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Conserved domains on  [gi|2217347213|ref|XP_047305282|]
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TPR and ankyrin repeat-containing protein 1 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HelD super family cl28314
DNA helicase IV [Replication, recombination and repair];
1429-1625 3.19e-11

DNA helicase IV [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG3973:

Pssm-ID: 443173 [Multi-domain]  Cd Length: 699  Bit Score: 69.12  E-value: 3.19e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213 1429 DEIQDFTQAELALLMKCIndPNSMF-LTGDTAQSImkgvaFRFSDLRSLfhyasRNTIDKqcAVRKPKKIHQLYQNYRSH 1507
Cdd:COG3973    476 DEAQDLSPMQWRVLKRRF--PSASFtIVGDLAQAI-----HPYRGAESW-----EEVLEP--LGGDRARLVELTKSYRST 541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213 1508 SGILNLASGVVDLLQF--YFPESFDRlprdsglfDGPKPTVLESCSVSDLAILLRGNKRKTQPIEFGAHQVI-------- 1577
Cdd:COG3973    542 AEIMEFANRVLRAAGPdlPPPESVRR--------HGEPPRVVRVPSEAELAAAVVEAVRELLAEGEGTIAVIcktareae 613

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217347213 1578 -----LVANETAKEKIPEELGLA---LVLTIYEAKGLEFDDVLLYNFftDSEAYKE 1625
Cdd:COG3973    614 alyaaLKAGLPVTLIDDESEELEagvVVLPAYLAKGLEFDAVVVVDP--DEIVYES 667
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
486-636 1.07e-09

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.28  E-value: 1.07e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  486 LIDSGALPDGLQESQERPVVTCLKHEDFELAFLLLTKGADPRAISlTEGDTPLHAA--------LHIFLEIKADIgfsfl 557
Cdd:COG0666    106 LLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQD-NDGNTPLHLAaangnleiVKLLLEAGADV----- 179

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217347213  558 shlldlfwsnptefdylnpNVQDSNGNTLMHILFQKGMLKRVKklldLLVKFDINFNLKNKEGKDARHRIKKNDSLLLA 636
Cdd:COG0666    180 -------------------NARDNDGETPLHLAAENGHLEIVK----LLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
219-389 1.13e-08

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.20  E-value: 1.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  219 PKLVQWLISIGASVETIGPYPLHALMRLciqARENHL--FRWLMDHKPEwkgrINQKDGDGCTVLHVVAAHspgylvkRQ 296
Cdd:COG0666    133 LEIVKLLLEAGADVNAQDNDGNTPLHLA---AANGNLeiVKLLLEAGAD----VNARDNDGETPLHLAAEN-------GH 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  297 TEDVQMLLRFGADPTLLDRQSRSVVDVLKRNKNFKAIEKINSHLEKLATcsKDLSGFSNGDGPTSENDIFRKVLEQLVKY 376
Cdd:COG0666    199 LEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA--KDKDGLTALLLAAAAGAALIVKLLLLALL 276

                          170
                   ....*....|...
gi 2217347213  377 MNSGNRLLHKNFL 389
Cdd:COG0666    277 LLAAALLDLLTLL 289
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
6-114 1.52e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.32  E-value: 1.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213    6 YAELLKESGNQVLKNGNFSLAIRKYDEAIQIllqlyqwgvpPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYV 85
Cdd:COG0457      7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALEL----------DPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDA 76

                           90       100
                   ....*....|....*....|....*....
gi 2217347213   86 KGYYRAGYSLLRLHQPYEAARMFFEGLRL 114
Cdd:COG0457     77 EALNNLGLALQALGRYEEALEDYDKALEL 105
 
Name Accession Description Interval E-value
HelD COG3973
DNA helicase IV [Replication, recombination and repair];
1429-1625 3.19e-11

DNA helicase IV [Replication, recombination and repair];


Pssm-ID: 443173 [Multi-domain]  Cd Length: 699  Bit Score: 69.12  E-value: 3.19e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213 1429 DEIQDFTQAELALLMKCIndPNSMF-LTGDTAQSImkgvaFRFSDLRSLfhyasRNTIDKqcAVRKPKKIHQLYQNYRSH 1507
Cdd:COG3973    476 DEAQDLSPMQWRVLKRRF--PSASFtIVGDLAQAI-----HPYRGAESW-----EEVLEP--LGGDRARLVELTKSYRST 541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213 1508 SGILNLASGVVDLLQF--YFPESFDRlprdsglfDGPKPTVLESCSVSDLAILLRGNKRKTQPIEFGAHQVI-------- 1577
Cdd:COG3973    542 AEIMEFANRVLRAAGPdlPPPESVRR--------HGEPPRVVRVPSEAELAAAVVEAVRELLAEGEGTIAVIcktareae 613

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217347213 1578 -----LVANETAKEKIPEELGLA---LVLTIYEAKGLEFDDVLLYNFftDSEAYKE 1625
Cdd:COG3973    614 alyaaLKAGLPVTLIDDESEELEagvVVLPAYLAKGLEFDAVVVVDP--DEIVYES 667
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
486-636 1.07e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.28  E-value: 1.07e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  486 LIDSGALPDGLQESQERPVVTCLKHEDFELAFLLLTKGADPRAISlTEGDTPLHAA--------LHIFLEIKADIgfsfl 557
Cdd:COG0666    106 LLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQD-NDGNTPLHLAaangnleiVKLLLEAGADV----- 179

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217347213  558 shlldlfwsnptefdylnpNVQDSNGNTLMHILFQKGMLKRVKklldLLVKFDINFNLKNKEGKDARHRIKKNDSLLLA 636
Cdd:COG0666    180 -------------------NARDNDGETPLHLAAENGHLEIVK----LLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
219-389 1.13e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.20  E-value: 1.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  219 PKLVQWLISIGASVETIGPYPLHALMRLciqARENHL--FRWLMDHKPEwkgrINQKDGDGCTVLHVVAAHspgylvkRQ 296
Cdd:COG0666    133 LEIVKLLLEAGADVNAQDNDGNTPLHLA---AANGNLeiVKLLLEAGAD----VNARDNDGETPLHLAAEN-------GH 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  297 TEDVQMLLRFGADPTLLDRQSRSVVDVLKRNKNFKAIEKINSHLEKLATcsKDLSGFSNGDGPTSENDIFRKVLEQLVKY 376
Cdd:COG0666    199 LEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA--KDKDGLTALLLAAAAGAALIVKLLLLALL 276

                          170
                   ....*....|...
gi 2217347213  377 MNSGNRLLHKNFL 389
Cdd:COG0666    277 LLAAALLDLLTLL 289
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
6-114 1.52e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.32  E-value: 1.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213    6 YAELLKESGNQVLKNGNFSLAIRKYDEAIQIllqlyqwgvpPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYV 85
Cdd:COG0457      7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALEL----------DPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDA 76

                           90       100
                   ....*....|....*....|....*....
gi 2217347213   86 KGYYRAGYSLLRLHQPYEAARMFFEGLRL 114
Cdd:COG0457     77 EALNNLGLALQALGRYEEALEDYDKALEL 105
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 5-112 4.13e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 49.21  E-value: 4.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213    5 AYAELLKESGNQVLKNgnfslaiRKYDEAIQillqLYQWGVPPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTY 84
Cdd:TIGR00990  125 KYAAKLKEKGNKAYRN-------KDFNKAIK----LYSKAIECKPDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDY 193

                           90       100
                   ....*....|....*....|....*...
gi 2217347213   85 VKgyyragySLLRLHQPYEAARMFFEGL 112
Cdd:TIGR00990  194 SK-------ALNRRANAYDGLGKYADAL 214
PHA03095 PHA03095
ankyrin-like protein; Provisional
 216-387 1.85e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.94  E-value: 1.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  216 EQVPKLVQWLISIGASVETI---GPYPLHALMRLCIQARenhLFRWLMDHKpewkGRINQKDGDGCTVLHVvaahspgYL 292
Cdd:PHA03095    60 EKVKDIVRLLLEAGADVNAPercGFTPLHLYLYNATTLD---VIKLLIKAG----ADVNAKDKVGRTPLHV-------YL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  293 -VKRQTEDV-QMLLRFGADPTLLDRQSRSVVDVLKRNKNfkaiekINSHLEKLAtcskdlsgFSNGDGPTSENDIFRKVL 370
Cdd:PHA03095   126 sGFNINPKViRLLLRKGADVNALDLYGMTPLAVLLKSRN------ANVELLRLL--------IDAGADVYAVDDRFRSLL 191

                          170
                   ....*....|....*..
gi 2217347213  371 EQLVKYMNSGNRLLHKN 387
Cdd:PHA03095   192 HHHLQSFKPRARIVREL 208
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 22-110 2.16e-03

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 43.24  E-value: 2.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213   22 NFSLAIRKYDEAIQIllqlyqwgVPPRdlAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVKGYYRAGYSLLRLHQp 101
Cdd:PLN03088    17 DFALAVDLYTQAIDL--------DPNN--AELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEE- 85


                   ....*....
gi 2217347213  102 YEAARMFFE 110
Cdd:PLN03088    86 YQTAKAALE 94
Ank_2 pfam12796
Ankyrin repeats (3 copies);
219-314 2.69e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.33  E-value: 2.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  219 PKLVQWLISIGASVETIGPYPLHALMrLCIQARENHLFRWLMDHkpewkGRINQKDgDGCTVLHVVAAHspgylvkRQTE 298
Cdd:pfam12796   10 LELVKLLLENGADANLQDKNGRTALH-LAAKNGHLEIVKLLLEH-----ADVNLKD-NGRTALHYAARS-------GHLE 75

                           90
                   ....*....|....*.
gi 2217347213  299 DVQMLLRFGADPTLLD 314
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
 
Name Accession Description Interval E-value
HelD COG3973
DNA helicase IV [Replication, recombination and repair];
1429-1625 3.19e-11

DNA helicase IV [Replication, recombination and repair];


Pssm-ID: 443173 [Multi-domain]  Cd Length: 699  Bit Score: 69.12  E-value: 3.19e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213 1429 DEIQDFTQAELALLMKCIndPNSMF-LTGDTAQSImkgvaFRFSDLRSLfhyasRNTIDKqcAVRKPKKIHQLYQNYRSH 1507
Cdd:COG3973    476 DEAQDLSPMQWRVLKRRF--PSASFtIVGDLAQAI-----HPYRGAESW-----EEVLEP--LGGDRARLVELTKSYRST 541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213 1508 SGILNLASGVVDLLQF--YFPESFDRlprdsglfDGPKPTVLESCSVSDLAILLRGNKRKTQPIEFGAHQVI-------- 1577
Cdd:COG3973    542 AEIMEFANRVLRAAGPdlPPPESVRR--------HGEPPRVVRVPSEAELAAAVVEAVRELLAEGEGTIAVIcktareae 613

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2217347213 1578 -----LVANETAKEKIPEELGLA---LVLTIYEAKGLEFDDVLLYNFftDSEAYKE 1625
Cdd:COG3973    614 alyaaLKAGLPVTLIDDESEELEagvVVLPAYLAKGLEFDAVVVVDP--DEIVYES 667
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
486-636 1.07e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.28  E-value: 1.07e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  486 LIDSGALPDGLQESQERPVVTCLKHEDFELAFLLLTKGADPRAISlTEGDTPLHAA--------LHIFLEIKADIgfsfl 557
Cdd:COG0666    106 LLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQD-NDGNTPLHLAaangnleiVKLLLEAGADV----- 179

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217347213  558 shlldlfwsnptefdylnpNVQDSNGNTLMHILFQKGMLKRVKklldLLVKFDINFNLKNKEGKDARHRIKKNDSLLLA 636
Cdd:COG0666    180 -------------------NARDNDGETPLHLAAENGHLEIVK----LLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
219-389 1.13e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.20  E-value: 1.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  219 PKLVQWLISIGASVETIGPYPLHALMRLciqARENHL--FRWLMDHKPEwkgrINQKDGDGCTVLHVVAAHspgylvkRQ 296
Cdd:COG0666    133 LEIVKLLLEAGADVNAQDNDGNTPLHLA---AANGNLeiVKLLLEAGAD----VNARDNDGETPLHLAAEN-------GH 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  297 TEDVQMLLRFGADPTLLDRQSRSVVDVLKRNKNFKAIEKINSHLEKLATcsKDLSGFSNGDGPTSENDIFRKVLEQLVKY 376
Cdd:COG0666    199 LEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA--KDKDGLTALLLAAAAGAALIVKLLLLALL 276

                          170
                   ....*....|...
gi 2217347213  377 MNSGNRLLHKNFL 389
Cdd:COG0666    277 LLAAALLDLLTLL 289
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
6-114 1.52e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.32  E-value: 1.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213    6 YAELLKESGNQVLKNGNFSLAIRKYDEAIQIllqlyqwgvpPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYV 85
Cdd:COG0457      7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALEL----------DPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDA 76

                           90       100
                   ....*....|....*....|....*....
gi 2217347213   86 KGYYRAGYSLLRLHQPYEAARMFFEGLRL 114
Cdd:COG0457     77 EALNNLGLALQALGRYEEALEDYDKALEL 105
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
454-656 1.74e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.65  E-value: 1.74e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  454 LIKDCNFSDLDICTIIPHLSTWDQRKKQLLGCLIDSGALPDGLQESQERPVVTCLKHEDFELAFLLLTKGADPRAISlTE 533
Cdd:COG0666     41 LLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARD-KD 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  534 GDTPLH-AALHIFLEIkadigfsfLSHLLDLfwsnptefdYLNPNVQDSNGNTLMHILFQKGMLKRVKklldLLVKFDIN 612
Cdd:COG0666    120 GETPLHlAAYNGNLEI--------VKLLLEA---------GADVNAQDNDGNTPLHLAAANGNLEIVK----LLLEAGAD 178

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2217347213  613 FNLKNKEGKDARHRIKKNDSLLLAwnKALME-----NRRRSRQDSAAHL 656
Cdd:COG0666    179 VNARDNDGETPLHLAAENGHLEIV--KLLLEagadvNAKDNDGKTALDL 225
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
6-106 2.68e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 51.07  E-value: 2.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213    6 YAELLKESGNQVLKNGNFSLAIRKYDEAIQIllqlyqwgVPprDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYV 85
Cdd:COG4785     72 LAQLYYERGVAYDSLGDYDLAIADFDQALEL--------DP--DLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYA 141

                           90       100
                   ....*....|....*....|.
gi 2217347213   86 KGYYRAGYSLLRLHQPYEAAR 106
Cdd:COG4785    142 YAYLNRGIALYYLGRYELAIA 162
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
219-334 4.69e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 51.11  E-value: 4.69e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  219 PKLVQWLISIGASVETIGPYPLHALMrlcIQARENHL--FRWLMDHKPEwkgrINQKDGDGCTVLHVVAAhspgylvKRQ 296
Cdd:COG0666    100 LEIVKLLLEAGADVNARDKDGETPLH---LAAYNGNLeiVKLLLEAGAD----VNAQDNDGNTPLHLAAA-------NGN 165

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2217347213  297 TEDVQMLLRFGADPTLLDRQSRSVVDVLKRNKNFKAIE 334
Cdd:COG0666    166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVK 203
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 5-112 4.13e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 49.21  E-value: 4.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213    5 AYAELLKESGNQVLKNgnfslaiRKYDEAIQillqLYQWGVPPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTY 84
Cdd:TIGR00990  125 KYAAKLKEKGNKAYRN-------KDFNKAIK----LYSKAIECKPDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDY 193

                           90       100
                   ....*....|....*....|....*...
gi 2217347213   85 VKgyyragySLLRLHQPYEAARMFFEGL 112
Cdd:TIGR00990  194 SK-------ALNRRANAYDGLGKYADAL 214
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 3-129 5.71e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.84  E-value: 5.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213    3 LTAYAELLKESGN--QVLKN-GNFSLAIRKYDEAIQILLQLYQwgVPPrDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQ 79
Cdd:COG3914     98 LALYRRALALNPDnaEALFNlGNLLLALGRLEEALAALRRALA--LNP-DFAEAYLNLGEALRRLGRLEEAIAALRRALE 174

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 2217347213   80 WDPTYVKGYYRAGYSLLRLHQPYEAARMFfegLRLVQRSQDQAPVADFLV 129
Cdd:COG3914    175 LDPDNAEALNNLGNALQDLGRLEEAIAAY---RRALELDPDNADAHSNLL 221
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 7-114 1.14e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.80  E-value: 1.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213    7 AELLKESGNQVLKNGNFSLAIRKYDEAIQILlqlyqwgvpPRDLAVLlCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVK 86
Cdd:COG4783      4 AEALYALAQALLLAGDYDEAEALLEKALELD---------PDNPEAF-ALLGEILLQLGDLDEAIVLLHEALELDPDEPE 73

                           90       100
                   ....*....|....*....|....*...
gi 2217347213   87 GYYRAGYSLLRLHQPYEAARMFFEGLRL 114
Cdd:COG4783     74 ARLNLGLALLKAGDYDEALALLEKALKL 101
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 3-114 1.23e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.41  E-value: 1.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213    3 LTAYAELLKESGNQV---LKNGNFSLAIRKYDEAIQILLQLYQwgVPPRDLAVLLcNKSNAFFSLGKWNEAFVAAKECLQ 79
Cdd:COG4783     24 EALLEKALELDPDNPeafALLGEILLQLGDLDEAIVLLHEALE--LDPDEPEARL-NLGLALLKAGDYDEALALLEKALK 100

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2217347213   80 WDPTYVKGYYRAGYSLLRLHQPYEAARMFFEGLRL 114
Cdd:COG4783    101 LDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
6-113 1.65e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.15  E-value: 1.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213    6 YAELLKESGNQVLKNGNFSLAIRKYDEAIQIllqlyqwgvpPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYV 85
Cdd:COG0457     75 DAEALNNLGLALQALGRYEEALEDYDKALEL----------DPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA 144

                           90       100
                   ....*....|....*....|....*...
gi 2217347213   86 KGYYRAGYSLLRLHQPYEAARMFFEGLR 113
Cdd:COG0457    145 DALYNLGIALEKLGRYEEALELLEKLEA 172
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 5-132 1.69e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.26  E-value: 1.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213    5 AYAELLKESGN--QVLKN-GNFSLAIRKYDEAIQILLQLYQWGvppRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWD 81
Cdd:COG2956     98 LLEKLLELDPDdaEALRLlAEIYEQEGDWEKAIEVLERLLKLG---PENAHAYCELAELYLEQGDYDEAIEALEKALKLD 174

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2217347213   82 PTYVKGYYRAGYSLLRLHQPYEAARMFfegLRLVQRSQDQAPVADFLVGVF 132
Cdd:COG2956    175 PDCARALLLLAELYLEQGDYEEAIAAL---ERALEQDPDYLPALPRLAELY 222
PHA03095 PHA03095
ankyrin-like protein; Provisional
 216-387 1.85e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.94  E-value: 1.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  216 EQVPKLVQWLISIGASVETI---GPYPLHALMRLCIQARenhLFRWLMDHKpewkGRINQKDGDGCTVLHVvaahspgYL 292
Cdd:PHA03095    60 EKVKDIVRLLLEAGADVNAPercGFTPLHLYLYNATTLD---VIKLLIKAG----ADVNAKDKVGRTPLHV-------YL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  293 -VKRQTEDV-QMLLRFGADPTLLDRQSRSVVDVLKRNKNfkaiekINSHLEKLAtcskdlsgFSNGDGPTSENDIFRKVL 370
Cdd:PHA03095   126 sGFNINPKViRLLLRKGADVNALDLYGMTPLAVLLKSRN------ANVELLRLL--------IDAGADVYAVDDRFRSLL 191

                          170
                   ....*....|....*..
gi 2217347213  371 EQLVKYMNSGNRLLHKN 387
Cdd:PHA03095   192 HHHLQSFKPRARIVREL 208
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
6-114 1.97e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.77  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213    6 YAELLKESGNQVLKNGNFSLAIRKYDEAIQILLqlyqwgvpprDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYV 85
Cdd:COG0457     41 DAEALYNLGLAYLRLGRYEEALADYEQALELDP----------DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDA 110

                           90       100
                   ....*....|....*....|....*....
gi 2217347213   86 KGYYRAGYSLLRLHQPYEAARMFFEGLRL 114
Cdd:COG0457    111 EALYNLGLALLELGRYDEAIEAYERALEL 139
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 2-125 8.98e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.92  E-value: 8.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213    2 DLTAYAELlkesGNQVLKNGNFSLAIRKYDEAIQILlqlyqwgvpPRDLAVLLcNKSNAFFSLGKWNEAFVAAKECLQWD 81
Cdd:COG4235     16 DAEGWLLL----GRAYLRLGRYDEALAAYEKALRLD---------PDNADALL-DLAEALLAAGDTEEAEELLERALALD 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2217347213   82 PTYVKGYYRAGYSLLRLHQpYEAARMFFEglRLVQRSQDQAPVA 125
Cdd:COG4235     82 PDNPEALYLLGLAAFQQGD-YAEAIAAWQ--KLLALLPADAPAR 122
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 271-356 2.05e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.73  E-value: 2.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  271 NQKDGDGCTVLHVVAAHspGYLvkrqtEDVQMLLRFGADPTLLDRQSRSVVDVLKRNKNFKAIEKINSHleklatCSKDL 350
Cdd:PTZ00322   109 NCRDYDGRTPLHIACAN--GHV-----QVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH------SQCHF 175


                   ....*.
gi 2217347213  351 SGFSNG 356
Cdd:PTZ00322   176 ELGANA 181
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 22-110 2.16e-03

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 43.24  E-value: 2.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213   22 NFSLAIRKYDEAIQIllqlyqwgVPPRdlAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVKGYYRAGYSLLRLHQp 101
Cdd:PLN03088    17 DFALAVDLYTQAIDL--------DPNN--AELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEE- 85


                   ....*....
gi 2217347213  102 YEAARMFFE 110
Cdd:PLN03088    86 YQTAKAALE 94
UvrD COG0210
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
1378-1519 2.48e-03

Superfamily I DNA or RNA helicase [Replication, recombination and repair];


Pssm-ID: 439980 [Multi-domain]  Cd Length: 721  Bit Score: 43.39  E-value: 2.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213 1378 EDRSEIYSLFSLYQQIRSQKGYFDEEDVLYNiSRRLskLRVLPWsIHELYG--------DEIQDFTQAELALLMKCINDP 1449
Cdd:COG0210    164 PEWRAAAELYEAYQERLRANNALDFDDLLLL-AVRL--LEENPE-VLEKYQnrfryilvDEYQDTNPAQYELLRLLAGDG 239

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213 1450 NSMFLTGDTAQSIMkgvAFRFSDLRSLFHYASRntidkqcavRKPKKIHQLYQNYRSHSGILNLASGVVD 1519
Cdd:COG0210    240 RNLCVVGDDDQSIY---GFRGADPENILRFEKD---------FPDAKVIKLEQNYRSTQNILDAANAVIA 297
Ank_2 pfam12796
Ankyrin repeats (3 copies);
219-314 2.69e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.33  E-value: 2.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213  219 PKLVQWLISIGASVETIGPYPLHALMrLCIQARENHLFRWLMDHkpewkGRINQKDgDGCTVLHVVAAHspgylvkRQTE 298
Cdd:pfam12796   10 LELVKLLLENGADANLQDKNGRTALH-LAAKNGHLEIVKLLLEH-----ADVNLKD-NGRTALHYAARS-------GHLE 75

                           90
                   ....*....|....*.
gi 2217347213  299 DVQMLLRFGADPTLLD 314
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 7-128 5.04e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.64  E-value: 5.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213    7 AELLKESGNQVLKNGNFSLAIRKYDEAIQILlqlyqwgvpPRDLAVLLcNKSNAFFSLGKWNEAFVAAKECLQWDPTYVK 86
Cdd:COG2956    144 AHAYCELAELYLEQGDYDEAIEALEKALKLD---------PDCARALL-LLAELYLEQGDYEEAIAALERALEQDPDYLP 213

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 2217347213   87 GYYRAGYSLLRLHQPYEAARMFFEGLRLVQRSQDQAPVADFL 128
Cdd:COG2956    214 ALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLL 255
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
18-114 5.67e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.61  E-value: 5.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213   18 LKNGNFSLAIRKYDEAIQILlqlyqwgvppRDLAVLLCNKSNAFFSLGKWNEAfVAAKECLQWDPTYVKGYYRAGYSLLR 97
Cdd:COG3063      3 LKLGDLEEAEEYYEKALELD----------PDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLE 71

                           90
                   ....*....|....*..
gi 2217347213   98 LHQPYEAARMFFEGLRL 114
Cdd:COG3063     72 LGDYDEALAYLERALEL 88
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
49-114 5.77e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.15  E-value: 5.77e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217347213   49 DLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVKGYYRAGYSLLRLHQPYEAARMFFEGLRL 114
Cdd:COG0457      6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL 71
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 18-114 6.08e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.94  E-value: 6.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217347213   18 LKNGNFSLAIRKYDEAIQILlqlyqwgvpPRDlAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVKGYYRAGYSLLR 97
Cdd:COG5010     65 NKLGDFEESLALLEQALQLD---------PNN-PELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLS 134

                           90
                   ....*....|....*..
gi 2217347213   98 LHQPYEAARMFFEGLRL 114
Cdd:COG5010    135 LGQDDEAKAALQRALGT 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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