BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907157827 125 DVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWA 197
Cdd:cd18494     1 SVETACEALQAAVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREWA 73

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907157827 125 DVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWA 197
Cdd:cd18494     1 SVETACEALQAAVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREWA 73

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  24 NNPQYSDICFVVGQerQEVFAHRCLLACRCNFFQRLLGPGVP----SPVVLSTVPAEAFLAVLEFLYTNSVKLHQhSVLE 99
Cdd:pfam00651   6 EQGELCDVTLVVGD--KEFRAHKAVLAACSPYFKALFSGQESessvSEITLDDVSPEDFEALLEFMYTGKLISEE-NVDD 82

                  ....*...
gi 1907157827 100 VLTTAVEY 107
Cdd:pfam00651  83 LLAAADKL 90

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907157827 129 VCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCV-DETELVQAARSWAR 198
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVpSEEEVFEAVIRWVK 71

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907157827 125 DVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWA 197
Cdd:cd18494     1 SVETACEALQAAVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREWA 73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  28 YSDICFVVGqeRQEVFAHRCLLACRCNFFQRLLGPGV----PSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTT 103
Cdd:cd18186     1 LCDVTLVVG--GREFPAHRAVLAARSPYFRAMFSSGMkessSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAA 78

                  ....
gi 1907157827 104 AVEY 107
Cdd:cd18186    79 ADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  17 TALRSLINNPQYSDICFVVgqERQEVFAHRCLLACRCNFFQRLL----GPGVPSPVVLSTVPAEAFLAVLEFLYTNSVKL 92
Cdd:cd18298     1 DSLRKAFNDPRTSDLKFRV--DGKYIYVHKAILKIRCEYFRSMFqshwNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDL 78

                          90
                  ....*....|....*.
gi 1907157827  93 HQHSVLEVLTTAVEYG 108
Cdd:cd18298    79 PPEDAIGLLDLANSYC 94

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907157827  20 RSLINNPQYSDICFVVgqERQEVFAHRCLLACRCNFFQRLLGPG----VPSPVVLSTVPAEAFLAVLEFLYTNSVKL 92
Cdd:cd18300     1 KLFLNKGLFSDVTFIV--EDGTIPAHKALLVARCDVMAAMFGGNfresSAKEVELPGVSKETFLALLEYLYTDQAPI 75

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  24 NNPQYSDICFVVGqeRQEVFAHRCLLACRCNFFQRLLGPGVPSP----VVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLE 99
Cdd:cd18314     2 NDSEFSDVVLCVG--DRKFFAHRIVLCARSPVFRSMLTGSMIESnlkeVTLEDVEPEIFETVLKYMYTGQVTLSEENVLD 79

                  ....*....
gi 1907157827 100 VLTTAVEYG 108
Cdd:cd18314    80 LLMLASKYQ 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  22 LINNPQYSDICFVVgqERQEVFAHRCLLACRCNFFQRLL--GPGVPSP--VVLSTVPAEAFLAVLEFLYTNSVKLHQHSV 97
Cdd:cd18297     6 YVNNPEMSDVTFLV--EGRPFYAHKIVLVTASDRFKSMLssGSTEAQTpvIEIPDIRYDIFQLMMQYLYTGGVESLDVAQ 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907157827  98 LEVLttaveygleelrelclefvvkvldvelvcEALQVAVTFGLGSLQERCIAFIEAH 155
Cdd:cd18297    84 DDAL-----------------------------ELLRAASFFQLDGLKRHCEILLSQQ 112

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  22 LINNPQYSDICFVVGQERQEVFAHRCLLACRCNFFQRLL-------------------------GPGVPSP----VVLST 72
Cdd:cd18308    17 LLESRQFCDVEFIVGEEEERIPAHIAFVAARSKWLRNKIlqarerqkqkaeqevedegseadssSASKNDSpmleVRLPE 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  73 VPAEAFLAVLEFLYTNSVKLhqhsvleVLTTAVEYGleelrelclefvvkVLDVELVCEALQVAVTFGLGSLQERCIAFI 152
Cdd:cd18308    97 ADPEAFELILSFIYTDKIDP-------TRKGQDPGS--------------NEVVLLMMDVYRLALQFQMSRLEQLCVQYL 155

                  .
gi 1907157827 153 E 153
Cdd:cd18308   156 E 156

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907157827  133 LQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVD-ETELVQAARSWAR 198
Cdd:smart00875   5 RRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVK 71

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  19 LRSLINNPQYSDICFVVGQErqEVFAHRCLLACRCNFFQRLLG---PGVPSpVVLST--VPAEAFLAVLEFLYTNSVKLH 93
Cdd:cd18295    10 LRRLLEQGSYSDVTFNVHGE--SFPAHRCILSARSPYFAEMFEtkwKDKRE-INLKHplVNPDAFRALLQYLYTGRLEIH 86

                  ....
gi 1907157827  94 QHSV 97
Cdd:cd18295    87 VDDV 90

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  16 STALRSLINNPQ--YSDICFVVGQERqEVFAHRCLLACRCNFFQRLLG------------PGVPSPVVLSTVPAEAFLAV 81
Cdd:cd18310     4 SSDLENLLDSPDlfYSDAEIIVEGGR-PVPVHRCILAARSPFFRDIFAsakaegantkpkLELRELIPGGIVGYDAFMLV 82

                          90
                  ....*....|.
gi 1907157827  82 LEFLYTNSVKL 92
Cdd:cd18310    83 LSYLYSGRLRL 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  22 LINNPQYSDICFVVGQER--QEVFAHRCLLACRCNFFQRLLGPGV---PSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHS 96
Cdd:cd18282     1 MFNNELMADVHFIVGPPGgtQRIPAHKYVLATGSSVFYAMFYGGLaenKNEIEIPDVEPAAFLNLLRYLYCDEIDLEPDT 80

                          90
                  ....*....|.
gi 1907157827  97 VLEVLTTAVEY 107
Cdd:cd18282    81 VLATLYAAKKY 91

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  25 NPQYSDICFVVGQERqeVFAHRCLLACRCNFFQRLL---------GPGVPSPVVLSTVPAEAFLAVLEFLYTNSVKLHQH 95
Cdd:cd18296    14 ELSFPDVCFQVEGHR--FPCHKAFFCGRSDYFKALLrdhfaeseeNNGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPE 91

                  ....*....
gi 1907157827  96 SVLEVLTTA 104
Cdd:cd18296    92 NAYDVLYVA 100

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907157827 125 DVELVCEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRS 179
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in mammalian neocortex.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827 130 CEALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWARV 199
Cdd:cd18524     7 CVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEV 76

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907157827 144 LQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWARVGAVEQIVEA 208
Cdd:cd18488    21 LMQRCWEVIDAQAELALKSEGFTEIDYKTLESILRRETLNAKESVVFEAALRWAEAECQRRGLEP 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  21 SLINNPQYSDICFVVGQ--ERQEVFAHRCLLACRCN-FFQRLLG--PGVPSPVVLSTVPAEAFLAVLEFLYTNSVKLHQH 95
Cdd:cd18349     1 LMFNNELMADVHFIVGPpgASQRVPAHKYVLAVGSSvFYAMFYGdlAEVKSEIHIPDVEPAAFLILLKYMYSDEIDLEAD 80

                          90
                  ....*....|..
gi 1907157827  96 SVLEVLTTAVEY 107
Cdd:cd18349    81 TVLATLYAAKKY 92

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907157827 133 LQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCV-DETELVQAARSWAR 198
Cdd:cd18480    10 LSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVpDEEAVLKAVLRWTK 76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  20 RSLINNPQYSDICFVVGQerQEVFAHRCLLACRCNFFQRLLGPGVpSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSV-- 97
Cdd:cd18303    10 ASLFDKELYSDITIKLAD--KSIPAHKFVLAARSEKWSNENLAST-NELDLSDISYEVVLALLRWLYTDELDLTLDDEfl 86

                          90
                  ....*....|....
gi 1907157827  98 LEVLTTAVEYGLEE 111
Cdd:cd18303    87 LELMKAAKRFQLTD 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907157827  44 AHRCLLACRCNFFQRLL-----GPGVPSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTA 104
Cdd:cd18330    32 AHRNILFANSGYFRALLihyiqDSGRHSTASLDIVTSEAFSIILDFLYSGKLDLCSENVIEVMSAA 97

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This subfamily includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907157827 143 SLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWARVGAVEQIVEA 208
Cdd:cd18487    20 QLASLCLETIDKNTAEALAAEGFTDIDLDTLCVVLERDTLGIRECKLFQAVLRWAEAECQRQGLSV 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907157827  30 DICFVVgqERQEVFAHRCLLACRCNFFQRLLGPGV----PSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTA 104
Cdd:cd18251    25 DVVLVV--EGKPIEAHRILLAASCDYFRGMFAGGLremqQTEVLIHGVSYNAMCKILDFIYTSELELSLDNVQETLTAA 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  28 YSDICFVVGQERQEVfaHRCLLACRCNFFQRLLGPGVP----SPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTT 103
Cdd:cd18256    20 FCDVQLQVGMELFSV--HRLVLAASSPYFAALFAGGMSesskDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVA 97

                  .
gi 1907157827 104 A 104
Cdd:cd18256    98 A 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907157827  44 AHRCLLACRCNFFQRLLGPGVPSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTA 104
Cdd:cd18208    39 AHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAA 99

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins; The family includes uncharacterized Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907157827 126 VELVCEALQVAVTF----GLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELVQAARSWARV 199
Cdd:cd18507     2 VDTVCALLASAERYdqykCTKTLVQKVLEFVDKHGTDVLNLPEFLLLPEHVVRLILSRDSLGADEMTKFQAALAWSRK 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907157827  30 DICFVVgqERQEVFAHRCLLACRCNFFQRLLGPGV----PSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTA 104
Cdd:cd18328    27 DVVLIV--QDQEYRTHRSVLAACSKYFKKLFTAGTladqPYVYEIDFVTPEALSAILEFAYTSTLTITTSNVKHILNAA 103

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  38 ERQEVFAHRCLLACRCNFFQRLLGPGVPSP---VVLSTVPAEAFLAVLEFLYTNSVKLHQHSVLEVLTTA 104
Cdd:cd18315     9 EGGSLKAHKLVLAAASPYFAALLKETPPDEhpvIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  37 QERQEVF-------------AHRCLLACRCNFFQRLLGPGV-----PSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVL 98
Cdd:cd18329    15 QRKQELFcdcsilvegqvfkAHRNVLFASSGYFKMLLSQNAketgqPTVATFDVFSPDTFTIILDFVYSGKLSLTSQNVI 94

                  ....*.
gi 1907157827  99 EVLTTA 104
Cdd:cd18329    95 EVMSAA 100

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907157827 131 EALQVAVTFGLGSLQERCIAFIEAHSQEALRTRGFLELSATALLPVLRSDKLCVDETELV-QAARSWA 197
Cdd:cd18472     8 ELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVfEAAVRWL 75

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907157827  26 PQYSDICFVVGQERqeVFAHRCLLACRCNFFQRLLGPGVPSPVVLS-----TVPA-EAFLAVLEFLYTNSVKL 92
Cdd:cd18309    18 GDFCDITLLLDGHP--IPAHKAILAARCSYFEAMFRSFMPEDNTVNisigeMVPSrQAFDSLLRYIYYGDVTM 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907157827  24 NNPQYSDICFVVGQErqEVFAHRCLLACRCNFFQRLLG-----PGVPSPVVLSTVPAEAFLAVLEFLYTNSVKLHQHSVL 98
Cdd:cd18207    23 SGGRFCDVLLRVGEE--SFPAHRAVLAACSEYFESVFSaqegdGGTPRELEMHTISSKVFGDILDFAYTSRIVVRLESFP 100