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Conserved domains on  [gi|1907075143|ref|XP_036011679|]
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thrombospondin-type laminin G domain and EAR repeat-containing protein isoform X4 [Mus musculus]

Protein Classification

EPTP domain-containing protein( domain architecture ID 10509911)

EPTP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 94-140 5.49e-13

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 62.87  E-value: 5.49e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1907075143  94 KFVSYQNIATHQAQSWRHFTIGKKIFLAVANFgpnergQEFSVIYKW 140
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANF------SGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 309-354 9.24e-13

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 62.10  E-value: 9.24e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907075143 309 FVKFQDIPTCSALDWEFFSVGEDHFLVVANsfdgntFSVNSIIYRW 354
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVAN------FSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 146-192 1.31e-12

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 61.72  E-value: 1.31e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1907075143 146 KFTLYQRIATHSARDWEAFEVDGEHFLVVAnhregdNHNIDSMVYRW 192
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVA------NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 199-244 2.24e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 46.69  E-value: 2.24e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907075143 199 FEANQSIATSGAYDWEFFTVGPYSFLVVANtFNGtstqvHSHLYIW 244
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVAN-FSG-----DSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 249-279 2.10e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 38.60  E-value: 2.10e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907075143 249 FQLFQSFLTFGAADWEVFHIGERIFLAVANS 279
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANF 32
 
Name Accession Description Interval E-value
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 94-140 5.49e-13

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 62.87  E-value: 5.49e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1907075143  94 KFVSYQNIATHQAQSWRHFTIGKKIFLAVANFgpnergQEFSVIYKW 140
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANF------SGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 309-354 9.24e-13

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 62.10  E-value: 9.24e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907075143 309 FVKFQDIPTCSALDWEFFSVGEDHFLVVANsfdgntFSVNSIIYRW 354
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVAN------FSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 146-192 1.31e-12

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 61.72  E-value: 1.31e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1907075143 146 KFTLYQRIATHSARDWEAFEVDGEHFLVVAnhregdNHNIDSMVYRW 192
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVA------NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 199-244 2.24e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 46.69  E-value: 2.24e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907075143 199 FEANQSIATSGAYDWEFFTVGPYSFLVVANtFNGtstqvHSHLYIW 244
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVAN-FSG-----DSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 249-279 2.10e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 38.60  E-value: 2.10e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907075143 249 FQLFQSFLTFGAADWEVFHIGERIFLAVANS 279
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANF 32
 
Name Accession Description Interval E-value
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 94-140 5.49e-13

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 62.87  E-value: 5.49e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1907075143  94 KFVSYQNIATHQAQSWRHFTIGKKIFLAVANFgpnergQEFSVIYKW 140
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANF------SGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 309-354 9.24e-13

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 62.10  E-value: 9.24e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907075143 309 FVKFQDIPTCSALDWEFFSVGEDHFLVVANsfdgntFSVNSIIYRW 354
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVAN------FSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 146-192 1.31e-12

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 61.72  E-value: 1.31e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1907075143 146 KFTLYQRIATHSARDWEAFEVDGEHFLVVAnhregdNHNIDSMVYRW 192
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVA------NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 199-244 2.24e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 46.69  E-value: 2.24e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907075143 199 FEANQSIATSGAYDWEFFTVGPYSFLVVANtFNGtstqvHSHLYIW 244
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVAN-FSG-----DSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 249-279 2.10e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 38.60  E-value: 2.10e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907075143 249 FQLFQSFLTFGAADWEVFHIGERIFLAVANS 279
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANF 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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