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Conserved domains on  [gi|1907206272|ref|XP_036018004|]
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WD repeat-containing protein 13 isoform X2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
80-391 7.93e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 7.93e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272  80 DEAVPRVRFANDDRhRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRC 159
Cdd:COG2319   120 TGAVRSVAFSPDGK-TLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 160 IREIPDPDGAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVK--GGSsklTGRVLALSFDAPGRLLWAGDDRGSVf 237
Cdd:COG2319   197 LRTLTGHTGA-VRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRtlTGH---SGSVRSVAFSPDGRLLASGSADGTV- 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 238 sFLFDMATGKLtkaKRLVVHEGSPVTSISArswvsreARDPSLLINACLNKLLlyRVVDNEGALQLKrsfPIEQSSHPVR 317
Cdd:COG2319   271 -RLWDLATGEL---LRTLTGHSGGVNSVAF-------SPDGKLLASGSDDGTV--RLWDLATGKLLR---TLTGHTGAVR 334

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907206272 318 SI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 391
Cdd:COG2319   335 SVaFSP-----DGKTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
80-391 7.93e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 7.93e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272  80 DEAVPRVRFANDDRhRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRC 159
Cdd:COG2319   120 TGAVRSVAFSPDGK-TLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 160 IREIPDPDGAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVK--GGSsklTGRVLALSFDAPGRLLWAGDDRGSVf 237
Cdd:COG2319   197 LRTLTGHTGA-VRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRtlTGH---SGSVRSVAFSPDGRLLASGSADGTV- 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 238 sFLFDMATGKLtkaKRLVVHEGSPVTSISArswvsreARDPSLLINACLNKLLlyRVVDNEGALQLKrsfPIEQSSHPVR 317
Cdd:COG2319   271 -RLWDLATGEL---LRTLTGHSGGVNSVAF-------SPDGKLLASGSDDGTV--RLWDLATGKLLR---TLTGHTGAVR 334

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907206272 318 SI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 391
Cdd:COG2319   335 SVaFSP-----DGKTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 83-389 1.40e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.08  E-value: 1.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272  83 VPRVRFaNDDRHRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIRE 162
Cdd:cd00200    12 VTCVAF-SPDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 163 IPDpDGAELLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVKGGSSKlTGRVLALSFDAPGRLLWAGDDRGSVfsFLFD 242
Cdd:cd00200    89 LTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQDGTI--KLWD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 243 MATGKLTkaKRLVVHEGsPVTSISARSwvsrearDPSLLINACLNKLLlyRVVDNEGALQLKRsfpIEQSSHPVRSI-FC 321
Cdd:cd00200   164 LRTGKCV--ATLTGHTG-EVNSVAFSP-------DGEKLLSSSSDGTI--KLWDLSTGKCLGT---LRGHENGVNSVaFS 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907206272 322 PLMSFrqgacVVTGSEDMCVHFFDVEraAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWR 389
Cdd:cd00200   229 PDGYL-----LASGSEDGTIRVWDLR--TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 114-152 5.22e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 5.22e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907206272  114 PPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 152
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
116-152 1.21e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907206272 116 TVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 152
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
80-391 7.93e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 7.93e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272  80 DEAVPRVRFANDDRhRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRC 159
Cdd:COG2319   120 TGAVRSVAFSPDGK-TLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 160 IREIPDPDGAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVK--GGSsklTGRVLALSFDAPGRLLWAGDDRGSVf 237
Cdd:COG2319   197 LRTLTGHTGA-VRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRtlTGH---SGSVRSVAFSPDGRLLASGSADGTV- 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 238 sFLFDMATGKLtkaKRLVVHEGSPVTSISArswvsreARDPSLLINACLNKLLlyRVVDNEGALQLKrsfPIEQSSHPVR 317
Cdd:COG2319   271 -RLWDLATGEL---LRTLTGHSGGVNSVAF-------SPDGKLLASGSDDGTV--RLWDLATGKLLR---TLTGHTGAVR 334

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907206272 318 SI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 391
Cdd:COG2319   335 SVaFSP-----DGKTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
3-391 1.13e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 1.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272   3 DFEDDPRALGARGHRRSVSRGSYQLQAQMNRAVYEDRPPGSVVPTSVAEASRAMAGDTSLSENYAFAGMYHVFDQHVDEA 82
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272  83 VPRVRFANDDRhRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIRE 162
Cdd:COG2319    81 VLSVAFSPDGR-LLASASADGTVRLWDL--ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 163 IPDPDGAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVKggssKLTG---RVLALSFDAPGRLLWAGDDRGSVfsF 239
Cdd:COG2319   158 LTGHSGA-VTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLR----TLTGhtgAVRSVAFSPDGKLLASGSADGTV--R 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 240 LFDMATGKLTkakRLVVHEGSPVTSISarswVSreaRDPSLLINACLNKLLlyRVVDNEGALQLKRsfpIEQSSHPVRSI 319
Cdd:COG2319   230 LWDLATGKLL---RTLTGHSGSVRSVA----FS---PDGRLLASGSADGTV--RLWDLATGELLRT---LTGHSGGVNSV 294

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907206272 320 -FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 391
Cdd:COG2319   295 aFSP-----DGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 83-389 1.40e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.08  E-value: 1.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272  83 VPRVRFaNDDRHRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIRE 162
Cdd:cd00200    12 VTCVAF-SPDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 163 IPDpDGAELLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVKGGSSKlTGRVLALSFDAPGRLLWAGDDRGSVfsFLFD 242
Cdd:cd00200    89 LTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQDGTI--KLWD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 243 MATGKLTkaKRLVVHEGsPVTSISARSwvsrearDPSLLINACLNKLLlyRVVDNEGALQLKRsfpIEQSSHPVRSI-FC 321
Cdd:cd00200   164 LRTGKCV--ATLTGHTG-EVNSVAFSP-------DGEKLLSSSSDGTI--KLWDLSTGKCLGT---LRGHENGVNSVaFS 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907206272 322 PLMSFrqgacVVTGSEDMCVHFFDVEraAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWR 389
Cdd:cd00200   229 PDGYL-----LASGSEDGTIRVWDLR--TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 118-389 9.00e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 9.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 118 LHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIREIPDPDGaELLCCTFQPVNNNLTVVGNAKhNVHVMN 197
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSDK-TIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 198 ISTGKKVkggsSKLTG---RVLALSFDAPGRLLWAGDDRGSVfsFLFDMATGKLTKAkrLVVHEGsPVTSISARSwvsre 274
Cdd:cd00200    80 LETGECV----RTLTGhtsYVSSVAFSPDGRILSSSSRDKTI--KVWDVETGKCLTT--LRGHTD-WVNSVAFSP----- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 275 arDPSLLINACLNKLLlyRVVDNEgALQLKRSFPIEQSshPVRSI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAA 353
Cdd:cd00200   146 --DGTFVASSSQDGTI--KLWDLR-TGKCVATLTGHTG--EVNSVaFSP-----DGEKLLSSSSDGTIKLWDL--STGKC 211

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1907206272 354 VNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWR 389
Cdd:cd00200   212 LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 114-152 5.22e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 5.22e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907206272  114 PPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 152
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
116-152 1.21e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.21e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907206272 116 TVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 152
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 354-388 3.44e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.44e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907206272  354 VNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVW 388
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
74-250 1.96e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.37  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272  74 VFDQHVDEAVPRVRFANDDRHRLACCSLDGSISLCQLVPAPPTVLHVLRGHTRGVSDFAWSLSNDIL-VSTSLDATMRIW 152
Cdd:COG3391    16 LALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVI 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907206272 153 ASEDGRCIREIPDPDGAELLCctFQPVNNNLTVVGNAKHNVHVMNISTGKKVKggSSKLTGRVLALSFDAPGRLLW---A 229
Cdd:COG3391    96 DLATGKVVATIPVGGGPRGLA--VDPDGGRLYVADSGNGRVSVIDTATGKVVA--TIPVGAGPHGIAVDPDGKRLYvanS 171

                         170       180
                  ....*....|....*....|.
gi 1907206272 230 GDDRGSVFSFLFDMATGKLTK 250
Cdd:COG3391   172 GSNTVSVIVSVIDTATGKVVA 192
WD40 pfam00400
WD domain, G-beta repeat;
354-388 2.59e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.59e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907206272 354 VNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVW 388
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 332-392 6.02e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.08  E-value: 6.02e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907206272 332 VVTGSEDMCVHFFDVERAAKaaVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRREQ 392
Cdd:cd00200    24 LATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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