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Conserved domains on  [gi|1907151623|ref|XP_036019090|]
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ATPase family gene 2 protein homolog A isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CDC48 super family cl36852
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
323-835 0e+00

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


The actual alignment was detected with superfamily member TIGR01243:

Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 651.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 323 FYFISSTTRINLRKICTNSKEQDSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTM 402
Cdd:TIGR01243 148 FVYVTEATEVEIREKPVREEIERKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTL 227
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 403 IARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMD 482
Cdd:TIGR01243 228 LAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMD 307
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 483 GIGSEGsegRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGA 562
Cdd:TIGR01243 308 GLKGRG---RVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMP-LAEDVDLDKLAEVTHGFVGA 383
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 563 DLKALCNEAGLHALRRVLRKQPNLPDSK-----VAGMVKITLNDFLQGMNDIRPSAMREVAIDVPNVSWSDIGGLENIKL 637
Cdd:TIGR01243 384 DLAALAKEAAMAALRRFIREGKINFEAEeipaeVLKELKVTMKDFMEALKMVEPSAIREVLVEVPNVRWSDIGGLEEVKQ 463
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 638 KLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKAR 717
Cdd:TIGR01243 464 ELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKAR 543
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 718 AVAPSIIFFDELDALAVERGSSSGAgNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLP 797
Cdd:TIGR01243 544 QAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLRPGRFDRLILVPPP 622
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1907151623 798 DAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 835
Cdd:TIGR01243 623 DEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGAD 660
CDC48_N super family cl21693
Cell division protein 48 (CDC48), N-terminal domain; This domain has a double psi-beta barrel ...
64-132 1.46e-04

Cell division protein 48 (CDC48), N-terminal domain; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases pfam00004 is a substrate 185-residue recognition domain.


The actual alignment was detected with superfamily member smart01073:

Pssm-ID: 451359 [Multi-domain]  Cd Length: 82  Bit Score: 41.06  E-value: 1.46e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907151623   64 NSLVHLGLNTMKSANICIGRPVLLTsldGKQEVY-TAWP-VAGFPGGKVGLSEMAQKNVGVRAGETIQVQP 132
Cdd:smart01073  14 RGIARLSPEDMDELGLFPGDYVLIT---GKRRTVaIVWPaYPEDPGGIIRIDGVQRKNAGVSIGDTVTVRK 81
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
323-835 0e+00

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 651.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 323 FYFISSTTRINLRKICTNSKEQDSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTM 402
Cdd:TIGR01243 148 FVYVTEATEVEIREKPVREEIERKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTL 227
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 403 IARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMD 482
Cdd:TIGR01243 228 LAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMD 307
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 483 GIGSEGsegRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGA 562
Cdd:TIGR01243 308 GLKGRG---RVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMP-LAEDVDLDKLAEVTHGFVGA 383
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 563 DLKALCNEAGLHALRRVLRKQPNLPDSK-----VAGMVKITLNDFLQGMNDIRPSAMREVAIDVPNVSWSDIGGLENIKL 637
Cdd:TIGR01243 384 DLAALAKEAAMAALRRFIREGKINFEAEeipaeVLKELKVTMKDFMEALKMVEPSAIREVLVEVPNVRWSDIGGLEEVKQ 463
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 638 KLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKAR 717
Cdd:TIGR01243 464 ELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKAR 543
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 718 AVAPSIIFFDELDALAVERGSSSGAgNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLP 797
Cdd:TIGR01243 544 QAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLRPGRFDRLILVPPP 622
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1907151623 798 DAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 835
Cdd:TIGR01243 623 DEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGAD 660
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
569-835 6.65e-109

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 336.98  E-value: 6.65e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 569 NEAGLHALRRVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMREVaidvPNVSWSDIGGLENIKLKLKQAVEWPLK 648
Cdd:COG1222    24 RLGVELALLLQPVKALELLEEAPALLLNDANLTQKRLGTPRGTAVPAES----PDVTFDDIGGLDEQIEEIREAVELPLK 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 649 HPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDE 728
Cdd:COG1222   100 NPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDE 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 729 LDALAVERGSSSGAGNVaDRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNL 808
Cdd:COG1222   180 IDAIAARRTDDGTSGEV-QRTVNQLLAELDGFESRGDVLIIAATNRPDLLDPALLRPGRFDRVIEVPLPDEEAREEILKI 258
                         250       260
                  ....*....|....*....|....*..
gi 1907151623 809 QFHSMPISNEVDLDELVLQTDTYSGAE 835
Cdd:COG1222   259 HLRDMPLADDVDLDKLAKLTEGFSGAD 285
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
635-794 9.22e-103

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 314.61  E-value: 9.22e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 635 IKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFR 714
Cdd:cd19511     1 VKRELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 715 KARAVAPSIIFFDELDALAVERGSSSGaGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYV 794
Cdd:cd19511    81 KARQAAPCIIFFDEIDSLAPRRGQSDS-SGVTDRVVSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLDKLIYV 159
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
587-835 9.80e-89

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 286.34  E-value: 9.80e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 587 PDSKVAgmvkitLN-------DFLQGMNDIRPSAMrEVaIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQ 659
Cdd:PRK03992   92 PGARVA------LNqqslaivEVLPSEKDPRVQAM-EV-IESPNVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIE 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 660 PPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVER--G 737
Cdd:PRK03992  164 PPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRtdS 243
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 738 SSSGAGNVaDRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISN 817
Cdd:PRK03992  244 GTSGDREV-QRTLMQLLAEMDGFDPRGNVKIIAATNRIDILDPAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKMNLAD 322
                         250
                  ....*....|....*...
gi 1907151623 818 EVDLDELVLQTDTYSGAE 835
Cdd:PRK03992  323 DVDLEELAELTEGASGAD 340
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
664-796 1.10e-52

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 179.33  E-value: 1.10e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 664 VLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSgaG 743
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGG--D 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907151623 744 NVADRVLAQLLTEMDGIEQLK-NVTVLAATNRPDRIDKALMrpGRIDRIIYVPL 796
Cdd:pfam00004  79 SESRRVVNQLLTELDGFTSSNsKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
660-798 3.95e-18

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 82.04  E-value: 3.95e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623  660 PPKGVLLYGPPGCSKTMIAKALANESGLN---FLAIKGPELM--------------NKYVGESERAVREIFRKARAVAPS 722
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDILeevldqllliivggKKASGSGELRLRLALALARKLKPD 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907151623  723 IIFFDELDALAVERGSssgagnvADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPgRIDRIIYVPLPD 798
Cdd:smart00382  81 VLILDEITSLLDAEQE-------ALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
CDC48_N smart01073
Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel ...
64-132 1.46e-04

Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases is a substrate 185-residue recognition domain.


Pssm-ID: 215012 [Multi-domain]  Cd Length: 82  Bit Score: 41.06  E-value: 1.46e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907151623   64 NSLVHLGLNTMKSANICIGRPVLLTsldGKQEVY-TAWP-VAGFPGGKVGLSEMAQKNVGVRAGETIQVQP 132
Cdd:smart01073  14 RGIARLSPEDMDELGLFPGDYVLIT---GKRRTVaIVWPaYPEDPGGIIRIDGVQRKNAGVSIGDTVTVRK 81
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
323-835 0e+00

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 651.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 323 FYFISSTTRINLRKICTNSKEQDSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTM 402
Cdd:TIGR01243 148 FVYVTEATEVEIREKPVREEIERKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTL 227
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 403 IARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMD 482
Cdd:TIGR01243 228 LAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMD 307
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 483 GIGSEGsegRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGA 562
Cdd:TIGR01243 308 GLKGRG---RVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMP-LAEDVDLDKLAEVTHGFVGA 383
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 563 DLKALCNEAGLHALRRVLRKQPNLPDSK-----VAGMVKITLNDFLQGMNDIRPSAMREVAIDVPNVSWSDIGGLENIKL 637
Cdd:TIGR01243 384 DLAALAKEAAMAALRRFIREGKINFEAEeipaeVLKELKVTMKDFMEALKMVEPSAIREVLVEVPNVRWSDIGGLEEVKQ 463
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 638 KLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKAR 717
Cdd:TIGR01243 464 ELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKAR 543
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 718 AVAPSIIFFDELDALAVERGSSSGAgNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLP 797
Cdd:TIGR01243 544 QAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLRPGRFDRLILVPPP 622
                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1907151623 798 DAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 835
Cdd:TIGR01243 623 DEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGAD 660
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
569-835 6.65e-109

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 336.98  E-value: 6.65e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 569 NEAGLHALRRVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPSAMREVaidvPNVSWSDIGGLENIKLKLKQAVEWPLK 648
Cdd:COG1222    24 RLGVELALLLQPVKALELLEEAPALLLNDANLTQKRLGTPRGTAVPAES----PDVTFDDIGGLDEQIEEIREAVELPLK 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 649 HPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDE 728
Cdd:COG1222   100 NPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDE 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 729 LDALAVERGSSSGAGNVaDRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNL 808
Cdd:COG1222   180 IDAIAARRTDDGTSGEV-QRTVNQLLAELDGFESRGDVLIIAATNRPDLLDPALLRPGRFDRVIEVPLPDEEAREEILKI 258
                         250       260
                  ....*....|....*....|....*..
gi 1907151623 809 QFHSMPISNEVDLDELVLQTDTYSGAE 835
Cdd:COG1222   259 HLRDMPLADDVDLDKLAKLTEGFSGAD 285
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
635-794 9.22e-103

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 314.61  E-value: 9.22e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 635 IKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFR 714
Cdd:cd19511     1 VKRELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 715 KARAVAPSIIFFDELDALAVERGSSSGaGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYV 794
Cdd:cd19511    81 KARQAAPCIIFFDEIDSLAPRRGQSDS-SGVTDRVVSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLDKLIYV 159
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
345-618 4.77e-97

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 306.16  E-value: 4.77e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 345 DSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEII 424
Cdd:COG1222    70 AESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELV 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 425 SKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVE-KRVVASLLTLMDGIGSEGSegrVLVLGATNRPQ 503
Cdd:COG1222   150 SKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEvQRTVNQLLAELDGFESRGD---VLIIAATNRPD 226
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 504 ALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRRvlrkq 583
Cdd:COG1222   227 LLDPALLRPGRFDRVIEVPLPDEEAREEILKIHLRDMP-LADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIRE----- 300
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1907151623 584 pnlpdskvaGMVKITLNDFLQGMNDIRPSAMREVA 618
Cdd:COG1222   301 ---------GRDTVTMEDLEKAIEKVKKKTETATN 326
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
587-835 9.80e-89

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 286.34  E-value: 9.80e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 587 PDSKVAgmvkitLN-------DFLQGMNDIRPSAMrEVaIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQ 659
Cdd:PRK03992   92 PGARVA------LNqqslaivEVLPSEKDPRVQAM-EV-IESPNVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIE 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 660 PPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVER--G 737
Cdd:PRK03992  164 PPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRtdS 243
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 738 SSSGAGNVaDRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISN 817
Cdd:PRK03992  244 GTSGDREV-QRTLMQLLAEMDGFDPRGNVKIIAATNRIDILDPAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKMNLAD 322
                         250
                  ....*....|....*...
gi 1907151623 818 EVDLDELVLQTDTYSGAE 835
Cdd:PRK03992  323 DVDLEELAELTEGASGAD 340
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
487-835 1.53e-88

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 286.04  E-value: 1.53e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 487 EGSEGRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLANNAHGYVGADLKA 566
Cdd:COG0464    19 DDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLALLAALLSALELLLLGELL 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 567 LCNEAGLHALRRVLRKQPNLPDSKVAGMVKITLNDFLQGMNDIRPsaMREVAIDVPNVSWSDIGGLENIKLKLKQAVEWP 646
Cdd:COG0464    99 LLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGG--LEEELLELREAILDDLGGLEEVKEELRELVALP 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 647 LKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFF 726
Cdd:COG0464   177 LKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLAPCVLFI 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 727 DELDALAVERGSSSGAgnVADRVLAQLLTEMDGIEqlKNVTVLAATNRPDRIDKALMRpgRIDRIIYVPLPDAATRREIL 806
Cdd:COG0464   257 DEADALAGKRGEVGDG--VGRRVVNTLLTEMEELR--SDVVVIAATNRPDLLDPALLR--RFDEIIFFPLPDAEERLEIF 330
                         330       340
                  ....*....|....*....|....*....
gi 1907151623 807 NLQFHSMPISNEVDLDELVLQTDTYSGAE 835
Cdd:COG0464   331 RIHLRKRPLDEDVDLEELAEATEGLSGAD 359
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
355-521 1.36e-87

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 274.94  E-value: 1.36e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 355 IGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAR 434
Cdd:cd19503     2 IGGLDEQIASLKELIELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEKN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIgseGSEGRVLVLGATNRPQALDAALRRPGR 514
Cdd:cd19503    82 LREIFEEARSHAPSIIFIDEIDALAPKREEDQREVERRVVAQLLTLMDGM---SSRGKVVVIAATNRPDAIDPALRRPGR 158

                  ....*..
gi 1907151623 515 FDKEIEI 521
Cdd:cd19503   159 FDREVEI 165
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
355-522 9.55e-84

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 264.68  E-value: 9.55e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 355 IGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAR 434
Cdd:cd19519     2 IGGCRKQLAQIREMVELPLRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIgseGSEGRVLVLGATNRPQALDAALRRPGR 514
Cdd:cd19519    82 LRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHGEVERRIVSQLLTLMDGL---KQRAHVIVMAATNRPNSIDPALRRFGR 158

                  ....*...
gi 1907151623 515 FDKEIEIG 522
Cdd:cd19519   159 FDREIDIG 166
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
635-794 3.38e-79

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 252.42  E-value: 3.38e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 635 IKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFR 714
Cdd:cd19529     1 VKQELKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 715 KARAVAPSIIFFDELDALAVERGSSSGAGnVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYV 794
Cdd:cd19529    81 KARQVAPCVIFFDEIDSIAPRRGTTGDSG-VTERVVNQLLTELDGLEEMNGVVVIAATNRPDIIDPALLRAGRFDRLIYI 159
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
597-835 3.63e-78

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 257.42  E-value: 3.63e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 597 ITLNDFLQGMNDIRPSAMrEVaIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTM 676
Cdd:TIGR01242  94 LTIVDVLPTSKDPLVKGM-EV-EERPNVSYEDIGGLEEQIREIREAVELPLKHPELFEEVGIEPPKGVLLYGPPGTGKTL 171
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 677 IAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGN-VADRVLAQLLT 755
Cdd:TIGR01242 172 LAKAVAHETNATFIRVVGSELVRKYIGEGARLVREIFELAKEKAPSIIFIDEIDAIAAKRTDSGTSGDrEVQRTLMQLLA 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 756 EMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 835
Cdd:TIGR01242 252 ELDGFDPRGNVKVIAATNRPDILDPALLRPGRFDRIIEVPLPDFEGRLEILKIHTRKMKLAEDVDLEAIAKMTEGASGAD 331
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
352-577 3.94e-78

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 258.30  E-value: 3.94e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 352 YDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGET 431
Cdd:COG0464   156 LDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGET 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 432 EARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIgsegsEGRVLVLGATNRPQALDAALRR 511
Cdd:COG0464   236 EKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGRRVVNTLLTEMEEL-----RSDVVVIAATNRPDLLDPALLR 310
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907151623 512 pgRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNEAGLHALR 577
Cdd:COG0464   311 --RFDEIIFFPLPDAEERLEIFRIHLRKRP-LDEDVDLEELAEATEGLSGADIRNVVRRAALQALR 373
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
635-794 1.32e-74

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 240.49  E-value: 1.32e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 635 IKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFR 714
Cdd:cd19528     1 VKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 715 KARAVAPSIIFFDELDALAVERGSSSG-AGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIY 793
Cdd:cd19528    81 KARAAAPCVLFFDELDSIAKARGGNIGdAGGAADRVINQILTEMDGMNTKKNVFIIGATNRPDIIDPAILRPGRLDQLIY 160

                  .
gi 1907151623 794 V 794
Cdd:cd19528   161 I 161
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
628-794 1.75e-73

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 237.57  E-value: 1.75e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 628 DIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESER 707
Cdd:cd19503     1 DIGGLDEQIASLKELIELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 708 AVREIFRKARAVAPSIIFFDELDALAVERGSSSGAgnVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGR 787
Cdd:cd19503    81 NLREIFEEARSHAPSIIFIDEIDALAPKREEDQRE--VERRVVAQLLTLMDGMSSRGKVVVIAATNRPDAIDPALRRPGR 158

                  ....*..
gi 1907151623 788 IDRIIYV 794
Cdd:cd19503   159 FDREVEI 165
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
349-610 1.01e-71

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 240.89  E-value: 1.01e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 349 KVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFY 428
Cdd:PRK03992  127 NVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFI 206
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 429 GETeARL-RQIFAEATLRHPSIIFIDELDALCPKR----EGAQSEVEkRVVASLLTLMDGIgseGSEGRVLVLGATNRPQ 503
Cdd:PRK03992  207 GEG-ARLvRELFELAREKAPSIIFIDEIDAIAAKRtdsgTSGDREVQ-RTLMQLLAEMDGF---DPRGNVKIIAATNRID 281
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 504 ALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVpHLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRRvLRKQ 583
Cdd:PRK03992  282 ILDPAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKM-NLADDVDLEELAELTEGASGADLKAICTEAGMFAIRD-DRTE 359
                         250       260
                  ....*....|....*....|....*..
gi 1907151623 584 pnlpdskvagmvkITLNDFLQGMNDIR 610
Cdd:PRK03992  360 -------------VTMEDFLKAIEKVM 373
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
620-835 7.60e-71

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 238.89  E-value: 7.60e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 620 DVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMN 699
Cdd:PTZ00454  138 EKPDVTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQ 217
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 700 KYVGESERAVREIFRKARAVAPSIIFFDELDALAVER-GSSSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRI 778
Cdd:PTZ00454  218 KYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRfDAQTGADREVQRILLELLNQMDGFDQTTNVKVIMATNRADTL 297
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907151623 779 DKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 835
Cdd:PTZ00454  298 DPALLRPGRLDRKIEFPLPDRRQKRLIFQTITSKMNLSEEVDLEDFVSRPEKISAAD 354
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
625-794 1.11e-70

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 230.30  E-value: 1.11e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 625 SWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGE 704
Cdd:cd19502     1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 705 SERAVREIFRKARAVAPSIIFFDELDALAVER-GSSSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALM 783
Cdd:cd19502    81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRfDSGTGGDREVQRTMLELLNQLDGFDPRGNIKVIMATNRPDILDPALL 160
                         170
                  ....*....|.
gi 1907151623 784 RPGRIDRIIYV 794
Cdd:cd19502   161 RPGRFDRKIEF 171
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
632-794 1.51e-68

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 223.90  E-value: 1.51e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 632 LENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRE 711
Cdd:cd19530     1 LDHVREELTMSILRPIKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 712 IFRKARAVAPSIIFFDELDALAVERGssSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRI 791
Cdd:cd19530    81 VFQRARASAPCVIFFDEVDALVPKRG--DGGSWASERVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLRPGRLDKT 158

                  ...
gi 1907151623 792 IYV 794
Cdd:cd19530   159 LYV 161
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
350-616 1.77e-67

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 238.65  E-value: 1.77e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 350 VTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVG 529
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 430 ETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSE-VEKRVVASLLTLMDGIgSEGSEgrVLVLGATNRPQALDAA 508
Cdd:TIGR01243 530 ESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTsVTDRIVNQLLTEMDGI-QELSN--VVVIAATNRPDILDPA 606
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 509 LRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRRVLRKQPN--- 585
Cdd:TIGR01243 607 LLRPGRFDRLILVPPPDEEARKEIFKIHTRSMP-LAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGSPAKekl 685
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1907151623 586 -LPDSKVAGMVKITLNDFLQGMNDIRPSAMRE 616
Cdd:TIGR01243 686 eVGEEEFLKDLKVEMRHFLEALKKVKPSVSKE 717
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
628-795 4.75e-67

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 220.00  E-value: 4.75e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 628 DIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESER 707
Cdd:cd19519     1 DIGGCRKQLAQIREMVELPLRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 708 AVREIFRKARAVAPSIIFFDELDALAVERGSSSgaGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGR 787
Cdd:cd19519    81 NLRKAFEEAEKNAPAIIFIDEIDAIAPKREKTH--GEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGR 158

                  ....*...
gi 1907151623 788 IDRIIYVP 795
Cdd:cd19519   159 FDREIDIG 166
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
622-835 3.36e-66

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 227.35  E-value: 3.36e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 622 PNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKY 701
Cdd:PTZ00361  178 PLESYADIGGLEQQIQEIKEAVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKY 257
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 702 VGESERAVREIFRKARAVAPSIIFFDELDALAVER-GSSSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDK 780
Cdd:PTZ00361  258 LGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRyDATSGGEKEIQRTMLELLNQLDGFDSRGDVKVIMATNRIESLDP 337
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907151623 781 ALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 835
Cdd:PTZ00361  338 ALIRPGRIDRKIEFPNPDEKTKRRIFEIHTSKMTLAEDVDLEEFIMAKDELSGAD 392
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
343-609 1.71e-65

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 223.14  E-value: 1.71e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 343 EQDSQFKVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPE 422
Cdd:TIGR01242 112 EVEERPNVSYEDIGGLEEQIREIREAVELPLKHPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSE 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 423 IISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQSEVEkRVVASLLTLMDGIGSEGSegrVLVLGA 498
Cdd:TIGR01242 192 LVRKYIGEGARLVREIFELAKEKAPSIIFIDEIDAIAAKRtdsgTSGDREVQ-RTLMQLLAELDGFDPRGN---VKVIAA 267
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 499 TNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILqKLLRRVPHLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRR 578
Cdd:TIGR01242 268 TNRPDILDPALLRPGRFDRIIEVPLPDFEGRLEIL-KIHTRKMKLAEDVDLEAIAKMTEGASGADLKAICTEAGMFAIRE 346
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1907151623 579 vlrkqpnlpdskvaGMVKITLNDFLQGMNDI 609
Cdd:TIGR01242 347 --------------ERDYVTMDDFIKAVEKV 363
pup_AAA TIGR03689
proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some ...
620-806 2.73e-65

proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some proteins are modified by ligation between an epsilon-amino group of a lysine side chain and the C-terminal carboxylate of the ubiquitin-like protein Pup. This modification leads to protein degradation by the archaeal-like proteasome found in the Actinobacteria. Members of this protein family belong to the AAA family of ATPases and tend to be clustered with the genes for Pup, the Pup ligase PafA, and structural components of the proteasome. This protein forms hexameric rings with ATPase activity. [Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 200312 [Multi-domain]  Cd Length: 512  Bit Score: 227.28  E-value: 2.73e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 620 DVPNVSWSDIGGL-ENIKLkLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALAN-------ESGLN--- 688
Cdd:TIGR03689 175 EVPDVTYADIGGLgSQIEQ-IRDAVELPFLHPELYREYGLKPPKGVLLYGPPGCGKTLIAKAVANslaarigAEGGGksy 253
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 689 FLAIKGPELMNKYVGESERAVREIFRKARAVA----PSIIFFDELDALAVERGS--SSgagNVADRVLAQLLTEMDGIEQ 762
Cdd:TIGR03689 254 FLNIKGPELLNKYVGETERQIRLIFQRAREKAsegrPVIVFFDEMDSLFRTRGSgvSS---DVETTVVPQLLAEIDGVES 330
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1907151623 763 LKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIL 806
Cdd:TIGR03689 331 LDNVIVIGASNREDMIDPAILRPGRLDVKIRIERPDAEAAADIF 374
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
635-793 6.23e-65

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 214.21  E-value: 6.23e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 635 IKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFR 714
Cdd:cd19526     1 VKKALEETIEWPSKYPKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFS 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907151623 715 KARAVAPSIIFFDELDALAVERGSSSGAgnVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIY 793
Cdd:cd19526    81 RAQSAKPCILFFDEFDSIAPKRGHDSTG--VTDRVVNQLLTQLDGVEGLDGVYVLAATSRPDLIDPALLRPGRLDKLVY 157
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
624-794 7.17e-64

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 211.71  E-value: 7.17e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 624 VSWSDIGGLENIKLKLKQAVEWpLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVG 703
Cdd:cd19501     1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 704 ESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGN-VADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKAL 782
Cdd:cd19501    80 VGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAGLGGGHdEREQTLNQLLVEMDGFESNTGVIVIAATNRPDVLDPAL 159
                         170
                  ....*....|..
gi 1907151623 783 MRPGRIDRIIYV 794
Cdd:cd19501   160 LRPGRFDRQVYV 171
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
602-835 9.45e-64

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 222.55  E-value: 9.45e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 602 FLQGMNDIRPSAM-------REVAIDVPNVSWSDIGGLENIKLKLKQAVEWpLKHPKSFNRMGIQPPKGVLLYGPPGCSK 674
Cdd:TIGR01241  23 FRRQMQGGGGRAFsfgkskaKLLNEEKPKVTFKDVAGIDEAKEELMEIVDF-LKNPSKFTKLGAKIPKGVLLVGPPGTGK 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 675 TMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGN-VADRVLAQL 753
Cdd:TIGR01241 102 TLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGGNdEREQTLNQL 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 754 LTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSG 833
Cdd:TIGR01241 182 LVEMDGFGTNTGVIVIAATNRPDVLDPALLRPGRFDRQVVVDLPDIKGREEILKVHAKNKKLAPDVDLKAVARRTPGFSG 261

                  ..
gi 1907151623 834 AE 835
Cdd:TIGR01241 262 AD 263
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
355-519 1.37e-63

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 210.72  E-value: 1.37e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 355 IGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAR 434
Cdd:cd19518     2 IGGMDSTLKELCELLIHPILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEEK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEG-RVLVLGATNRPQALDAALRRPG 513
Cdd:cd19518    82 IRELFDQAISNAPCIVFIDEIDAITPKRESAQREMERRIVSQLLTCMDELNNEKTAGgPVLVIGATNRPDSLDPALRRAG 161

                  ....*.
gi 1907151623 514 RFDKEI 519
Cdd:cd19518   162 RFDREI 167
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
635-794 3.96e-63

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 209.06  E-value: 3.96e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 635 IKLKLKQAVEWPLKHPKSFnRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFR 714
Cdd:cd19481     1 LKASLREAVEAPRRGSRLR-RYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 715 KARAVAPSIIFFDELDALAVERGSSSGAGnVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYV 794
Cdd:cd19481    80 RARRLAPCILFIDEIDAIGRKRDSSGESG-ELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALLRPGRFDEVIEF 158
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
363-519 1.18e-58

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 197.12  E-value: 1.18e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 363 KAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEA 442
Cdd:cd19511     3 RELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQKA 82
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907151623 443 TLRHPSIIFIDELDALCPKREGAQS-EVEKRVVASLLTLMDGIgsEGSEGrVLVLGATNRPQALDAALRRPGRFDKEI 519
Cdd:cd19511    83 RQAAPCIIFFDEIDSLAPRRGQSDSsGVTDRVVSQLLTELDGI--ESLKG-VVVIAATNRPDMIDPALLRPGRLDKLI 157
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
351-521 2.45e-58

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 196.79  E-value: 2.45e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 351 TYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGE 430
Cdd:cd19502     1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 431 TEARLRQIFAEATLRHPSIIFIDELDALCPKRE----GAQSEVEkRVVASLLTLMDGIgseGSEGRVLVLGATNRPQALD 506
Cdd:cd19502    81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRFdsgtGGDREVQ-RTMLELLNQLDGF---DPRGNIKVIMATNRPDILD 156
                         170
                  ....*....|....*
gi 1907151623 507 AALRRPGRFDKEIEI 521
Cdd:cd19502   157 PALLRPGRFDRKIEF 171
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
622-835 2.86e-58

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 209.51  E-value: 2.86e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 622 PNVSWSDIGGLENIKLKLKQAVEWpLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKY 701
Cdd:COG0465   137 PKVTFDDVAGVDEAKEELQEIVDF-LKDPEKFTRLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMF 215
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 702 VG--ESeRaVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGNvaD---RVLAQLLTEMDGIEQLKNVTVLAATNRPD 776
Cdd:COG0465   216 VGvgAS-R-VRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGGH--DereQTLNQLLVEMDGFEGNEGVIVIAATNRPD 291
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907151623 777 RIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 835
Cdd:COG0465   292 VLDPALLRPGRFDRQVVVDLPDVKGREAILKVHARKKPLAPDVDLEVIARRTPGFSGAD 350
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
353-571 3.77e-58

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 198.95  E-value: 3.77e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 353 DMIGGlNSQLKAIREIIElPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETE 432
Cdd:COG1223     3 DVVGQ-EEAKKKLKLIIK-ELRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 433 ARLRQIFAEATlRHPSIIFIDELDALCpKREGAQSEV-E-KRVVASLLTLMDGIGSEgsegrVLVLGATNRPQALDAALR 510
Cdd:COG1223    81 RNLRKLFDFAR-RAPCVIFFDEFDAIA-KDRGDQNDVgEvKRVVNALLQELDGLPSG-----SVVIAATNHPELLDSALW 153
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907151623 511 RpgRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNEA 571
Cdd:COG1223   154 R--RFDEVIEFPLPDKEERKEILELNLKKFP-LPFELDLKKLAKKLEGLSGADIEKVLKTA 211
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
361-521 1.65e-57

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 193.65  E-value: 1.65e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 361 QLKAIREIIELPLKQPELFKsYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFA 440
Cdd:cd19481     1 LKASLREAVEAPRRGSRLRR-YGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 441 EATLRHPSIIFIDELDALCPKREG-AQSEVEKRVVASLLTLMDGIgseGSEGRVLVLGATNRPQALDAALRRPGRFDKEI 519
Cdd:cd19481    80 RARRLAPCILFIDEIDAIGRKRDSsGESGELRRVLNQLLTELDGV---NSRSKVLVIAATNRPDLLDPALLRPGRFDEVI 156

                  ..
gi 1907151623 520 EI 521
Cdd:cd19481   157 EF 158
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
635-794 7.91e-56

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 189.26  E-value: 7.91e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 635 IKLKLKQAVEWPLKHPKSFNRmGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFR 714
Cdd:cd19527     1 VKKEILDTIQLPLEHPELFSS-GLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 715 KARAVAPSIIFFDELDALAVERGSSSGAGNVADRVLAQLLTEMDGIEQ-LKNVTVLAATNRPDRIDKALMRPGRIDRIIY 793
Cdd:cd19527    80 KARDAKPCVIFFDELDSLAPSRGNSGDSGGVMDRVVSQLLAELDGMSSsGQDVFVIGATNRPDLLDPALLRPGRFDKLLY 159

                  .
gi 1907151623 794 V 794
Cdd:cd19527   160 L 160
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
626-835 1.09e-54

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 189.32  E-value: 1.09e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 626 WSDIGGLENIKLKLKQAVEWpLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGES 705
Cdd:COG1223     1 LDDVVGQEEAKKKLKLIIKE-LRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGET 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 706 ERAVREIFRKARAvAPSIIFFDELDALAVERGSSSGAGNVAdRVLAQLLTEMDGIEQlkNVTVLAATNRPDRIDKALMRp 785
Cdd:COG1223    80 ARNLRKLFDFARR-APCVIFFDEFDAIAKDRGDQNDVGEVK-RVVNALLQELDGLPS--GSVVIAATNHPELLDSALWR- 154
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907151623 786 gRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 835
Cdd:COG1223   155 -RFDEVIEFPLPDKEERKEILELNLKKFPLPFELDLKKLAKKLEGLSGAD 203
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
365-521 1.56e-54

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 185.78  E-value: 1.56e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 365 IREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATL 444
Cdd:cd19529     5 LKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFRKARQ 84
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907151623 445 RHPSIIFIDELDALCPKR-EGAQSEVEKRVVASLLTLMDGIGSEGSegrVLVLGATNRPQALDAALRRPGRFDKEIEI 521
Cdd:cd19529    85 VAPCVIFFDEIDSIAPRRgTTGDSGVTERVVNQLLTELDGLEEMNG---VVVIAATNRPDIIDPALLRAGRFDRLIYI 159
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
350-578 2.79e-54

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 193.44  E-value: 2.79e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 350 VTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:PTZ00454  142 VTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLG 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 430 ETEARLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQSEVEkRVVASLLTLMDGIGSEGSegrVLVLGATNRPQAL 505
Cdd:PTZ00454  222 EGPRMVRDVFRLARENAPSIIFIDEVDSIATKRfdaqTGADREVQ-RILLELLNQMDGFDQTTN---VKVIMATNRADTL 297
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907151623 506 DAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVpHLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRR 578
Cdd:PTZ00454  298 DPALLRPGRLDRKIEFPLPDRRQKRLIFQTITSKM-NLSEEVDLEDFVSRPEKISAADIAAICQEAGMQAVRK 369
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
355-521 1.20e-53

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 183.32  E-value: 1.20e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 355 IGGLNSQLKAIREIIELPLKQPELFKsyGIPA-PRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEA 433
Cdd:cd19509     1 IAGLDDAKEALKEAVILPSLRPDLFP--GLRGpPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 434 RLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEgSEGRVLVLGATNRPQALDAALRRpg 513
Cdd:cd19509    79 IVRALFALARELQPSIIFIDEIDSLLSERGSGEHEASRRVKTEFLVQMDGVLNK-PEDRVLVLGATNRPWELDEAFLR-- 155

                  ....*...
gi 1907151623 514 RFDKEIEI 521
Cdd:cd19509   156 RFEKRIYI 163
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
664-796 1.10e-52

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 179.33  E-value: 1.10e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 664 VLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSgaG 743
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGG--D 78
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907151623 744 NVADRVLAQLLTEMDGIEQLK-NVTVLAATNRPDRIDKALMrpGRIDRIIYVPL 796
Cdd:pfam00004  79 SESRRVVNQLLTELDGFTSSNsKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
351-577 1.13e-52

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 189.98  E-value: 1.13e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 351 TYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGE 430
Cdd:PTZ00361  181 SYADIGGLEQQIQEIKEAVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLGD 260
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 431 TEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEK---RVVASLLTLMDGIGSEGSegrVLVLGATNRPQALDA 507
Cdd:PTZ00361  261 GPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDATSGGEKeiqRTMLELLNQLDGFDSRGD---VKVIMATNRIESLDP 337
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 508 ALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVpHLLTKAELLRLANNAHGYVGADLKALCNEAGLHALR 577
Cdd:PTZ00361  338 ALIRPGRIDRKIEFPNPDEKTKRRIFEIHTSKM-TLAEDVDLEEFIMAKDELSGADIKAICTEAGLLALR 406
ftsH CHL00176
cell division protein; Validated
624-835 3.72e-52

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 193.34  E-value: 3.72e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 624 VSWSDIGGLENIKLKLKQAVEWpLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVG 703
Cdd:CHL00176  180 ITFRDIAGIEEAKEEFEEVVSF-LKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVG 258
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 704 ESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGN-VADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKAL 782
Cdd:CHL00176  259 VGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRGAGIGGGNdEREQTLNQLLTEMDGFKGNKGVIVIAATNRVDILDAAL 338
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907151623 783 MRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 835
Cdd:CHL00176  339 LRPGRFDRQITVSLPDREGRLDILKVHARNKKLSPDVSLELIARRTPGFSGAD 391
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
355-518 3.07e-51

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 176.93  E-value: 3.07e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 355 IGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVI-----NGPEIISKFYG 429
Cdd:cd19517     2 IGGLSHYINQLKEMVFFPLLYPEVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSKGGQKVsffmrKGADCLSKWVG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 430 ETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIgseGSEGRVLVLGATNRPQALDAAL 509
Cdd:cd19517    82 EAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGL---DNRGQVVVIGATNRPDALDPAL 158

                  ....*....
gi 1907151623 510 RRPGRFDKE 518
Cdd:cd19517   159 RRPGRFDRE 167
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
345-578 4.15e-51

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 187.11  E-value: 4.15e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 345 DSQFKVTYDMIGGLNSQLKAIREIIELpLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEII 424
Cdd:TIGR01241  47 EEKPKVTFKDVAGIDEAKEELMEIVDF-LKNPSKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFV 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 425 SKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKRE----GAQSEVEkRVVASLLTLMDGIGseGSEGrVLVLGATN 500
Cdd:TIGR01241 126 EMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGaglgGGNDERE-QTLNQLLVEMDGFG--TNTG-VIVIAATN 201
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907151623 501 RPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRR 578
Cdd:TIGR01241 202 RPDVLDPALLRPGRFDRQVVVDLPDIKGREEILKVHAKNKK-LAPDVDLKAVARRTPGFSGADLANLLNEAALLAARK 278
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
390-522 6.45e-51

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 174.32  E-value: 6.45e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 390 LLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEV 469
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907151623 470 EKRVVASLLTLMDGIgsEGSEGRVLVLGATNRPQALDAALRrpGRFDKEIEIG 522
Cdd:pfam00004  81 SRRVVNQLLTELDGF--TSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
629-794 8.44e-51

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 175.62  E-value: 8.44e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 629 IGGLENIKLKLKQAVEWPLKHPKSFnRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERA 708
Cdd:cd19509     1 IAGLDDAKEALKEAVILPSLRPDLF-PGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 709 VREIFRKARAVAPSIIFFDELDALAVERGSSSGAGNVadRVLAQLLTEMDGIEQLKN--VTVLAATNRPDRIDKALMRpg 786
Cdd:cd19509    80 VRALFALARELQPSIIFIDEIDSLLSERGSGEHEASR--RVKTEFLVQMDGVLNKPEdrVLVLGATNRPWELDEAFLR-- 155

                  ....*...
gi 1907151623 787 RIDRIIYV 794
Cdd:cd19509   156 RFEKRIYI 163
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
362-517 2.13e-49

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 171.52  E-value: 2.13e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 362 LKAIREIIEL----PLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQ 437
Cdd:cd19530     1 LDHVREELTMsilrPIKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 438 IFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIgsegsEGR--VLVLGATNRPQALDAALRRPGRF 515
Cdd:cd19530    81 VFQRARASAPCVIFFDEVDALVPKRGDGGSWASERVVNQLLTEMDGL-----EERsnVFVIAATNRPDIIDPAMLRPGRL 155

                  ..
gi 1907151623 516 DK 517
Cdd:cd19530   156 DK 157
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
628-792 3.75e-49

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 171.05  E-value: 3.75e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 628 DIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESER 707
Cdd:cd19518     1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 708 AVREIFRKARAVAPSIIFFDELDALAVERGSSSgaGNVADRVLAQLLTEMDGIEQLKN----VTVLAATNRPDRIDKALM 783
Cdd:cd19518    81 KIRELFDQAISNAPCIVFIDEIDAITPKRESAQ--REMERRIVSQLLTCMDELNNEKTaggpVLVIGATNRPDSLDPALR 158

                  ....*....
gi 1907151623 784 RPGRIDRII 792
Cdd:cd19518   159 RAGRFDREI 167
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
612-835 9.55e-49

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 183.31  E-value: 9.55e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 612 SAMREVAIDVPNVSWSDIGGLENIKLKLKQAVEWpLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLA 691
Cdd:PRK10733  137 SKARMLTEDQIKTTFADVAGCDEAKEEVAELVEY-LREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFT 215
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 692 IKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSGAG-NVADRVLAQLLTEMDGIEQLKNVTVLA 770
Cdd:PRK10733  216 ISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGLGGGhDEREQTLNQMLVEMDGFEGNEGIIVIA 295
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907151623 771 ATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILNLQFHSMPISNEVDLDELVLQTDTYSGAE 835
Cdd:PRK10733  296 ATNRPDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDIDAAIIARGTPGFSGAD 360
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
628-793 2.26e-47

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 166.15  E-value: 2.26e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 628 DIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESG-----LNFLAIKGPELMNKYV 702
Cdd:cd19517     1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSkggqkVSFFMRKGADCLSKWV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 703 GESERAVREIFRKARAVAPSIIFFDELDALAVERgsSSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKAL 782
Cdd:cd19517    81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVR--SSKQEQIHASIVSTLLALMDGLDNRGQVVVIGATNRPDALDPAL 158
                         170
                  ....*....|.
gi 1907151623 783 MRPGRIDRIIY 793
Cdd:cd19517   159 RRPGRFDREFY 169
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
365-521 3.84e-46

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 162.29  E-value: 3.84e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 365 IREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEATL 444
Cdd:cd19528     5 LQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 445 RHPSIIFIDELDALCPKREGA---QSEVEKRVVASLLTLMDGIGSEGSegrVLVLGATNRPQALDAALRRPGRFDKEIEI 521
Cdd:cd19528    85 AAPCVLFFDELDSIAKARGGNigdAGGAADRVINQILTEMDGMNTKKN---VFIIGATNRPDIIDPAILRPGRLDQLIYI 161
ftsH CHL00176
cell division protein; Validated
350-578 2.95e-45

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 172.93  E-value: 2.95e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 350 VTYDMIGGLNSQLKAIREIIELpLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:CHL00176  180 ITFRDIAGIEEAKEEFEEVVSF-LKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVG 258
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 430 ETEARLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQSEVEKrVVASLLTLMDGIgsEGSEGrVLVLGATNRPQAL 505
Cdd:CHL00176  259 VGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRgagiGGGNDEREQ-TLNQLLTEMDGF--KGNKG-VIVIAATNRVDIL 334
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907151623 506 DAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRR 578
Cdd:CHL00176  335 DAALLRPGRFDRQITVSLPDREGRLDILKVHARNKK-LSPDVSLELIARRTPGFSGADLANLLNEAAILTARR 406
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
350-521 3.42e-45

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 160.09  E-value: 3.42e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 350 VTYDMIGGLNSQLKAIREIIELpLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:cd19501     1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 430 ETEARLRQIFAEATLRHPSIIFIDELDALCPKRE----GAQSEVEkRVVASLLTLMDGIGSegSEGrVLVLGATNRPQAL 505
Cdd:cd19501    80 VGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGaglgGGHDERE-QTLNQLLVEMDGFES--NTG-VIVIAATNRPDVL 155
                         170
                  ....*....|....*.
gi 1907151623 506 DAALRRPGRFDKEIEI 521
Cdd:cd19501   156 DPALLRPGRFDRQVYV 171
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
363-520 5.92e-45

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 158.75  E-value: 5.92e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 363 KAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEA 442
Cdd:cd19526     3 KALEETIEWPSKYPKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFSRA 82
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907151623 443 TLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIgsEGSEGrVLVLGATNRPQALDAALRRPGRFDKEIE 520
Cdd:cd19526    83 QSAKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQLDGV--EGLDG-VYVLAATSRPDLIDPALLRPGRLDKLVY 157
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
349-578 6.26e-45

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 170.99  E-value: 6.26e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 349 KVTYDMIGGLNSQLKAIREIIELpLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGayvsV----INGPEII 424
Cdd:COG0465   138 KVTFDDVAGVDEAKEELQEIVDF-LKDPEKFTRLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAG----VpffsISGSDFV 212
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 425 SKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKReGA--------------QsevekrvvasLLTLMDGIgsEGSE 490
Cdd:COG0465   213 EMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQR-GAglggghdereqtlnQ----------LLVEMDGF--EGNE 279
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 491 GrVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNE 570
Cdd:COG0465   280 G-VIVIAATNRPDVLDPALLRPGRFDRQVVVDLPDVKGREAILKVHARKKP-LAPDVDLEVIARRTPGFSGADLANLVNE 357

                  ....*...
gi 1907151623 571 AGLHALRR 578
Cdd:COG0465   358 AALLAARR 365
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
345-577 1.10e-44

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 171.37  E-value: 1.10e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 345 DSQFKVTYDMIGGLNSQLKAIREIIELpLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEII 424
Cdd:PRK10733  144 EDQIKTTFADVAGCDEAKEEVAELVEY-LREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFV 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 425 SKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKRE---GAQSEVEKRVVASLLTLMDGIgsEGSEGrVLVLGATNR 501
Cdd:PRK10733  223 EMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGaglGGGHDEREQTLNQMLVEMDGF--EGNEG-IIVIAATNR 299
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907151623 502 PQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRVPhLLTKAELLRLANNAHGYVGADLKALCNEAGLHALR 577
Cdd:PRK10733  300 PDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVP-LAPDIDAAIIARGTPGFSGADLANLVNEAALFAAR 374
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
349-521 6.75e-44

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 156.18  E-value: 6.75e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 349 KVTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPApRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFY 428
Cdd:cd19521     3 NVKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRKPW-SGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWM 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 429 GETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEgSEGrVLVLGATNRPQALDAA 508
Cdd:cd19521    82 GESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASRRIKTELLVQMNGVGND-SQG-VLVLGATNIPWQLDSA 159
                         170
                  ....*....|...
gi 1907151623 509 LRRpgRFDKEIEI 521
Cdd:cd19521   160 IRR--RFEKRIYI 170
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
350-521 4.78e-43

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 154.76  E-value: 4.78e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 350 VTYDMIGGLNSQLKAIREIIELPLKQPELFKSYGIPaPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:cd19525    19 INWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRGP-PKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVG 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 430 ETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSeGSEGRVLVLGATNRPQALDAAL 509
Cdd:cd19525    98 EGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATT-SSEDRILVVGATNRPQEIDEAA 176
                         170
                  ....*....|..
gi 1907151623 510 RRpgRFDKEIEI 521
Cdd:cd19525   177 RR--RLVKRLYI 186
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
628-784 6.45e-43

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 153.35  E-value: 6.45e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 628 DIGGLENIKLKLKQAVEWPLKHPKSFNRMGI-QPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESE 706
Cdd:cd19520     1 DIGGLDEVITELKELVILPLQRPELFDNSRLlQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 707 RAVREIFRKARAVAPSIIFFDELDALAVERgsSSGAGNVADRVLAQLLTEMDGI--EQLKNVTVLAATNRPDRIDKALMR 784
Cdd:cd19520    81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQR--SSTDHEATAMMKAEFMSLWDGLstDGNCRVIVMGATNRPQDLDEAILR 158
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
363-517 6.96e-43

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 153.05  E-value: 6.96e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 363 KAIREIIELPLKQPELFKSyGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEARLRQIFAEA 442
Cdd:cd19527     3 KEILDTIQLPLEHPELFSS-GLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKA 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907151623 443 TLRHPSIIFIDELDALCPKR--EGAQSEVEKRVVASLLTLMDGIGSEGSEgrVLVLGATNRPQALDAALRRPGRFDK 517
Cdd:cd19527    82 RDAKPCVIFFDELDSLAPSRgnSGDSGGVMDRVVSQLLAELDGMSSSGQD--VFVIGATNRPDLLDPALLRPGRFDK 156
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
628-794 3.13e-42

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 151.68  E-value: 3.13e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 628 DIGGLENIKLKLKQAVEWPLKHPKSFNrmGIQPP-KGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESE 706
Cdd:cd19522     1 DIADLEEAKKLLEEAVVLPMWMPEFFK--GIRRPwKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 707 RAVREIFRKARAVAPSIIFFDELDALAVERGSSSgAGNVADRVLAQLLTEMDGI-------EQLKNVTVLAATNRPDRID 779
Cdd:cd19522    79 KLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSE-EHEASRRVKSELLVQMDGVggasendDPSKMVMVLAATNFPWDID 157
                         170
                  ....*....|....*
gi 1907151623 780 KALMRpgRIDRIIYV 794
Cdd:cd19522   158 EALRR--RLEKRIYI 170
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
622-794 6.50e-42

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 150.78  E-value: 6.50e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 622 PNVSWSDIGGLENIKLKLKQAVEWPLKHPKSF--NRmgiQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMN 699
Cdd:cd19521     2 PNVKWEDVAGLEGAKEALKEAVILPVKFPHLFtgNR---KPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 700 KYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGssSGAGNVADRVLAQLLTEMDGI-EQLKNVTVLAATNRPDRI 778
Cdd:cd19521    79 KWMGESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRG--EGESEASRRIKTELLVQMNGVgNDSQGVLVLGATNIPWQL 156
                         170
                  ....*....|....*.
gi 1907151623 779 DKALMRpgRIDRIIYV 794
Cdd:cd19521   157 DSAIRR--RFEKRIYI 170
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
355-515 5.13e-41

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 147.96  E-value: 5.13e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 355 IGGLNSQLKAIREIIELPLKQPELFKSYGI-PAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEA 433
Cdd:cd19520     2 IGGLDEVITELKELVILPLQRPELFDNSRLlQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 434 RLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEgRVLVLGATNRPQALDAALRR-- 511
Cdd:cd19520    82 LVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNC-RVIVMGATNRPQDLDEAILRrm 160

                  ....
gi 1907151623 512 PGRF 515
Cdd:cd19520   161 PKRF 164
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
650-789 1.19e-40

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 147.25  E-value: 1.19e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 650 PKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANE-SGLNFLAIKGPELMNKYVGESERAVREIFRKA----RAVAPS-- 722
Cdd:cd19504    24 PEIVEQLGCKHVKGILLYGPPGTGKTLMARQIGKMlNAREPKIVNGPEILNKYVGESEANIRKLFADAeeeqRRLGANsg 103
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907151623 723 --IIFFDELDALAVERGSSSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRID 789
Cdd:cd19504   104 lhIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRKDLIDEALLRPGRLE 172
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
614-794 2.00e-40

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 147.06  E-value: 2.00e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 614 MREVAIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNrmGIQ-PPKGVLLYGPPGCSKTMIAKALANESGLNFLAI 692
Cdd:cd19525     9 MSEIMDHGPPINWADIAGLEFAKKTIKEIVVWPMLRPDIFT--GLRgPPKGILLFGPPGTGKTLIGKCIASQSGATFFSI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 693 KGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGnvADRVLAQLLTEMDGIEQLKN--VTVLA 770
Cdd:cd19525    87 SASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHES--SRRIKTEFLVQLDGATTSSEdrILVVG 164
                         170       180
                  ....*....|....*....|....
gi 1907151623 771 ATNRPDRIDKALMRpgRIDRIIYV 794
Cdd:cd19525   165 ATNRPQEIDEAARR--RLVKRLYI 186
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
355-511 1.54e-39

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 143.84  E-value: 1.54e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 355 IGGLNSQLKAIREIIELPLKQPELFKSYGIPaPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAR 434
Cdd:cd19524     2 IAGQDLAKQALQEMVILPSLRPELFTGLRAP-ARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907151623 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEgRVLVLGATNRPQALD-AALRR 511
Cdd:cd19524    81 VRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVQSNGDD-RVLVMGATNRPQELDdAVLRR 157
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
355-521 1.64e-39

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 143.97  E-value: 1.64e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 355 IGGLNSQLKAIREIIELPLKQPELFKsyGIPAP-RGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEA 433
Cdd:cd19522     2 IADLEEAKKLLEEAVVLPMWMPEFFK--GIRRPwKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 434 RLRQIFAEATLRHPSIIFIDELDALCPKR-EGAQSEVEKRVVASLLTLMDGIG----SEGSEGRVLVLGATNRPQALDAA 508
Cdd:cd19522    80 LVRLLFEMARFYAPTTIFIDEIDSICSRRgTSEEHEASRRVKSELLVQMDGVGgaseNDDPSKMVMVLAATNFPWDIDEA 159
                         170
                  ....*....|...
gi 1907151623 509 LRRpgRFDKEIEI 521
Cdd:cd19522   160 LRR--RLEKRIYI 170
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
355-521 1.40e-36

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 135.70  E-value: 1.40e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 355 IGGLNSQLKAI-REIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAY-VSVINGPEIISKFYGETE 432
Cdd:cd19504     2 IGGLDKEFSDIfRRAFASRVFPPEIVEQLGCKHVKGILLYGPPGTGKTLMARQIGKMLNARePKIVNGPEILNKYVGESE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 433 ARLRQIFAEATLRHPS--------IIFIDELDALCPKR--EGAQSEVEKRVVASLLTLMDGIGSEGSegrVLVLGATNRP 502
Cdd:cd19504    82 ANIRKLFADAEEEQRRlgansglhIIIFDEIDAICKQRgsMAGSTGVHDTVVNQLLSKIDGVEQLNN---ILVIGMTNRK 158
                         170
                  ....*....|....*....
gi 1907151623 503 QALDAALRRPGRFDKEIEI 521
Cdd:cd19504   159 DLIDEALLRPGRLEVQMEI 177
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
628-794 8.54e-35

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 130.35  E-value: 8.54e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 628 DIGGLENIKLKLKQAVEWPLKHPKSFNRMGiQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESER 707
Cdd:cd19524     1 DIAGQDLAKQALQEMVILPSLRPELFTGLR-APARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 708 AVREIFRKARAVAPSIIFFDELDALAVERgsSSGAGNVADRVLAQLLTEMDGIEQLKN--VTVLAATNRPDRIDKALMRp 785
Cdd:cd19524    80 LVRALFAVARELQPSIIFIDEVDSLLSER--SEGEHEASRRLKTEFLIEFDGVQSNGDdrVLVMGATNRPQELDDAVLR- 156

                  ....*....
gi 1907151623 786 gRIDRIIYV 794
Cdd:cd19524   157 -RFTKRVYV 164
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
628-794 1.09e-32

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 124.02  E-value: 1.09e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 628 DIGGLENIKlklkqavEWPLKHPKSFN----RMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVG 703
Cdd:cd19507     1 DVGGLDNLK-------DWLKKRKAAFSkqasAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVG 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 704 ESERAVREIFRKARAVAPSIIFFDELDAlAVERGSSSGAGNVADRVLAQLLTEMDgiEQLKNVTVLAATNRPDRIDKALM 783
Cdd:cd19507    74 ESESRLRQMIQTAEAIAPCVLWIDEIEK-GFSNADSKGDSGTSSRVLGTFLTWLQ--EKKKPVFVVATANNVQSLPPELL 150
                         170
                  ....*....|.
gi 1907151623 784 RPGRIDRIIYV 794
Cdd:cd19507   151 RKGRFDEIFFV 161
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
630-796 1.60e-28

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 111.85  E-value: 1.60e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 630 GGLENIKLKLKQAVEWPlkhpksfnrmgiqPPKGVLLYGPPGCSKTMIAKALANES---GLNFLAIKGPELMNKYVGESE 706
Cdd:cd00009     1 VGQEEAIEALREALELP-------------PPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAEL 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 707 R---AVREIFRKARAVAPSIIFFDELDALAVErgsssgagnVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALM 783
Cdd:cd00009    68 FghfLVRLLFELAEKAKPGVLFIDEIDSLSRG---------AQNALLRVLETLNDLRIDRENVRVIGATNRPLLGDLDRA 138
                         170
                  ....*....|...
gi 1907151623 784 RPGRIDRIIYVPL 796
Cdd:cd00009   139 LYDRLDIRIVIPL 151
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
355-521 4.18e-28

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 111.13  E-value: 4.18e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 355 IGGLNSQLKAIREIIELPLKQPELFKSYGIPaPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAR 434
Cdd:cd19523     2 IAGLGALKAAIKEEVLWPLLRPDAFSGLLRL-PRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVeKRVVASLLTLMDGIGSEGSEGrVLVLGATNRPQALDAALRRpgR 514
Cdd:cd19523    81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASPV-GRLQVELLAQLDGVLGSGEDG-VLVVCTTSKPEEIDESLRR--Y 156

                  ....*..
gi 1907151623 515 FDKEIEI 521
Cdd:cd19523   157 FSKRLLV 163
ycf46 CHL00195
Ycf46; Provisional
622-835 4.67e-28

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 118.97  E-value: 4.67e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 622 PNVSWSDIGGLENIKLKLKqavewplKHPKSFNRM----GIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPEL 697
Cdd:CHL00195  223 VNEKISDIGGLDNLKDWLK-------KRSTSFSKQasnyGLPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKL 295
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 698 MNKYVGESERAVREIFRKARAVAPSIIFFDELDAlAVERGSSSGAGNVADRVLAQLLTEMDgiEQLKNVTVLAATNRPDR 777
Cdd:CHL00195  296 FGGIVGESESRMRQMIRIAEALSPCILWIDEIDK-AFSNSESKGDSGTTNRVLATFITWLS--EKKSPVFVVATANNIDL 372
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907151623 778 IDKALMRPGRIDRIIYVPLPDAATRREIlnLQFHSMPIS----NEVDLDELVLQTDTYSGAE 835
Cdd:CHL00195  373 LPLEILRKGRFDEIFFLDLPSLEEREKI--FKIHLQKFRpkswKKYDIKKLSKLSNKFSGAE 432
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
628-784 3.06e-26

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 105.74  E-value: 3.06e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 628 DIGGLENIKLKLKQAVEWPLKHPKSFNRMgIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESER 707
Cdd:cd19523     1 DIAGLGALKAAIKEEVLWPLLRPDAFSGL-LRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEK 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907151623 708 AVREIFRKARAVAPSIIFFDELDALAVERGSSSGAGNvadRVLAQLLTEMDGI--EQLKNVTVLAATNRPDRIDKALMR 784
Cdd:cd19523    80 ILQASFLAARCRQPSVLFISDLDALLSSQDDEASPVG---RLQVELLAQLDGVlgSGEDGVLVVCTTSKPEEIDESLRR 155
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
356-522 8.55e-25

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 101.07  E-value: 8.55e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 356 GGLNSQLKAIREIIELPlkqpelfksygipAPRGLLLYGPPGTGKTMIARAVANEV---GAYVSVINGPEIISKFYGETE 432
Cdd:cd00009     1 VGQEEAIEALREALELP-------------PPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAEL 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 433 AR---LRQIFAEATLRHPSIIFIDELDALcpkREGAQSEVekrvvasLLTLMDGIGSEGSEGRVLVLGATNRPQALDAAL 509
Cdd:cd00009    68 FGhflVRLLFELAEKAKPGVLFIDEIDSL---SRGAQNAL-------LRVLETLNDLRIDRENVRVIGATNRPLLGDLDR 137
                         170
                  ....*....|...
gi 1907151623 510 RRPGRFDKEIEIG 522
Cdd:cd00009   138 ALYDRLDIRIVIP 150
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
355-516 1.98e-22

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 94.74  E-value: 1.98e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 355 IGGLNsQLKAIREIIELPLKQPElfKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAR 434
Cdd:cd19507     2 VGGLD-NLKDWLKKRKAAFSKQA--SAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESR 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 435 LRQIFAEATLRHPSIIFIDELD-ALCPKREGAQSEVEKRVVASLLTLMdgigSEGSEgRVLVLGATNRPQALDAALRRPG 513
Cdd:cd19507    79 LRQMIQTAEAIAPCVLWIDEIEkGFSNADSKGDSGTSSRVLGTFLTWL----QEKKK-PVFVVATANNVQSLPPELLRKG 153

                  ...
gi 1907151623 514 RFD 516
Cdd:cd19507   154 RFD 156
ycf46 CHL00195
Ycf46; Provisional
349-575 9.20e-20

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 93.55  E-value: 9.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 349 KVTYDMIGGLNSqLKAIREiielplKQPELF----KSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEII 424
Cdd:CHL00195  224 NEKISDIGGLDN-LKDWLK------KRSTSFskqaSNYGLPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLF 296
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 425 SKFYGETEARLRQI--FAEATlrHPSIIFIDELD-ALCPKREGAQSEVEKRVVASLLTLMdgigsegSEGR--VLVLGAT 499
Cdd:CHL00195  297 GGIVGESESRMRQMirIAEAL--SPCILWIDEIDkAFSNSESKGDSGTTNRVLATFITWL-------SEKKspVFVVATA 367
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907151623 500 NRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQKLLRRV-PHLLTKAELLRLANNAHGYVGADLKALCNEAGLHA 575
Cdd:CHL00195  368 NNIDLLPLEILRKGRFDEIFFLDLPSLEEREKIFKIHLQKFrPKSWKKYDIKKLSKLSNKFSGAEIEQSIIEAMYIA 444
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
365-521 1.58e-19

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 86.25  E-value: 1.58e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 365 IREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIiskfyGETEARLRQIFAEATL 444
Cdd:cd19510     1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEV-----VLTDDRLNHLLNTAPK 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 445 RhpSIIFIDELDALCPKREGAQSEVEK-----RVVAS-LLTLMDGIGSegSEGRVLVLgATNRPQALDAALRRPGRFDKE 518
Cdd:cd19510    76 Q--SIILLEDIDAAFESREHNKKNPSAygglsRVTFSgLLNALDGVAS--SEERIVFM-TTNHIERLDPALIRPGRVDMK 150

                  ...
gi 1907151623 519 IEI 521
Cdd:cd19510   151 IYM 153
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
660-798 3.95e-18

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 82.04  E-value: 3.95e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623  660 PPKGVLLYGPPGCSKTMIAKALANESGLN---FLAIKGPELM--------------NKYVGESERAVREIFRKARAVAPS 722
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDILeevldqllliivggKKASGSGELRLRLALALARKLKPD 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907151623  723 IIFFDELDALAVERGSssgagnvADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPgRIDRIIYVPLPD 798
Cdd:smart00382  81 VLILDEITSLLDAEQE-------ALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
639-794 7.45e-18

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 81.24  E-value: 7.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 639 LKQAVEWPLKHPKSFNRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFlaikgpelmnkYVGESERAVREIFRKAR- 717
Cdd:cd19510     1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDI-----------CDLNLSEVVLTDDRLNHl 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 718 -AVAP--SIIFFDELDALAVER---GSSSGAGNVADRV-LAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDR 790
Cdd:cd19510    70 lNTAPkqSIILLEDIDAAFESRehnKKNPSAYGGLSRVtFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDM 149

                  ....
gi 1907151623 791 IIYV 794
Cdd:cd19510   150 KIYM 153
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
387-525 6.13e-16

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 75.49  E-value: 6.13e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623  387 PRGLLLYGPPGTGKTMIARAVANEVGAY---VSVINGPEI--------------ISKFYGETEARLRQIFAEATLRHPSI 449
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDIleevldqllliivgGKKASGSGELRLRLALALARKLKPDV 81
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907151623  450 IFIDELDALCPKREGAQSEVEKRVVASLLTLmdgigsegSEGRVLVLGATNRPQALDAALRRPgRFDKEIEIGIPN 525
Cdd:smart00382  82 LILDEITSLLDAEQEALLLLLEELRLLLLLK--------SEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
388-520 1.52e-12

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 66.01  E-value: 1.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 388 RGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEiISKFYGETEARLRQIFAEA-TLRHPSIIFIDELDALCPKRegAQ 466
Cdd:cd19512    23 RNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAIHKVFDWAnTSRRGLLLFVDEADAFLRKR--ST 99
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907151623 467 SEVEKRVVASLLTLMDGIGsEGSEGRVLVLgATNRPQALDAALRrpGRFDKEIE 520
Cdd:cd19512   100 EKISEDLRAALNAFLYRTG-EQSNKFMLVL-ASNQPEQFDWAIN--DRIDEMVE 149
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
664-794 1.68e-12

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 67.09  E-value: 1.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 664 VLLYGPPGCSKTMIAKALANESGLN---------FLAIKGPELMNKYVGESERAVREIFRKARAVA--PSIIFF---DEL 729
Cdd:cd19508    55 VLLHGPPGTGKTSLCKALAQKLSIRlssryrygqLIEINSHSLFSKWFSESGKLVTKMFQKIQELIddKDALVFvliDEV 134
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907151623 730 DALAVERGSSSGAGNVAD--RVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMrpGRIDRIIYV 794
Cdd:cd19508   135 ESLAAARSASSSGTEPSDaiRVVNAVLTQIDRIKRYHNNVILLTSNLLEKIDVAFV--DRADIKQYI 199
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
361-520 5.87e-11

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 66.02  E-value: 5.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 361 QLKAIREIIELPLKQPElfksYGIPAP---RGLLLYGPPGTGKTMIARAVANEVgAYVSVINGPEI--------ISKFYG 429
Cdd:TIGR03922 287 QVAALKSSTAMALARAE----RGLPVAqtsNHMLFAGPPGTGKTTIARVVAKIY-CGLGVLRKPLVrevsradlIGQYIG 361
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 430 ETEARLRQIFAEATLRhpsIIFIDELDALCPKREGAQSEVEKRVVASLLTLMdgigsEGSEGRVLVLGATNRpQALDAAL 509
Cdd:TIGR03922 362 ESEAKTNEIIDSALGG---VLFLDEAYTLVETGYGQKDPFGLEAIDTLLARM-----ENDRDRLVVIGAGYR-KDLDKFL 432
                         170
                  ....*....|....*
gi 1907151623 510 R-RPG---RFDKEIE 520
Cdd:TIGR03922 433 EvNEGlrsRFTRVIE 447
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
662-792 2.51e-10

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 59.46  E-value: 2.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 662 KGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPEL--MNKyvgESERAVREIFRKARAVAPSIIFF-DELDALAVERgS 738
Cdd:cd19512    23 RNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVapMGR---EGVTAIHKVFDWANTSRRGLLLFvDEADAFLRKR-S 98
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907151623 739 SSGAGNVADRVLAQLLTEMDgiEQLKNVTVLAATNRPDRIDKALMrpGRIDRII 792
Cdd:cd19512    99 TEKISEDLRAALNAFLYRTG--EQSNKFMLVLASNQPEQFDWAIN--DRIDEMV 148
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
388-509 6.94e-10

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 59.38  E-value: 6.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 388 RGLLLYGPPGTGKTMIARAVANEVGAYVSV---------INGPEIISKFYGETEARLRQIF---AEATLRHPSIIF--ID 453
Cdd:cd19508    53 RLVLLHGPPGTGKTSLCKALAQKLSIRLSSryrygqlieINSHSLFSKWFSESGKLVTKMFqkiQELIDDKDALVFvlID 132
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 454 ELDALCPKREGAQSEVEK----RVVASLLTLMDGIGSEGSegrVLVLGATNRPQALDAAL 509
Cdd:cd19508   133 EVESLAAARSASSSGTEPsdaiRVVNAVLTQIDRIKRYHN---NVILLTSNLLEKIDVAF 189
44 PHA02544
clamp loader, small subunit; Provisional
363-539 1.87e-09

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 60.00  E-value: 1.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 363 KAIREIIeLPLKQPELFKSY----GIPAprgLLLYGP-PGTGKTMIARAVANEVGAYVSVINGPEIISKFygeTEARLRQ 437
Cdd:PHA02544   18 STIDECI-LPAADKETFKSIvkkgRIPN---MLLHSPsPGTGKTTVAKALCNEVGAEVLFVNGSDCRIDF---VRNRLTR 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 438 IFAEATLR-HPSIIFIDELDalcpkREGAqSEVEKrvvaSLLTLMdgigsEGSEGRVLVLGATNRPQALDAALRrpGRFD 516
Cdd:PHA02544   91 FASTVSLTgGGKVIIIDEFD-----RLGL-ADAQR----HLRSFM-----EAYSKNCSFIITANNKNGIIEPLR--SRCR 153
                         170       180
                  ....*....|....*....|...
gi 1907151623 517 kEIEIGIPNAQDRLDILQKLLRR 539
Cdd:PHA02544  154 -VIDFGVPTKEEQIEMMKQMIVR 175
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
390-460 1.96e-09

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 60.48  E-value: 1.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 390 LLLYGPPGTGKTMIARAVANEVGAYVSVINGpeIISKFygeteARLRQIFAEATLRHPS----IIFIDEL--------DA 457
Cdd:PRK13342   39 MILWGPPGTGKTTLARIIAGATDAPFEALSA--VTSGV-----KDLREVIEEARQRRSAgrrtILFIDEIhrfnkaqqDA 111

                  ...
gi 1907151623 458 LCP 460
Cdd:PRK13342  112 LLP 114
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
548-582 5.30e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 52.54  E-value: 5.30e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907151623 548 ELLRLANNAHGYVGADLKALCNEAGLHALRRVLRK 582
Cdd:pfam17862   3 DLEELAERTEGFSGADLEALCREAALAALRRGLEA 37
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
655-794 7.15e-09

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 55.46  E-value: 7.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 655 RMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAI--------------KGPELMNKYVGESERAVREIFRKARAVA 720
Cdd:cd19505     6 RLGLSPSKGILLIGSIETGRSYLIKSLAANSYVPLIRIslnkllynkpdfgnDDWIDGMLILKESLHRLNLQFELAKAMS 85
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907151623 721 PSIIFFDELDALAVERGSSSGAGNvADRVLAQLLTEM-DGIEQ--LKNVTVLAATNRPDRIDKALMRPGRIDRIIYV 794
Cdd:cd19505    86 PCIIWIPNIHELNVNRSTQNLEED-PKLLLGLLLNYLsRDFEKssTRNILVIASTHIPQKVDPALIAPNRLDTCINI 161
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
390-474 1.63e-08

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 57.76  E-value: 1.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 390 LLLYGPPGTGKTMIARAVANEVGAYVSVINGpeIISkfygeTEARLRQIFAEATLRH----PSIIFIDEL--------DA 457
Cdd:COG2256    52 MILWGPPGTGKTTLARLIANATDAEFVALSA--VTS-----GVKDIREVIEEARERRaygrRTILFVDEIhrfnkaqqDA 124
                          90
                  ....*....|....*..
gi 1907151623 458 LCPkregaqsEVEKRVV 474
Cdd:COG2256   125 LLP-------HVEDGTI 134
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
385-506 2.89e-08

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 53.69  E-value: 2.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 385 PAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGET--EARLRQIFAEATLRHPSIIFIDELDAL---- 458
Cdd:cd19506    24 PLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGDAEKTfykk 103
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1907151623 459 CPKREGAQSevEKRVVASLLTLMDGIgseGSEGRVLVLGATNRPQALD 506
Cdd:cd19506   104 VPKTEKQLD--PKRLKKDLPKILKSL---KPEDRVLIVGTTSRPFEAD 146
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
390-553 9.93e-08

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 54.40  E-value: 9.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 390 LLLYGPPGTGKTMIARAVANEVGAYVSVIN-----------GPEIISKFYGETEARLRQIFAeatlrhpSIIFIDELDal 458
Cdd:COG0714    34 LLLEGVPGVGKTTLAKALARALGLPFIRIQftpdllpsdilGTYIYDQQTGEFEFRPGPLFA-------NVLLADEIN-- 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 459 cpkRegAQSEVEkrvvASLLTLMDgigsegsEGRVLVLGAT----NRPQAL---------------DAALRrpgRFDKEI 519
Cdd:COG0714   105 ---R--APPKTQ----SALLEAME-------ERQVTIPGGTyklpEPFLVIatqnpieqegtyplpEAQLD---RFLLKL 165
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1907151623 520 EIGIPNAQDRLDILQKLLRR----VPHLLTKAELLRLA 553
Cdd:COG0714   166 YIGYPDAEEEREILRRHTGRhlaeVEPVLSPEELLALQ 203
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
383-521 3.03e-07

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 50.84  E-value: 3.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 383 GIPAPRGLLLYGPPGTGKTMIARAVANEvgAYVSVI---------NGPEIISK-------FYGETEARLRQIFAEATLRH 446
Cdd:cd19505     8 GLSPSKGILLIGSIETGRSYLIKSLAAN--SYVPLIrislnkllyNKPDFGNDdwidgmlILKESLHRLNLQFELAKAMS 85
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907151623 447 PSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEGR-VLVLGATNRPQALDAALRRPGRFDKEIEI 521
Cdd:cd19505    86 PCIIWIPNIHELNVNRSTQNLEEDPKLLLGLLLNYLSRDFEKSSTRnILVIASTHIPQKVDPALIAPNRLDTCINI 161
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
390-463 1.04e-06

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 51.53  E-value: 1.04e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907151623 390 LLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIiskfygeteARLRQIFAEATLRHP-SIIFIDELDALCPKRE 463
Cdd:TIGR00635  33 LLLYGPPGLGKTTLAHIIANEMGVNLKITSGPAL---------EKPGDLAAILTNLEEgDVLFIDEIHRLSPAVE 98
PRK13341 PRK13341
AAA family ATPase;
390-460 1.32e-06

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 51.98  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 390 LLLYGPPGTGKTMIARAVANEVGAYVSVINgpeiiSKFYGETEarLRQIFAEATLRHP-----SIIFIDEL--------D 456
Cdd:PRK13341   55 LILYGPPGVGKTTLARIIANHTRAHFSSLN-----AVLAGVKD--LRAEVDRAKERLErhgkrTILFIDEVhrfnkaqqD 127

                  ....
gi 1907151623 457 ALCP 460
Cdd:PRK13341  128 ALLP 131
PRK04195 PRK04195
replication factor C large subunit; Provisional
659-732 1.51e-06

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 51.46  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 659 QPPKGVLLYGPPGCSKTMIAKALANESGLNFLaikgpEL----------MNKYVGESERaVREIFRKARavapSIIFFDE 728
Cdd:PRK04195   37 KPKKALLLYGPPGVGKTSLAHALANDYGWEVI-----ELnasdqrtadvIERVAGEAAT-SGSLFGARR----KLILLDE 106

                  ....
gi 1907151623 729 LDAL 732
Cdd:PRK04195  107 VDGI 110
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
664-737 1.80e-06

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 51.21  E-value: 1.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 664 VLLYGPPGCSKTMIAKALANESGLNFLAIkgpelmnkyvgeseRAV-------REIFRKARAVA----PSIIFFDEL--- 729
Cdd:COG2256    52 MILWGPPGTGKTTLARLIANATDAEFVAL--------------SAVtsgvkdiREVIEEARERRaygrRTILFVDEIhrf 117
                          90
                  ....*....|....*
gi 1907151623 730 -----DAL--AVERG 737
Cdd:COG2256   118 nkaqqDALlpHVEDG 132
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
664-737 1.80e-06

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 51.24  E-value: 1.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 664 VLLYGPPGCSKTMIAKALANESGLNFLAIKGpelmnkyVGESERAVREIFRKARAVAPS----IIFFDEL--------DA 731
Cdd:PRK13342   39 MILWGPPGTGKTTLARIIAGATDAPFEALSA-------VTSGVKDLREVIEEARQRRSAgrrtILFIDEIhrfnkaqqDA 111

                  ....*...
gi 1907151623 732 L--AVERG 737
Cdd:PRK13342  112 LlpHVEDG 119
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
389-515 2.20e-06

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 47.67  E-value: 2.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 389 GLLLYGPPGTGKTMIARAVA----NEVGAYVSvingpeiISKFYgeTEARLRQIFAEATL-------------RHPSIIF 451
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAaalsNRPVFYVQ-------LTRDT--TEEDLFGRRNIDPGgaswvdgplvraaREGEIAV 71
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907151623 452 IDELDalcpkregaqsEVEKRVVASLLTL--------MDGIGSEGSEG-RVLVLGATNRPQA----LDAALRRpgRF 515
Cdd:pfam07728  72 LDEIN-----------RANPDVLNSLLSLlderrlllPDGGELVKAAPdGFRLIATMNPLDRglneLSPALRS--RF 135
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
356-442 2.65e-06

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 50.39  E-value: 2.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 356 GGLNSQLKAiREIIELPLkqpELFKSYGIpAPRGLLLYGPPGTGKTMIARAVANEVGAYV--SVINGPEIISKFYGETEA 433
Cdd:pfam06068  24 GGLVGQEKA-REAAGVIV---EMIKEGKI-AGRAVLIAGPPGTGKTALAIAISKELGEDTpfTSISGSEVYSLEMKKTEA 98

                  ....*....
gi 1907151623 434 rLRQIFAEA 442
Cdd:pfam06068  99 -LTQAFRKA 106
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
386-438 4.23e-06

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 49.97  E-value: 4.23e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907151623 386 APRGLLLYGPPGTGKTMIARAVANEVGA---YVSvINGPEIISKFYGETEARLRQI 438
Cdd:COG1224    63 AGKGILIVGPPGTGKTALAVAIARELGEdtpFVA-ISGSEIYSAELKKTEFLMQAL 117
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
664-824 6.13e-06

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 49.01  E-value: 6.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 664 VLLYGPPGCSKTMIAKALANESGLNFLAIKG-PELM-NKYVGES---ERAVREIFRKaRAVAPSIIFFDELDalaveRgs 738
Cdd:COG0714    34 LLLEGVPGVGKTTLAKALARALGLPFIRIQFtPDLLpSDILGTYiydQQTGEFEFRP-GPLFANVLLADEIN-----R-- 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 739 ssgagnvAD-RVLAQLLTEMDgiEqlKNVT-------------VLAATNRPDRI----------DKALMRpgridriIYV 794
Cdd:COG0714   106 -------APpKTQSALLEAME--E--RQVTipggtyklpepflVIATQNPIEQEgtyplpeaqlDRFLLK-------LYI 167
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1907151623 795 PLPDAATRREILNLQ--FHSMPISNEVDLDEL 824
Cdd:COG0714   168 GYPDAEEEREILRRHtgRHLAEVEPVLSPEEL 199
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
661-741 1.24e-05

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 46.60  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 661 PKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMN-KYVGeseRAVREIFRKaraVAPSIIFFDELDALAVERGSS 739
Cdd:cd19498    46 PKNILMIGPTGVGKTEIARRLAKLAGAPFIKVEATKFTEvGYVG---RDVESIIRD---LVEGIVFIDEIDKIAKRGGSS 119

                  ..
gi 1907151623 740 SG 741
Cdd:cd19498   120 GP 121
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
390-454 1.37e-05

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 48.20  E-value: 1.37e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907151623 390 LLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIiskfygETEARLRQIFaeATLRHPSIIFIDE 454
Cdd:PRK00080   54 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAL------EKPGDLAAIL--TNLEEGDVLFIDE 110
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
390-454 1.60e-05

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 45.95  E-value: 1.60e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907151623 390 LLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIiskfygeteARLRQIFAEAT-LRHPSIIFIDE 454
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAI---------ERPGDLAAILTnLEPGDVLFIDE 92
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
663-784 2.20e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 44.98  E-value: 2.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 663 GVLLYGPPGCSKTMIAKALANE-SGLNFLAIKGPELMNK---------YVGESERAVREIFRKARavAPSIIFFDEldal 732
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAAlSNRPVFYVQLTRDTTEedlfgrrniDPGGASWVDGPLVRAAR--EGEIAVLDE---- 74
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907151623 733 aVERGSSSgagnVADRVLAQL----LTEMDGIEQLK----NVTVLAATNRPDR----IDKALMR 784
Cdd:pfam07728  75 -INRANPD----VLNSLLSLLderrLLLPDGGELVKaapdGFRLIATMNPLDRglneLSPALRS 133
PRK08116 PRK08116
hypothetical protein; Validated
334-426 4.23e-05

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 46.17  E-value: 4.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 334 LRKICTNSKEQ-DSQFKvTYDMIGGLNSQLKAIREIielpLKQPELFKSYGIpaprGLLLYGPPGTGKTMIARAVANEV- 411
Cdd:PRK08116   69 LKSNSLLDEKFrNSTFE-NFLFDKGSEKAYKIARKY----VKKFEEMKKENV----GLLLWGSVGTGKTYLAACIANELi 139
                          90
                  ....*....|....*..
gi 1907151623 412 --GAYVSVINGPEIISK 426
Cdd:PRK08116  140 ekGVPVIFVNFPQLLNR 156
PRK04195 PRK04195
replication factor C large subunit; Provisional
359-412 7.07e-05

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 46.07  E-value: 7.07e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907151623 359 NSQLKAIREIIELPLKqpelfksyGIPaPRGLLLYGPPGTGKTMIARAVANEVG 412
Cdd:PRK04195   20 EKAKEQLREWIESWLK--------GKP-KKALLLYGPPGVGKTSLAHALANDYG 64
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
377-496 7.34e-05

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 44.03  E-value: 7.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 377 ELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEV---GAYVSVINGPEIISkFYGETEARLRQIFAEATLRHPSIIFID 453
Cdd:pfam13191  14 DALDRVRSGRPPSVLLTGEAGTGKTTLLRELLRALerdGGYFLRGKCDENLP-YSPLLEALTREGLLRQLLDELESSLLE 92
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907151623 454 ELDALCPKREGAQSEVEKRVVASLLTLMDGI---GSEGSEGRVLVL 496
Cdd:pfam13191  93 AWRAALLEALAPVPELPGDLAERLLDLLLRLldlLARGERPLVLVL 138
CDC48_N smart01073
Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel ...
64-132 1.46e-04

Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases is a substrate 185-residue recognition domain.


Pssm-ID: 215012 [Multi-domain]  Cd Length: 82  Bit Score: 41.06  E-value: 1.46e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907151623   64 NSLVHLGLNTMKSANICIGRPVLLTsldGKQEVY-TAWP-VAGFPGGKVGLSEMAQKNVGVRAGETIQVQP 132
Cdd:smart01073  14 RGIARLSPEDMDELGLFPGDYVLIT---GKRRTVaIVWPaYPEDPGGIIRIDGVQRKNAGVSIGDTVTVRK 81
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
655-793 2.28e-04

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 42.93  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 655 RMGIQPPK---GVLLY-GPPGCSKTMIAKALA---NESGLNFLAIKGPELMNK------------YVGESERAVreIFRK 715
Cdd:cd19499    31 RAGLSDPNrpiGSFLFlGPTGVGKTELAKALAellFGDEDNLIRIDMSEYMEKhsvsrligappgYVGYTEGGQ--LTEA 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 716 ARAVAPSIIFFDEldalaVERGSSsgagNVADRVLAQL----LTEMDGIE-QLKNVTVLAATN--RPDRIdkalmrpGRI 788
Cdd:cd19499   109 VRRKPYSVVLLDE-----IEKAHP----DVQNLLLQVLddgrLTDSHGRTvDFKNTIIIMTSNhfRPEFL-------NRI 172

                  ....*
gi 1907151623 789 DRIIY 793
Cdd:cd19499   173 DEIVV 177
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
664-697 2.50e-04

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 42.49  E-value: 2.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907151623 664 VLLYGPPGCSKTMIAKALANESGLNFLAIKGPEL 697
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAI 69
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
384-466 2.55e-04

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 43.62  E-value: 2.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 384 IPAPRGLLLYGPPGTGKTMIARAVANE-VGAYVSV--INGPEIISKFY-GETEARLRQIFaeATLRHPSIIFIDELDALC 459
Cdd:COG1484    96 IERGENLILLGPPGTGKTHLAIALGHEaCRAGYRVrfTTAPDLVNELKeARADGRLERLL--KRLAKVDLLILDELGYLP 173

                  ....*..
gi 1907151623 460 PKREGAQ 466
Cdd:COG1484   174 LDAEGAE 180
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
359-506 2.73e-04

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 44.07  E-value: 2.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 359 NSQLKAIREIIElPLKQPELfksygipaPRGLLLYGPPGTGKTMIARAVANEVG------------AYV---------SV 417
Cdd:COG1474    32 EEEIEELASALR-PALRGER--------PSNVLIYGPTGTGKTAVAKYVLEELEeeaeergvdvrvVYVncrqastryRV 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 418 INgpEIISKFYGETE--------ARLRQIFAEATLRH--PSIIFIDELDALcPKREGaqseveKRVVASLLTLMDGIgse 487
Cdd:COG1474   103 LS--RILEELGSGEDipstglstDELFDRLYEALDERdgVLVVVLDEIDYL-VDDEG------DDLLYQLLRANEEL--- 170
                         170
                  ....*....|....*....
gi 1907151623 488 gSEGRVLVLGATNRPQALD 506
Cdd:COG1474   171 -EGARVGVIGISNDLEFLE 188
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
390-423 3.40e-04

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 43.53  E-value: 3.40e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907151623 390 LLLYGPPGTGKTMIARAVANEVGAYVSVINGPEI 423
Cdd:COG2255    57 VLLYGPPGLGKTTLAHIIANEMGVNIRITSGPAI 90
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
387-483 3.50e-04

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 42.37  E-value: 3.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 387 PRGLLLYGPPGTGKTMIARAVANEVGA-YVSVingpeIISKFygeTEARLRQIFAEATLRH--PSIIFIDELDALCPKRE 463
Cdd:cd19498    46 PKNILMIGPTGVGKTEIARRLAKLAGApFIKV-----EATKF---TEVGYVGRDVESIIRDlvEGIVFIDEIDKIAKRGG 117
                          90       100
                  ....*....|....*....|.
gi 1907151623 464 GAQSEVEKR-VVASLLTLMDG 483
Cdd:cd19498   118 SSGPDVSREgVQRDLLPIVEG 138
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
662-728 5.35e-04

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 41.36  E-value: 5.35e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907151623 662 KGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGES--ERAVREIFRKARAVAPSIIFFDE 728
Cdd:cd19506    27 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGD 95
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
386-558 6.96e-04

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 43.22  E-value: 6.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 386 APRGLLLYGPPGTGKTMIARAVANEVGAY-------VSV---------ING--PEIISKFYGETEARLRQIFAEATL--R 445
Cdd:COG1401   220 TKKNVILAGPPGTGKTYLARRLAEALGGEdngriefVQFhpswsyedfLLGyrPSLDEGKYEPTPGIFLRFCLKAEKnpD 299
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 446 HPSIIFIDELDalcpkRegaqSEVEKrVVASLLTLMD---------------GIGSEGSEGR-VLVLGATN---RPQAL- 505
Cdd:COG1401   300 KPYVLIIDEIN-----R----ANVEK-YFGELLSLLEsdkrgeelsielpysGEGEEFSIPPnLYIIGTMNtddRSLALs 369
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907151623 506 DAALRRpgRFD------KEIEIGIPNAQDRLDILQKLLRRVPHLLTKAELLRLANNAHG 558
Cdd:COG1401   370 DKALRR--RFTfefldpDLDKLSNEEVVDLLEELNEILEKRDFQIGHRALLLLDGLLSG 426
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
662-716 8.10e-04

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 42.65  E-value: 8.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907151623 662 KGVLLYGPPGCSKTMIAKALANESGLN--FLAIKGPELMNKYVGESErAVREIFRKA 716
Cdd:COG1224    65 KGILIVGPPGTGKTALAVAIARELGEDtpFVAISGSEIYSAELKKTE-FLMQALRKA 120
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
387-588 1.10e-03

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 41.88  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 387 PRGLLLYGPPGTGKTMIARAVANEVG-----------------------AYVSVINgPEIISKFYGETEAR-LRQIFAEA 442
Cdd:COG0470    18 PHALLLHGPPGIGKTTLALALARDLLcenpeggkacgqchsrlmaagnhPDLLELN-PEEKSDQIGIDQIReLGEFLSLT 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 443 TLRHPS-IIFIDELDALcpkREGAQSevekrvvaSLLTLMDgigsEGSEGRVLVLgATNRPQALDAALR---RPgrfdke 518
Cdd:COG0470    97 PLEGGRkVVIIDEADAM---NEAAAN--------ALLKTLE----EPPKNTPFIL-IANDPSRLLPTIRsrcQV------ 154
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 519 IEIGIPNAQDRLDILQKllrrvpHLLTKAELLRLANNAHGYVGADLKALCNEAGLHALRRVLRKQPNLPD 588
Cdd:COG0470   155 IRFRPPSEEEALAWLRE------EGVDEDALEAILRLAGGDPRAAINLLQALAGRKELLEDLAALLSRDR 218
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
390-485 1.20e-03

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 39.41  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 390 LLLYGPPGTGKTMIARAVAN---EVGAYVSVINGPEIIskfygetearLRQIFAEATLRHPSIIFIDELDALCPKREGAQ 466
Cdd:cd01120     1 ILITGPPGSGKTTLLLQFAEqalLSDEPVIFISFLDTI----------LEAIEDLIEEKKLDIIIIDSLSSLARASQGDR 70
                          90
                  ....*....|....*....
gi 1907151623 467 SEVEKRVVASLLTLMDGIG 485
Cdd:cd01120    71 SSELLEDLAKLLRAARNTG 89
DEXXQc_Helz-like cd18038
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ...
358-408 1.23e-03

DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350796 [Multi-domain]  Cd Length: 229  Bit Score: 41.45  E-value: 1.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907151623 358 LNS-QLKAIREIIELPLKqpelfksygiPAPrgLLLYGPPGTGKTM-IARAVA 408
Cdd:cd18038     2 LNDeQKLAVRNIVTGTSR----------PPP--YIIFGPPGTGKTVtLVEAIL 42
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
391-701 1.38e-03

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 42.52  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 391 LLYGPPGTGKTMIARAVANEV--GAYVSVINGPEIIS----------KFYGETEARLRQIFAEATLRHPSIIFIDELDAL 458
Cdd:PRK11034  211 LLVGESGVGKTAIAEGLAWRIvqGDVPEVMADCTIYSldigsllagtKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTI 290
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 459 CpkreGAQSEVEKRVVASLLtlmdgIGSEGSEGRVLVLGATNRPQ-----ALDAALRRpgRFDKeIEIGIPNAQDRLDIL 533
Cdd:PRK11034  291 I----GAGAASGGQVDAANL-----IKPLLSSGKIRVIGSTTYQEfsnifEKDRALAR--RFQK-IDITEPSIEETVQII 358
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 534 QKllrrvphLLTKAEllrlannAHGYVGADLKALCNEAGLHALRRVLRkqpNLPDSKV-----AG----MVKITLNDFLQ 604
Cdd:PRK11034  359 NG-------LKPKYE-------AHHDVRYTAKAVRAAVELAVKYINDR---HLPDKAIdvideAGararLMPVSKRKKTV 421
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 605 GMNDIRPSAMREVAIDVPNVSWSDIGGLENIKLKLK-------QAVEwPLKHPKSFNRMGI----QPPKGVLLYGPPGCS 673
Cdd:PRK11034  422 NVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKmlvfgqdKAIE-ALTEAIKMSRAGLghehKPVGSFLFAGPTGVG 500
                         330       340
                  ....*....|....*....|....*...
gi 1907151623 674 KTMIAKALANESGLNFLAIKGPELMNKY 701
Cdd:PRK11034  501 KTEVTVQLSKALGIELLRFDMSEYMERH 528
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
390-405 1.51e-03

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 41.95  E-value: 1.51e-03
                          10
                  ....*....|....*.
gi 1907151623 390 LLLYGPPGTGKTMIAR 405
Cdd:COG0606   214 LLMIGPPGSGKTMLAR 229
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
661-730 1.54e-03

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 40.26  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 661 PKGV-LLYGPPGCSKTMIAKALANESGL---NFLAIKGPELMNK------------YVGESERAVreIFRKARAVAPSII 724
Cdd:pfam07724   2 PIGSfLFLGPTGVGKTELAKALAELLFGderALIRIDMSEYMEEhsvsrligappgYVGYEEGGQ--LTEAVRRKPYSIV 79

                  ....*.
gi 1907151623 725 FFDELD 730
Cdd:pfam07724  80 LIDEIE 85
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
664-697 1.80e-03

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 41.27  E-value: 1.80e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1907151623 664 VLLYGPPGCSKTMIAKALANESGLNFLAIKGPEL 697
Cdd:PRK00080   54 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAL 87
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
390-406 2.20e-03

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 40.21  E-value: 2.20e-03
                          10
                  ....*....|....*..
gi 1907151623 390 LLLYGPPGTGKTMIARA 406
Cdd:pfam01078  25 LLMIGPPGSGKTMLAKR 41
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
391-460 2.22e-03

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 39.87  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 391 LLYGPPGTGKTMIARAVANEVGAY---VSVINGPE-----IISKFYGETEARLRQ----IFAEATLRHP-SIIFIDELDA 457
Cdd:pfam07724   7 LFLGPTGVGKTELAKALAELLFGDeraLIRIDMSEymeehSVSRLIGAPPGYVGYeeggQLTEAVRRKPySIVLIDEIEK 86

                  ...
gi 1907151623 458 LCP 460
Cdd:pfam07724  87 AHP 89
AAA_22 pfam13401
AAA domain;
390-458 2.38e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 38.86  E-value: 2.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 390 LLLYGPPGTGKTMIARAVANEVGA------YVSVING-------PEIISKF-----YGETEARLRQIFAEA--TLRHPSI 449
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLEQLPEvrdsvvFVDLPSGtspkdllRALLRALglplsGRLSKEELLAALQQLllALAVAVV 87

                  ....*....
gi 1907151623 450 IFIDELDAL 458
Cdd:pfam13401  88 LIIDEAQHL 96
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
658-736 4.18e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 39.76  E-value: 4.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907151623 658 IQPPKGVLLYGPPGCSKTMIAKALANE---SGLNFLAIKGPELMNK-YVGESERAVREIFRKARAVAPSIIffDELDALA 733
Cdd:COG1484    96 IERGENLILLGPPGTGKTHLAIALGHEacrAGYRVRFTTAPDLVNElKEARADGRLERLLKRLAKVDLLIL--DELGYLP 173

                  ...
gi 1907151623 734 VER 736
Cdd:COG1484   174 LDA 176
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
383-424 5.92e-03

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 39.13  E-value: 5.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1907151623 383 GIPAPRGLLLYGPPGTGKT------MIARAVANEVGAYVSVINGPEII 424
Cdd:COG0467    16 GLPRGSSTLLSGPPGTGKTtlalqfLAEGLRRGEKGLYVSFEESPEQL 63
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
664-695 8.57e-03

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 39.29  E-value: 8.57e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907151623 664 VLLYGPPGCSKTMIAKALANESGLNFLAIKGP 695
Cdd:COG2255    57 VLLYGPPGLGKTTLAHIIANEMGVNIRITSGP 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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