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Conserved domains on  [gi|2514326112|ref|XP_016279217|]
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adenomatous polyposis coli protein isoform X2 [Monodelphis domestica]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 791-1077 1.97e-159

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435476  Cd Length: 293  Bit Score: 494.49  E-value: 1.97e-159
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  791 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKTSHRPKQRHKQSVYGEYALDASRHDDS-- 868
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  869 RPDAFSTGNLTVLSPYLNSTVLPGSSSSRT--SLESSRSEKDRSLDRERAVALSTFHPAADSPGNPSKRLGMQLSTTTAQ 946
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSRDSrgNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRIGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  947 IAKVMEEVSAIH-AQEDQSSASTTDLHCVAEERSTLRRASAAHAHSNTYNFPKPDNSNRTCAMPYAKVEYKRSSNDSLNS 1025
Cdd:pfam16629  161 IAKVMEEVSSMHiSQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2514326112 1026 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDND 1077
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDND 292
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2280-2625 2.06e-91

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


:

Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 301.41  E-value: 2.06e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2280 SISRGRTMIHIPGIRNSSSSTSPVSKKGPSLKTPTSKSPSEGPTSSTS-PRGAKPSVKSELSPVTRQTSQPGGSSKGPSR 2358
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2359 SGSRDSTPSRPSQQPLSRPMQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTSSTKssgsgkiSYTSPGRQMSQQNLTKQ 2438
Cdd:pfam05956   81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTKKSGSHK-------TQKSPVRIPFMQTPTKQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2439 TGLSKNTSNI------PRSESASKGLNqisnsNGTNKKVELSRMSSTKSSGSESDRSerpVLVRQSTFIKETPSPTLRRK 2512
Cdd:pfam05956  154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2513 LEESASLESLSSSsRPDSPTKSQvqtpilsPSLPDMSLSTHSSIQTGSWRKLPPNLNPSIEFNDGRSTKRHDIARSHSES 2592
Cdd:pfam05956  226 LELSASESLSPSS-QPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSES 297

                          330       340       350
                   ....*....|....*....|....*....|...
gi 2514326112 2593 PSRLPVnRSGTWKREHSKHSSSLPRVSTWRRTG 2625
Cdd:pfam05956  298 PSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2727-2901 2.07e-81

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


:

Pssm-ID: 399141  Cd Length: 174  Bit Score: 265.71  E-value: 2.07e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2727 RSGRSPTGNTPPVIDNVAEKVSSGNKESKDNQGKPNGGNGSsAPARTVGLENRLNSFIQIDSPDKKAAETKSGQVNLVPA 2806
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGN-VPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPT 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2807 PETSETSVAERTPFSSTSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSSAARPSQIPTPVNNSTKKRDSKTENTESSGT 2886
Cdd:pfam05937   80 PETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGN 159

                          170
                   ....*....|....*
gi 2514326112 2887 QSPKRHSGSYLVTSV 2901
Cdd:pfam05937  160 QSPKRHSGSYLVTSV 174
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1095-1194 3.90e-55

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406923  Cd Length: 100  Bit Score: 187.42  E-value: 3.90e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 1095 LNSGRQSPSQNDRWARPKHVIEDEIKQNEQRQARGQNTPFSAYSESTDDKHMKFQSRFGQQECVSPYRSRGASGSEQNRV 1174
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 2514326112 1175 SSGHGINQKVNQSLCHEDDY 1194
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 452-525 2.84e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


:

Pssm-ID: 465870  Cd Length: 74  Bit Score: 155.40  E-value: 2.84e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2514326112  452 SQPDDKRGRREIRVLHLLEQIRAYCETCWQWQEAHEQGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 525
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1805-1896 2.14e-43

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435479  Cd Length: 94  Bit Score: 153.84  E-value: 2.14e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 1805 IMDQIQQASASSSGNSKNPLDSEKKKPTSPVKPMPQSAEYRTRIRKNAESK-NVNVERSYSD-KDSKKLSLKNNARDFLD 1882
Cdd:pfam16635    1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKnNLNSERSYPDnKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 2514326112 1883 KMPNNEDRVRGSFT 1896
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1342-1428 5.03e-40

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435478  Cd Length: 89  Bit Score: 143.86  E-value: 5.03e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 1342 AEDEI-GRDQTTRGSETTNTLQIAELKENSASVSTGDTGSEVPSTSQHIRTKANRLQTTSLSPSDSTRHKAVEFSSGAKS 1420
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 2514326112 1421 PAKSGAQT 1428
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1933-2003 1.45e-29

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435480  Cd Length: 81  Bit Score: 113.80  E-value: 1.45e-29
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2514326112 1933 REKAEL-KGKEAKETEAKVSNHLELTSNQQSANRAQICAKHPVERGQSKPLLQKQSTFPQSSKDMPDRVAAT 2003
Cdd:pfam16636   10 REKAELrKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1721-1774 1.86e-27

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406927  Cd Length: 54  Bit Score: 106.80  E-value: 1.86e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2514326112 1721 IESPPNELAGVEGTSTGALLGDFEKRDTIPTEGRSTDDIQIGKSSNVNTSAFDD 1774
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 98-149 1.49e-22

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


:

Pssm-ID: 435517  Cd Length: 52  Bit Score: 92.74  E-value: 1.49e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2514326112   98 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 149
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 221-301 8.80e-13

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


:

Pssm-ID: 463275  Cd Length: 82  Bit Score: 66.12  E-value: 8.80e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  221 SRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 299
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 2514326112  300 TC 301
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1696-1719 1.69e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 49.30  E-value: 1.69e-07
                           10        20
                   ....*....|....*....|....
gi 2514326112 1696 DVPRVYCVEGTPINFSTATSLSDL 1719
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 708-748 2.49e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.27  E-value: 2.49e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2514326112   708 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 748
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2090-2109 8.98e-06

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 44.51  E-value: 8.98e-06
                           10        20
                   ....*....|....*....|
gi 2514326112 2090 DSEDDLLQECISSAMPKKKR 2109
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 1343-1527 9.11e-04

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.07  E-value: 9.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 1343 EDEIGRDQTTRGSETTNTLQIAELKENSASVSTGDTgSEVPSTSQHIRTKANRLQTTSLSPSDSTRHKAVEFSSGAKSPA 1422
Cdd:PTZ00449   502 EDSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDS-KESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPE 580

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 1423 -KSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFESrsiassvqsepcsgmvsgiispSDLPDSPGQTMPPSRSKTPPP 1501
Cdd:PTZ00449   581 fPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPEL----------------------LDIPKSPKRPESPKSPKRPPP 638

                          170       180
                   ....*....|....*....|....*.
gi 2514326112 1502 PQTGQTKREATKSKLPSAEKRESGPR 1527
Cdd:PTZ00449   639 PQRPSSPERPEGPKIIKSPKPPKSPK 664
SCC2 super family cl15115
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid ...
 585-776 2.04e-03

Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid cohesion protein 2 (Scc2) and its homolog (Scc2 homolog, also called Nipped-B-like protein or NIPBL). Scc2/NIPBL and Scc4 form a complex that is responsible for loading the cohesin protein onto sister chromatids during mitosis and meiosis. Cohesin is a ring-shaped protein complex that encircles the sister chromatids and helps to hold them together until they are ready to be separated during cell division. In addition to its role in chromosome segregation, cohesin also plays important roles in other cellular processes such as transcription, chromosome condensation, and DNA repair.


The actual alignment was detected with superfamily member cd23958:

Pssm-ID: 472763 [Multi-domain]  Cd Length: 1197  Bit Score: 43.82  E-value: 2.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  585 MRALVAQLKSESEDLEQVIASVLRNlswrADVNSKKTLREVGS--VKALME---CALEVKKESTLKSVLSALWNLSAHCt 659
Cdd:cd23958    635 IVDVVAACRKGLDLLEQLLKRLLKS----KEDKEDKSVRKACKqlVDCLVElilELEEDDDESSESDLVACLSTLHLFA- 709

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  660 enKADICAVDGALA-----FLVGTLTYRS----QTNTLAIIESGGGILRNVSSLIATnedhrqilrenSCLQTLLQHLKS 730
Cdd:cd23958    710 --KADPKLLLVEHAetlqpYLKSKCSTREdqqvLRYVLRILRSVLPLLSHPSESFLE-----------ELEEDLLKLLLK 776

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2514326112  731 HSLTIVSNACGTLWNLSARNTKDQEALWDMgAVSMLKNLIHSKHKM 776
Cdd:cd23958    777 HSVTVLQEAIACLCAVVNKLTKNYERLRKA-LQSCLKLLRKYKRQA 821
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1778-1796 3.24e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.19  E-value: 3.24e-03
                           10
                   ....*....|....*....
gi 2514326112 1778 EEGEILAECINSAMPKGKS 1796
Cdd:pfam05924    4 DEDDLLQECINSAMPKKRR 22
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 518-569 5.05e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 5.05e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2514326112   518 DEEHRHAMNELGGLQAIAELLQvdcemygltsdHYSVTLRRYAGMALTNLTF 569
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1316-1333 6.83e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.20  E-value: 6.83e-03
                           10
                   ....*....|....*...
gi 2514326112 1316 ETIQTYCVEDTPICFSRC 1333
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 399-451 8.27e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 8.27e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2514326112   399 SQDSCISMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 451
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 791-1077 1.97e-159

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 494.49  E-value: 1.97e-159
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  791 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKTSHRPKQRHKQSVYGEYALDASRHDDS-- 868
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  869 RPDAFSTGNLTVLSPYLNSTVLPGSSSSRT--SLESSRSEKDRSLDRERAVALSTFHPAADSPGNPSKRLGMQLSTTTAQ 946
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSRDSrgNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRIGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  947 IAKVMEEVSAIH-AQEDQSSASTTDLHCVAEERSTLRRASAAHAHSNTYNFPKPDNSNRTCAMPYAKVEYKRSSNDSLNS 1025
Cdd:pfam16629  161 IAKVMEEVSSMHiSQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2514326112 1026 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDND 1077
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDND 292
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2280-2625 2.06e-91

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 301.41  E-value: 2.06e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2280 SISRGRTMIHIPGIRNSSSSTSPVSKKGPSLKTPTSKSPSEGPTSSTS-PRGAKPSVKSELSPVTRQTSQPGGSSKGPSR 2358
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2359 SGSRDSTPSRPSQQPLSRPMQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTSSTKssgsgkiSYTSPGRQMSQQNLTKQ 2438
Cdd:pfam05956   81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTKKSGSHK-------TQKSPVRIPFMQTPTKQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2439 TGLSKNTSNI------PRSESASKGLNqisnsNGTNKKVELSRMSSTKSSGSESDRSerpVLVRQSTFIKETPSPTLRRK 2512
Cdd:pfam05956  154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2513 LEESASLESLSSSsRPDSPTKSQvqtpilsPSLPDMSLSTHSSIQTGSWRKLPPNLNPSIEFNDGRSTKRHDIARSHSES 2592
Cdd:pfam05956  226 LELSASESLSPSS-QPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSES 297

                          330       340       350
                   ....*....|....*....|....*....|...
gi 2514326112 2593 PSRLPVnRSGTWKREHSKHSSSLPRVSTWRRTG 2625
Cdd:pfam05956  298 PSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2727-2901 2.07e-81

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 265.71  E-value: 2.07e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2727 RSGRSPTGNTPPVIDNVAEKVSSGNKESKDNQGKPNGGNGSsAPARTVGLENRLNSFIQIDSPDKKAAETKSGQVNLVPA 2806
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGN-VPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPT 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2807 PETSETSVAERTPFSSTSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSSAARPSQIPTPVNNSTKKRDSKTENTESSGT 2886
Cdd:pfam05937   80 PETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGN 159

                          170
                   ....*....|....*
gi 2514326112 2887 QSPKRHSGSYLVTSV 2901
Cdd:pfam05937  160 QSPKRHSGSYLVTSV 174
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1095-1194 3.90e-55

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 187.42  E-value: 3.90e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 1095 LNSGRQSPSQNDRWARPKHVIEDEIKQNEQRQARGQNTPFSAYSESTDDKHMKFQSRFGQQECVSPYRSRGASGSEQNRV 1174
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 2514326112 1175 SSGHGINQKVNQSLCHEDDY 1194
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 452-525 2.84e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 155.40  E-value: 2.84e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2514326112  452 SQPDDKRGRREIRVLHLLEQIRAYCETCWQWQEAHEQGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 525
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1805-1896 2.14e-43

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 153.84  E-value: 2.14e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 1805 IMDQIQQASASSSGNSKNPLDSEKKKPTSPVKPMPQSAEYRTRIRKNAESK-NVNVERSYSD-KDSKKLSLKNNARDFLD 1882
Cdd:pfam16635    1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKnNLNSERSYPDnKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 2514326112 1883 KMPNNEDRVRGSFT 1896
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1342-1428 5.03e-40

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 143.86  E-value: 5.03e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 1342 AEDEI-GRDQTTRGSETTNTLQIAELKENSASVSTGDTGSEVPSTSQHIRTKANRLQTTSLSPSDSTRHKAVEFSSGAKS 1420
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 2514326112 1421 PAKSGAQT 1428
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1933-2003 1.45e-29

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 113.80  E-value: 1.45e-29
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2514326112 1933 REKAEL-KGKEAKETEAKVSNHLELTSNQQSANRAQICAKHPVERGQSKPLLQKQSTFPQSSKDMPDRVAAT 2003
Cdd:pfam16636   10 REKAELrKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1721-1774 1.86e-27

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 106.80  E-value: 1.86e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2514326112 1721 IESPPNELAGVEGTSTGALLGDFEKRDTIPTEGRSTDDIQIGKSSNVNTSAFDD 1774
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 98-149 1.49e-22

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


Pssm-ID: 435517  Cd Length: 52  Bit Score: 92.74  E-value: 1.49e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2514326112   98 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 149
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 221-301 8.80e-13

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 66.12  E-value: 8.80e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  221 SRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 299
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 2514326112  300 TC 301
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1696-1719 1.69e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 49.30  E-value: 1.69e-07
                           10        20
                   ....*....|....*....|....
gi 2514326112 1696 DVPRVYCVEGTPINFSTATSLSDL 1719
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 708-748 2.49e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.27  E-value: 2.49e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2514326112   708 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 748
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 708-748 3.25e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 3.25e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2514326112  708 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 748
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2090-2109 8.98e-06

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 44.51  E-value: 8.98e-06
                           10        20
                   ....*....|....*....|
gi 2514326112 2090 DSEDDLLQECISSAMPKKKR 2109
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1343-1527 9.11e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.07  E-value: 9.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 1343 EDEIGRDQTTRGSETTNTLQIAELKENSASVSTGDTgSEVPSTSQHIRTKANRLQTTSLSPSDSTRHKAVEFSSGAKSPA 1422
Cdd:PTZ00449   502 EDSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDS-KESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPE 580

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 1423 -KSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFESrsiassvqsepcsgmvsgiispSDLPDSPGQTMPPSRSKTPPP 1501
Cdd:PTZ00449   581 fPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPEL----------------------LDIPKSPKRPESPKSPKRPPP 638

                          170       180
                   ....*....|....*....|....*.
gi 2514326112 1502 PQTGQTKREATKSKLPSAEKRESGPR 1527
Cdd:PTZ00449   639 PQRPSSPERPEGPKIIKSPKPPKSPK 664
SCC2 cd23958
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid ...
 585-776 2.04e-03

Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid cohesion protein 2 (Scc2) and its homolog (Scc2 homolog, also called Nipped-B-like protein or NIPBL). Scc2/NIPBL and Scc4 form a complex that is responsible for loading the cohesin protein onto sister chromatids during mitosis and meiosis. Cohesin is a ring-shaped protein complex that encircles the sister chromatids and helps to hold them together until they are ready to be separated during cell division. In addition to its role in chromosome segregation, cohesin also plays important roles in other cellular processes such as transcription, chromosome condensation, and DNA repair.


Pssm-ID: 467937 [Multi-domain]  Cd Length: 1197  Bit Score: 43.82  E-value: 2.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  585 MRALVAQLKSESEDLEQVIASVLRNlswrADVNSKKTLREVGS--VKALME---CALEVKKESTLKSVLSALWNLSAHCt 659
Cdd:cd23958    635 IVDVVAACRKGLDLLEQLLKRLLKS----KEDKEDKSVRKACKqlVDCLVElilELEEDDDESSESDLVACLSTLHLFA- 709

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  660 enKADICAVDGALA-----FLVGTLTYRS----QTNTLAIIESGGGILRNVSSLIATnedhrqilrenSCLQTLLQHLKS 730
Cdd:cd23958    710 --KADPKLLLVEHAetlqpYLKSKCSTREdqqvLRYVLRILRSVLPLLSHPSESFLE-----------ELEEDLLKLLLK 776

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2514326112  731 HSLTIVSNACGTLWNLSARNTKDQEALWDMgAVSMLKNLIHSKHKM 776
Cdd:cd23958    777 HSVTVLQEAIACLCAVVNKLTKNYERLRKA-LQSCLKLLRKYKRQA 821
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 750-790 2.47e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.47e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2514326112  750 NTKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 790
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1778-1796 3.24e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.19  E-value: 3.24e-03
                           10
                   ....*....|....*....
gi 2514326112 1778 EEGEILAECINSAMPKGKS 1796
Cdd:pfam05924    4 DEDDLLQECINSAMPKKRR 22
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1431-1453 3.61e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.97  E-value: 3.61e-03
                           10        20
                   ....*....|....*....|....
gi 2514326112 1431 SPPEHY-VQETPLMFSRCTSVSSL 1453
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 518-569 5.05e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 5.05e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2514326112   518 DEEHRHAMNELGGLQAIAELLQvdcemygltsdHYSVTLRRYAGMALTNLTF 569
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2306-2621 5.25e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 5.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2306 KGPSLKTPTSKSPSEGPTSSTSPRGAKPSvkSELSPVTRQTSQPGGSSKGPSRSGSRDSTPSRPSQQPLSRPMQSPGRNS 2385
Cdd:PHA03247  2706 PTPEPAPHALVSATPLPPGPAAARQASPA--LPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL 2783

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2386 ISPGRNGISPPNKLSQLPRTSSPSTSSTKSSGSGKISYTSPGrqmsqqnltkqTGLSKNTSNIPRSESASKGLNQISNSN 2465
Cdd:PHA03247  2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA-----------GPLPPPTSAQPTAPPPPPGPPPPSLPL 2852

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2466 G--TNKKVELSRMSSTKSSGSESDRSERPVLVRqstfikeTPSPTLRRKLEESASLESLSSSSR-PDSPTKSQVQTPILS 2542
Cdd:PHA03247  2853 GgsVAPGGDVRRRPPSRSPAAKPAAPARPPVRR-------LARPAVSRSTESFALPPDQPERPPqPQAPPPPQPQPQPPP 2925

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2543 PSLPDMSLSTHSSIQTgswrKLPPNLNPSiefNDGRSTKRHDIARSHSESPSRLPVNRSGTWK----RE------HSKHS 2612
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQP----PLAPTTDPA---GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQpapsREapasstPPLTG 2998


                   ....*....
gi 2514326112 2613 SSLPRVSTW 2621
Cdd:PHA03247  2999 HSLSRVSSW 3007
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1316-1333 6.83e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.20  E-value: 6.83e-03
                           10
                   ....*....|....*...
gi 2514326112 1316 ETIQTYCVEDTPICFSRC 1333
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 399-451 8.27e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 8.27e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2514326112   399 SQDSCISMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 451
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 791-1077 1.97e-159

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 494.49  E-value: 1.97e-159
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  791 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKTSHRPKQRHKQSVYGEYALDASRHDDS-- 868
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  869 RPDAFSTGNLTVLSPYLNSTVLPGSSSSRT--SLESSRSEKDRSLDRERAVALSTFHPAADSPGNPSKRLGMQLSTTTAQ 946
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSRDSrgNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRIGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  947 IAKVMEEVSAIH-AQEDQSSASTTDLHCVAEERSTLRRASAAHAHSNTYNFPKPDNSNRTCAMPYAKVEYKRSSNDSLNS 1025
Cdd:pfam16629  161 IAKVMEEVSSMHiSQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2514326112 1026 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDND 1077
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDND 292
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2280-2625 2.06e-91

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 301.41  E-value: 2.06e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2280 SISRGRTMIHIPGIRNSSSSTSPVSKKGPSLKTPTSKSPSEGPTSSTS-PRGAKPSVKSELSPVTRQTSQPGGSSKGPSR 2358
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2359 SGSRDSTPSRPSQQPLSRPMQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTSSTKssgsgkiSYTSPGRQMSQQNLTKQ 2438
Cdd:pfam05956   81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTKKSGSHK-------TQKSPVRIPFMQTPTKQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2439 TGLSKNTSNI------PRSESASKGLNqisnsNGTNKKVELSRMSSTKSSGSESDRSerpVLVRQSTFIKETPSPTLRRK 2512
Cdd:pfam05956  154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2513 LEESASLESLSSSsRPDSPTKSQvqtpilsPSLPDMSLSTHSSIQTGSWRKLPPNLNPSIEFNDGRSTKRHDIARSHSES 2592
Cdd:pfam05956  226 LELSASESLSPSS-QPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSES 297

                          330       340       350
                   ....*....|....*....|....*....|...
gi 2514326112 2593 PSRLPVnRSGTWKREHSKHSSSLPRVSTWRRTG 2625
Cdd:pfam05956  298 PSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2727-2901 2.07e-81

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 265.71  E-value: 2.07e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2727 RSGRSPTGNTPPVIDNVAEKVSSGNKESKDNQGKPNGGNGSsAPARTVGLENRLNSFIQIDSPDKKAAETKSGQVNLVPA 2806
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGN-VPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPT 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2807 PETSETSVAERTPFSSTSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSSAARPSQIPTPVNNSTKKRDSKTENTESSGT 2886
Cdd:pfam05937   80 PETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGN 159

                          170
                   ....*....|....*
gi 2514326112 2887 QSPKRHSGSYLVTSV 2901
Cdd:pfam05937  160 QSPKRHSGSYLVTSV 174
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1095-1194 3.90e-55

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 187.42  E-value: 3.90e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 1095 LNSGRQSPSQNDRWARPKHVIEDEIKQNEQRQARGQNTPFSAYSESTDDKHMKFQSRFGQQECVSPYRSRGASGSEQNRV 1174
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 2514326112 1175 SSGHGINQKVNQSLCHEDDY 1194
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 452-525 2.84e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 155.40  E-value: 2.84e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2514326112  452 SQPDDKRGRREIRVLHLLEQIRAYCETCWQWQEAHEQGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 525
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1805-1896 2.14e-43

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 153.84  E-value: 2.14e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 1805 IMDQIQQASASSSGNSKNPLDSEKKKPTSPVKPMPQSAEYRTRIRKNAESK-NVNVERSYSD-KDSKKLSLKNNARDFLD 1882
Cdd:pfam16635    1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKnNLNSERSYPDnKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 2514326112 1883 KMPNNEDRVRGSFT 1896
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1342-1428 5.03e-40

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 143.86  E-value: 5.03e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 1342 AEDEI-GRDQTTRGSETTNTLQIAELKENSASVSTGDTGSEVPSTSQHIRTKANRLQTTSLSPSDSTRHKAVEFSSGAKS 1420
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 2514326112 1421 PAKSGAQT 1428
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1933-2003 1.45e-29

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 113.80  E-value: 1.45e-29
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2514326112 1933 REKAEL-KGKEAKETEAKVSNHLELTSNQQSANRAQICAKHPVERGQSKPLLQKQSTFPQSSKDMPDRVAAT 2003
Cdd:pfam16636   10 REKAELrKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1721-1774 1.86e-27

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 106.80  E-value: 1.86e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2514326112 1721 IESPPNELAGVEGTSTGALLGDFEKRDTIPTEGRSTDDIQIGKSSNVNTSAFDD 1774
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 98-149 1.49e-22

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


Pssm-ID: 435517  Cd Length: 52  Bit Score: 92.74  E-value: 1.49e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2514326112   98 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 149
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 221-301 8.80e-13

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 66.12  E-value: 8.80e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  221 SRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 299
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 2514326112  300 TC 301
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1696-1719 1.69e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 49.30  E-value: 1.69e-07
                           10        20
                   ....*....|....*....|....
gi 2514326112 1696 DVPRVYCVEGTPINFSTATSLSDL 1719
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 708-748 2.49e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.27  E-value: 2.49e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2514326112   708 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 748
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 708-748 3.25e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 3.25e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2514326112  708 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 748
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2090-2109 8.98e-06

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 44.51  E-value: 8.98e-06
                           10        20
                   ....*....|....*....|
gi 2514326112 2090 DSEDDLLQECISSAMPKKKR 2109
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1343-1527 9.11e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.07  E-value: 9.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 1343 EDEIGRDQTTRGSETTNTLQIAELKENSASVSTGDTgSEVPSTSQHIRTKANRLQTTSLSPSDSTRHKAVEFSSGAKSPA 1422
Cdd:PTZ00449   502 EDSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDS-KESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPE 580

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 1423 -KSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFESrsiassvqsepcsgmvsgiispSDLPDSPGQTMPPSRSKTPPP 1501
Cdd:PTZ00449   581 fPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPEL----------------------LDIPKSPKRPESPKSPKRPPP 638

                          170       180
                   ....*....|....*....|....*.
gi 2514326112 1502 PQTGQTKREATKSKLPSAEKRESGPR 1527
Cdd:PTZ00449   639 PQRPSSPERPEGPKIIKSPKPPKSPK 664
SCC2 cd23958
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid ...
 585-776 2.04e-03

Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid cohesion protein 2 (Scc2) and its homolog (Scc2 homolog, also called Nipped-B-like protein or NIPBL). Scc2/NIPBL and Scc4 form a complex that is responsible for loading the cohesin protein onto sister chromatids during mitosis and meiosis. Cohesin is a ring-shaped protein complex that encircles the sister chromatids and helps to hold them together until they are ready to be separated during cell division. In addition to its role in chromosome segregation, cohesin also plays important roles in other cellular processes such as transcription, chromosome condensation, and DNA repair.


Pssm-ID: 467937 [Multi-domain]  Cd Length: 1197  Bit Score: 43.82  E-value: 2.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  585 MRALVAQLKSESEDLEQVIASVLRNlswrADVNSKKTLREVGS--VKALME---CALEVKKESTLKSVLSALWNLSAHCt 659
Cdd:cd23958    635 IVDVVAACRKGLDLLEQLLKRLLKS----KEDKEDKSVRKACKqlVDCLVElilELEEDDDESSESDLVACLSTLHLFA- 709

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112  660 enKADICAVDGALA-----FLVGTLTYRS----QTNTLAIIESGGGILRNVSSLIATnedhrqilrenSCLQTLLQHLKS 730
Cdd:cd23958    710 --KADPKLLLVEHAetlqpYLKSKCSTREdqqvLRYVLRILRSVLPLLSHPSESFLE-----------ELEEDLLKLLLK 776

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2514326112  731 HSLTIVSNACGTLWNLSARNTKDQEALWDMgAVSMLKNLIHSKHKM 776
Cdd:cd23958    777 HSVTVLQEAIACLCAVVNKLTKNYERLRKA-LQSCLKLLRKYKRQA 821
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 750-790 2.47e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.47e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2514326112  750 NTKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 790
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1778-1796 3.24e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.19  E-value: 3.24e-03
                           10
                   ....*....|....*....
gi 2514326112 1778 EEGEILAECINSAMPKGKS 1796
Cdd:pfam05924    4 DEDDLLQECINSAMPKKRR 22
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1431-1453 3.61e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.97  E-value: 3.61e-03
                           10        20
                   ....*....|....*....|....
gi 2514326112 1431 SPPEHY-VQETPLMFSRCTSVSSL 1453
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 518-569 5.05e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 5.05e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2514326112   518 DEEHRHAMNELGGLQAIAELLQvdcemygltsdHYSVTLRRYAGMALTNLTF 569
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2306-2621 5.25e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 5.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2306 KGPSLKTPTSKSPSEGPTSSTSPRGAKPSvkSELSPVTRQTSQPGGSSKGPSRSGSRDSTPSRPSQQPLSRPMQSPGRNS 2385
Cdd:PHA03247  2706 PTPEPAPHALVSATPLPPGPAAARQASPA--LPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL 2783

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2386 ISPGRNGISPPNKLSQLPRTSSPSTSSTKSSGSGKISYTSPGrqmsqqnltkqTGLSKNTSNIPRSESASKGLNQISNSN 2465
Cdd:PHA03247  2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA-----------GPLPPPTSAQPTAPPPPPGPPPPSLPL 2852

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2466 G--TNKKVELSRMSSTKSSGSESDRSERPVLVRqstfikeTPSPTLRRKLEESASLESLSSSSR-PDSPTKSQVQTPILS 2542
Cdd:PHA03247  2853 GgsVAPGGDVRRRPPSRSPAAKPAAPARPPVRR-------LARPAVSRSTESFALPPDQPERPPqPQAPPPPQPQPQPPP 2925

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2543 PSLPDMSLSTHSSIQTgswrKLPPNLNPSiefNDGRSTKRHDIARSHSESPSRLPVNRSGTWK----RE------HSKHS 2612
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQP----PLAPTTDPA---GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQpapsREapasstPPLTG 2998


                   ....*....
gi 2514326112 2613 SSLPRVSTW 2621
Cdd:PHA03247  2999 HSLSRVSSW 3007
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1316-1333 6.83e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.20  E-value: 6.83e-03
                           10
                   ....*....|....*...
gi 2514326112 1316 ETIQTYCVEDTPICFSRC 1333
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 399-451 8.27e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 8.27e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2514326112   399 SQDSCISMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 451
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 2284-2380 8.81e-03

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 41.61  E-value: 8.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2514326112 2284 GRTMIHIPGIRNSSSSTSPVSKKG---PSLKTPTSKSPSEGPTSSTSP----RGAKPSVKSELspVTRQTSQPGGSSKGP 2356
Cdd:PLN02217   552 GKGVPYIPGLFAGNPGSTNSTPTGsaaSSNTTFSSDSPSTVVAPSTSPpaghLGSPPATPSKI--VSPSTSPPASHLGSP 629

                           90       100
                   ....*....|....*....|....
gi 2514326112 2357 SRSGSRDSTPSRPSQQPLSRPMQS 2380
Cdd:PLN02217   630 STTPSSPESSIKVASTETASPESS 653
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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