Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1034644191   76 RRGQQDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIV 112
Cdd:pfam18193    1 RRGGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1034644191  662 GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC 705
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1034644191  959 DECIHPVPGKFRMDACCCA-VGAAWGTECEECPKPGTKEYETLC 1001
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034644191 2354 VTKSECCCD-GGRGWGHQCELCPLPGTAQYKKIC 2386
Cdd:pfam00683   11 VTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1034644191 1320 CEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKC 1355
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1034644191 2444 CSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTC 2479
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1034644191  2162 DTDECSIGNPCGNG-TCTNVIGSFECNCNEGFEPGpmMNCE 2201
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1034644191  1883 DVDECE-RHPCGNG-TCKNTVGSYNCLCYPGFELTHN 1917
Cdd:smart00179    1 DIDECAsGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|.
gi 1034644191  855 RCEVNINGATLKSECC-ATLGAAWGSPCERC 884
Cdd:pfam00683    2 RCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1034644191  1599 DIDECQELPGLCQGGNCINTFGSFQCECPQGYylsEDTRICE 1640
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1034644191  1107 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1139
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1034644191  2005 DINECdEDPNICLFGS-CTNTPGGFQCLCPPGFVlsdNGRRC 2045
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNC 38

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1034644191  1922 DIDECSSffGQVCRNG-RCFNEIGSFKCLCNEGYEltpDGKNCI 1964
Cdd:smart00179    1 DIDECAS--GNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 1034644191  2563 DVDECDGNHRCQHG--CQNILGGYRCGCPQGY 2592
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034644191 2481 DLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG 2510
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 1034644191  1149 DINECSlSDNLCRNG-KCVNMIGTYQCSCNPGYQ 1181
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1034644191  2398 DIDECKvMPNLCTNG-QCINTMGSFRCFCKVGYTtdiSGTSCI 2439
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034644191  276 DVDECQAIPGIC-QGGNCINTVGSFECRCPAG 306
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1034644191  1440 DIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRT 1475
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1034644191 2243 DLDECAEGLHDCeSRGMMCKNLIGTFMCICPPG 2275
Cdd:pfam07645    1 DVDECATGTHNC-PANTVCVNTIGSFECRCPDG 32

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1034644191   76 RRGQQDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIV 112
Cdd:pfam18193    1 RRGGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1034644191  662 GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC 705
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1034644191  959 DECIHPVPGKFRMDACCCA-VGAAWGTECEECPKPGTKEYETLC 1001
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034644191 2354 VTKSECCCD-GGRGWGHQCELCPLPGTAQYKKIC 2386
Cdd:pfam00683   11 VTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1034644191 1320 CEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKC 1355
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1034644191 2444 CSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTC 2479
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1034644191  2162 DTDECSIGNPCGNG-TCTNVIGSFECNCNEGFEPGpmMNCE 2201
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034644191 2438 CIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKT 2478
Cdd:cd01475    184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|.
gi 1034644191  607 DVDECQTPGICMNGH-CINSEGSFRCDCPPG 636
Cdd:cd00054      1 DIDECASGNPCQNGGtCVNTVGSYRCSCPPG 31

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1034644191 1357 DLDECSNGtHQCSINAQCVNTPGSYRCACSEGFTGD 1392
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1034644191 1883 DVDECE-RHPCGN-GTCKNTVGSYNCLCYPGFELTH 1916
Cdd:cd00054      1 DIDECAsGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1034644191   524 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFeltTDGKNCV 565
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1034644191  1599 DIDECQELPGLCQGGNCINTFGSFQCECPQGYylsEDTRICE 1640
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1034644191  759 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRT 794
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1034644191  1107 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1139
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034644191 1107 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHEL 1140
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1034644191  2005 DINECdEDPNICLFGS-CTNTPGGFQCLCPPGFVlsdNGRRC 2045
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNC 38

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1034644191  1922 DIDECSSffGQVCRNG-RCFNEIGSFKCLCNEGYEltpDGKNCI 1964
Cdd:smart00179    1 DIDECAS--GNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034644191 1836 NGACVDRNECLEIPNVCSHGlCVDLQGSYQCICHNGFKASQDQ 1878
Cdd:cd01475    181 GKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034644191 2120 DVNEClESPGICSN-GQCINTDGSFRCECPMGynldYTGVRCV 2161
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPG----YTGRNCE 38

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034644191 2481 DLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG 2510
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1034644191 2476 GKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFT 2512
Cdd:cd01475    181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYA 217

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1034644191  524 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTT 559
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 1034644191  1757 DIDECKEiPGICANG-VCINQIGSFRCECPTGFS 1789
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1034644191  2398 DIDECKvMPNLCTNG-QCINTMGSFRCFCKVGYTtdiSGTSCI 2439
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1034644191  484 DVDECTS-NPCTN-GDCVNTPGSYYCKCHAGFQ 514
Cdd:cd00054      1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1034644191   717 DINECAlDPDICANG-ICENLRGSYRCNCNSGYEpdaSGRNCI 758
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034644191  904 DVNECEVFPGVCP-NGRCVNSKGSFHCECPEG 934
Cdd:pfam07645    1 DVDECATGTHNCPaNTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 1034644191   276 DVDECqAIPGICQ-GGNCINTVGSFECRCPAG 306
Cdd:smart00179    1 DIDEC-ASGNPCQnGGTCVNTVGSYRCECPPG 31

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1034644191  1440 DIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRT 1475
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034644191 1064 DIDECRISPDLC-GSGICVNTPGSFECECFEG 1094
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1034644191 2563 DVDECDGNHRCQHG--CQNILGGYRCGCPQGYI 2593
Cdd:cd00054      1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.