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Conserved domains on  [gi|973201572|ref|XP_015220786|]
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PREDICTED: adenomatous polyposis coli protein 2 [Lepisosteus oculatus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2017-2365 1.06e-132

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


:

Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 419.67  E-value: 1.06e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572  2017 VVFRGRTVIYMPNpKKETNSSQKPPLKKTSPKTETPVKNPNLAQQRSRSLHRLGRANDSTELSLPKRSSTPPARIPKSTS 2096
Cdd:pfam05956    1 VVFRGRTVIYMPG-VKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSLHRLGKPSELADLSPPKRSATPPARISKAPS 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572  2097 SGSSQNSTPSRQPQKKLTSPSQSSKQIPKKDVKPTNSPTDKKTSPAASPSPKSPAHkKTQKSPVRIPFMQTPSRQPMASR 2176
Cdd:pfam05956   80 SGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTKKSGSH-KTQKSPVRIPFMQTPTKQTGLPR 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572  2177 TISPLVTNQPSPgisRQNTQLK--RTLPANRLDLVRMSSTRSSSSESDRAGFLRQLTFIKESPS-LLRQRSEIPSSRSV- 2252
Cdd:pfam05956  159 NPSPLVTNQPEP---RSESASKglRSLPGKRLDLVRMSSARSSGSESDRSGFLRQLTFIKESPSlLLRRRLELSASESLs 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572  2253 PTSKCASPRKMRPGAPAAFLCSSRCQELKGVGQGPRETQdegqgqgaqrqraalSRASSSDRGLSGVRPARRTSSESPCR 2332
Cdd:pfam05956  236 PSSQPASPRRSRPGLPAVFLCSSRCQELKGWRKQPPNPN---------------SRAEPSDRPLTRRRPPRRTSSESPSR 300

                          330       340       350
                   ....*....|....*....|....*....|...
gi 973201572  2333 APQKNISgawqRERDTFKRHSSSPHINILKRAT 2365
Cdd:pfam05956  301 LPVRNGT----WKRETFKRYSSLPHINVWRRTG 329
Arm_APC_u3 super family cl25003
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 773-1032 1.92e-40

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


The actual alignment was detected with superfamily member pfam16629:

Pssm-ID: 435476  Cd Length: 293  Bit Score: 152.82  E-value: 1.92e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572   773 NRPPKYKDAAVVSPGSCMPSLYMRKQKALEAELDAKHLAETFDSIEkQQSPKLQSINKPlRHIESLAKDYASDSGCFDDd 852
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNID-NLSPKASHRNKQ-RHKQNVYSEYVLDSGRHDD- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572   853 eAPNVSTSLDTGSFSMLSMFLNSSNFLQGQSRK-----KGSEPERDVDPQAEDGKKP---QPADDDVSVAAEKLAKKITT 924
Cdd:pfam16629   78 -SVCRSDNFNTGNVTVLSPYLNTTVLPSSSSRDsrgnaESSRSEKDRSLDRERGAGLsnfHPATENSGNSSKRIGMQIST 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572   925 TVAKIDKLVEDIT-MHTSSEDSFSLSSEDHfvdwQYGSDELHEARaKSCSPCRLSDTSSFARRERLSRAHALLRLKTAHT 1003
Cdd:pfam16629  157 TAAQIAKVMEEVSsMHISQEDRSSGSTSDM----HCMQDDRNSIR-RSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYK 231

                          250       260
                   ....*....|....*....|....*....
gi 973201572  1004 SLSTDSLNSGSTSDGYsGSKDQIRPSARS 1032
Cdd:pfam16629  232 RASNDSLNSVSSSDGY-GKRGQMKPSVES 259
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 431-507 5.86e-32

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


:

Pssm-ID: 465870  Cd Length: 74  Bit Score: 120.34  E-value: 5.86e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 973201572   431 SQPDEGQARREMRVLHVLEQIRAHCEGGWDWVETHRSPAGQEgssATATPEPVEPQICQAMCAIMKLSFEEEYRRAM 507
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGD---SNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 30-81 2.45e-19

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


:

Pssm-ID: 435517  Cd Length: 52  Bit Score: 83.50  E-value: 2.45e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 973201572    30 ASYDQLVRQVEALRKENTHLRRELEDNSNHLSKLENETSDMKEVLKQLQCKL 81
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 192-269 2.93e-15

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


:

Pssm-ID: 463275  Cd Length: 82  Bit Score: 72.67  E-value: 2.93e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 973201572   192 TAQHLEDLCKERTLLLSEIEKEERERRWYYSQLQGLSQRLAELPRVET-FSMQMDLIRQQLEFEAQQLRSVMEERFGTS 269
Cdd:pfam11414    4 MLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGTyFDYGSDAQQERLEFLLARIQEVNRCLGGLI 82
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 691-730 7.78e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.45  E-value: 7.78e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 973201572   691 DDYRQILRDHNCLQTLLQHLRSHSLTIVSNACGTLWNLSA 730
Cdd:pfam00514    2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1487-1508 1.02e-04

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 41.04  E-value: 1.02e-04
                           10        20
                   ....*....|....*....|..
gi 973201572  1487 NSDDDIEILKECINSAMPSKFR 1508
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 732-770 6.29e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 973201572   732 SPKDQELLWDLGAVSMLRNLIHSKHKMIAMGSAAALRNL 770
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
 
Name Accession Description Interval E-value
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2017-2365 1.06e-132

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 419.67  E-value: 1.06e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572  2017 VVFRGRTVIYMPNpKKETNSSQKPPLKKTSPKTETPVKNPNLAQQRSRSLHRLGRANDSTELSLPKRSSTPPARIPKSTS 2096
Cdd:pfam05956    1 VVFRGRTVIYMPG-VKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSLHRLGKPSELADLSPPKRSATPPARISKAPS 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572  2097 SGSSQNSTPSRQPQKKLTSPSQSSKQIPKKDVKPTNSPTDKKTSPAASPSPKSPAHkKTQKSPVRIPFMQTPSRQPMASR 2176
Cdd:pfam05956   80 SGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTKKSGSH-KTQKSPVRIPFMQTPTKQTGLPR 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572  2177 TISPLVTNQPSPgisRQNTQLK--RTLPANRLDLVRMSSTRSSSSESDRAGFLRQLTFIKESPS-LLRQRSEIPSSRSV- 2252
Cdd:pfam05956  159 NPSPLVTNQPEP---RSESASKglRSLPGKRLDLVRMSSARSSGSESDRSGFLRQLTFIKESPSlLLRRRLELSASESLs 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572  2253 PTSKCASPRKMRPGAPAAFLCSSRCQELKGVGQGPRETQdegqgqgaqrqraalSRASSSDRGLSGVRPARRTSSESPCR 2332
Cdd:pfam05956  236 PSSQPASPRRSRPGLPAVFLCSSRCQELKGWRKQPPNPN---------------SRAEPSDRPLTRRRPPRRTSSESPSR 300

                          330       340       350
                   ....*....|....*....|....*....|...
gi 973201572  2333 APQKNISgawqRERDTFKRHSSSPHINILKRAT 2365
Cdd:pfam05956  301 LPVRNGT----WKRETFKRYSSLPHINVWRRTG 329
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 773-1032 1.92e-40

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 152.82  E-value: 1.92e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572   773 NRPPKYKDAAVVSPGSCMPSLYMRKQKALEAELDAKHLAETFDSIEkQQSPKLQSINKPlRHIESLAKDYASDSGCFDDd 852
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNID-NLSPKASHRNKQ-RHKQNVYSEYVLDSGRHDD- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572   853 eAPNVSTSLDTGSFSMLSMFLNSSNFLQGQSRK-----KGSEPERDVDPQAEDGKKP---QPADDDVSVAAEKLAKKITT 924
Cdd:pfam16629   78 -SVCRSDNFNTGNVTVLSPYLNTTVLPSSSSRDsrgnaESSRSEKDRSLDRERGAGLsnfHPATENSGNSSKRIGMQIST 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572   925 TVAKIDKLVEDIT-MHTSSEDSFSLSSEDHfvdwQYGSDELHEARaKSCSPCRLSDTSSFARRERLSRAHALLRLKTAHT 1003
Cdd:pfam16629  157 TAAQIAKVMEEVSsMHISQEDRSSGSTSDM----HCMQDDRNSIR-RSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYK 231

                          250       260
                   ....*....|....*....|....*....
gi 973201572  1004 SLSTDSLNSGSTSDGYsGSKDQIRPSARS 1032
Cdd:pfam16629  232 RASNDSLNSVSSSDGY-GKRGQMKPSVES 259
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 431-507 5.86e-32

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 120.34  E-value: 5.86e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 973201572   431 SQPDEGQARREMRVLHVLEQIRAHCEGGWDWVETHRSPAGQEgssATATPEPVEPQICQAMCAIMKLSFEEEYRRAM 507
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGD---SNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 30-81 2.45e-19

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


Pssm-ID: 435517  Cd Length: 52  Bit Score: 83.50  E-value: 2.45e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 973201572    30 ASYDQLVRQVEALRKENTHLRRELEDNSNHLSKLENETSDMKEVLKQLQCKL 81
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 192-269 2.93e-15

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 72.67  E-value: 2.93e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 973201572   192 TAQHLEDLCKERTLLLSEIEKEERERRWYYSQLQGLSQRLAELPRVET-FSMQMDLIRQQLEFEAQQLRSVMEERFGTS 269
Cdd:pfam11414    4 MLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGTyFDYGSDAQQERLEFLLARIQEVNRCLGGLI 82
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 691-730 7.78e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.45  E-value: 7.78e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 973201572   691 DDYRQILRDHNCLQTLLQHLRSHSLTIVSNACGTLWNLSA 730
Cdd:pfam00514    2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 690-730 1.37e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.04  E-value: 1.37e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 973201572    690 RDDYRQILRDHNCLQTLLQHLRSHSLTIVSNACGTLWNLSA 730
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1487-1508 1.02e-04

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 41.04  E-value: 1.02e-04
                           10        20
                   ....*....|....*....|..
gi 973201572  1487 NSDDDIEILKECINSAMPSKFR 1508
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 2030-2180 5.99e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.45  E-value: 5.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572 2030 PKKETNSSQKPPLKKTSPKTETPVKNPNlaqQRSRSLHRLGRANDSTELSLPKRSStpPARIPKstssgssqnstPSRQP 2109
Cdd:PTZ00449  510 PPEGPEASGLPPKAPGDKEGEEGEHEDS---KESDEPKEGGKPGETKEGEVGKKPG--PAKEHK-----------PSKIP 573

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 973201572 2110 --QKKLTSPSQSSKqiPKKDVKPTNSPTDKKTS-PAASPSPKSPAHKKTQKSPVRIPFMQTPSRQPMASRTISP 2180
Cdd:PTZ00449  574 tlSKKPEFPKDPKH--PKDPEEPKKPKRPRSAQrPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSP 645
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 732-770 6.29e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 973201572   732 SPKDQELLWDLGAVSMLRNLIHSKHKMIAMGSAAALRNL 770
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
34-105 3.03e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 42.92  E-value: 3.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572   34 QLVRQVEALRKENTHLRRELEDNSNHLSKLENETSDMK-----------EV------LKQLQCKLEQEARTLASTGRTdv 96
Cdd:COG2433   417 RLEEQVERLEAEVEELEAELEEKDERIERLERELSEARseerreirkdrEIsrldreIERLERELEEERERIEELKRK-- 494


                  ....*....
gi 973201572   97 LDQLKELHM 105
Cdd:COG2433   495 LERLKELWK 503
 
Name Accession Description Interval E-value
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2017-2365 1.06e-132

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 419.67  E-value: 1.06e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572  2017 VVFRGRTVIYMPNpKKETNSSQKPPLKKTSPKTETPVKNPNLAQQRSRSLHRLGRANDSTELSLPKRSSTPPARIPKSTS 2096
Cdd:pfam05956    1 VVFRGRTVIYMPG-VKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSLHRLGKPSELADLSPPKRSATPPARISKAPS 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572  2097 SGSSQNSTPSRQPQKKLTSPSQSSKQIPKKDVKPTNSPTDKKTSPAASPSPKSPAHkKTQKSPVRIPFMQTPSRQPMASR 2176
Cdd:pfam05956   80 SGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTKKSGSH-KTQKSPVRIPFMQTPTKQTGLPR 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572  2177 TISPLVTNQPSPgisRQNTQLK--RTLPANRLDLVRMSSTRSSSSESDRAGFLRQLTFIKESPS-LLRQRSEIPSSRSV- 2252
Cdd:pfam05956  159 NPSPLVTNQPEP---RSESASKglRSLPGKRLDLVRMSSARSSGSESDRSGFLRQLTFIKESPSlLLRRRLELSASESLs 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572  2253 PTSKCASPRKMRPGAPAAFLCSSRCQELKGVGQGPRETQdegqgqgaqrqraalSRASSSDRGLSGVRPARRTSSESPCR 2332
Cdd:pfam05956  236 PSSQPASPRRSRPGLPAVFLCSSRCQELKGWRKQPPNPN---------------SRAEPSDRPLTRRRPPRRTSSESPSR 300

                          330       340       350
                   ....*....|....*....|....*....|...
gi 973201572  2333 APQKNISgawqRERDTFKRHSSSPHINILKRAT 2365
Cdd:pfam05956  301 LPVRNGT----WKRETFKRYSSLPHINVWRRTG 329
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 773-1032 1.92e-40

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 152.82  E-value: 1.92e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572   773 NRPPKYKDAAVVSPGSCMPSLYMRKQKALEAELDAKHLAETFDSIEkQQSPKLQSINKPlRHIESLAKDYASDSGCFDDd 852
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNID-NLSPKASHRNKQ-RHKQNVYSEYVLDSGRHDD- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572   853 eAPNVSTSLDTGSFSMLSMFLNSSNFLQGQSRK-----KGSEPERDVDPQAEDGKKP---QPADDDVSVAAEKLAKKITT 924
Cdd:pfam16629   78 -SVCRSDNFNTGNVTVLSPYLNTTVLPSSSSRDsrgnaESSRSEKDRSLDRERGAGLsnfHPATENSGNSSKRIGMQIST 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572   925 TVAKIDKLVEDIT-MHTSSEDSFSLSSEDHfvdwQYGSDELHEARaKSCSPCRLSDTSSFARRERLSRAHALLRLKTAHT 1003
Cdd:pfam16629  157 TAAQIAKVMEEVSsMHISQEDRSSGSTSDM----HCMQDDRNSIR-RSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYK 231

                          250       260
                   ....*....|....*....|....*....
gi 973201572  1004 SLSTDSLNSGSTSDGYsGSKDQIRPSARS 1032
Cdd:pfam16629  232 RASNDSLNSVSSSDGY-GKRGQMKPSVES 259
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 431-507 5.86e-32

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 120.34  E-value: 5.86e-32
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 973201572   431 SQPDEGQARREMRVLHVLEQIRAHCEGGWDWVETHRSPAGQEgssATATPEPVEPQICQAMCAIMKLSFEEEYRRAM 507
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGD---SNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 30-81 2.45e-19

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


Pssm-ID: 435517  Cd Length: 52  Bit Score: 83.50  E-value: 2.45e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 973201572    30 ASYDQLVRQVEALRKENTHLRRELEDNSNHLSKLENETSDMKEVLKQLQCKL 81
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 192-269 2.93e-15

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 72.67  E-value: 2.93e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 973201572   192 TAQHLEDLCKERTLLLSEIEKEERERRWYYSQLQGLSQRLAELPRVET-FSMQMDLIRQQLEFEAQQLRSVMEERFGTS 269
Cdd:pfam11414    4 MLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGTyFDYGSDAQQERLEFLLARIQEVNRCLGGLI 82
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 691-730 7.78e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.45  E-value: 7.78e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 973201572   691 DDYRQILRDHNCLQTLLQHLRSHSLTIVSNACGTLWNLSA 730
Cdd:pfam00514    2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 690-730 1.37e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.04  E-value: 1.37e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 973201572    690 RDDYRQILRDHNCLQTLLQHLRSHSLTIVSNACGTLWNLSA 730
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1487-1508 1.02e-04

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 41.04  E-value: 1.02e-04
                           10        20
                   ....*....|....*....|..
gi 973201572  1487 NSDDDIEILKECINSAMPSKFR 1508
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 2030-2180 5.99e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.45  E-value: 5.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572 2030 PKKETNSSQKPPLKKTSPKTETPVKNPNlaqQRSRSLHRLGRANDSTELSLPKRSStpPARIPKstssgssqnstPSRQP 2109
Cdd:PTZ00449  510 PPEGPEASGLPPKAPGDKEGEEGEHEDS---KESDEPKEGGKPGETKEGEVGKKPG--PAKEHK-----------PSKIP 573

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 973201572 2110 --QKKLTSPSQSSKqiPKKDVKPTNSPTDKKTS-PAASPSPKSPAHKKTQKSPVRIPFMQTPSRQPMASRTISP 2180
Cdd:PTZ00449  574 tlSKKPEFPKDPKH--PKDPEEPKKPKRPRSAQrPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRPSSP 645
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 732-770 6.29e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 973201572   732 SPKDQELLWDLGAVSMLRNLIHSKHKMIAMGSAAALRNL 770
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 2035-2192 6.74e-04

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 44.77  E-value: 6.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572  2035 NSSQKPPLKKTSPKTETPVKNPNLAQQR-SRSLHRLGRANDSTEL-------SLPKRSSTPPARIPKSTSSGSSQNSTPS 2106
Cdd:pfam13254  159 NRPESPKPKAQPSQPAQPAWMKELNKIRqSRASVDLGRPNSFKEVtpvglmrSPAPGGHSKSPSVSGISADSSPTKEEPS 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572  2107 RQPQKKLTSPSQSSKQIPKKDVKPTNSPTDKKTSPAASPSPKSPAHKKTQKS-PVRIPFMQTPSRQPMASRTISPLVTNQ 2185
Cdd:pfam13254  239 EEADTLSTDKEQSPAPTSASEPPPKTKELPKDSEEPAAPSKSAEASTEKKEPdTESSPETSSEKSAPSLLSPVSKASIDK 318


                   ....*..
gi 973201572  2186 PSPGISR 2192
Cdd:pfam13254  319 PLSSPDR 325
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2063-2340 9.41e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 9.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572 2063 SRSLHRLGRANDSTELSLPKRSSTPPARIPKSTSSGSSQNSTPSRQPQKKLTSPSQSSKQIPKKDVKPTNSPTDKKTSPA 2142
Cdd:PHA03307   75 PGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPA 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572 2143 A--------------------SPSPKSPAHKKTQKSPVRIPFMQTPSRQPMASRTISPLVTNQPSPGISRQNTQlKRTLP 2202
Cdd:PHA03307  155 AgaspaavasdaassrqaalpLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSA-ADDAG 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572 2203 ANRLDLVRMSSTRSSSSESDRAGFLRQLTFIKESPSLLRQRSEIPSSRSVPTSKCASPR----KMRPGAPAAFLCSSRCQ 2278
Cdd:PHA03307  234 ASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRerspSPSPSSPGSGPAPSSPR 313

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 973201572 2279 ELKGVGQGPRETQDEGQGQGAQRQRAALSRASSSDRGLSGVRPARRTSSESPCRAPQKNISG 2340
Cdd:PHA03307  314 ASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAP 375
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
34-105 3.03e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 42.92  E-value: 3.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973201572   34 QLVRQVEALRKENTHLRRELEDNSNHLSKLENETSDMK-----------EV------LKQLQCKLEQEARTLASTGRTdv 96
Cdd:COG2433   417 RLEEQVERLEAEVEELEAELEEKDERIERLERELSEARseerreirkdrEIsrldreIERLERELEEERERIEELKRK-- 494


                  ....*....
gi 973201572   97 LDQLKELHM 105
Cdd:COG2433   495 LERLKELWK 503
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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