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Conserved domains on  [gi|1720432752|ref|XP_030100468|]
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uncharacterized protein LOC71640 isoform X2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-38 3.67e-15

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 69.93  E-value: 3.67e-15
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720432752    2 LYRSVMLETYNSLLSLGQCIPKPELIFKLEQGEEPWT 38
Cdd:smart00349  25 LYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
216-564 1.20e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 216 KATFSKKYNLTKHQATNSGRKSCKCLES--KKTFPSELDIIEHQRTHNQKKDHVCIQCEKPFSTK--------------- 278
Cdd:COG5048    40 TDSFSRLEHLTRHIRSHTGEKPSQCSYSgcDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKasssslsssssnsnd 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 279 ----SSLTIHQRIHTGEKPYGCSECNKTFRQKSA--------------------------------LIVHERTHTGVKPF 322
Cdd:COG5048   120 nnllSSHSLPPSSRDPQLPDLLSISNLRNNPLPGnnsssvntpqsnslhpplpanslskdpssnlsLLISSNVSTSIPSS 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 323 ECCECGKAFQHKWYLKTHQRTHTGEKPYACIECGKAFLKKSYLKMHQGTHKSDKPYECEKCGKTFHNRSYFNMHHRTHTG 402
Cdd:COG5048   200 SENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESD 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 403 E-------KPYACSECGKAFYQKSDLRRHQR--IHNSEKL--HECKE--CGKAFQNKSYLKTHQKVHTGEKPYECK--EC 467
Cdd:COG5048   280 SssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNS 359

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 468 GKAFQNKSYLNKHQIIH-----TGEKPYEC--NKCGKTFQWKLVLSKHHRTHTGEKPYEC--IQCGKMFGYKSSLIVHEL 538
Cdd:COG5048   360 SSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKK 439

                         410       420
                  ....*....|....*....|....*.
gi 1720432752 539 IHSGEKPYECNvCRKTFSQKSNLSRH 564
Cdd:COG5048   440 IHTNHAPLLCS-ILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-38 3.67e-15

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 69.93  E-value: 3.67e-15
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720432752    2 LYRSVMLETYNSLLSLGQCIPKPELIFKLEQGEEPWT 38
Cdd:smart00349  25 LYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
216-564 1.20e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 216 KATFSKKYNLTKHQATNSGRKSCKCLES--KKTFPSELDIIEHQRTHNQKKDHVCIQCEKPFSTK--------------- 278
Cdd:COG5048    40 TDSFSRLEHLTRHIRSHTGEKPSQCSYSgcDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKasssslsssssnsnd 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 279 ----SSLTIHQRIHTGEKPYGCSECNKTFRQKSA--------------------------------LIVHERTHTGVKPF 322
Cdd:COG5048   120 nnllSSHSLPPSSRDPQLPDLLSISNLRNNPLPGnnsssvntpqsnslhpplpanslskdpssnlsLLISSNVSTSIPSS 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 323 ECCECGKAFQHKWYLKTHQRTHTGEKPYACIECGKAFLKKSYLKMHQGTHKSDKPYECEKCGKTFHNRSYFNMHHRTHTG 402
Cdd:COG5048   200 SENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESD 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 403 E-------KPYACSECGKAFYQKSDLRRHQR--IHNSEKL--HECKE--CGKAFQNKSYLKTHQKVHTGEKPYECK--EC 467
Cdd:COG5048   280 SssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNS 359

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 468 GKAFQNKSYLNKHQIIH-----TGEKPYEC--NKCGKTFQWKLVLSKHHRTHTGEKPYEC--IQCGKMFGYKSSLIVHEL 538
Cdd:COG5048   360 SSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKK 439

                         410       420
                  ....*....|....*....|....*.
gi 1720432752 539 IHSGEKPYECNvCRKTFSQKSNLSRH 564
Cdd:COG5048   440 IHTNHAPLLCS-ILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
336-359 3.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.65e-04
                          10        20
                  ....*....|....*....|....
gi 1720432752 336 YLKTHQRTHTGEKPYACIECGKAF 359
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-18 1.96e-03

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 36.29  E-value: 1.96e-03
                          10
                  ....*....|....*..
gi 1720432752   2 LYRSVMLETYNSLLSLG 18
Cdd:pfam01352  26 LYRDVMLENYRNLVSLG 42
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-38 3.67e-15

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 69.93  E-value: 3.67e-15
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1720432752    2 LYRSVMLETYNSLLSLGQCIPKPELIFKLEQGEEPWT 38
Cdd:smart00349  25 LYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
216-564 1.20e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 216 KATFSKKYNLTKHQATNSGRKSCKCLES--KKTFPSELDIIEHQRTHNQKKDHVCIQCEKPFSTK--------------- 278
Cdd:COG5048    40 TDSFSRLEHLTRHIRSHTGEKPSQCSYSgcDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKasssslsssssnsnd 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 279 ----SSLTIHQRIHTGEKPYGCSECNKTFRQKSA--------------------------------LIVHERTHTGVKPF 322
Cdd:COG5048   120 nnllSSHSLPPSSRDPQLPDLLSISNLRNNPLPGnnsssvntpqsnslhpplpanslskdpssnlsLLISSNVSTSIPSS 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 323 ECCECGKAFQHKWYLKTHQRTHTGEKPYACIECGKAFLKKSYLKMHQGTHKSDKPYECEKCGKTFHNRSYFNMHHRTHTG 402
Cdd:COG5048   200 SENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESD 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 403 E-------KPYACSECGKAFYQKSDLRRHQR--IHNSEKL--HECKE--CGKAFQNKSYLKTHQKVHTGEKPYECK--EC 467
Cdd:COG5048   280 SssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNS 359

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 468 GKAFQNKSYLNKHQIIH-----TGEKPYEC--NKCGKTFQWKLVLSKHHRTHTGEKPYEC--IQCGKMFGYKSSLIVHEL 538
Cdd:COG5048   360 SSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKK 439

                         410       420
                  ....*....|....*....|....*.
gi 1720432752 539 IHSGEKPYECNvCRKTFSQKSNLSRH 564
Cdd:COG5048   440 IHTNHAPLLCS-ILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-569 7.57e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 7.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 239 KCLESKKTFPSELDIIEHQRTHNQKKDHVC--IQCEKPFSTKSSLTIHQRIHTGEKPYGCSECNKTFRQKSALIVHER-T 315
Cdd:COG5048    35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSsS 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 316 HTGVKPFECCECGKAFQHKWYLK--THQRTHTGEKP-YACIECGKAFLKKSYLKM--------------------HQGTH 372
Cdd:COG5048   115 SNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPlPGNNSSSVNTPQSNSLHPplpanslskdpssnlsllisSNVST 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 373 KSDKPYECEKCGKTFHNRSYFNMHHRTHTgEKPYACSECGKAFYQKSDLRRHQRIHNSEKLHECKECGKAFQNKSYLKTH 452
Cdd:COG5048   195 SIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 453 QKVHTGE-------KPYECKECGKAFQNKSYLNKHQ--IIHTGE--KPYEC--NKCGKTFQWKLVLSKHHRTHTGEKPYE 519
Cdd:COG5048   274 SPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720432752 520 CIQCGKMFGYKSSL-------IVHELIHSGEKPYECNV--CRKTFSQKSNLSRHQRTHR 569
Cdd:COG5048   354 EKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHL 412
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
373-436 1.07e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 1.07e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720432752 373 KSDKPYECEKCGKTFHNRSYFNMHHRTHTGEKPYACS--ECGKAFYQKSDLRRHQRIHNSEKLHEC 436
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-H2C2_2 pfam13465
Zinc-finger double domain;
336-359 3.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.65e-04
                          10        20
                  ....*....|....*....|....
gi 1720432752 336 YLKTHQRTHTGEKPYACIECGKAF 359
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 346-401 5.18e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 5.18e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720432752 346 GEKPYAC--IECGKAFLKKSYLKMH-------------------QGTHKSDKPYECEKCGKTFHNRSYFNmHHRTHT 401
Cdd:COG5189   346 DGKPYKCpvEGCNKKYKNQNGLKYHmlhghqnqklhenpspekmNIFSAKDKPYRCEVCDKRYKNLNGLK-YHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
448-471 6.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.70e-04
                          10        20
                  ....*....|....*....|....
gi 1720432752 448 YLKTHQKVHTGEKPYECKECGKAF 471
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
261-481 9.09e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 9.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 261 NQKKDHVCIQCEKPFSTKSSLTIHQR--IHTGE--KPYGCSE--CNKTFRQKSALIVHERTHTGVKPFeccecgkafqhK 334
Cdd:COG5048   285 GFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA-----------K 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 335 WYLKTHQRTHTGEKPYaciecgkafLKKSYLKMHQGTHKsDKPYECE--KCGKTFHNRSYFNMHHRTHTGEKPYACSecg 412
Cdd:COG5048   354 EKLLNSSSKFSPLLNN---------EPPQSLQQYKDLKN-DKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCK--- 420

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720432752 413 kafyqksdlrrhqrihnseklheCKECGKAFQNKSYLKTHQKVHTGEKPYECKECGKAFQNKSYLNKHQ 481
Cdd:COG5048   421 -----------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 486-570 1.56e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 486 GEKPYECN--KCGKTFQWKLVLsKHHRTHTgekpyeciQCGKMFGYKSSLIVHELIHSGEKPYECNVCRKTFSQKSNLSR 563
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*..
gi 1720432752 564 HqRTHRH 570
Cdd:COG5189   417 H-RKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 402-480 1.58e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720432752 402 GEKPYACS--ECGKAFYQKSDLRRHQRI-HNSEKLHECKECGKafqnksylktHQKVHTGEKPYECKECGKAFQNKSYLN 478
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ..
gi 1720432752 479 KH 480
Cdd:COG5189   416 YH 417
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-18 1.96e-03

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 36.29  E-value: 1.96e-03
                          10
                  ....*....|....*..
gi 1720432752   2 LYRSVMLETYNSLLSLG 18
Cdd:pfam01352  26 LYRDVMLENYRNLVSLG 42
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 546-568 2.19e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|...
gi 1720432752 546 YECNVCRKTFSQKSNLSRHQRTH 568
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
505-527 2.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.20e-03
                          10        20
                  ....*....|....*....|...
gi 1720432752 505 LSKHHRTHTGEKPYECIQCGKMF 527
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
476-499 3.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.81e-03
                          10        20
                  ....*....|....*....|....
gi 1720432752 476 YLNKHQIIHTGEKPYECNKCGKTF 499
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
392-417 5.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.22e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720432752 392 YFNMHHRTHTGEKPYACSECGKAFYQ 417
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 406-428 5.96e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.96e-03
                          10        20
                  ....*....|....*....|...
gi 1720432752 406 YACSECGKAFYQKSDLRRHQRIH 428
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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