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Conserved domains on  [gi|1034581142|ref|XP_016875306|]
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sin3 histone deacetylase corepressor complex component SDS3 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sds3 super family cl21737
Sds3-like; Repression of gene transcription is mediated by histone deacetylases containing ...
 49-152 3.04e-13

Sds3-like; Repression of gene transcription is mediated by histone deacetylases containing repressor-co-repressor complexes, which are recruited to promoters of target genes via interactions with sequence-specific transcription factors. The co-repressor complex contains a core of at least seven proteins. This family represents the conserved region found in Sds3, Dep1 and BRMS1-homolog p40 proteins.


The actual alignment was detected with superfamily member pfam08598:

Pssm-ID: 430099  Cd Length: 218  Bit Score: 67.38  E-value: 3.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581142  49 RMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENL 128
Cdd:pfam08598  18 KLYRNKLTALQTELQLLHQGSHPELLQYYRDLEEERDAELKRLRLREEYQLKRIDIETKADRTAAHQEFKKLVKLLKEKL 97

                          90       100
                  ....*....|....*....|....
gi 1034581142 129 IAELEEKKKMIENEKLTMELTGDS 152
Cdd:pfam08598  98 YDETTQKIYRLNEERRLLDLANTN 121
 
Name Accession Description Interval E-value
Sds3 pfam08598
Sds3-like; Repression of gene transcription is mediated by histone deacetylases containing ...
 49-152 3.04e-13

Sds3-like; Repression of gene transcription is mediated by histone deacetylases containing repressor-co-repressor complexes, which are recruited to promoters of target genes via interactions with sequence-specific transcription factors. The co-repressor complex contains a core of at least seven proteins. This family represents the conserved region found in Sds3, Dep1 and BRMS1-homolog p40 proteins.


Pssm-ID: 430099  Cd Length: 218  Bit Score: 67.38  E-value: 3.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581142  49 RMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENL 128
Cdd:pfam08598  18 KLYRNKLTALQTELQLLHQGSHPELLQYYRDLEEERDAELKRLRLREEYQLKRIDIETKADRTAAHQEFKKLVKLLKEKL 97

                          90       100
                  ....*....|....*....|....
gi 1034581142 129 IAELEEKKKMIENEKLTMELTGDS 152
Cdd:pfam08598  98 YDETTQKIYRLNEERRLLDLANTN 121
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 48-145 2.86e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 39.42  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581142  48 KRMYQDKLASLKRQLQQLQEgtlqEYQKRMKKLDQQYKERIRNAelflQLETEQV---ERNYIKEKKAAVK--EFEDKKV 122
Cdd:PRK00409  543 LKEAEKLKEELEEKKEKLQE----EEDKLLEEAEKEAQQAIKEA----KKEADEIikeLRQLQKGGYASVKahELIEARK 614

                          90       100
                  ....*....|....*....|....
gi 1034581142 123 ELKE-NLIAELEEKKKMIENEKLT 145
Cdd:PRK00409  615 RLNKaNEKKEKKKKKQKEKQEELK 638
 
Name Accession Description Interval E-value
Sds3 pfam08598
Sds3-like; Repression of gene transcription is mediated by histone deacetylases containing ...
 49-152 3.04e-13

Sds3-like; Repression of gene transcription is mediated by histone deacetylases containing repressor-co-repressor complexes, which are recruited to promoters of target genes via interactions with sequence-specific transcription factors. The co-repressor complex contains a core of at least seven proteins. This family represents the conserved region found in Sds3, Dep1 and BRMS1-homolog p40 proteins.


Pssm-ID: 430099  Cd Length: 218  Bit Score: 67.38  E-value: 3.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581142  49 RMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENL 128
Cdd:pfam08598  18 KLYRNKLTALQTELQLLHQGSHPELLQYYRDLEEERDAELKRLRLREEYQLKRIDIETKADRTAAHQEFKKLVKLLKEKL 97

                          90       100
                  ....*....|....*....|....
gi 1034581142 129 IAELEEKKKMIENEKLTMELTGDS 152
Cdd:pfam08598  98 YDETTQKIYRLNEERRLLDLANTN 121
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 48-145 2.86e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 39.42  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581142  48 KRMYQDKLASLKRQLQQLQEgtlqEYQKRMKKLDQQYKERIRNAelflQLETEQV---ERNYIKEKKAAVK--EFEDKKV 122
Cdd:PRK00409  543 LKEAEKLKEELEEKKEKLQE----EEDKLLEEAEKEAQQAIKEA----KKEADEIikeLRQLQKGGYASVKahELIEARK 614

                          90       100
                  ....*....|....*....|....
gi 1034581142 123 ELKE-NLIAELEEKKKMIENEKLT 145
Cdd:PRK00409  615 RLNKaNEKKEKKKKKQKEKQEELK 638
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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