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Conserved domains on  [gi|1039746857|ref|XP_017171679|]
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G protein-coupled receptor 137C isoform X2 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
 36-142 8.73e-39

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd21475:

Pssm-ID: 475119  Cd Length: 319  Bit Score: 133.76  E-value: 8.73e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746857  36 PGSVQLALSVLHALLYAALFAFAYLQLWRLLLYRERRLSYQSLCLFLCLAWAALRTTLFSAAFSlsgslpLLRPPSRLHF 115
Cdd:cd21475     4 PPSVELGLTVLYTVLYSALFLFAYLQLWLLLHYRHKRLSYQSLFLFLCLLWAALRTTLFSFYFK------NCVQANQLQP 77

                          90       100
                  ....*....|....*....|....*..
gi 1039746857 116 FPHWLLYCFPSCLQFSTLCLLNLYLAE 142
Cdd:cd21475    78 FPHWLLYCFPVCLQFFTLCLLNLYFAQ 104
 
Name Accession Description Interval E-value
7tm_GPR137C cd21475
Integral membrane protein GPR137C, an orphan receptor member of the seven-transmembrane G ...
 36-142 8.73e-39

Integral membrane protein GPR137C, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily; GPR137C, also called transmembrane 7 superfamily member 1-like 2 protein (TM7SF1L2), is an orphan G protein-coupled receptor (GPCR) of unknown function. Bioinformatics analysis identified it as a likely key player in the prognosis of small cell lung cancer. GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 410552  Cd Length: 319  Bit Score: 133.76  E-value: 8.73e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746857  36 PGSVQLALSVLHALLYAALFAFAYLQLWRLLLYRERRLSYQSLCLFLCLAWAALRTTLFSAAFSlsgslpLLRPPSRLHF 115
Cdd:cd21475     4 PPSVELGLTVLYTVLYSALFLFAYLQLWLLLHYRHKRLSYQSLFLFLCLLWAALRTTLFSFYFK------NCVQANQLQP 77

                          90       100
                  ....*....|....*....|....*..
gi 1039746857 116 FPHWLLYCFPSCLQFSTLCLLNLYLAE 142
Cdd:cd21475    78 FPHWLLYCFPVCLQFFTLCLLNLYFAQ 104
 
Name Accession Description Interval E-value
7tm_GPR137C cd21475
Integral membrane protein GPR137C, an orphan receptor member of the seven-transmembrane G ...
 36-142 8.73e-39

Integral membrane protein GPR137C, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily; GPR137C, also called transmembrane 7 superfamily member 1-like 2 protein (TM7SF1L2), is an orphan G protein-coupled receptor (GPCR) of unknown function. Bioinformatics analysis identified it as a likely key player in the prognosis of small cell lung cancer. GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 410552  Cd Length: 319  Bit Score: 133.76  E-value: 8.73e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746857  36 PGSVQLALSVLHALLYAALFAFAYLQLWRLLLYRERRLSYQSLCLFLCLAWAALRTTLFSAAFSlsgslpLLRPPSRLHF 115
Cdd:cd21475     4 PPSVELGLTVLYTVLYSALFLFAYLQLWLLLHYRHKRLSYQSLFLFLCLLWAALRTTLFSFYFK------NCVQANQLQP 77

                          90       100
                  ....*....|....*....|....*..
gi 1039746857 116 FPHWLLYCFPSCLQFSTLCLLNLYLAE 142
Cdd:cd21475    78 FPHWLLYCFPVCLQFFTLCLLNLYFAQ 104
7tm_GPR137 cd21464
GPR137 family belonging to the seven-transmembrane G protein-coupled receptor superfamily; The ...
 36-142 4.02e-34

GPR137 family belonging to the seven-transmembrane G protein-coupled receptor superfamily; The GPR137 family includes GPR137A, GPR137B, and GPR137C, which are all orphan G protein-coupled receptors (GPCRs). GPR137A, also called GPR137 or transmembrane 7 superfamily member 1-like 1 protein (TM7SF1L1), is expressed in the central nervous system (CNS), endocrine gland, thymus, and lung. It is associated with different cancers including gastric cancer, pancreatic cancer, colon cancer, and malignant glioma. GPR137B, also called transmembrane 7 superfamily member 1 (TM7SF1), is a lysosome integral membrane protein that is strongly expressed in the heart, liver, kidney, and brain. It is associated with M2 macrophage polarization, and has been shown to perform a regulatory function in controlling dynamic Rag and mTORC1 localization and activity, as well as lysosome morphology. GPR137C, also called transmembrane 7 superfamily member 1-like 2 protein (TM7SF1L2), may be a key player in the prognosis of small cell lung cancer. GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 410550  Cd Length: 310  Bit Score: 121.18  E-value: 4.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746857  36 PGSVQLALSVLHALLYAALFAFAYLQLWRLLLYRERRLSYQSLCLFLCLAWAALRTTLFSAAFSLSgslpllRPPSRLHF 115
Cdd:cd21464     4 SPAVHLGLTIVFTVLYALLFIFVYVQLWLILYYRHKRLSYQTVFLFLCLLWSGLRTTLFSFYFKNC------ILANNLSF 77

                          90       100
                  ....*....|....*....|....*..
gi 1039746857 116 FPHWLLYCFPSCLQFSTLCLLNLYLAE 142
Cdd:cd21464    78 FPYWLLYCFPVCLQFLTLCLLVLYFAQ 104
7tm_GPR137A cd21474
Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G ...
 36-142 5.29e-24

Integral membrane protein GPR137A, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily; GPR137A, also called GPR137 or transmembrane 7 superfamily member 1-like 1 protein (TM7SF1L1), is an orphan G protein-coupled receptor (GPCR) expressed in the central nervous system (CNS), endocrine gland, thymus, and lung. It is associated with different cancers including gastric cancer, pancreatic cancer, colon cancer, and malignant glioma. It is highly expressed in ovarian cancer and plays a pro-oncogenic role in the disease, promoting cell proliferation and metastasis through regulation of the PI3K/AKT pathway. GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 410551  Cd Length: 310  Bit Score: 94.45  E-value: 5.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746857  36 PGSVQLALSVLHALLYAALFAFAYLQLWRLLLYRERRLSYQSLCLFLCLAWAALRTTLFSAAFSLSgslpllRPPSRLHF 115
Cdd:cd21474     4 PPAVKLGLTALYTTLYALLFLSVYAQLWLVLLYRHKRLSYQTVFLFLCLLWAALRTTLFSFYFRDT------LKANHLGP 77

                          90       100
                  ....*....|....*....|....*..
gi 1039746857 116 FPHWLLYCFPSCLQFSTLCLLNLYLAE 142
Cdd:cd21474    78 FLFWLLYCCPVCLQFFTLTLMNLYFAQ 104
7tm_GPR137B cd21476
Integral membrane protein GPR137B, an orphan receptor member of the seven-transmembrane G ...
 36-142 2.14e-21

Integral membrane protein GPR137B, an orphan receptor member of the seven-transmembrane G protein-coupled receptor superfamily; GPR137B, also called transmembrane 7 superfamily member 1 (TM7SF1), is a lysosome integral membrane protein that is strongly expressed in the heart, liver, kidney, and brain. It is an orphan G protein-coupled receptor (GPCR) associated with M2 macrophage polarization, and has been shown to perform a regulatory function in controlling dynamic Rag and mTORC1 localization and activity, as well as lysosome morphology. It also plays a role in bone remodeling in mouse and zebrafish, functioning as a negative regulator of osteoclast activity essential for normal resorption and patterning of the skeleton. GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 410553  Cd Length: 320  Bit Score: 87.95  E-value: 2.14e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746857  36 PGSVQLALSVLHALLYAALFAFAYLQLWRLLLYRERRLSYQSLCLFLCLAWAALRTTLFSAAFSLSGSLPLLRPpsrlhf 115
Cdd:cd21476     4 PPYVKLGLTAVYTVFYALLFVFIYVQLWLVLRYRHKRFSYQTVFLFLCLFWASLRTVLFSFYFRDFVAANSLSP------ 77

                          90       100
                  ....*....|....*....|....*..
gi 1039746857 116 FPHWLLYCFPSCLQFSTLCLLNLYLAE 142
Cdd:cd21476    78 FVFWLLYCFPVCLQFFTLTLMNLYFTQ 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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