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Conserved domains on  [gi|2217282619|ref|XP_047282825|]
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leucine zipper protein 2 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 25-142 1.26e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 1.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282619   25 EELEKQLKEVFKERSTILRQLTKTSRELDGIKVNLQSLKNDEQSAKTDVQKLLELGQKQREEMKSLQEAL---QNQLKET 101
Cdd:TIGR02168  701 AELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLeeaEEELAEA 780

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2217282619  102 SEKAEKHQATINFLKTEVERKSKMIRDLQNEMEGTNITHHQ 142
Cdd:TIGR02168  781 EAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAAN 821
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 25-142 1.26e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 1.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282619   25 EELEKQLKEVFKERSTILRQLTKTSRELDGIKVNLQSLKNDEQSAKTDVQKLLELGQKQREEMKSLQEAL---QNQLKET 101
Cdd:TIGR02168  701 AELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLeeaEEELAEA 780

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2217282619  102 SEKAEKHQATINFLKTEVERKSKMIRDLQNEMEGTNITHHQ 142
Cdd:TIGR02168  781 EAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAAN 821
SseC pfam04888
Secretion system effector C (SseC) like family; SseC is a secreted protein that forms a ...
 56-107 1.72e-03

Secretion system effector C (SseC) like family; SseC is a secreted protein that forms a complex together with SecB and SecD on the surface of Salmonella. All these proteins are secreted by the type III secretion system. Many mucosal pathogens use type III secretion systems for the injection of effector proteins into target cells. SecB, SseC and SecD are inserted into the target cell membrane. where they form a small pore or translocon. In addition to SseC, this family includes the bacterial secreted proteins PopB, PepB, YopB and EspD which are thought to be directly involved in pore formation, and type III secretion system translocon.


Pssm-ID: 428175 [Multi-domain]  Cd Length: 312  Bit Score: 38.26  E-value: 1.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217282619  56 KVNLQSL--KNDEQSAKTDVQKLLELGQKQREEMKSLQEALQNQLKETSEKAEK 107
Cdd:pfam04888   2 MAMLTELtsKLDEKSLASKLKLLQEAQEKREAEMEKQVEKIQEQVNKAEEKAKK 55
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
24-146 4.16e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 37.30  E-value: 4.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282619  24 YEELEKQLKEVFKERSTILRQLTKTSRELDGIKVNLQSLkndEQSAKTDVQKLLELGQKQREEMKSLQEALQNQLKETSE 103
Cdd:COG3206   265 IQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAAL---RAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEA 341

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2217282619 104 KAE---KHQATINFLKTEVERKSKMIRDLQNEMEGTNITHHQSINN 146
Cdd:COG3206   342 RLAelpELEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGN 387
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 25-142 1.26e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 1.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282619   25 EELEKQLKEVFKERSTILRQLTKTSRELDGIKVNLQSLKNDEQSAKTDVQKLLELGQKQREEMKSLQEAL---QNQLKET 101
Cdd:TIGR02168  701 AELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLeeaEEELAEA 780

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 2217282619  102 SEKAEKHQATINFLKTEVERKSKMIRDLQNEMEGTNITHHQ 142
Cdd:TIGR02168  781 EAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAAN 821
SseC pfam04888
Secretion system effector C (SseC) like family; SseC is a secreted protein that forms a ...
 56-107 1.72e-03

Secretion system effector C (SseC) like family; SseC is a secreted protein that forms a complex together with SecB and SecD on the surface of Salmonella. All these proteins are secreted by the type III secretion system. Many mucosal pathogens use type III secretion systems for the injection of effector proteins into target cells. SecB, SseC and SecD are inserted into the target cell membrane. where they form a small pore or translocon. In addition to SseC, this family includes the bacterial secreted proteins PopB, PepB, YopB and EspD which are thought to be directly involved in pore formation, and type III secretion system translocon.


Pssm-ID: 428175 [Multi-domain]  Cd Length: 312  Bit Score: 38.26  E-value: 1.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2217282619  56 KVNLQSL--KNDEQSAKTDVQKLLELGQKQREEMKSLQEALQNQLKETSEKAEK 107
Cdd:pfam04888   2 MAMLTELtsKLDEKSLASKLKLLQEAQEKREAEMEKQVEKIQEQVNKAEEKAKK 55
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
24-146 4.16e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 37.30  E-value: 4.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282619  24 YEELEKQLKEVFKERSTILRQLTKTSRELDGIKVNLQSLkndEQSAKTDVQKLLELGQKQREEMKSLQEALQNQLKETSE 103
Cdd:COG3206   265 IQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAAL---RAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEA 341

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2217282619 104 KAE---KHQATINFLKTEVERKSKMIRDLQNEMEGTNITHHQSINN 146
Cdd:COG3206   342 RLAelpELEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGN 387
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 22-134 6.26e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 36.97  E-value: 6.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282619   22 QDYE--ELEKQLKEVFKERSTILRQLTKTSRELDGIKVNLQSLkNDEQSAKtdVQKLLELGQKQREEMKSLQEALQNQLK 99
Cdd:TIGR02169  221 REYEgyELLKEKEALERQKEAIERQLASLEEELEKLTEEISEL-EKRLEEI--EQLLEELNKKIKDLGEEEQLRVKEKIG 297

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2217282619  100 ETSEKAEKHQATINFLKTEVERKSKMIRDLQNEME 134
Cdd:TIGR02169  298 ELEAEIASLERSIAEKERELEDAEERLAKLEAEID 332
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 21-134 7.11e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 36.97  E-value: 7.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217282619   21 RQDYEELEKQLKEVFKERSTILRQLTKTSRELDGIKVNLQSLKNDEQSAKTDV----QKLLELGQKQRE---EMKSLQEA 93
Cdd:TIGR02169  370 RAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELadlnAAIAGIEAKINEleeEKEDKALE 449

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2217282619   94 LQNQ---LKETSEKAEKHQATINFLKTEVERKSKMIRDLQNEME 134
Cdd:TIGR02169  450 IKKQewkLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELA 493
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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