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Conserved domains on  [gi|767962196|ref|XP_011537831|]
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phosphatidylinositide phosphatase SAC2 isoform X5 [Homo sapiens]

Protein Classification

hSac2 domain-containing protein( domain architecture ID 10575559)

hSac2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
hSac2 pfam12456
Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 ...
 108-211 2.47e-26

Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with pfam02383. hSac2 functions as an inositol polyphosphate 5-phosphatase.


:

Pssm-ID: 463592  Cd Length: 115  Bit Score: 103.82  E-value: 2.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767962196  108 SHQELISQLLQSYMKLLLPD-DEKFHGGWALIDCDPSLIDATHRDVDVLLLLSNSAYYVAYYDDEVDKVNQYQRLSLENL 186
Cdd:pfam12456   5 SRPKIREQAIEDCKKLVLADeDEEFIGGWTLLSPDHWNTLRSLPEEERVLLLTDKALYICKYDFNLEKVVQFERVPLNDI 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767962196  187 EKIEIGP------EPTLFGKPKFSCMRLHYR 211
Cdd:pfam12456  85 DRIQLGTyitstlSLAQRDERRNYGLRIHYD 115
COG5329 super family cl34984
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
14-81 1.00e-20

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5329:

Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 96.30  E-value: 1.00e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767962196  14 IYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVIDLMQG 81
Cdd:COG5329  435 IHRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLG 502
 
Name Accession Description Interval E-value
hSac2 pfam12456
Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 ...
 108-211 2.47e-26

Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with pfam02383. hSac2 functions as an inositol polyphosphate 5-phosphatase.


Pssm-ID: 463592  Cd Length: 115  Bit Score: 103.82  E-value: 2.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767962196  108 SHQELISQLLQSYMKLLLPD-DEKFHGGWALIDCDPSLIDATHRDVDVLLLLSNSAYYVAYYDDEVDKVNQYQRLSLENL 186
Cdd:pfam12456   5 SRPKIREQAIEDCKKLVLADeDEEFIGGWTLLSPDHWNTLRSLPEEERVLLLTDKALYICKYDFNLEKVVQFERVPLNDI 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767962196  187 EKIEIGP------EPTLFGKPKFSCMRLHYR 211
Cdd:pfam12456  85 DRIQLGTyitstlSLAQRDERRNYGLRIHYD 115
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
14-81 1.00e-20

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 96.30  E-value: 1.00e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767962196  14 IYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVIDLMQG 81
Cdd:COG5329  435 IHRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLG 502
 
Name Accession Description Interval E-value
hSac2 pfam12456
Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 ...
 108-211 2.47e-26

Inositol phosphatase; This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with pfam02383. hSac2 functions as an inositol polyphosphate 5-phosphatase.


Pssm-ID: 463592  Cd Length: 115  Bit Score: 103.82  E-value: 2.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767962196  108 SHQELISQLLQSYMKLLLPD-DEKFHGGWALIDCDPSLIDATHRDVDVLLLLSNSAYYVAYYDDEVDKVNQYQRLSLENL 186
Cdd:pfam12456   5 SRPKIREQAIEDCKKLVLADeDEEFIGGWTLLSPDHWNTLRSLPEEERVLLLTDKALYICKYDFNLEKVVQFERVPLNDI 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767962196  187 EKIEIGP------EPTLFGKPKFSCMRLHYR 211
Cdd:pfam12456  85 DRIQLGTyitstlSLAQRDERRNYGLRIHYD 115
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
14-81 1.00e-20

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 96.30  E-value: 1.00e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767962196  14 IYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVIDLMQG 81
Cdd:COG5329  435 IHRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLG 502
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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