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Conserved domains on  [gi|1907094140|ref|XP_036014004|]
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transcription termination factor 3, mitochondrial isoform X1 [Mus musculus]

Protein Classification

mTERF domain-containing protein( domain architecture ID 139977)

mTERF (mitochondrial transcription termination factor) domain-containing protein may function as a transcription termination factor that binds promoter DNA and regulates mitochondrial replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mTERF super family cl47744
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 148-363 5.25e-17

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


The actual alignment was detected with superfamily member pfam02536:

Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 81.11  E-value: 5.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907094140 148 SKTLQKLVQLGVDLSKIEKHPDAANLLLRLDFEKHIKQILLFLKDLGLEDNQLGPFLTKNYAIFSEDLENLKT------R 221
Cdd:pfam02536  70 STSVDFLKEIGVDKSSIGGALRSWPSILGMRVGNNIKNNVEYLRELGVPQKLLARLLISRPQLLALDLVYLMKpktfeeK 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907094140 222 VAYLQSKNFSKTDIARMVKNAPFLLSFSVERLDNRLGFFQKELELNVKKTRDLVVRLPRLLTGSLEPVKENMKvYHLELG 301
Cdd:pfam02536 150 VEFLKELGFSVEDVWKIIKKCPEILGLSIEKKLKKKIEFLKKCGLSEEELPRVIKKYPQILSLSERTILNRVE-FLLGLG 228

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907094140 302 FKHNEIQHMVIKIPKMLTANKRKLTEIFDYVHNVMNIPHHIIVKFPQ-LShcidfWSLGKR--PR 363
Cdd:pfam02536 229 FSKEEVAKMVKRFPQLLGLSIEVLKPKLEFLVKEMKWPLKEVVEYPRvFG-----YSLEKRikPR 288
 
Name Accession Description Interval E-value
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 148-363 5.25e-17

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 81.11  E-value: 5.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907094140 148 SKTLQKLVQLGVDLSKIEKHPDAANLLLRLDFEKHIKQILLFLKDLGLEDNQLGPFLTKNYAIFSEDLENLKT------R 221
Cdd:pfam02536  70 STSVDFLKEIGVDKSSIGGALRSWPSILGMRVGNNIKNNVEYLRELGVPQKLLARLLISRPQLLALDLVYLMKpktfeeK 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907094140 222 VAYLQSKNFSKTDIARMVKNAPFLLSFSVERLDNRLGFFQKELELNVKKTRDLVVRLPRLLTGSLEPVKENMKvYHLELG 301
Cdd:pfam02536 150 VEFLKELGFSVEDVWKIIKKCPEILGLSIEKKLKKKIEFLKKCGLSEEELPRVIKKYPQILSLSERTILNRVE-FLLGLG 228

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907094140 302 FKHNEIQHMVIKIPKMLTANKRKLTEIFDYVHNVMNIPHHIIVKFPQ-LShcidfWSLGKR--PR 363
Cdd:pfam02536 229 FSKEEVAKMVKRFPQLLGLSIEVLKPKLEFLVKEMKWPLKEVVEYPRvFG-----YSLEKRikPR 288
PLN03196 PLN03196
MOC1-like protein; Provisional
 183-347 2.40e-09

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 58.95  E-value: 2.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907094140 183 IKQILLFLKDLGLEDNQLGPFLTKNYAIFSEDLEN-LKTRVAYLQSKNFSKTDIARMVKNAPFLLSFSVE-RLDNRLGFF 260
Cdd:PLN03196  232 IKPKVDYLESLGLPRLAVARILEKRPYILGFDLEEtVKPNVECLLEFGVRKEALPSVIAQYPDILGLDLKaKLAEQQYWL 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907094140 261 QKELELNVKKTRDLVVRLPRLLTgslepVKENMKVYHLEL----GFKHNEIQHMVIKIPKMLTANKRKLTEIFDYVHNVM 336
Cdd:PLN03196  312 TSKLKIDPEDFGRVIEKLPQIVS-----LNRNVALKHVEFlrgrGFSAQDVAKMVVRCPQILALNLEIMKPSLEFFKKEM 386

                         170
                  ....*....|.
gi 1907094140 337 NIPHHIIVKFP 347
Cdd:PLN03196  387 KRPLKELVEFP 397
 
Name Accession Description Interval E-value
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 148-363 5.25e-17

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 81.11  E-value: 5.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907094140 148 SKTLQKLVQLGVDLSKIEKHPDAANLLLRLDFEKHIKQILLFLKDLGLEDNQLGPFLTKNYAIFSEDLENLKT------R 221
Cdd:pfam02536  70 STSVDFLKEIGVDKSSIGGALRSWPSILGMRVGNNIKNNVEYLRELGVPQKLLARLLISRPQLLALDLVYLMKpktfeeK 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907094140 222 VAYLQSKNFSKTDIARMVKNAPFLLSFSVERLDNRLGFFQKELELNVKKTRDLVVRLPRLLTGSLEPVKENMKvYHLELG 301
Cdd:pfam02536 150 VEFLKELGFSVEDVWKIIKKCPEILGLSIEKKLKKKIEFLKKCGLSEEELPRVIKKYPQILSLSERTILNRVE-FLLGLG 228

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907094140 302 FKHNEIQHMVIKIPKMLTANKRKLTEIFDYVHNVMNIPHHIIVKFPQ-LShcidfWSLGKR--PR 363
Cdd:pfam02536 229 FSKEEVAKMVKRFPQLLGLSIEVLKPKLEFLVKEMKWPLKEVVEYPRvFG-----YSLEKRikPR 288
PLN03196 PLN03196
MOC1-like protein; Provisional
 183-347 2.40e-09

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 58.95  E-value: 2.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907094140 183 IKQILLFLKDLGLEDNQLGPFLTKNYAIFSEDLEN-LKTRVAYLQSKNFSKTDIARMVKNAPFLLSFSVE-RLDNRLGFF 260
Cdd:PLN03196  232 IKPKVDYLESLGLPRLAVARILEKRPYILGFDLEEtVKPNVECLLEFGVRKEALPSVIAQYPDILGLDLKaKLAEQQYWL 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907094140 261 QKELELNVKKTRDLVVRLPRLLTgslepVKENMKVYHLEL----GFKHNEIQHMVIKIPKMLTANKRKLTEIFDYVHNVM 336
Cdd:PLN03196  312 TSKLKIDPEDFGRVIEKLPQIVS-----LNRNVALKHVEFlrgrGFSAQDVAKMVVRCPQILALNLEIMKPSLEFFKKEM 386

                         170
                  ....*....|.
gi 1907094140 337 NIPHHIIVKFP 347
Cdd:PLN03196  387 KRPLKELVEFP 397
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 151-349 2.94e-09

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 58.00  E-value: 2.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907094140 151 LQKLVQLGVDLSKIEKHPDAANLLLRLDFEKHIKQILLFLKDLGLEDNQLGPFLTKNYAIFSEDL-ENLKTRVAYLQSKN 229
Cdd:pfam02536   1 LSLLESLGVTDSQISKILTRYPPVLHADVEKDLAPKLQFLLSLGASSSDLGKILSKYPRILGFKLeETMSTSVDFLKEIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907094140 230 FSKTDIARMVKNAPFLLSFSVER-LDNRLGFFqKELELNVKKTRDLVVRLPRLLTGSL------EPVKENMKVYHlELGF 302
Cdd:pfam02536  81 VDKSSIGGALRSWPSILGMRVGNnIKNNVEYL-RELGVPQKLLARLLISRPQLLALDLvylmkpKTFEEKVEFLK-ELGF 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907094140 303 KHNEIQHMVIKIPKMLTAN-KRKLTEIFDYVhNVMNIPHH----IIVKFPQL 349
Cdd:pfam02536 159 SVEDVWKIIKKCPEILGLSiEKKLKKKIEFL-KKCGLSEEelprVIKKYPQI 209
PLN03196 PLN03196
MOC1-like protein; Provisional
 221-287 7.94e-06

MOC1-like protein; Provisional


Pssm-ID: 215628 [Multi-domain]  Cd Length: 487  Bit Score: 47.78  E-value: 7.94e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907094140 221 RVAYLQSKNFSKTDIARMVKNAPFLLSFSVERLDNRLGFFQKELELNVKKtrdlVVRLPRLLTGSLE 287
Cdd:PLN03196  343 HVEFLRGRGFSAQDVAKMVVRCPQILALNLEIMKPSLEFFKKEMKRPLKE----LVEFPAYFTYGLE 405
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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