|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
570-819 |
8.01e-146 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 437.68 E-value: 8.01e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 570 LLLHQKQALAWLLWRESQKPQGGIL-DDMGLGKTLTMIALILTQKNQEKKEEKEKSTALT-WLSKDDSCDFTSHGTLIIC 647
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPRGGILaDDMGLGKTLTMIALILAQKNTQNRKEEEKEKALTeWESKKDSTLVPSAGTLVVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 648 PASLIHHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVLSTYDIVITTYSLVAKEIPTNKQEaeipganlnveGTSTPLLR 727
Cdd:cd18072 81 PASLVHQWKNEVESRVASNKLRVCLYHGPNRERIGEVLRDYDIVITTYSLVAKEIPTYKEE-----------SRSSPLFR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 728 IAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDNGSKKGGER 807
Cdd:cd18072 150 IAWARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDDLKVWKKQVDNKSRKGGER 229
|
250
....*....|..
gi 2217271652 808 LSILTKSLLLRR 819
Cdd:cd18072 230 LNILTKSLLLRR 241
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
559-1141 |
5.16e-124 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 396.90 E-value: 5.16e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 559 VAEDPAGLKVPLLLHQKQALAWLLWRESQKPqGGIL-DDMGLGKTLTMIALILTQKNQEKKEEkekstaltwlskddscd 637
Cdd:COG0553 231 LESLPAGLKATLRPYQLEGAAWLLFLRRLGL-GGLLaDDMGLGKTIQALALLLELKERGLARP----------------- 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 638 ftshgTLIICPASLIHHWKNEVEKRVNSnkLRVYLYHGP-NRDSRARVLSTYDIVITTYSLVAKEIPTnkqeaeipganl 716
Cdd:COG0553 293 -----VLIVAPTSLVGNWQRELAKFAPG--LRVLVLDGTrERAKGANPFEDADLVITSYGLLRRDIEL------------ 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 717 nvegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFL---RCSPFDEFN-L 792
Cdd:COG0553 354 --------LAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLnpgLLGSLKAFReR 425
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 793 WRSQVDNGSKKGGERLSILTKSLLLRRTKDQLdstgrpLVILPQRKFQLHHLKLSEDEETVYNvffarsrsALQSYLKRH 872
Cdd:COG0553 426 FARPIEKGDEEALERLRRLLRPFLLRRTKEDV------LKDLPEKTEETLYVELTPEQRALYE--------AVLEYLRRE 491
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 873 esrgnqsgrspnnpfsrvalefgseeprhsEAADSPRSSTVHILSQLLRLRQCCCHLSLLksaldpmelkgeglvlsLEE 952
Cdd:COG0553 492 ------------------------------LEGAEGIRRRGLILAALTRLRQICSHPALL-----------------LEE 524
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 953 QLSaltlSELRDSepsstvslngtffKMELFegmrestkissllaeLEAIQRNSASQKSVIV-SQWTNMLKVVALHLKKH 1031
Cdd:COG0553 525 GAE----LSGRSA-------------KLEAL---------------LELLEELLAEGEKVLVfSQFTDTLDLLEERLEER 572
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 1032 GLTYATIDGSVNPKQRMDLVEAFNHSRGPQVMLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQQKDVV 1111
Cdd:COG0553 573 GIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQ 652
|
570 580 590
....*....|....*....|....*....|
gi 2217271652 1112 IHRFVCEGTVEEKILQLQEKKKDLAKQVLS 1141
Cdd:COG0553 653 VYKLVAEGTIEEKILELLEEKRALAESVLG 682
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
570-819 |
1.85e-100 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 317.69 E-value: 1.85e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 570 LLLHQKQALAWLLWResqkpqGGIL-DDMGLGKTLTMIALILTQKNQEKKEEKEKSTaltwLSKDDSCDFTSHGTLIICP 648
Cdd:cd18008 1 LLPYQKQGLAWMLPR------GGILaDEMGLGKTIQALALILATRPQDPKIPEELEE----NSSDPKKLYLSKTTLIVVP 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 649 ASLIHHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVLSTYDIVITTYSLVAKEIPTNKQeaeiPGANLNVEGTSTPLLRI 728
Cdd:cd18008 71 LSLLSQWKDEIEKHTKPGSLKVYVYHGSKRIKSIEELSDYDIVITTYGTLASEFPKNKK----GGGRDSKEKEASPLHRI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 729 AWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQV----DNGSKKG 804
Cdd:cd18008 147 RWYRVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDIskpfSKNDRKA 226
|
250
....*....|....*
gi 2217271652 805 GERLSILTKSLLLRR 819
Cdd:cd18008 227 LERLQALLKPILLRR 241
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
573-932 |
1.14e-71 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 240.66 E-value: 1.14e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGIL-DDMGLGKTLTMIALILTQKNQEKkeekekstaltwlskddscdFTSHGTLIICPASL 651
Cdd:pfam00176 1 YQIEGVNWMLSLENNLGRGGILaDEMGLGKTLQTISLLLYLKHVDK--------------------NWGGPTLIVVPLSL 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 652 IHHWKNEVEKRVNSNKLRVYLYHGPNRDSRA-----RVLSTYDIVITTYSLVAKEiptnkqeaeipganlnvegtSTPLL 726
Cdd:pfam00176 61 LHNWMNEFERWVSPPALRVVVLHGNKRPQERwkndpNFLADFDVVITTYETLRKH--------------------KELLK 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 727 RIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDN-----GS 801
Cdd:pfam00176 121 KVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRpiergGG 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 802 KKGGERLSILTKSLLLRRTKDQLDSTgrplviLPQRKFQLHHLKLSEDEETVYNVFFarsrsalqsylkrHESRGNQsgr 881
Cdd:pfam00176 201 KKGVSRLHKLLKPFLLRRTKKDVEKS------LPPKVEYILFCRLSKLQRKLYQTFL-------------LKKDLNA--- 258
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2217271652 882 spnnpfsrVALEFGSEEPRHSeaadsprsstvhILSQLLRLRQCCCHLSLL 932
Cdd:pfam00176 259 --------IKTGEGGREIKAS------------LLNILMRLRKICNHPGLI 289
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
570-819 |
5.03e-62 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 211.56 E-value: 5.03e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 570 LLLHQKQALAWLLWRE-----------------------SQK--PQ---GGIL-DDMGLGKTLTMIALILTQKnqekkee 620
Cdd:cd18071 1 LLPHQKQALAWMVSREnsqdlppfweeavglflntitnfSQKkrPElvrGGILaDDMGLGKTLTTISLILANF------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 621 kekstaltwlskddscdftshgTLIICPASLIHHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVLSTYDIVITTYSLVAK 700
Cdd:cd18071 74 ----------------------TLIVCPLSVLSNWETQFEEHVKPGQLKVYTYHGGERNRDPKLLSKYDIVLTTYNTLAS 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 701 EiptnkqeaeipganlnvEGT--STPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSL 778
Cdd:cd18071 132 D-----------------FGAkgDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSL 194
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2217271652 779 LKFLRCSPFDEFNLWRS----QVDNGSKKGGERLSILTKSLLLRR 819
Cdd:cd18071 195 LSFLHLKPFSNPEYWRRliqrPLTMGDPTGLKRLQVLMKQITLRR 239
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
570-818 |
1.17e-53 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 188.32 E-value: 1.17e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 570 LLLHQKQALAWLLWResqkpqGGIL-DDMGLGKTLTMIALILTQKNQEKKeekekSTALTWLSKDDSC---------DFT 639
Cdd:cd18070 1 LLPYQRRAVNWMLVP------GGILaDEMGLGKTVEVLALILLHPRPDND-----LDAADDDSDEMVCcpdclvaetPVS 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 640 SHGTLIICPASLIHHWKNEVEKRVNSNkLRVYLYHGPNRDS-----RARVLSTYDIVITTYSLVAKEIptnkQEAEIPGA 714
Cdd:cd18070 70 SKATLIVCPSAILAQWLDEINRHVPSS-LKVLTYQGVKKDGalaspAPEILAEYDIVVTTYDVLRTEL----HYAEANRS 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 715 NL------NVEGTSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFD 788
Cdd:cd18070 145 NRrrrrqkRYEAPPSPLVLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPFC 224
|
250 260 270
....*....|....*....|....*....|..
gi 2217271652 789 EFNLWRSQVDN--GSKKGGERLSILTKSLLLR 818
Cdd:cd18070 225 DSDWWARVLIRpqGRNKAREPLAALLKELLWR 256
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
989-1116 |
5.72e-52 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 178.44 E-value: 5.72e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 989 STKISSLLAELEAIQRNSasQKSVIVSQWTNMLKVVALHLKKHGLTYATIDGSVNPKQRMDLVEAFNHSRGPQVMLISLL 1068
Cdd:cd18793 10 SGKLEALLELLEELREPG--EKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTK 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 2217271652 1069 AGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQQKDVVIHRFV 1116
Cdd:cd18793 88 AGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
570-794 |
3.17e-51 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 178.53 E-value: 3.17e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 570 LLLHQKQALAWLLWRESQKPqGGIL-DDMGLGKTLTMIALILTQKNQekkeekekstaltwlsKDDSCDFtshgtLIICP 648
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGP-GGILaDEMGLGKTLQAIAFLAYLLKE----------------GKERGPV-----LVVCP 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 649 ASLIHHWKNEVEKRVNSnkLRVYLYHGPNRDSRAR----VLSTYDIVITTYSLVAKEIPTnkqeaeipganlnvegtstp 724
Cdd:cd17919 59 LSVLENWEREFEKWTPD--LRVVVYHGSQRERAQIrakeKLDKFDVVLTTYETLRRDKAS-------------------- 116
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 725 LLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCsPFdefnLWR 794
Cdd:cd17919 117 LRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPLQNNLEELWALLDFLDP-PF----LLR 181
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
574-821 |
5.75e-48 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 170.44 E-value: 5.75e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 574 QKQALAWLlWRESQKPQGGIL-DDMGLGKTLTMIALILTQKNQEKkeekekstaltwlskddscdftSHGTLIICPASLI 652
Cdd:cd18012 9 QKEGFNWL-SFLRHYGLGGILaDDMGLGKTLQTLALLLSRKEEGR----------------------KGPSLVVAPTSLI 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 653 HHWKNEVEKRvnSNKLRVYLYHGPNRDSRA-RVLSTYDIVITTYSLVAKEIptnkqEAeipganlnvegtstpLLRIAWA 731
Cdd:cd18012 66 YNWEEEAAKF--APELKVLVIHGTKRKREKlRALEDYDLVITSYGLLRRDI-----EL---------------LKEVKFH 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 732 RIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLrcSP-----FDEFN-LWRSQVDNGSKKGG 805
Cdd:cd18012 124 YLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPIENHLGELWSIFDFL--NPgllgsYKRFKkRFAKPIEKDGDEEA 201
|
250
....*....|....*..
gi 2217271652 806 -ERLSILTKSLLLRRTK 821
Cdd:cd18012 202 lEELKKLISPFILRRLK 218
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
563-1132 |
7.75e-39 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 157.65 E-value: 7.75e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 563 PAGLKVPLLLHQKQALAWLLwRESQKPQGGIL-DDMGLGKTLTMIALiltqknqekkeekekstaLTWLSkdDSCDFTS- 640
Cdd:PLN03142 163 PSCIKGKMRDYQLAGLNWLI-RLYENGINGILaDEMGLGKTLQTISL------------------LGYLH--EYRGITGp 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 641 HgtLIICPASLIHHWKNEVEKRVNSnkLRVYLYHGpNRDSRAR------VLSTYDIVITTYSLVAKEiptnkqeaeipga 714
Cdd:PLN03142 222 H--MVVAPKSTLGNWMNEIRRFCPV--LRAVKFHG-NPEERAHqreellVAGKFDVCVTSFEMAIKE------------- 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 715 nlnvegtSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF---DEFN 791
Cdd:PLN03142 284 -------KTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFssaETFD 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 792 LWRSQvdNGSKKGGERLSILTKSL---LLRRTKDQLDSTgrplviLPQRKFQLHHLKLSEDEETVYnvffarsRSALQSY 868
Cdd:PLN03142 357 EWFQI--SGENDQQEVVQQLHKVLrpfLLRRLKSDVEKG------LPPKKETILKVGMSQMQKQYY-------KALLQKD 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 869 LKrhesrgnqsgrspnnpfsrvALEFGSEEPRhseaadsprsstvhILSQLLRLRQCCCHLSLLKSAL-DPMELKGEGLV 947
Cdd:PLN03142 422 LD--------------------VVNAGGERKR--------------LLNIAMQLRKCCNHPYLFQGAEpGPPYTTGEHLV 467
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 948 lsleeqlsaltlselrdsEPSStvslngtffKMELFEgmrestkisSLLAELEaiQRNSasqKSVIVSQWTNMLKVVALH 1027
Cdd:PLN03142 468 ------------------ENSG---------KMVLLD---------KLLPKLK--ERDS---RVLIFSQMTRLLDILEDY 506
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 1028 LKKHGLTYATIDGSVNPKQRMDLVEAFNHSRGPQ-VMLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQ 1106
Cdd:PLN03142 507 LMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQ 586
|
570 580
....*....|....*....|....*.
gi 2217271652 1107 QKDVVIHRFVCEGTVEEKILQLQEKK 1132
Cdd:PLN03142 587 KKEVQVFRFCTEYTIEEKVIERAYKK 612
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
573-782 |
2.52e-31 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 123.23 E-value: 2.52e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALIltqknqekkeekekstALTWLSKDDSCDFTSHGTLIICPASLI 652
Cdd:cd17999 4 YQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCIL----------------ASDHHKRANSFNSENLPSLVVCPPTLV 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 653 HHWKNEVEKRVNSNKLRVYLYHGPNRDSRARV--LSTYDIVITTYSLVAKEIPTnkqeaeipganlnvegtstpLLRIAW 730
Cdd:cd17999 68 GHWVAEIKKYFPNAFLKPLAYVGPPQERRRLReqGEKHNVIVASYDVLRNDIEV--------------------LTKIEW 127
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 2217271652 731 ARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFL 782
Cdd:cd17999 128 NYCVLDEGHIIKNSKTKLSKAVKQLKANHRLILSGTPIQNNVLELWSLFDFL 179
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
573-782 |
2.84e-30 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 120.17 E-value: 2.84e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLlWRESQKPQGGIL-DDMGLGKTLTMIALIltqknqekkEEKEKSTALtwlskddscdftsHGTLIICPASL 651
Cdd:cd18001 4 HQREGVAWL-WSLHDGGKGGILaDDMGLGKTVQICAFL---------SGMFDSGLI-------------KSVLVVMPTSL 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 652 IHHWKNEVEKRVNSnkLRVYLYHGPNRDSRAR----VLSTYDIVITTYSLVakeipTNKQEAeipganLNVEGTSTpllr 727
Cdd:cd18001 61 IPHWVKEFAKWTPG--LRVKVFHGTSKKERERnlerIQRGGGVLLTTYGMV-----LSNTEQ------LSADDHDE---- 123
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 2217271652 728 IAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFL 782
Cdd:cd18001 124 FKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFA 178
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
570-833 |
7.44e-30 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 119.41 E-value: 7.44e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 570 LLLHQKQALAWLLWReSQKPQGGIL-DDMGLGKTLTMIALILT-------------QKNQEKKEEKEKSTALTWLskdds 635
Cdd:cd18005 1 LRDYQREGVEFMYDL-YKNGRGGILgDDMGLGKTVQVIAFLAAvlgktgtrrdrenNRPRFKKKPPASSAKKPVL----- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 636 cdftshgtlIICPASLIHHWKNEVEKRvnsNKLRVYLYHGPNRD----SRARvLSTYDIVITTYSLVAKEIPTnkqeaei 711
Cdd:cd18005 75 ---------IVAPLSVLYNWKDELDTW---GHFEVGVYHGSRKDdeleGRLK-AGRLEVVVTTYDTLRRCIDS------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 712 pganlnvegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFN 791
Cdd:cd18005 135 -------------LNSINWSAVIADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRS 201
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2217271652 792 LWRSQVDNGSKKGGERLSILTKSLLLRRTKDQLDSTGRPLVI 833
Cdd:cd18005 202 QFKKHFSEPIKRGQRHTATARELRLGRKRKQELAVKLSKFFL 243
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
573-781 |
2.60e-29 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 115.88 E-value: 2.60e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKpQGGIL-DDMGLGKTLTMIALIltqknqekkeekekstaltwlskdDSCDFTSHG---TLIICP 648
Cdd:cd18000 4 YQQTGVQWLWELHCQR-VGGILgDEMGLGKTIQIIAFL------------------------AALHHSKLGlgpSLIVCP 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 649 ASLIHHWKNEVEK----------------RVNSNKLRVYLYHGPNRDsraRVLSTYDIVITTYSLVAKEiptnkqeaeip 712
Cdd:cd18000 59 ATVLKQWVKEFHRwwppfrvvvlhssgsgTGSEEKLGSIERKSQLIR---KVVGDGGILITTYEGFRKH----------- 124
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2217271652 713 ganlnvegtSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKF 781
Cdd:cd18000 125 ---------KDLLLNHNWQYVILDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNNLKELWSLFDF 184
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
573-819 |
1.09e-27 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 112.76 E-value: 1.09e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWL----LWRESQKPQGGIL-DDMGLGKTLTMIALILTQKNQekkeekekstaltwlSKDDSCdfTSHGTLIIC 647
Cdd:cd18004 4 HQREGVQFLydclTGRRGYGGGGAILaDEMGLGKTLQAIALVWTLLKQ---------------GPYGKP--TAKKALIVC 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 648 PASLIHHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVL-----STYDIVITTYSLVAKEiptnkqeaeipgANLNVEGTS 722
Cdd:cd18004 67 PSSLVGNWKAEFDKWLGLRRIKVVTADGNAKDVKASLDffssaSTYPVLIISYETLRRH------------AEKLSKKIS 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 723 TPLLriawariILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDNGSK 802
Cdd:cd18004 135 IDLL-------ICDEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPIL 207
|
250 260 270
....*....|....*....|....*....|...
gi 2217271652 803 KGGER----------------LSILTKSLLLRR 819
Cdd:cd18004 208 RSRDPdaseedkelgaersqeLSELTSRFILRR 240
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
573-821 |
4.51e-26 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 107.41 E-value: 4.51e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLwreSQKPQG--GIL-DDMGLGKTLTMIALI--LTQ-KNQEKkeekekstaltwlskddscdftSHgtLII 646
Cdd:cd17997 7 YQIRGLNWLI---SLFENGinGILaDEMGLGKTLQTISLLgyLKHyKNING----------------------PH--LII 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 647 CPASLIHHWKNEVEKRVNSnkLRVYLYHGpNRDSRARVLST------YDIVITTYSLVAKEiptnkqeaeipganlnveg 720
Cdd:cd17997 60 VPKSTLDNWMREFKRWCPS--LRVVVLIG-DKEERADIIRDvllpgkFDVCITSYEMVIKE------------------- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 721 tSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF---DEFNLW--RS 795
Cdd:cd17997 118 -KTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFtssEDFDEWfnVN 196
|
250 260
....*....|....*....|....*.
gi 2217271652 796 QVDNGSKKGGERLSILTKSLLLRRTK 821
Cdd:cd17997 197 NCDDDNQEVVQRLHKVLRPFLLRRIK 222
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
573-819 |
1.96e-25 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 105.90 E-value: 1.96e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALiltqknqekkeekekstaLTWLSkddsCDFTSHGT-LIICPASL 651
Cdd:cd18003 4 YQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIAL------------------LAHLA----CEKGNWGPhLIVVPTSV 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 652 IHHWKNEVEKRVNSNKLRVYlYHGPNRDSRARV----LSTYDIVITTYSLVAKEiptnkqeaeipganlnvegtSTPLLR 727
Cdd:cd18003 62 MLNWEMEFKRWCPGFKILTY-YGSAKERKLKRQgwmkPNSFHVCITSYQLVVQD--------------------HQVFKR 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 728 IAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF---DEFNLWRSQVDNGSKKG 804
Cdd:cd18003 121 KKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFqshQEFKEWFSNPLTAMSEG 200
|
250 260
....*....|....*....|...
gi 2217271652 805 GE--------RLSILTKSLLLRR 819
Cdd:cd18003 201 SQeeneelvrRLHKVLRPFLLRR 223
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
569-797 |
3.14e-21 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 92.94 E-value: 3.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 569 PLLLHQKQALAWLLWREsqkpQGGIL-DDMGLGKTLTMIALILTQKNQEKKEEkekstaltwlskddscdftshgTLIIC 647
Cdd:smart00487 8 PLRPYQKEAIEALLSGL----RDVILaAPTGSGKTLAALLPALEALKRGKGGR----------------------VLVLV 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 648 P-ASLIHHWKNEVEKRVNSNKLR-VYLYHGPNRDSRARVLST--YDIVITTYSLVAKEIPTNKqeaeipganlnvegtst 723
Cdd:smart00487 62 PtRELAEQWAEELKKLGPSLGLKvVGLYGGDSKREQLRKLESgkTDILVTTPGRLLDLLENDK----------------- 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2217271652 724 pLLRIAWARIILDEAHNVKNP--RVQTSIAVCKLQACA-RWAVTGTPIQNNLLDMYSLLK-FLRCSPFDEFNLWRSQV 797
Cdd:smart00487 125 -LSLSNVDLVILDEAHRLLDGgfGDQLEKLLKLLPKNVqLLLLSATPPEEIENLLELFLNdPVFIDVGFTPLEPIEQF 201
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
570-821 |
1.27e-20 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 92.06 E-value: 1.27e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 570 LLLHQKQALAWL--LWresQKPQGGIL-DDMGLGKTLTMIALIltqknqekkeekekstALTWLSKDDScdftshGTLII 646
Cdd:cd18009 4 MRPYQLEGMEWLrmLW---ENGINGILaDEMGLGKTIQTIALL----------------AHLRERGVWG------PFLVI 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 647 CPASLIHHWKNEVEKRVNSnkLRVYLYHGPN---------RDSRARVLSTYDIVITTYslvakEIPTNKQEAeipganln 717
Cdd:cd18009 59 APLSTLPNWVNEFARFTPS--VPVLLYHGTKeererlrkkIMKREGTLQDFPVVVTSY-----EIAMRDRKA-------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 718 vegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFD---EFNLW- 793
Cdd:cd18009 124 -------LQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDdlsSFESWf 196
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2217271652 794 -----RSQVDNGSKKGGERLSILTKSL-------LLRRTK 821
Cdd:cd18009 197 dfsslSDNAADISNLSEEREQNIVHMLhailkpfLLRRLK 236
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
569-821 |
1.56e-20 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 92.00 E-value: 1.56e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 569 PLLLHQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALILTQKNQEKKEEKEkstaltwlskddscdftshgtLIICP 648
Cdd:cd18065 15 TLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPH---------------------MVLVP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 649 ASLIHHWKNEVEKRVNSnkLRVYLYHGpNRDSRARVL------STYDIVITTYSLVAKEIPTNKqeaeipganlnvegts 722
Cdd:cd18065 74 KSTLHNWMNEFKRWVPS--LRAVCLIG-DKDARAAFIrdvmmpGEWDVCVTSYEMVIKEKSVFK---------------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 723 tpllRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF---DEFNLWRSQVDN 799
Cdd:cd18065 135 ----KFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFnsaDDFDSWFDTKNC 210
|
250 260
....*....|....*....|...
gi 2217271652 800 -GSKKGGERLSILTKSLLLRRTK 821
Cdd:cd18065 211 lGDQKLVERLHAVLKPFLLRRIK 233
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
574-819 |
1.65e-20 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 91.54 E-value: 1.65e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 574 QKQALAWLL--WRESQkpqGGIL-DDMGLGKTLTMIALIltqknqekkeekekstaltwlskdDSCdFTSHGT----LII 646
Cdd:cd17995 5 QLEGVNWLLfnWYNRR---NCILaDEMGLGKTIQSIAFL------------------------EHL-YQVEGIrgpfLVI 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 647 CPASLIHHWKNEVEKRVNsnkLRVYLYHGpNRDSRARVLS-----------------TYDIVITTYSLVAKEIPTnkqea 709
Cdd:cd17995 57 APLSTIPNWQREFETWTD---MNVVVYHG-SGESRQIIQQyemyfkdaqgrkkkgvyKFDVLITTYEMVIADAEE----- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 710 eipganlnvegtstpLLRIAWARIILDEAHNVKNP--RVQTSIAVCKLQACArwAVTGTPIQNNLLDMYSLLKFLRCSPF 787
Cdd:cd17995 128 ---------------LRKIPWRVVVVDEAHRLKNRnsKLLQGLKKLTLEHKL--LLTGTPLQNNTEELWSLLNFLEPEKF 190
|
250 260 270
....*....|....*....|....*....|....*
gi 2217271652 788 DefNLWRSQVDNGSKKGGE---RLSILTKSLLLRR 819
Cdd:cd17995 191 P--SSEEFLEEFGDLKTAEqveKLQALLKPYMLRR 223
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
570-783 |
1.65e-20 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 91.97 E-value: 1.65e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 570 LLLHQKQALAWLlWR-------ESQKPQGGIL-DDMGLGKTLTMIALILTqknqekkeekekstaltWLSKDDscdFTSH 641
Cdd:cd18007 1 LKPHQVEGVRFL-WSnlvgtdvGSDEGGGCILaHTMGLGKTLQVITFLHT-----------------YLAAAP---RRSR 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 642 gTLIICPASLIHHWKNEVEK----RVNSNKLRVYLYHGPNRDSRARVLSTY----DIVITTYS----LVAKEIPTNKQEA 709
Cdd:cd18007 60 -PLVLCPASTLYNWEDEFKKwlppDLRPLLVLVSLSASKRADARLRKINKWhkegGVLLIGYElfrnLASNATTDPRLKQ 138
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217271652 710 EIPGANLnVEGTSTpllriawarIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLR 783
Cdd:cd18007 139 EFIAALL-DPGPDL---------LVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFAR 202
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
573-819 |
7.71e-20 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 89.42 E-value: 7.71e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLL-WRESQkpQGGIL-DDMGLGKTLTMIALILTQKNQEKKEEKEkstaltwlskddscdftshgtLIICPAS 650
Cdd:cd18006 4 YQLEGVNWLLqCRAEQ--HGCILgDEMGLGKTCQTISLLWYLAGRLKLLGPF---------------------LVLCPLS 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 651 LIHHWKNEVEKRVNSnkLRVYLYHGpNRDSRA------RVLSTYDIVITTYSLVAKEiptnkqeaeipganlnvegtSTP 724
Cdd:cd18006 61 VLDNWKEELNRFAPD--LSVITYMG-DKEKRLdlqqdiKSTNRFHVLLTTYEICLKD--------------------ASF 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 725 LLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF-----DEFNLWRSQVDN 799
Cdd:cd18006 118 LKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEPNVFpkdklDDFIKAYSETDD 197
|
250 260
....*....|....*....|
gi 2217271652 800 GSKKGGErLSILTKSLLLRR 819
Cdd:cd18006 198 ESETVEE-LHLLLQPFLLRR 216
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
573-786 |
2.56e-19 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 88.36 E-value: 2.56e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKP----QGGIL-DDMGLGKTLTMIALILTQKNQEKkeekekstaltwlskdDSCDFTSHGTLIIC 647
Cdd:cd18066 4 HQREGIEFLYECVMGMRvnerFGAILaDEMGLGKTLQCISLIWTLLRQGP----------------YGGKPVIKRALIVT 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 648 PASLIHHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVLSTYDIVITTYSLVAKEIptnkqeAEIPGANLNVegtstpllr 727
Cdd:cd18066 68 PGSLVKNWKKEFQKWLGSERIKVFTVDQDHKVEEFIASPLYSVLIISYEMLLRSL------DQISKLNFDL--------- 132
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 2217271652 728 iawarIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFlrCSP 786
Cdd:cd18066 133 -----VICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDF--VNP 184
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
573-791 |
4.79e-19 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 87.42 E-value: 4.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALIltqknqekkeekeksTALTWLSKDdscdftsHGT-LIICPASL 651
Cdd:cd17996 7 YQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLI---------------TYLMEKKKN-------NGPyLVIVPLST 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 652 IHHWKNEVEKRVNSnkLRVYLYHGPnRDSRARVLST-----YDIVITTYSLVAKEIPTnkqeaeipganlnvegtstpLL 726
Cdd:cd17996 65 LSNWVSEFEKWAPS--VSKIVYKGT-PDVRKKLQSQiragkFNVLLTTYEYIIKDKPL--------------------LS 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 727 RIAWARIILDEAHNVKNprvqtsiAVCKL--------QACARWAVTGTPIQNNLLDMYSLLKFL------RCSPFDE-FN 791
Cdd:cd17996 122 KIKWKYMIIDEGHRMKN-------AQSKLtqtlntyyHARYRLLLTGTPLQNNLPELWALLNFLlpkifkSCKTFEQwFN 194
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
991-1105 |
5.64e-19 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 83.41 E-value: 5.64e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 991 KISSLLAELEAIQRNsasqKSVIVSQWTNMLKVVALhLKKHGLTYATIDGSVNPKQRMDLVEAFNhsRGPQVMLISLLAG 1070
Cdd:pfam00271 2 KLEALLELLKKERGG----KVLIFSQTKKTLEAELL-LEKEGIKVARLHGDLSQEEREEILEDFR--KGKIDVLVATDVA 74
|
90 100 110
....*....|....*....|....*....|....*
gi 2217271652 1071 GVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVG 1105
Cdd:pfam00271 75 ERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
573-787 |
1.36e-18 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 84.74 E-value: 1.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALI--LTQKNqekkeekekstaltwlskddscdftSHGT-LIICPA 649
Cdd:cd17998 4 YQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLayLKEIG-------------------------IPGPhLVVVPS 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 650 SLIHHWKNEVEKRVNSnkLRVYLYHGpNRDSRARV-------LSTYDIVITTYSLVAkeipTNKQEAE-IPGANLNVegt 721
Cdd:cd17998 59 STLDNWLREFKRWCPS--LKVEPYYG-SQEERKHLrydilkgLEDFDVIVTTYNLAT----SNPDDRSfFKRLKLNY--- 128
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2217271652 722 stpllriawarIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF 787
Cdd:cd17998 129 -----------VVYDEGHMLKNMTSERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
573-830 |
3.44e-18 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 85.49 E-value: 3.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALILTQKNQEKKEEKEkstaltwlskddscdftshgtLIICPASLI 652
Cdd:cd18064 19 YQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPH---------------------MVLVPKSTL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 653 HHWKNEVEKRVNSnkLRVYLYHGpNRDSRARVL------STYDIVITTYSLVAKEIPTNKqeaeipganlnvegtstpll 726
Cdd:cd18064 78 HNWMAEFKRWVPT--LRAVCLIG-DKDQRAAFVrdvllpGEWDVCVTSYEMLIKEKSVFK-------------------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 727 RIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF---DEFNLWRSQVDN-GSK 802
Cdd:cd18064 135 KFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFnsaEDFDSWFDTNNClGDQ 214
|
250 260
....*....|....*....|....*...
gi 2217271652 803 KGGERLSILTKSLLLRRTKDQLDSTGRP 830
Cdd:cd18064 215 KLVERLHMVLRPFLLRRIKADVEKSLPP 242
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
573-819 |
8.65e-18 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 83.71 E-value: 8.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALiltqknqekkeekekstaLTWLSKDdscdftsHGT----LIICP 648
Cdd:cd18002 4 YQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAV------------------LAHLAEE-------HNIwgpfLVIAP 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 649 ASLIHHWKNEVEKRVNsnKLRVYLYHGPNRD--------SRARVL---STYDIVITTYSLVAKEIPTnkqeaeipganln 717
Cdd:cd18002 59 ASTLHNWQQEISRFVP--QFKVLPYWGNPKDrkvlrkfwDRKNLYtrdAPFHVVITSYQLVVQDEKY------------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 718 vegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFD---EFNLWR 794
Cdd:cd18002 124 -------FQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDshdEFNEWF 196
|
250 260 270
....*....|....*....|....*....|...
gi 2217271652 795 SQ-VDNGSKKGG-------ERLSILTKSLLLRR 819
Cdd:cd18002 197 SKdIESHAENKTglnehqlKRLHMILKPFMLRR 229
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
570-819 |
7.59e-17 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 80.71 E-value: 7.59e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 570 LLLHQKQALAWLLWREsqkpqGGIL--DDMGLGKTLTMIALILTQKNQekkeekekstaltW-LskddscdftshgtLII 646
Cdd:cd18010 1 LLPFQREGVCFALRRG-----GRVLiaDEMGLGKTVQAIAIAAYYREE-------------WpL-------------LIV 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 647 CPASLIHHWKNEVEKRVNS-NKLRVYLYHGPNRDSRArvlSTYDIVITTYSLVAKEiptnkqeaeipganlnvegtSTPL 725
Cdd:cd18010 50 CPSSLRLTWADEIERWLPSlPPDDIQVIVKSKDGLRD---GDAKVVIVSYDLLRRL--------------------EKQL 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 726 LRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAV--TGTPIQNNLLDMYSLLKFLR---CSPFDEFNLWRSQVDNG 800
Cdd:cd18010 107 LARKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVIllSGTPALSRPIELFTQLDALDpklFGRFHDFGRRYCAAKQG 186
|
250 260
....*....|....*....|....*..
gi 2217271652 801 SK----KGGERL----SILTKSLLLRR 819
Cdd:cd18010 187 GFgwdySGSSNLeelhLLLLATIMIRR 213
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1024-1105 |
2.36e-16 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 74.94 E-value: 2.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 1024 VALHLKKHGLTYATIDGSVNPKQRMDLVEAFNhsRGPQVMLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYR 1103
Cdd:smart00490 3 LAELLKELGIKVARLHGGLSQEEREEILDKFN--NGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 2217271652 1104 VG 1105
Cdd:smart00490 81 AG 82
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
574-819 |
3.05e-16 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 78.94 E-value: 3.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 574 QKQALAWL--LWresQKPQGGIL-DDMGLGKTLTMIALiltqknqekkeekekstaLTWLSKDdscdFTSHGT-LIICPA 649
Cdd:cd17993 6 QLTGLNWLahSW---CKGNNGILaDEMGLGKTVQTISF------------------LSYLFHS----QQQYGPfLVVVPL 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 650 SLIHHWKNEVEKRVNSNKLRVYLyhgPNRDSRArVLSTYD------------IVITTYSLVAKEiptnKQEaeipganln 717
Cdd:cd17993 61 STMPAWQREFAKWAPDMNVIVYL---GDIKSRD-TIREYEfyfsqtkklkfnVLLTTYEIILKD----KAF--------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 718 vegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQV 797
Cdd:cd17993 124 -------LGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEEH 196
|
250 260
....*....|....*....|..
gi 2217271652 798 DNGSKKGGERLSILTKSLLLRR 819
Cdd:cd17993 197 DEEQEKGIADLHKELEPFILRR 218
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
573-819 |
3.90e-14 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 72.78 E-value: 3.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALILTQKNQEKKEEKekstaltwlskddscdftshgtLIICPASLI 652
Cdd:cd18060 4 YQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPF----------------------LVIAPLSTI 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 653 HHWKNEVEKRVNSNKLrvyLYHGP-------------NRDSRARVLS---TYDIVITTYSLVAKEIPTnkqeaeipganl 716
Cdd:cd18060 62 TNWEREFNTWTEMNTI---VYHGSlasrqmiqqyemyCKDSRGRLIPgayKFDALITTFEMILSDCPE------------ 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 717 nvegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF-DEFNLWRS 795
Cdd:cd18060 127 --------LREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFpSESEFLKD 198
|
250 260
....*....|....*....|....
gi 2217271652 796 QVDNGSKKGGERLSILTKSLLLRR 819
Cdd:cd18060 199 FGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
570-782 |
1.86e-13 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 70.40 E-value: 1.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 570 LLLHQKQALAWLLwreSQKPQGGIL-DDMGLGKTLTMIALILtqknqekkeekekstALTWLSKDDSCdftshgtLIICP 648
Cdd:cd18011 1 PLPHQIDAVLRAL---RKPPVRLLLaDEVGLGKTIEAGLIIK---------------ELLLRGDAKRV-------LILCP 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 649 ASLIHHWKNEVEKRVNSNKLRVY-LYHGPNRDSRARVLSTYDIVITTYSLVakeiptnKQEAEIPGAnlnvegtstpLLR 727
Cdd:cd18011 56 ASLVEQWQDELQDKFGLPFLILDrETAAQLRRLIGNPFEEFPIVIVSLDLL-------KRSEERRGL----------LLS 118
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2217271652 728 IAWARIILDEAHNVKN---PRVQTSIAVCKLQACARWAV---TGTPIQNNLLDMYSLLKFL 782
Cdd:cd18011 119 EEWDLVVVDEAHKLRNsggGKETKRYKLGRLLAKRARHVlllTATPHNGKEEDFRALLSLL 179
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
573-819 |
3.40e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 70.07 E-value: 3.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIaliltqknqekkeekekstalTWLSKDDSCDFtsHGT-LIICPASL 651
Cdd:cd18058 4 YQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSI---------------------TFLSEIFLMGI--RGPfLIIAPLST 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 652 IHHWKNEVEKRVNSNklrVYLYHGPN-------------RDSRARVLS---TYDIVITTYSLVAKEIPTnkqeaeipgan 715
Cdd:cd18058 61 ITNWEREFRTWTEMN---AIVYHGSQisrqmiqqyemyyRDEQGNPLSgifKFQVVITTFEMILADCPE----------- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 716 lnvegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF-DEFNLWR 794
Cdd:cd18058 127 ---------LKKINWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFpSETTFLE 197
|
250 260
....*....|....*....|....*
gi 2217271652 795 SQVDNGSKKGGERLSILTKSLLLRR 819
Cdd:cd18058 198 EFGDLKTEEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
573-819 |
5.17e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 70.03 E-value: 5.17e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALiltqknqekkeekekstaLTWLskddscdFTSHGT----LIICP 648
Cdd:cd18054 24 YQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISF------------------LSYL-------FHQHQLygpfLLVVP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 649 ASLIHHWKNEVEKRVNSNKLRVYLYHGPNRD---------SRARVLStYDIVITTYSLVAKEiptnkqeaeipganlnve 719
Cdd:cd18054 79 LSTLTSWQREFEIWAPEINVVVYIGDLMSRNtireyewihSQTKRLK-FNALITTYEILLKD------------------ 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 720 gtSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDN 799
Cdd:cd18054 140 --KTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGK 217
|
250 260
....*....|....*....|
gi 2217271652 800 GSKKGGERLSILTKSLLLRR 819
Cdd:cd18054 218 GRENGYQSLHKVLEPFLLRR 237
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
573-782 |
7.00e-13 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 69.30 E-value: 7.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLwresQKPQGGILDDMGLGKTLTMIaliltqknqekkeekeksTALTWLSKDdscDFTSHgTLIICPASLI 652
Cdd:cd18013 4 YQKVAINFII----EHPYCGLFLDMGLGKTVTTL------------------TALSDLQLD---DFTRR-VLVIAPLRVA 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 653 HH-WKNEVEKRVNSNKLRVYLYHGPNRDSRARVLSTYDIVITTYSLVAKEIptNKQEAEIPganlnvegtstpllriaWA 731
Cdd:cd18013 58 RStWPDEVEKWNHLRNLTVSVAVGTERQRSKAANTPADLYVINRENLKWLV--NKSGDPWP-----------------FD 118
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2217271652 732 RIILDEAHNVKNPRVQTSIAVCKLQACARWAV--TGTPIQNNLLDMYSLLKFL 782
Cdd:cd18013 119 MVVIDELSSFKSPRSKRFKALRKVRPVIKRLIglTGTPSPNGLMDLWAQIALL 171
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
573-781 |
7.79e-12 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 66.72 E-value: 7.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLlWR--ESQKPQGG----ILDDMGLGKTLTMIALILTqknqekkeekekstaltWLSKDDSCDFTSHGTLII 646
Cdd:cd18067 4 HQREGVKFL-YRcvTGRRIRGShgciMADEMGLGKTLQCITLMWT-----------------LLRQSPQCKPEIDKAIVV 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 647 CPASLIHHWKNEVEKRVNSNKLRVYLyHGPNRDSRARVLStydivittyslvakeiptnkQEAEIPGANLnvegtSTPLL 726
Cdd:cd18067 66 SPSSLVKNWANELGKWLGGRLQPLAI-DGGSKKEIDRKLV--------------------QWASQQGRRV-----STPVL 119
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 727 RIAW---------------ARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKF 781
Cdd:cd18067 120 IISYetfrlhvevlqkgevGLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNF 189
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
573-821 |
4.72e-11 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 64.31 E-value: 4.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALIltqknqekkeekekstalTWLSKDDSCDFTshgTLIICPASLI 652
Cdd:cd18063 27 YQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALI------------------TYLMEHKRLNGP---YLIIVPLSTL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 653 HHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVLST--YDIVITTYSLVAKEiptnkqeaeipganlnvegtSTPLLRIAW 730
Cdd:cd18063 86 SNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSgkFNVLLTTYEYIIKD--------------------KHILAKIRW 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 731 ARIILDEAHNVKNPRVQ-TSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFL------RCSPFDE-----FNLWRSQVD 798
Cdd:cd18063 146 KYMIVDEGHRMKNHHCKlTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLlptifkSCSTFEQwfnapFAMTGERVD 225
|
250 260
....*....|....*....|....*.
gi 2217271652 799 NGSKKG---GERLSILTKSLLLRRTK 821
Cdd:cd18063 226 LNEEETiliIRRLHKVLRPFLLRRLK 251
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
573-819 |
1.31e-10 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 62.74 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALILTqknqekkeekekstalTWLSKddscdftSHGT-LIICPASL 651
Cdd:cd18059 4 YQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYE----------------IYLKG-------IHGPfLVIAPLST 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 652 IHHWKNEVEkrvNSNKLRVYLYHGPN-------------RDSRARVLS---TYDIVITTYSLVAKEIPTnkqeaeipgan 715
Cdd:cd18059 61 IPNWEREFR---TWTELNVVVYHGSQasrrtiqlyemyfKDPQGRVIKgsyKFHAIITTFEMILTDCPE----------- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 716 lnvegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF-DEFNLWR 794
Cdd:cd18059 127 ---------LRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFpSETTFMQ 197
|
250 260
....*....|....*....|....*
gi 2217271652 795 SQVDNGSKKGGERLSILTKSLLLRR 819
Cdd:cd18059 198 EFGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
573-821 |
2.08e-10 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 62.37 E-value: 2.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALIltqknqekkeekekstalTWLSKDDSCDFTshgTLIICPASLI 652
Cdd:cd18062 27 YQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALI------------------TYLMEHKRINGP---FLIIVPLSTL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 653 HHWKNEVEKRVNSnkLRVYLYHGPNRDSRARV----LSTYDIVITTYSLVAKEiptnkqeaeipganlnvegtSTPLLRI 728
Cdd:cd18062 86 SNWVYEFDKWAPS--VVKVSYKGSPAARRAFVpqlrSGKFNVLLTTYEYIIKD--------------------KQILAKI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 729 AWARIILDEAHNVKNPRVQ-TSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFL------RCSPFDE-----FNLWRSQ 796
Cdd:cd18062 144 RWKYMIVDEGHRMKNHHCKlTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLlptifkSCSTFEQwfnapFAMTGEK 223
|
250 260
....*....|....*....|....*...
gi 2217271652 797 VDNGSKKG---GERLSILTKSLLLRRTK 821
Cdd:cd18062 224 VDLNEEETiliIRRLHKVLRPFLLRRLK 251
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
573-819 |
2.29e-10 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 61.95 E-value: 2.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALIltqknqekkeekeKSTALTWLSKDdscdftshgTLIICPASLI 652
Cdd:cd18061 4 YQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFL-------------YEILLTGIRGP---------FLIIAPLSTI 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 653 HHWKNEVEKRVNSNklrVYLYHGP-------------NRDSRARVLS---TYDIVITTYSLVAkeiptnkqeaeipganl 716
Cdd:cd18061 62 ANWEREFRTWTDLN---VVVYHGSlisrqmiqqyemyFRDSQGRIIRgayRFQAIITTFEMIL----------------- 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 717 nveGTSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQ 796
Cdd:cd18061 122 ---GGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQE 198
|
250 260
....*....|....*....|....
gi 2217271652 797 V-DNGSKKGGERLSILTKSLLLRR 819
Cdd:cd18061 199 FgDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
570-819 |
6.29e-10 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 60.80 E-value: 6.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 570 LLLHQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALILTqknqekkeekekstaltwLSKDDScdfTSHGTLIICPA 649
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYS------------------LYKEGH---TKGPFLVSAPL 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 650 SLIHHWKNEVEkrVNSNKLRVYLYHGpNRDSRARVLSTYDIVITTYSLVAKEIPTNKQEAEIpgaNLNVEGTSTPLL--- 726
Cdd:cd18055 60 STIINWEREFQ--MWAPDFYVVTYTG-DKDSRAIIRENEFSFDDNAVKGGKKAFKMKREAQV---KFHVLLTSYELVtid 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 727 -----RIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDNGS 801
Cdd:cd18055 134 qaalgSIRWACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADIS 213
|
250
....*....|....*....
gi 2217271652 802 KKGG-ERLSILTKSLLLRR 819
Cdd:cd18055 214 KEDQiKKLHDLLGPHMLRR 232
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
573-819 |
6.38e-10 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 60.15 E-value: 6.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALILTqknqekkeekekstaltwLSKDDSCD--FtshgtLIICPAS 650
Cdd:cd17994 4 YQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYS------------------LYKEGHSKgpF-----LVSAPLS 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 651 LIHHWKNEVEkrVNSNKLRVYLYHGPNrdsrarvlstydIVITTYSLVAKEIPTnkqeaeipganlnvegtstpLLRIAW 730
Cdd:cd17994 61 TIINWEREFE--MWAPDFYVVTYVGDH------------VLLTSYELISIDQAI--------------------LGSIDW 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 731 ARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDNGSKKGG-ERLS 809
Cdd:cd17994 107 AVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFADISKEDQiKKLH 186
|
250
....*....|
gi 2217271652 810 ILTKSLLLRR 819
Cdd:cd17994 187 DLLGPHMLRR 196
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
573-819 |
5.51e-09 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 58.15 E-value: 5.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALILTqknqekkeekekstaltwLSKDDScdfTSHGTLIICPASLI 652
Cdd:cd18057 4 YQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYS------------------LYKEGH---SKGPYLVSAPLSTI 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 653 HHWKNEVEkrVNSNKLRVYLYHGpNRDSRARV----LSTYDIVITTyslvAKEIPTNKQEAEIpgaNLNVEGTSTPLL-- 726
Cdd:cd18057 63 INWEREFE--MWAPDFYVVTYTG-DKESRSVIreneFSFEDNAIRS----GKKVFRMKKEAQI---KFHVLLTSYELIti 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 727 ------RIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDNG 800
Cdd:cd18057 133 dqailgSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADI 212
|
250 260
....*....|....*....|
gi 2217271652 801 SKKGG-ERLSILTKSLLLRR 819
Cdd:cd18057 213 SKEDQiKKLHDLLGPHMLRR 232
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
584-783 |
1.05e-08 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 57.21 E-value: 1.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 584 RESQKPQG--GILDD-MGLGKTLTMIALILTqknqekkeekekstaLTWLSKDDSCDftshGTLIICPASLIHHWKNEVE 660
Cdd:cd18068 21 KKTKKSPGsgCILAHcMGLGKTLQVVTFLHT---------------VLLCEKLENFS----RVLVVCPLNTVLNWLNEFE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 661 KRV----NSNKLRVY---LYHGPNRDSRA--RVLSTYDIVITTYSL-----VAKEIPTNKQEAEI-------PGANLnve 719
Cdd:cd18068 82 KWQeglkDEEKIEVNelaTYKRPQERSYKlqRWQEEGGVMIIGYDMyrilaQERNVKSREKLKEIfnkalvdPGPDF--- 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2217271652 720 gtstpllriawarIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLR 783
Cdd:cd18068 159 -------------VVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVK 209
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
597-783 |
3.49e-08 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 55.59 E-value: 3.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 597 MGLGKTLTMIALIltqknqekkeekekstaltwlskDDSCDFTSHGT-LIICPASLIHHWKNEVEK---------RVNSN 666
Cdd:cd18069 37 MGLGKTLQVISFL-----------------------DVLLRHTGAKTvLAIVPVNTLQNWLSEFNKwlpppealpNVRPR 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 667 KLRVYLYHGPNR--DSRARVLSTYD----IVITTYSLVAKEiptnkqeaeiPGANLnvegtstpllriawarIILDEAHN 740
Cdd:cd18069 94 PFKVFILNDEHKttAARAKVIEDWVkdggVLLMGYEMFRLR----------PGPDV----------------VICDEGHR 147
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2217271652 741 VKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLR 783
Cdd:cd18069 148 IKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVR 190
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
573-819 |
5.65e-08 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 55.06 E-value: 5.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALiltqknqekkeekekstaLTWLskddscdFTSHGT----LIICP 648
Cdd:cd18053 24 YQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISF------------------LNYL-------FHEHQLygpfLLVVP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 649 ASLIHHWKNEVEKRVNSNKLRVYLYHGPNRD---------SRARVLStYDIVITTYSLVAKEiptnkqeaeipganlnve 719
Cdd:cd18053 79 LSTLTSWQREIQTWAPQMNAVVYLGDINSRNmirthewmhPQTKRLK-FNILLTTYEILLKD------------------ 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 720 gtSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDN 799
Cdd:cd18053 140 --KSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGK 217
|
250 260
....*....|....*....|
gi 2217271652 800 GSKKGGERLSILTKSLLLRR 819
Cdd:cd18053 218 GREYGYASLHKELEPFLLRR 237
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
560-767 |
9.83e-08 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 56.19 E-value: 9.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 560 AEDPAGLKVPLLLHQKQAL-AWLLWRESQKPQGGILDDMGLGKTLTMIALILTQKNQEKkeekekstaltwlskddscdf 638
Cdd:COG1061 71 GDEASGTSFELRPYQQEALeALLAALERGGGRGLVVAPTGTGKTVLALALAAELLRGKR--------------------- 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 639 tshgTLIICP-ASLIHHWKNEVEKrvnsnKLRVYLYHGPNRDSrarvlsTYDIVITTYSLVAKEIPTNKqeaeipganln 717
Cdd:COG1061 130 ----VLVLVPrRELLEQWAEELRR-----FLGDPLAGGGKKDS------DAPITVATYQSLARRAHLDE----------- 183
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2217271652 718 vegtstplLRIAWARIILDEAHNVKNPRVQTSIAvcKLQACARWAVTGTP 767
Cdd:COG1061 184 --------LGDRFGLVIIDEAHHAGAPSYRRILE--AFPAAYRLGLTATP 223
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
573-782 |
1.80e-07 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 53.53 E-value: 1.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPQGGILDDMGLGKTLTMIALILTqknqekkeekekstaltwLSKDDScdftSHGTLII-CPASL 651
Cdd:cd18056 4 YQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYS------------------LYKEGH----SKGPFLVsAPLST 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 652 IHHWKNEVEkrVNSNKLRVYLYHGpNRDSRARV----LSTYDIVITTyslvAKEIPTNKQEAEIpgaNLNVEGTSTPLL- 726
Cdd:cd18056 62 IINWEREFE--MWAPDMYVVTYVG-DKDSRAIIreneFSFEDNAIRG----GKKASRMKKEASV---KFHVLLTSYELIt 131
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217271652 727 -------RIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFL 782
Cdd:cd18056 132 idmailgSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFL 194
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
573-741 |
1.38e-06 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 49.23 E-value: 1.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 573 HQKQALAWLLWRESQKPqgGILDdM--GLGKTLTMIALIltqknqekkeekekstaltwlskddsCDFTSHGTLIICP-A 649
Cdd:cd17926 4 YQEEALEAWLAHKNNRR--GILV-LptGSGKTLTALALI--------------------------AYLKELRTLIVVPtD 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 650 SLIHHWKNEVEKRVNSNKLRvYLYHGPNRDSRARvlstyDIVITTYSLVakeipTNKQEAEIPGANlnvegtstpllriA 729
Cdd:cd17926 55 ALLDQWKERFEDFLGDSSIG-LIGGGKKKDFDDA-----NVVVATYQSL-----SNLAEEEKDLFD-------------Q 110
|
170
....*....|..
gi 2217271652 730 WARIILDEAHNV 741
Cdd:cd17926 111 FGLLIVDEAHHL 122
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
4-39 |
8.07e-06 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 43.93 E-value: 8.07e-06
10 20 30
....*....|....*....|....*....|....*....
gi 2217271652 4 VRCPeHGTFCFLKTGVRDGPNKGKSFYVC---RADTCSF 39
Cdd:pfam06839 1 PLCP-CGQRAVLLTVRKTGPNPGRQFYKCpvgREKQCGF 38
|
|
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
147-378 |
1.92e-03 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 42.73 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 147 EEKKADKKQREKGDQLFDQKK--EQKPEMMEKDLSSGLVPKKKQSVVQEKKQEEGAEIQCEAETGGTHKRDFSEIKSQQC 224
Cdd:PTZ00108 1148 EEKEIAKEQRLKSKTKGKASKlrKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQED 1227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 225 QGNELTRPSASSQEKSSGKSQDVQRESEPLREKVTQLL---------PQNVHSHNSISKPQKGGPLNKEYTNW-EAKETK 294
Cdd:PTZ00108 1228 DEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLskegkpknaPKRVSAVQYSPPPPSKRPDGESNGGSkPSSPTK 1307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217271652 295 AKDGPSIQATQKSLPQGhfqERPETHSVPAPGGPAAQAAPAAPGLSLGEGREAATSSDDEEEDDVVFVSSKPGSPLLFDS 374
Cdd:PTZ00108 1308 KKVKKRLEGSLAALKKK---KKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSEDEDDEDD 1384
|
....
gi 2217271652 375 TLDL 378
Cdd:PTZ00108 1385 EDDD 1388
|
|
| |
