKDNGRTALHYAARSGHLEIVKLLLEKGA 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
264-345 7.13e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 43.84  E-value: 7.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553490  264 APEMPTNVCLMVTSSTSLTVSFQeplSVNAAVVTRYKVEWSMSED--FSPLAgeiimdNLQTLRCTITGLTMGQQYFVQV 341
Cdd:COG3401    232 PPSAPTGLTATADTPGSVTLSWD---PVTESDATGYRVYRSNSGDgpFTKVA------TVTTTSYTDTGLTNGTTYYYRV 302


                   ....
gi 2462553490  342 SAYN 345
Cdd:COG3401    303 TAVD 306
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 265-358 1.19e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 1.19e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553490  265 PEMPTNVCLMVTSSTSLTVSFQEPLSVNAAVvTRYKVEWSmsEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAY 344
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPI-TGYVVEYR--EKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....
gi 2462553490  345 NMKGWGPAQTTTPA 358
Cdd:cd00063     78 NGGGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
268-351 1.96e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 1.96e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553490  268 PTNVCLMVTSSTSLTVSFQEPLSVNAaVVTRYKVEWSMSEDFSPLAgEIIMDNlQTLRCTITGLTMGQQYFVQVSAYNMK 347
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNG-PITGYEVEYRPKNSGEPWN-EITVPG-TTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 2462553490  348 GWGP 351
Cdd:pfam00041   80 GEGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 265-350 1.57e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.39  E-value: 1.57e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553490   265 PEMPTNVCLMVTSSTSLTVSFQEPLSvnaAVVTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAY 344
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPD---DGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 2462553490   345 NMKGWG 350
Cdd:smart00060   78 NGAGEG 83
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
128-192 4.90e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.65  E-value: 4.90e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462553490  128 NFQGNEAMFEAVEQQDMDAVQILLYQYTpeelDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGA 192
Cdd:COG0666    150 DNDGNTPLHLAAANGNLEIVKLLLEAGA----DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
128-192 2.55e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 50.72  E-value: 2.55e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462553490  128 NFQGNEAMFEAVEQQDMDAVQILLYQytpeELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGA 192
Cdd:COG0666     84 DDGGNTLLHAAARNGDLEIVKLLLEA----GADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA 144
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
127-192 5.46e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.57  E-value: 5.46e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462553490  127 VNFQGNEAMFEAVEQQDMDAVQILLyqytpeEL--DLNTPNSEGLTPLDIAIMTNNVPIARILLRTGA 192
Cdd:COG0666    116 RDKDGETPLHLAAYNGNLEIVKLLL------EAgaDVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177
Ank_2 pfam12796
Ankyrin repeats (3 copies);
131-192 3.36e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.57  E-value: 3.36e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462553490  131 GNEAMFEAVEQQDMDAVQILLyqytpEELDLNtPNSEGLTPLDIAIMTNNVPIARILLRTGA 192
Cdd:pfam12796   30 GRTALHLAAKNGHLEIVKLLL-----EHADVN-LKDNGRTALHYAARSGHLEIVKLLLEKGA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
135-188 2.64e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.87  E-value: 2.64e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462553490  135 MFEAVEQQDMDAVQILLYqytpEELDLNTPNSEGLTPLDIAIMTNNVPIARILL 188
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLE----NGADANLQDKNGRTALHLAAKNGHLEIVKLLL 50
Ank_4 pfam13637
Ankyrin repeats (many copies);
131-188 2.70e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 2.70e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462553490  131 GNEAMFEAVEQQDMDAVQILLYQytpeELDLNTPNSEGLTPLDIAIMTNNVPIARILL 188
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEK----GADINAVDGNGETALHFAASNGNVEVLKLLL 54
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
264-345 7.13e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 43.84  E-value: 7.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553490  264 APEMPTNVCLMVTSSTSLTVSFQeplSVNAAVVTRYKVEWSMSED--FSPLAgeiimdNLQTLRCTITGLTMGQQYFVQV 341
Cdd:COG3401    232 PPSAPTGLTATADTPGSVTLSWD---PVTESDATGYRVYRSNSGDgpFTKVA------TVTTTSYTDTGLTNGTTYYYRV 302


                   ....
gi 2462553490  342 SAYN 345
Cdd:COG3401    303 TAVD 306
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
264-345 1.14e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 43.07  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553490  264 APEMPTNVCLMVTSSTSLTVSFQEPLSVNaavVTRYKVEWSMSEDFSPlagEIIMDNLQTLRCTITGLTMGQQYFVQVSA 343
Cdd:COG3401    326 PPAAPSGLTATAVGSSSITLSWTASSDAD---VTGYNVYRSTSGGGTY---TKIAETVTTTSYTDTGLTPGTTYYYKVTA 399


                   ..
gi 2462553490  344 YN 345
Cdd:COG3401    400 VD 401
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
127-194 1.58e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.86  E-value: 1.58e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462553490  127 VNFQGNEAMFEAVEQQDMDAVQILLyqytpeEL--DLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARE 194
Cdd:COG0666    182 RDNDGETPLHLAAENGHLEIVKLLL------EAgaDVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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