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Conserved domains on  [gi|2217377905|ref|XP_047279575|]
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DENN domain-containing protein 1A isoform X12 [Homo sapiens]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655395)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  1.10.287.2550|3.40.50.11500|3.30.450.200
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 113-291 5.65e-64

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 213.98  E-value: 5.65e-64
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905   113 SCFCILSYLPWFEVFYKLLNILADYTTKRQENQwNELLETLHKLPIPDPG-----VSVHLSVHSYFTVPDTRELPSIPen 187
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905   188 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 267
Cdd:smart00799   80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                           170       180
                    ....*....|....*....|....
gi 2217377905   268 HLSLMEKVRNMALDDVVILNVDTN 291
Cdd:smart00799  160 HSSYFEEVKELPDEDVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 48-109 1.40e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 84.31  E-value: 1.40e-19
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217377905    48 DPEVQRQFPE-DYSDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 109
Cdd:smart00800   25 KPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 323-389 5.03e-17

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 76.17  E-value: 5.03e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905   323 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGR 389
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 662-1013 4.49e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 67.66  E-value: 4.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  662 DDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilnpsdkeevptPTLGSITIPRPQGRKTPELGIVPPPPIPRPAK 741
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD------------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  742 LQAAGAALGDVSErlqtdrdrraALSPGLLPGVVPQgPTELLQPLSPGPGAAGTSSDALLALLDPLSTAwSGSTLPSRPA 821
Cdd:PHA03247  2688 ARPTVGSLTSLAD----------PPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPA 2755

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  822 TPNV-ATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPfgaPPASLGPAFASGLLLSSAGFCAPHR 900
Cdd:PHA03247  2756 RPARpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPT 2832

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  901 S-QPNLSALSMPNLFGQMPMGTHTSPLQPL---GPPAVAPSRI--RTLPLARSSARAA--ETKQGLALRPGDPPLLPprp 972
Cdd:PHA03247  2833 SaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPaaPARPPVRRLARPAvsRSTESFALPPDQPERPP--- 2909

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 2217377905  973 pqgleptlQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1013
Cdd:PHA03247  2910 --------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 113-291 5.65e-64

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 213.98  E-value: 5.65e-64
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905   113 SCFCILSYLPWFEVFYKLLNILADYTTKRQENQwNELLETLHKLPIPDPG-----VSVHLSVHSYFTVPDTRELPSIPen 187
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905   188 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 267
Cdd:smart00799   80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                           170       180
                    ....*....|....*....|....
gi 2217377905   268 HLSLMEKVRNMALDDVVILNVDTN 291
Cdd:smart00799  160 HSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 114-291 2.70e-44

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 158.51  E-value: 2.70e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  114 CFCILSYLPWFEVFYKLLNILAdytTKRQENQWNELLET-----LHKLPIPDPGVSVHLSVHS-----YFTVPDTRELPS 183
Cdd:pfam02141    5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  184 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 263
Cdd:pfam02141   82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159

                          170       180
                   ....*....|....*....|....*...
gi 2217377905  264 LIGIHLSLMEKVRNmALDDVVILNVDTN 291
Cdd:pfam02141  160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 48-109 1.40e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 84.31  E-value: 1.40e-19
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217377905    48 DPEVQRQFPE-DYSDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 109
Cdd:smart00800   25 KPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 323-389 5.03e-17

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 76.17  E-value: 5.03e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905   323 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGR 389
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 49-107 1.41e-11

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 60.32  E-value: 1.41e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905   49 PEVQRQFPE-DYSDQEVLQTLTKFCFPFYVDSLtVSQVGQNFTFVLTDIDSKQRFGFCRL 107
Cdd:pfam03456    1 PEVLDRYPEdDWSDPPLPDGIPMFCFPEGLETL-SSREPTFFSFVLTDEDGSRLYGACLT 59
PHA03247 PHA03247
large tegument protein UL36; Provisional
 662-1013 4.49e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 67.66  E-value: 4.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  662 DDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilnpsdkeevptPTLGSITIPRPQGRKTPELGIVPPPPIPRPAK 741
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD------------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  742 LQAAGAALGDVSErlqtdrdrraALSPGLLPGVVPQgPTELLQPLSPGPGAAGTSSDALLALLDPLSTAwSGSTLPSRPA 821
Cdd:PHA03247  2688 ARPTVGSLTSLAD----------PPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPA 2755

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  822 TPNV-ATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPfgaPPASLGPAFASGLLLSSAGFCAPHR 900
Cdd:PHA03247  2756 RPARpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPT 2832

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  901 S-QPNLSALSMPNLFGQMPMGTHTSPLQPL---GPPAVAPSRI--RTLPLARSSARAA--ETKQGLALRPGDPPLLPprp 972
Cdd:PHA03247  2833 SaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPaaPARPPVRRLARPAvsRSTESFALPPDQPERPP--- 2909

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 2217377905  973 pqgleptlQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1013
Cdd:PHA03247  2910 --------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 355-406 8.16e-08

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 49.50  E-value: 8.16e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217377905  355 FCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 406
Cdd:pfam03455    1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 659-1015 1.13e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 1.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  659 LGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPqnrdsilnPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPR 738
Cdd:pfam03154  167 LQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPT--------PSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLH 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  739 PAKLQAAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPtellQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPS 818
Cdd:pfam03154  239 PQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMP----HSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPS 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  819 rpatPNVATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTL-PLVSTPAGPFGAPPASLGPAFASGlllsSAGFCA 897
Cdd:pfam03154  315 ----PAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIkPPPTTPIPQLPNPQSHKHPPHLSG----PSPFQM 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  898 PHRSQPNLSALSMPNLFGQMPMGTHTSPLQ------PLGPPAVAPSRIRTLPLARSSARAAETKQGLALRPGDPPLLPPR 971
Cdd:pfam03154  387 NSNLPPPPALKPLSSLSTHHPPSAHPPPLQlmpqsqQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHP 466

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2217377905  972 PPQGLEPT-LQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDS 1015
Cdd:pfam03154  467 FVPGGPPPiTPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVS 511
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
772-878 3.39e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 41.28  E-value: 3.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  772 PGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVATPFTPQFSFPPAGTPTPFPQPPLNP 851
Cdd:COG3469    108 GTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATA 187

                           90       100
                   ....*....|....*....|....*..
gi 2217377905  852 FVPSMPAAPPTLPLVSTPAGPFGAPPA 878
Cdd:COG3469    188 TTASGATTPSATTTATTTGPPTPGLPK 214
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 113-291 5.65e-64

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 213.98  E-value: 5.65e-64
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905   113 SCFCILSYLPWFEVFYKLLNILADYTTKRQENQwNELLETLHKLPIPDPG-----VSVHLSVHSYFTVPDTRELPSIPen 187
Cdd:smart00799    3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905   188 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 267
Cdd:smart00799   80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                           170       180
                    ....*....|....*....|....
gi 2217377905   268 HLSLMEKVRNMALDDVVILNVDTN 291
Cdd:smart00799  160 HSSYFEEVKELPDEDVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 114-291 2.70e-44

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 158.51  E-value: 2.70e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  114 CFCILSYLPWFEVFYKLLNILAdytTKRQENQWNELLET-----LHKLPIPDPGVSVHLSVHS-----YFTVPDTRELPS 183
Cdd:pfam02141    5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  184 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 263
Cdd:pfam02141   82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159

                          170       180
                   ....*....|....*....|....*...
gi 2217377905  264 LIGIHLSLMEKVRNmALDDVVILNVDTN 291
Cdd:pfam02141  160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 48-109 1.40e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 84.31  E-value: 1.40e-19
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2217377905    48 DPEVQRQFPE-DYSDQEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 109
Cdd:smart00800   25 KPEILQRYPEkDFEDFPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 323-389 5.03e-17

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 76.17  E-value: 5.03e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905   323 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGR 389
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 49-107 1.41e-11

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 60.32  E-value: 1.41e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905   49 PEVQRQFPE-DYSDQEVLQTLTKFCFPFYVDSLtVSQVGQNFTFVLTDIDSKQRFGFCRL 107
Cdd:pfam03456    1 PEVLDRYPEdDWSDPPLPDGIPMFCFPEGLETL-SSREPTFFSFVLTDEDGSRLYGACLT 59
PHA03247 PHA03247
large tegument protein UL36; Provisional
 662-1013 4.49e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 67.66  E-value: 4.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  662 DDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilnpsdkeevptPTLGSITIPRPQGRKTPELGIVPPPPIPRPAK 741
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD------------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRA 2687

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  742 LQAAGAALGDVSErlqtdrdrraALSPGLLPGVVPQgPTELLQPLSPGPGAAGTSSDALLALLDPLSTAwSGSTLPSRPA 821
Cdd:PHA03247  2688 ARPTVGSLTSLAD----------PPPPPPTPEPAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPA 2755

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  822 TPNV-ATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPfgaPPASLGPAFASGLLLSSAGFCAPHR 900
Cdd:PHA03247  2756 RPARpPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP---PAAVLAPAAALPPAASPAGPLPPPT 2832

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  901 S-QPNLSALSMPNLFGQMPMGTHTSPLQPL---GPPAVAPSRI--RTLPLARSSARAA--ETKQGLALRPGDPPLLPprp 972
Cdd:PHA03247  2833 SaQPTAPPPPPGPPPPSLPLGGSVAPGGDVrrrPPSRSPAAKPaaPARPPVRRLARPAvsRSTESFALPPDQPERPP--- 2909

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 2217377905  973 pqgleptlQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1013
Cdd:PHA03247  2910 --------QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
PHA03247 PHA03247
large tegument protein UL36; Provisional
 481-952 1.75e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.18  E-value: 1.75e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  481 PEEQLPKTAPSPLVEAKDPKLREDRRPI--TVHFGQVRPPRPHVVKRPKSNIAVEG--RRTSVPS----------PEQPQ 546
Cdd:PHA03247  2551 PPPPLPPAAPPAAPDRSVPPPRPAPRPSepAVTSRARRPDAPPQSARPRAPVDDRGdpRGPAPPSplppdthapdPPPPS 2630

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  547 PYRTLRESDSAEGDEAESPEQQVRKSTGPVPAPPDRAASIDLLEDVFSNLD---MEAALQPLGQAKSLEDLRAPKDLREq 623
Cdd:PHA03247  2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQrprRRAARPTVGSLTSLADPPPPPPTPE- 2709

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  624 pgtfdyqrldlggsERSRGVTVALKLTHPYNklwSLGQDDMAIPSKP-PAASPEKPSALLGnslalPRRPQNRDSILNPs 702
Cdd:PHA03247  2710 --------------PAPHALVSATPLPPGPA---AARQASPALPAAPaPPAVPAGPATPGG-----PARPARPPTTAGP- 2766

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  703 dkeevPTPTLGSITIPRPQGRKTPelgivppppiprpaklqAAGAALGDVSERLQTDRDRRAALSPGLLPGVVpQGPTEL 782
Cdd:PHA03247  2767 -----PAPAPPAAPAAGPPRRLTR-----------------PAVASLSESRESLPSPWDPADPPAAVLAPAAA-LPPAAS 2823

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  783 LQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLP---------SRPATPNVATPFTPQFSF----PPAGTPTPFPQPPL 849
Cdd:PHA03247  2824 PAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvrrrppSRSPAAKPAAPARPPVRRlarpAVSRSTESFALPPD 2903

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  850 NPFVPSMPAAP------PTLPLVSTPAGPFGAPPASLGPAfASGLLLSSAGFCAPHRSQPNLSALSMPNLfgQMPMGTHT 923
Cdd:PHA03247  2904 QPERPPQPQAPpppqpqPQPPPPPQPQPPPPPPPRPQPPL-APTTDPAGAGEPSGAVPQPWLGALVPGRV--AVPRFRVP 2980

                          490       500
                   ....*....|....*....|....*....
gi 2217377905  924 SPLQPLGPPAVAPSRIRTLPLARSSARAA 952
Cdd:PHA03247  2981 QPAPSREAPASSTPPLTGHSLSRVSSWAS 3009
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 355-406 8.16e-08

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 49.50  E-value: 8.16e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2217377905  355 FCEEAFVSHyRSGAMRQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 406
Cdd:pfam03455    1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
812-1013 1.19e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.02  E-value: 1.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  812 SGSTLPSRPATPNVATPfTPQFSFPPAGTPTPfpqpplnpfvPSMPAAPPTLPLVSTPAGPFGAPPASLGPAFASGLLLS 891
Cdd:PRK12323   369 GGGAGPATAAAAPVAQP-APAAAAPAAAAPAP----------AAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAAR 437

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  892 SAGFCAP-HRSQPNLSALSMPnlfgqmPMGTHTSPLQPLGPPAVAPSRIRTLPLARSSARAA------ETKQGLALRPGD 964
Cdd:PRK12323   438 QASARGPgGAPAPAPAPAAAP------AAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADddpppwEELPPEFASPAP 511

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2217377905  965 PPLLPPRPPQGLEPTLQPsAPQQARDPFEDLLQKTKQDVSPSPALAPAP 1013
Cdd:PRK12323   512 AQPDAAPAGWVAESIPDP-ATADPDDAFETLAPAPAAAPAPRAAAATEP 559
PHA03247 PHA03247
large tegument protein UL36; Provisional
 478-885 4.67e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 4.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  478 APTPEEQLPKTAPSPLVEAKDPklREDRRPITVHFGQVRPPR------PHVVKRPKSNIAVEGRrTSVPSPEQPQPYRTL 551
Cdd:PHA03247  2734 ALPAAPAPPAVPAGPATPGGPA--RPARPPTTAGPPAPAPPAapaagpPRRLTRPAVASLSESR-ESLPSPWDPADPPAA 2810

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  552 RESDSAEGDEAESPEQQVRKSTGPVPAPPDRAASidlledvfsnldmeaalqPLGQAKSLEDLRAPkdlreqpgtfdyqr 631
Cdd:PHA03247  2811 VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG------------------PPPPSLPLGGSVAP-------------- 2858

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  632 ldlGGSERSRGvtvalklthpynklwslgqddmaiPSKPPAASPEKPSALLGNSLALPRRPQNRDSILNPSDKEE-VPTP 710
Cdd:PHA03247  2859 ---GGDVRRRP------------------------PSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPErPPQP 2911

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  711 TLGsitiPRPQGRKTPELGIVPPPPIPRPAKLQAAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPTELLQPLSPGP 790
Cdd:PHA03247  2912 QAP----PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSRE 2987

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  791 GAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVA---TPFTPQ-----------FSFPP---AGTPTPFPQPPLNPFV 853
Cdd:PHA03247  2988 APASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSlkqTLWPPDdtedsdadslfDSDSErsdLEALDPLPPEPHDPFA 3067

                          410       420       430
                   ....*....|....*....|....*....|..
gi 2217377905  854 PSMPAAPPTLPLVSTPAGPFGAPPASLGPAFA 885
Cdd:PHA03247  3068 HEPDPATPEAGARESPSSQFGPPPLSANAALS 3099
PHA03247 PHA03247
large tegument protein UL36; Provisional
 474-952 7.43e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 7.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  474 ENGCAPTPEEQLPKTAPSPLVEAKDPKLREDRRPiTVHFGQVRPPRPHVVKRPKSNIAVEGRRTSVPSPEQPQPYRTLRE 553
Cdd:PHA03247  2640 PHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA-AQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSA 2718

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  554 SDSAEGDEAESPEQQVRKSTgPVPAPPDRAASIDLLEDVFSNLDMEAALQPLGQAKSLEDLRAPKDLREQPGTFDYQRLD 633
Cdd:PHA03247  2719 TPLPPGPAAARQASPALPAA-PAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  634 LGGSERSRGVTVALKLTHPYNKLWSLGQDDMAIPSKPPAASPEKPSALLGNSLAL----------PRRPQNRDSILNPSD 703
Cdd:PHA03247  2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvapggdvRRRPPSRSPAAKPAA 2877

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  704 KEEVPTPTLgsitiPRPQGRKTPElgivppppiprpaklqaAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPTELL 783
Cdd:PHA03247  2878 PARPPVRRL-----ARPAVSRSTE-----------------SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP 2935

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  784 QPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVATPFtpqfSFPPAGTPTPFPQPPLNPFVPSMPAAPPTL 863
Cdd:PHA03247  2936 PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ----PAPSREAPASSTPPLTGHSLSRVSSWASSL 3011

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  864 PL-VSTPAGPFGA-----PPASLGPAFASGLLLSSAGFCAPHRSQPN----LSALSMPNLFGQMPMGTHTSPLQPLGPPA 933
Cdd:PHA03247  3012 ALhEETDPPPVSLkqtlwPPDDTEDSDADSLFDSDSERSDLEALDPLppepHDPFAHEPDPATPEAGARESPSSQFGPPP 3091

                          490
                   ....*....|....*....
gi 2217377905  934 VAPSRIRTLPLARSSARAA 952
Cdd:PHA03247  3092 LSANAALSRRYVRSTGRSA 3110
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 659-1015 1.13e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 1.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  659 LGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPqnrdsilnPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPR 738
Cdd:pfam03154  167 LQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPT--------PSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLH 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  739 PAKLQAAGAALGDVSERLQTDRDRRAALSPGLLPGVVPQGPtellQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPS 818
Cdd:pfam03154  239 PQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMP----HSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPS 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  819 rpatPNVATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTL-PLVSTPAGPFGAPPASLGPAFASGlllsSAGFCA 897
Cdd:pfam03154  315 ----PAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIkPPPTTPIPQLPNPQSHKHPPHLSG----PSPFQM 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  898 PHRSQPNLSALSMPNLFGQMPMGTHTSPLQ------PLGPPAVAPSRIRTLPLARSSARAAETKQGLALRPGDPPLLPPR 971
Cdd:pfam03154  387 NSNLPPPPALKPLSSLSTHHPPSAHPPPLQlmpqsqQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHP 466

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2217377905  972 PPQGLEPT-LQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDS 1015
Cdd:pfam03154  467 FVPGGPPPiTPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVS 511
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 503-900 2.09e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 2.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  503 EDRRPITVHFG--QVRPPRPHVVKRPKSNIAVE----GRRTSVPSPEQPQPYRTLRESD----------SAEGDEAESPE 566
Cdd:PHA03307    28 PGDAADDLLSGsqGQLVSDSAELAAVTVVAGAAacdrFEPPTGPPPGPGTEAPANESRStptwslstlaPASPAREGSPT 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  567 QQVRKSTGPVPAPPDRAASI-DLLEDVFSNLDMEAALQPLGQAKSLEDLRAPKDLREQPGTFDYQRLDLGGSERSRGVTV 645
Cdd:PHA03307   108 PPGPSSPDPPPPTPPPASPPpSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPS 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  646 ALKLTHPYNKLWSLGQDDMAIPSKPPAASPEKPSALLGNSLALPRRPQNRDSILNPS------DKEEVPTPTLGSITIPR 719
Cdd:PHA03307   188 SPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESsgcgwgPENECPLPRPAPITLPT 267

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  720 PQGRKTPelgivppppiprpAKLQAAGAalGDVSERlQTDRDRRAALSPG--LLPGVVPQGPTELLQPLSPGPGAAGTSS 797
Cdd:PHA03307   268 RIWEASG-------------WNGPSSRP--GPASSS-SSPRERSPSPSPSspGSGPAPSSPRASSSSSSSRESSSSSTSS 331

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  798 DALLALLDPLSTAWSGSTLPSRPATPNVATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTPAGPFGAPP 877
Cdd:PHA03307   332 SSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGR 411

                          410       420
                   ....*....|....*....|...
gi 2217377905  878 ASLGPAFASGlllSSAGFCAPHR 900
Cdd:PHA03307   412 PRPSPLDAGA---ASGAFYARYP 431
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
772-878 3.39e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 41.28  E-value: 3.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  772 PGVVPQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRPATPNVATPFTPQFSFPPAGTPTPFPQPPLNP 851
Cdd:COG3469    108 GTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATA 187

                           90       100
                   ....*....|....*....|....*..
gi 2217377905  852 FVPSMPAAPPTLPLVSTPAGPFGAPPA 878
Cdd:COG3469    188 TTASGATTPSATTTATTTGPPTPGLPK 214
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 665-1020 5.99e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 5.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  665 AIPSKPPAASPEKPSALLGNSLALPRRPQNRDSilNPSDKEEVPTPTLGSITIPRPQGRKTPELGIVPPPPIPRPAKLQA 744
Cdd:PRK07764   427 AAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPA--AAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPA 504

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  745 AGAALGDVSER----LQTDRDRRAALSPGLLPGVV---PQGPTELLQPLSPGPGAA------------------------ 793
Cdd:PRK07764   505 GADDAATLRERwpeiLAAVPKRSRKTWAILLPEATvlgVRGDTLVLGFSTGGLARRfaspgnaevlvtalaeelggdwqv 584

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  794 ----GTSSDALLALLDPLSTAWSGSTLPSRPATPnvATPFTPQFSFPPAGTPTPFPQPPLNPFVPSMPAAPPTLPLVSTP 869
Cdd:PRK07764   585 eavvGPAPGAAGGEGPPAPASSGPPEEAARPAAP--AAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA 662

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  870 AGPFGAPPASLGPAFASglllssagfcaphrsqpnlsalsmpnlfGQMPMGTHTSPLQPLG--PPAVAPSRIRTLPLARS 947
Cdd:PRK07764   663 SDGGDGWPAKAGGAAPA----------------------------APPPAPAPAAPAAPAGaaPAQPAPAPAATPPAGQA 714

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2217377905  948 SARAAETKQGLALRPGDPPLLPPRPPQGLEPTLQPSAPQQARDPFEDLLQKTKQDVSPSPALAPAPDSVEQLR 1020
Cdd:PRK07764   715 DDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE 787
PHA03378 PHA03378
EBNA-3B; Provisional
 776-955 6.32e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 6.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  776 PQGPTELLQPLSPGPGAAGTSSDALLALLDPLSTAWSGSTLPSRP--ATPNVATPFTPQFSFPPAGTPTPFPQPPLNPFV 853
Cdd:PHA03378   717 PAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPgrARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTP 796

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2217377905  854 PSMPAAPPTLPLVSTPagpfgAPPASLGPAFASGLLLSSAGFCAPHRSQPNLSALSMPNLFGQMP-----MGTHTSPLQP 928
Cdd:PHA03378   797 QPPPQAGPTSMQLMPR-----AAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPspgsgTSDKIVQAPV 871

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2217377905  929 LGPPAVAPSRI-----RTLPLARSSARAAETK 955
Cdd:PHA03378   872 FYPPVLQPIQVmrqlgSVRAAAASTVTQAPTE 903
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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