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Conserved domains on  [gi|767989259|ref|XP_011521110|]
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M-phase phosphoprotein 6 isoform X1 [Homo sapiens]

Protein Classification

MPP6 family protein( domain architecture ID 10562780)

MPP6 family protein similar to Homo sapiens M-phase phosphoprotein 6, which is a RNA-binding protein that associates with the RNA exosome complex, is involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and plays a role in recruiting the RNA exosome complex to pre-rRNA

Gene Ontology:  GO:0000460|GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MPP6 pfam10175
M-phase phosphoprotein 6; This family represents the M-phase phosphoprotein 6 (MPP6) which is ...
 25-117 3.38e-30

M-phase phosphoprotein 6; This family represents the M-phase phosphoprotein 6 (MPP6) which is involved in the generation of the 3' end of the 5.8S rRNA precursor. MPP6 is required for the integrity maintenance of the rRNA processing complex as it mediates the interaction between MTR4 (RNA helicase) and RRP6 (an 3'-5' exonuclease), and the recruitment of Nuclear VCP-like 2 (NVL2) to the nuclear exosome.


:

Pssm-ID: 462978  Cd Length: 131  Bit Score: 105.58  E-value: 3.38e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989259   25 HWYLDLPELKEKESFIIEEQSFLLCEDLLYGRMSFRGFNPEVEKLMLQMNAKHKAEEVEDETVELDVSDEEMARRY-ETL 103
Cdd:pfam10175  38 EWVLDGPELLEKKLKIKSEPSYVGCENLIFGRMSFGGFNPEIEKLMKKEEKKEEEEEEEEEEKEEDVSDEEMAKRYkSTL 117

                          90
                  ....*....|....
gi 767989259  104 VGTIGKKFARKRDH 117
Cdd:pfam10175 118 VGTISKKFKKKRKR 131
 
Name Accession Description Interval E-value
MPP6 pfam10175
M-phase phosphoprotein 6; This family represents the M-phase phosphoprotein 6 (MPP6) which is ...
 25-117 3.38e-30

M-phase phosphoprotein 6; This family represents the M-phase phosphoprotein 6 (MPP6) which is involved in the generation of the 3' end of the 5.8S rRNA precursor. MPP6 is required for the integrity maintenance of the rRNA processing complex as it mediates the interaction between MTR4 (RNA helicase) and RRP6 (an 3'-5' exonuclease), and the recruitment of Nuclear VCP-like 2 (NVL2) to the nuclear exosome.


Pssm-ID: 462978  Cd Length: 131  Bit Score: 105.58  E-value: 3.38e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989259   25 HWYLDLPELKEKESFIIEEQSFLLCEDLLYGRMSFRGFNPEVEKLMLQMNAKHKAEEVEDETVELDVSDEEMARRY-ETL 103
Cdd:pfam10175  38 EWVLDGPELLEKKLKIKSEPSYVGCENLIFGRMSFGGFNPEIEKLMKKEEKKEEEEEEEEEEKEEDVSDEEMAKRYkSTL 117

                          90
                  ....*....|....
gi 767989259  104 VGTIGKKFARKRDH 117
Cdd:pfam10175 118 VGTISKKFKKKRKR 131
 
Name Accession Description Interval E-value
MPP6 pfam10175
M-phase phosphoprotein 6; This family represents the M-phase phosphoprotein 6 (MPP6) which is ...
 25-117 3.38e-30

M-phase phosphoprotein 6; This family represents the M-phase phosphoprotein 6 (MPP6) which is involved in the generation of the 3' end of the 5.8S rRNA precursor. MPP6 is required for the integrity maintenance of the rRNA processing complex as it mediates the interaction between MTR4 (RNA helicase) and RRP6 (an 3'-5' exonuclease), and the recruitment of Nuclear VCP-like 2 (NVL2) to the nuclear exosome.


Pssm-ID: 462978  Cd Length: 131  Bit Score: 105.58  E-value: 3.38e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989259   25 HWYLDLPELKEKESFIIEEQSFLLCEDLLYGRMSFRGFNPEVEKLMLQMNAKHKAEEVEDETVELDVSDEEMARRY-ETL 103
Cdd:pfam10175  38 EWVLDGPELLEKKLKIKSEPSYVGCENLIFGRMSFGGFNPEIEKLMKKEEKKEEEEEEEEEEKEEDVSDEEMAKRYkSTL 117

                          90
                  ....*....|....
gi 767989259  104 VGTIGKKFARKRDH 117
Cdd:pfam10175 118 VGTISKKFKKKRKR 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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