BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  339 SLGLLVADFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQYVNNEGFSA-VEDGVLTQRVLLGDVSTEAARTF 417
Cdd:cd18288      1 SLGKLAADFSAMVNNPHLSDVQFQTDSGEVLYAHSFVLYARCPLLIQMVHSEGFSVeEEGGVTTRRVLLGDVSGEAARCF 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2462551323  418 LHYLYTADTGLPPGLSSELSSLAHRFGVSELVHLCE 453
Cdd:cd18288     81 LQYLYTADTGLPPGLSPHVSELADRFGVSELVHLCE 116

Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462551323 1420 EALRCYIRSKPALYQKVLLYQPFELRELQAELRQNG--LRVSSRRLLDFLDTHCITFTT 1476
Cdd:pfam09494    2 EAITELIKSDPSLYEKILTYEPIVLEDLTAWLNEGGflIEVDPGTLKEWCDSQGICFTN 60

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  339 SLGLLVADFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQYVNNEGFSA-VEDGVLTQRVLLGDVSTEAARTF 417
Cdd:cd18288      1 SLGKLAADFSAMVNNPHLSDVQFQTDSGEVLYAHSFVLYARCPLLIQMVHSEGFSVeEEGGVTTRRVLLGDVSGEAARCF 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2462551323  418 LHYLYTADTGLPPGLSSELSSLAHRFGVSELVHLCE 453
Cdd:cd18288     81 LQYLYTADTGLPPGLSPHVSELADRFGVSELVHLCE 116

Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462551323 1420 EALRCYIRSKPALYQKVLLYQPFELRELQAELRQNG--LRVSSRRLLDFLDTHCITFTT 1476
Cdd:pfam09494    2 EAITELIKSDPSLYEKILTYEPIVLEDLTAWLNEGGflIEVDPGTLKEWCDSQGICFTN 60

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323   365 SGEVLYAHKFVLYARCPLLIQYVNNEGFSAVEDgvltqRVLLGDVSTEAARTFLHYLYTADTGLPPGLSSELSSLAHRFG 444
Cdd:smart00225    7 GGKKFHAHKAVLAAHSPYFKALFSSDFKESDKS-----EIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQ 81

                            90
                    ....*....|
gi 2462551323   445 VSELVHLCEQ 454
Cdd:smart00225   82 IPGLVELCEE 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  339 SLGLLVADFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQYVNNEGFSA-VEDGVLTQRVLLGDVSTEAARTF 417
Cdd:cd18288      1 SLGKLAADFSAMVNNPHLSDVQFQTDSGEVLYAHSFVLYARCPLLIQMVHSEGFSVeEEGGVTTRRVLLGDVSGEAARCF 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2462551323  418 LHYLYTADTGLPPGLSSELSSLAHRFGVSELVHLCE 453
Cdd:cd18288     81 LQYLYTADTGLPPGLSPHVSELADRFGVSELVHLCE 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  343 LVADFGAMVNNPHLSDVQFQ-TDSGEVLYAHKFVLYARCPLlIQYVNNEGFSAVEDgvlTQRVLLGDVSTEAARTFLHYL 421
Cdd:cd18294      1 FAADMKSLINNPEFSDVKFLvGPERQEIFAHKCILAARCEV-FRAMFLTGPQKEST---QSPLVLSDIEPEVFRAVLEFI 76

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2462551323  422 YTADTGLPPGLSSELSSLAHRFGVSELVHLCEQ 454
Cdd:cd18294     77 YTNCVTLSNHTVIEVLAAAVEYGLDELRKLCER 109

Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462551323 1420 EALRCYIRSKPALYQKVLLYQPFELRELQAELRQNG--LRVSSRRLLDFLDTHCITFTT 1476
Cdd:pfam09494    2 EAITELIKSDPSLYEKILTYEPIVLEDLTAWLNEGGflIEVDPGTLKEWCDSQGICFTN 60

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  346 DFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCP---LLIqyvnnegfsavedGVLTQRVLLGDVSTEAARTFLHYLY 422
Cdd:cd18299      2 DLRNLLHSPSCADVVFILQGGVRIFAHRIVLAAASSvfaDLF-------------LMMTVVTLDSDITPEAFRRVLEFLY 68

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2462551323  423 TADTGLPPGLSSELSSLAHRFGVSELVHLCEQV 455
Cdd:cd18299     69 TGVLDENEDDLKELKDAAELLELFDLVMMCTNV 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  352 NNPHLSDVQFQTDsGEVLYAHKFVLYARCplliQYVNNEgFSAVEDGVLTQRVLLGDVSTEAARTFLHYLYTADTGLPPG 431
Cdd:cd18298      8 NDPRTSDLKFRVD-GKYIYVHKAILKIRC----EYFRSM-FQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPE 81

                           90       100
                   ....*....|....*....|...
gi 2462551323  432 LSSELSSLAHRFGVSELVHLCEQ 454
Cdd:cd18298     82 DAIGLLDLANSYCEERLKKLCED 104

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  347 FGAMVNNPHLSDVQFQTDsGEVLYAHKFVLYARCPLLiqyvnNEGFSAVEDGVLTQRVLLGDVSTEAARTFLHYLYTaDT 426
Cdd:pfam00651    1 LNELREQGELCDVTLVVG-DKEFRAHKAVLAACSPYF-----KALFSGQESESSVSEITLDDVSPEDFEALLEFMYT-GK 73

                           90       100
                   ....*....|....*....|....*...
gi 2462551323  427 GLPPGLSSELSSLAHRFGVSELVHLCEQ 454
Cdd:pfam00651   74 LISEENVDDLLAAADKLQIPSLVDKCEE 101

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  348 GAMVNNPHLSDVQFQTdSGEVLYAHKFVLYARCPLLIQYVNneGFSAVEDGVLtqrVLLGDVSTEAARTFLHYLYTaDTG 427
Cdd:cd18360      2 GLFFNSPLLADVVFKI-QGTTVPAHRAVLVARCEVMAAMFN--GNYAEAKSFL---VPIYGVSKDTFLSFLEYLYT-DSC 74

                           90       100
                   ....*....|....*....|....*...
gi 2462551323  428 LPPGLSSELSSL--AHRFGVSELVHLCE 453
Cdd:cd18360     75 CPASILQAMALLicAEMYQVSRLQHICE 102

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323   365 SGEVLYAHKFVLYARCPLLIQYVNNEGFSAVEDgvltqRVLLGDVSTEAARTFLHYLYTADTGLPPGLSSELSSLAHRFG 444
Cdd:smart00225    7 GGKKFHAHKAVLAAHSPYFKALFSSDFKESDKS-----EIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQ 81

                            90
                    ....*....|
gi 2462551323   445 VSELVHLCEQ 454
Cdd:smart00225   82 IPGLVELCEE 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  352 NNPHLSDVQFQTDsGEVLYAHKFVLYARCP---LLIQYVNNEGFSAVedgvltqrVLLGDVSTEAARTFLHYLYTADTGL 428
Cdd:cd18353     16 DSPETSDLKFRVD-GKYIHVHKAVLKIRCEhfrTMFQSHWNEDMKEV--------IEIDQFSYPVYRAFLEYLYTDSVDL 86

                           90       100
                   ....*....|....*....|....*..
gi 2462551323  429 PPGLSSELSSLAHRFGVSELVHLCEQV 455
Cdd:cd18353     87 PPEDAIGLLDLATSYCENRLKKLCQHI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  346 DFGAMVNNPHLSDVQFQTDsGEVLYAHKFVLYARCPlliqYVNNEGFSAVEDGVlTQRVLLGDVSTEAARTFLHYLYT-- 423
Cdd:cd18280      4 HFGALLESEEGADVTFNVD-GEKFRAHKLVLAARSP----VFRSMLFGPMREEN-EGEIVIEDVEPPVFKALLHFIYKde 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2462551323  424 -----ADTGLPPGLSSE-----LSSLAHRFGVSELVHLCE 453
Cdd:cd18280     78 lpddvEPAGSDSSSLDTtmaqhLLAAADRYALERLRLLCE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  343 LVADFGAMVNNPHLSDVQFQTdSGEVLYAHKFVLYARCPlliqyVNNEGFSAVEDGVLTQRVLLGDVSTEAARTFLHYLY 422
Cdd:cd18345      5 LSDDLGLLFERSAFSDVTLCV-GGREFQAHKAILAARSP-----VFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIY 78

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462551323  423 TADTGLPPGLSSELSSLAHRFGVSELVHLCEQ 454
Cdd:cd18345     79 TGKAPNLDKMADDLLAAADKYALERLKVMCEE 110

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  341 GLLVADFGAMVNNPHL--SDVQFQTDSGEVLYAHKFVLYARCPLLIQYvnnegFSAVEDGVLTQRVLL--------GDVS 410
Cdd:cd18310      1 KKLSSDLENLLDSPDLfySDAEIIVEGGRPVPVHRCILAARSPFFRDI-----FASAKAEGANTKPKLelrelipgGIVG 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462551323  411 TEAARTFLHYLYTADTGLPPGLSS--------------------ELSSLAHRFGVSELVHLCEQ 454
Cdd:cd18310     76 YDAFMLVLSYLYSGRLRLVPKEGSacvdsdcwhvacrpavdfalEVLYAASVFQIPELVSLFQR 139

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  356 LSDVQFQTDSGEVLyAHKFVLYARCPLLIQYVnneGFSAVEDGvlTQRVLLGDVSTEAARTFLHYLYTADTGLPPGLSS- 434
Cdd:cd18359     20 FSDVTFMLDDGTIS-AHKPLLISSCDWMAAMF---GGPFVESS--TTEVVFPYTSRSSMRAVLEYLYTGQFSSSPDLDDm 93

                           90       100
                   ....*....|....*....|
gi 2462551323  435 ELSSLAHRFGVSELVHLCEQ 454
Cdd:cd18359     94 KLIILANRLCLPHLVALTEQ 113

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  346 DFGAMVNNPHLSDVQFQT-DSGEVLYAHKFVLYARCPLLI---------------QYVNNEGFSAVEDGVLTQR-----V 404
Cdd:cd18308     13 DFGRLLESRQFCDVEFIVgEEEERIPAHIAFVAARSKWLRnkilqarerqkqkaeQEVEDEGSEADSSSASKNDspmleV 92

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462551323  405 LLGDVSTEAARTFLHYLYT-----ADTGLPPG------LSSELSSLAHRFGVSELVHLCEQ 454
Cdd:cd18308     93 RLPEADPEAFELILSFIYTdkidpTRKGQDPGsnevvlLMMDVYRLALQFQMSRLEQLCVQ 153

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  343 LVADFGAMVNNPHLSDVQFQTdSGEVLYAHKFVLYARCPlliqyVNNEGFSAVEDGVLTQRVLLGDVSTEAARTFLHYLY 422
Cdd:cd18343      8 LAEDLGNLWENSRFTDCSLFV-GGQEFKAHKSILAARSP-----VFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIY 81

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462551323  423 TADTGLPPGLSSELSSLAHRFGVSELVHLCEQ 454
Cdd:cd18343     82 TGKAPNLDKMADNLLAAADKYALERLKVMCEE 113

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551323  354 PHLSDVQFQTDSGEVLYAHKFVLYARcpllIQYVNNEGFSAVEDGVLTQRVLLgDVSTEAARTFLHYLYTADT-GLPPGL 432
Cdd:cd18302      3 SDLYDVTIVSEDGKEFPCHKCVLVAR----LEYFHSMLSSSWIEASSCSALTM-PIPSDILEIILDYLYTDEAsAVKESQ 77

                           90       100
                   ....*....|....*....|....*
gi 2462551323  433 SSELSS----LAHRFGVSELVHLCE 453
Cdd:cd18302     78 NVEFLCnvlvIADQLLITRLKEICE 102