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Conserved domains on  [gi|1720372709|ref|XP_030102697|]
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leucine-rich repeat-containing protein 74A isoform X2 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 64-304 2.07e-40

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 149.94  E-value: 2.07e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709  64 NIGQKELYLEACKLSNTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENnSSLWKLK 143
Cdd:COG5238   164 RLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGN-KSLTTLD 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 144 LSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTL 223
Cdd:COG5238   243 LSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTL 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 224 KKLDVSMNGFGNEGALALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKR 303
Cdd:COG5238   323 HTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT 402


                  .
gi 1720372709 304 N 304
Cdd:COG5238   403 N 403
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 64-304 2.07e-40

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 149.94  E-value: 2.07e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709  64 NIGQKELYLEACKLSNTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENnSSLWKLK 143
Cdd:COG5238   164 RLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGN-KSLTTLD 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 144 LSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTL 223
Cdd:COG5238   243 LSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTL 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 224 KKLDVSMNGFGNEGALALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKR 303
Cdd:COG5238   323 HTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT 402


                  .
gi 1720372709 304 N 304
Cdd:COG5238   403 N 403
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 70-295 1.73e-30

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 120.15  E-value: 1.73e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709  70 LYLEACKLSNTTVL-KLELGDNCIQEEGiMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENNSSLWKLKLSGNS 148
Cdd:cd00116    70 LQSLLQGLTKGCGLqELDLSDNALGPDG-CGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNR 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 149 FKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDV 228
Cdd:cd00116   149 LEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNL 228

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720372709 229 SMNGFGNEGALALGDALR-LNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAY 295
Cdd:cd00116   229 GDNNLTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQ 296
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 64-304 2.07e-40

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 149.94  E-value: 2.07e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709  64 NIGQKELYLEACKLSNTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENnSSLWKLK 143
Cdd:COG5238   164 RLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGN-KSLTTLD 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 144 LSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTL 223
Cdd:COG5238   243 LSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTL 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 224 KKLDVSMNGFGNEGALALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKR 303
Cdd:COG5238   323 HTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT 402


                  .
gi 1720372709 304 N 304
Cdd:COG5238   403 N 403
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 81-305 2.53e-36

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 138.38  E-value: 2.53e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709  81 TVLKLELGDNCIQEEGIMSLMEMLHE--NYYLQELNVSDNNLGLEGARIISNFLQENNSsLWKLKLSGNSFKEECAALLC 158
Cdd:COG5238   151 LGGNAVHLLGLAARLGLLAAISMAKAlqNNSVETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILA 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 159 QALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGA 238
Cdd:COG5238   230 EALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGA 309

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720372709 239 LALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKRNP 305
Cdd:COG5238   310 IALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT 376
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 70-295 1.73e-30

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 120.15  E-value: 1.73e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709  70 LYLEACKLSNTTVL-KLELGDNCIQEEGiMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENNSSLWKLKLSGNS 148
Cdd:cd00116    70 LQSLLQGLTKGCGLqELDLSDNALGPDG-CGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNR 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 149 FKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDV 228
Cdd:cd00116   149 LEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNL 228

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720372709 229 SMNGFGNEGALALGDALR-LNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAY 295
Cdd:cd00116   229 GDNNLTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQ 296
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 79-274 7.85e-30

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 120.28  E-value: 7.85e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709  79 NTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQeNNSSLWKLKLSGNSFKEECAALLC 158
Cdd:COG5238   235 NKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQ-GNTTLTSLDLSVNRIGDEGAIALA 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 159 QALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGA 238
Cdd:COG5238   314 EGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGA 393

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1720372709 239 LALGDALRLNScLVYVDVSRNGITNEGASKISKGLE 274
Cdd:COG5238   394 EALIDALQTNR-LHTLILDGNLIGAEAQQRLEQLLE 428
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 118-306 4.50e-29

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 118.35  E-value: 4.50e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 118 NNLGLEGARIISNFLQenNSSLWKLKLSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQS 197
Cdd:COG5238   163 ARLGLLAAISMAKALQ--NNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTT 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 198 LNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGALALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNE 277
Cdd:COG5238   241 LDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNK 320

                         170       180
                  ....*....|....*....|....*....
gi 1720372709 278 CLQVLKLFLNPLSLEGAYSLIMAIKRNPK 306
Cdd:COG5238   321 TLHTLNLAYNGIGAQGAIALAKALQENTT 349
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 76-337 5.97e-27

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 110.14  E-value: 5.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709  76 KLSNTTVLKLElgDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLG--LEGARIISNFLQeNNSSLWKLKLSGNSFKEEC 153
Cdd:cd00116    21 KLLCLQVLRLE--GNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLT-KGCGLQELDLSDNALGPDG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 154 AALLcQALSSNYRIRSLNLSHNEFSDIGGEHLG---QMLALNvgLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSM 230
Cdd:cd00116    98 CGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAkglKDLPPA--LEKLVLGRNRLEGASCEALAKALRANRDLKELNLAN 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 231 NGFGNEGALALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIkRNPKSRME 310
Cdd:cd00116   175 NGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASAL-LSPNISLL 253

                         250       260
                  ....*....|....*....|....*..
gi 1720372709 311 DIDISNVLVSEQFVKVLDGVCAIHPQL 337
Cdd:cd00116   254 TLSLSCNDITDDGAKDLAEVLAEKESL 280
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-250 6.41e-22

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 95.89  E-value: 6.41e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709  84 KLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENnSSLWKLKLSGNSFKEECAALLCQALSS 163
Cdd:cd00116   141 KLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLAS 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 164 NYRIRSLNLSHNEFSDIGGEHL-GQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGALALG 242
Cdd:cd00116   220 LKSLEVLNLGDNNLTDAGAAALaSALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLA 299


                  ....*...
gi 1720372709 243 DALRLNSC 250
Cdd:cd00116   300 ESLLEPGN 307
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 78-201 6.99e-12

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 66.22  E-value: 6.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709  78 SNTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENNSSLWKLKLSGNSFKEECAALL 157
Cdd:cd00116   191 ANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDL 270

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1720372709 158 CQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALN-VGLQSLNLS 201
Cdd:cd00116   271 AEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPgNELESLWVK 315
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 247-361 1.75e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 1.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 247 LNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKRNPKSRMedIDISNVLVSEQFVKV 326
Cdd:COG5238   178 QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTT--LDLSNNQIGDEGVIA 255

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720372709 327 LDGVCAIHPQLDVVY---------------KGLQGLSTKKSISLGTNPMR 361
Cdd:COG5238   256 LAEALKNNTTVETLYlsgnqigaegaialaKALQGNTTLTSLDLSVNRIG 305
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
121-290 2.34e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 2.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 121 GLEGARIISNFLQENNSSLWKLKLSGNSFKEecaalLCQALSSNYRIRSLNLSHNEFSDIGGEhlgqmLALNVGLQSLNL 200
Cdd:COG4886    97 NLTELDLSGNEELSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLTDLPEP-----LGNLTNLKSLDL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 201 SWNhfNIRGavaLCNGLRSNVTLKKLDVSMNGFGNegalaLGDALRLNSCLVYVDVSRNGITNegaskISKGLENNECLQ 280
Cdd:COG4886   167 SNN--QLTD---LPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLE 231

                         170
                  ....*....|
gi 1720372709 281 VLKLFLNPLS 290
Cdd:COG4886   232 TLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
9-263 8.67e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.46  E-value: 8.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709   9 VESETKDEAEAELTPQDSDVTLYCEAEVLPSVEKEKSAREDSETDLEIEDTEKFFNIGQKELYLEACKLSNTTVLKLELG 88
Cdd:COG4886    14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709  89 DNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIisnflqENNSSLWKLKLSGNSFKEecaalLCQALSSNYRIR 168
Cdd:COG4886    94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEEL------ANLTNLKELDLSNNQLTD-----LPEPLGNLTNLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720372709 169 SLNLSHNEFSDIgGEHLGQMlalnVGLQSLNLSWNHFNirgavALCNGLRSNVTLKKLDVSMNGFGNegalaLGDALRLN 248
Cdd:COG4886   163 SLDLSNNQLTDL-PEELGNL----TNLKELDLSNNQIT-----DLPEPLGNLTNLEELDLSGNQLTD-----LPEPLANL 227

                         250
                  ....*....|....*
gi 1720372709 249 SCLVYVDVSRNGITN 263
Cdd:COG4886   228 TNLETLDLSNNQLTD 242
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 72-149 2.88e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 2.88e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720372709  72 LEACKLSNTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENNSSLWKLKLSGNSF 149
Cdd:cd00116   242 ASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDDSF 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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