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Conserved domains on  [gi|688532955|ref|XP_009290261|]
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integrin, alpha 6b isoform X1 [Danio rerio]

Protein Classification

Int_alpha and Integrin_alpha2 domain-containing protein( domain architecture ID 12192626)

protein containing domains FG-GAP, Int_alpha, and Integrin_alpha2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 469-932 1.90e-165

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 494.15  E-value: 1.90e-165
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688532955   469 RSVINIEKTVTTTPKELDLTKKNCNNGNN--ICLDVKACFKFSVKPKtYNPTLKVAYTIRVESERKKlNLPSRVIFNprS 546
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGTpvSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLFL--D 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688532955   547 NNDYESTGIVELKGQGTESCIYRNLMLQETLKDKLRGIPIEVSVEILnqnKRRRRQAALPNLLPILDSNQEATTVAMVQF 626
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR---VDPRAPSDLPGLKPILDQNQPSTVQEQANF 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688532955   627 IKEgCGADHLCQSDLQLQYKFHTREPNKDnffpfdeekgvpiLSLSDQKEIALEIKAVNLGEDAYETQLTASFPKSLSYS 706
Cdd:pfam08441  154 LKD-CGEDNVCVPDLQLSAKFDSRESDEP-------------LLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYS 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688532955   707 AVRTQSGDKQISCLVNQNGS--QADCDLGNPFKKDAETTFYIILSTGGISLDTTEIEIDLKLKTTSEQK-QLQAVKAKAI 783
Cdd:pfam08441  220 GVRREGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsNSNPVSLKVP 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688532955   784 VKIQLLLSLSGVAKPSQVFFtGEVKGESAMK--MAGDVGSPIDYEFRVTNLGKPlkSFGRASMIIQWPKHNSQGKWLLYL 861
Cdd:pfam08441  300 VVAEAQLSLSGVSKPDQVVG-GSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPYELSNGKWLLYL 376

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688532955   862 MKMTSTGldSLSCTNSDEVNKLGL-------KELSVSRTKREVGETSAAEGKTAFFTDkrkYTLLSCDDGAECITFIC 932
Cdd:pfam08441  377 LDVQGQG--KGECSPQNEINPLNLtqslessKPLRTSRVHHVVKRRDVLKSEKATQTA---SVLLSCDSGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 374-425 2.20e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 57.00  E-value: 2.20e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 688532955    374 AYSMFGLAVENMGDVNLDGYQDVAVSAPYDSNGA--GNVIIFHGSPQGLKKSQV 425
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFGSSGGGNSIPL 54
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 317-355 6.11e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 55.21  E-value: 6.11e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 688532955   317 FGYDLAVLDINGDGWQDIVVGAPQYfikDGDIGGAIYVY 355
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGE---GGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 37-98 4.34e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 41.98  E-value: 4.34e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688532955     37 ANSLFGFSMAMHRQLRPADKRMLLVGSPKAKALPNqrskiTGGLYNCDINIPGQSCQRVMFD 98
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGE-----TGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 254-292 1.81e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.35  E-value: 1.81e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 688532955    254 ANSYLGFSLDSGKMLTKRGQLTIVAGAPRANHS---GAVVLL 292
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVY 42
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 469-932 1.90e-165

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 494.15  E-value: 1.90e-165
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688532955   469 RSVINIEKTVTTTPKELDLTKKNCNNGNN--ICLDVKACFKFSVKPKtYNPTLKVAYTIRVESERKKlNLPSRVIFNprS 546
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGTpvSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLFL--D 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688532955   547 NNDYESTGIVELKGQGTESCIYRNLMLQETLKDKLRGIPIEVSVEILnqnKRRRRQAALPNLLPILDSNQEATTVAMVQF 626
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR---VDPRAPSDLPGLKPILDQNQPSTVQEQANF 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688532955   627 IKEgCGADHLCQSDLQLQYKFHTREPNKDnffpfdeekgvpiLSLSDQKEIALEIKAVNLGEDAYETQLTASFPKSLSYS 706
Cdd:pfam08441  154 LKD-CGEDNVCVPDLQLSAKFDSRESDEP-------------LLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYS 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688532955   707 AVRTQSGDKQISCLVNQNGS--QADCDLGNPFKKDAETTFYIILSTGGISLDTTEIEIDLKLKTTSEQK-QLQAVKAKAI 783
Cdd:pfam08441  220 GVRREGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsNSNPVSLKVP 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688532955   784 VKIQLLLSLSGVAKPSQVFFtGEVKGESAMK--MAGDVGSPIDYEFRVTNLGKPlkSFGRASMIIQWPKHNSQGKWLLYL 861
Cdd:pfam08441  300 VVAEAQLSLSGVSKPDQVVG-GSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPYELSNGKWLLYL 376

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688532955   862 MKMTSTGldSLSCTNSDEVNKLGL-------KELSVSRTKREVGETSAAEGKTAFFTDkrkYTLLSCDDGAECITFIC 932
Cdd:pfam08441  377 LDVQGQG--KGECSPQNEINPLNLtqslessKPLRTSRVHHVVKRRDVLKSEKATQTA---SVLLSCDSGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 374-425 2.20e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 57.00  E-value: 2.20e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 688532955    374 AYSMFGLAVENMGDVNLDGYQDVAVSAPYDSNGA--GNVIIFHGSPQGLKKSQV 425
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFGSSGGGNSIPL 54
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 317-355 6.11e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 55.21  E-value: 6.11e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 688532955   317 FGYDLAVLDINGDGWQDIVVGAPQYfikDGDIGGAIYVY 355
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGE---GGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 315-365 1.36e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 54.69  E-value: 1.36e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 688532955    315 SSFGYDLA-VLDINGDGWQDIVVGAPQYfiKDGDIGGAIYVYLNEEGAWDKI 365
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRA--NDAGETGAVYVYFGSSGGGNSI 52
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 37-98 4.34e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 41.98  E-value: 4.34e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688532955     37 ANSLFGFSMAMHRQLRPADKRMLLVGSPKAKALPNqrskiTGGLYNCDINIPGQSCQRVMFD 98
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGE-----TGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 386-413 8.11e-05

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 40.57  E-value: 8.11e-05
                           10        20
                   ....*....|....*....|....*....
gi 688532955   386 GDVNLDGYQDVAVSAPY-DSNGAGNVIIF 413
Cdd:pfam01839    8 GDLNGDGYADLAVGAPGeGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 254-292 1.81e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.35  E-value: 1.81e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 688532955    254 ANSYLGFSLDSGKMLTKRGQLTIVAGAPRANHS---GAVVLL 292
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVY 42
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 469-932 1.90e-165

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 494.15  E-value: 1.90e-165
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688532955   469 RSVINIEKTVTTTPKELDLTKKNCNNGNN--ICLDVKACFKFSVKPKtYNPTLKVAYTIRVESERKKlNLPSRVIFNprS 546
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGTpvSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLFL--D 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688532955   547 NNDYESTGIVELKGQGTESCIYRNLMLQETLKDKLRGIPIEVSVEILnqnKRRRRQAALPNLLPILDSNQEATTVAMVQF 626
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR---VDPRAPSDLPGLKPILDQNQPSTVQEQANF 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688532955   627 IKEgCGADHLCQSDLQLQYKFHTREPNKDnffpfdeekgvpiLSLSDQKEIALEIKAVNLGEDAYETQLTASFPKSLSYS 706
Cdd:pfam08441  154 LKD-CGEDNVCVPDLQLSAKFDSRESDEP-------------LLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYS 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688532955   707 AVRTQSGDKQISCLVNQNGS--QADCDLGNPFKKDAETTFYIILSTGGISLDTTEIEIDLKLKTTSEQK-QLQAVKAKAI 783
Cdd:pfam08441  220 GVRREGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNsNSNPVSLKVP 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688532955   784 VKIQLLLSLSGVAKPSQVFFtGEVKGESAMK--MAGDVGSPIDYEFRVTNLGKPlkSFGRASMIIQWPKHNSQGKWLLYL 861
Cdd:pfam08441  300 VVAEAQLSLSGVSKPDQVVG-GSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPYELSNGKWLLYL 376

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688532955   862 MKMTSTGldSLSCTNSDEVNKLGL-------KELSVSRTKREVGETSAAEGKTAFFTDkrkYTLLSCDDGAECITFIC 932
Cdd:pfam08441  377 LDVQGQG--KGECSPQNEINPLNLtqslessKPLRTSRVHHVVKRRDVLKSEKATQTA---SVLLSCDSGARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 374-425 2.20e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 57.00  E-value: 2.20e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 688532955    374 AYSMFGLAVENMGDVNLDGYQDVAVSAPYDSNGA--GNVIIFHGSPQGLKKSQV 425
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFGSSGGGNSIPL 54
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 317-355 6.11e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 55.21  E-value: 6.11e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 688532955   317 FGYDLAVLDINGDGWQDIVVGAPQYfikDGDIGGAIYVY 355
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGE---GGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 315-365 1.36e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 54.69  E-value: 1.36e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 688532955    315 SSFGYDLA-VLDINGDGWQDIVVGAPQYfiKDGDIGGAIYVYLNEEGAWDKI 365
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRA--NDAGETGAVYVYFGSSGGGNSI 52
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 325-398 2.47e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 48.38  E-value: 2.47e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 688532955   325 DINGDGWQDIVVGAPqyfikdgdigGAIYVYLNE-EGAWDKITPKRIDGPAYSMfGLAVenmGDVNLDGYQDVAV 398
Cdd:pfam13517    1 DLDGDGKLDLVVAND----------GGLRLYLNNgDGTFTFITSVSLGGGGGGL-SVAV---GDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 37-98 4.34e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 41.98  E-value: 4.34e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688532955     37 ANSLFGFSMAMHRQLRPADKRMLLVGSPKAKALPNqrskiTGGLYNCDINIPGQSCQRVMFD 98
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGE-----TGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 386-413 8.11e-05

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 40.57  E-value: 8.11e-05
                           10        20
                   ....*....|....*....|....*....
gi 688532955   386 GDVNLDGYQDVAVSAPY-DSNGAGNVIIF 413
Cdd:pfam01839    8 GDLNGDGYADLAVGAPGeGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 254-292 1.81e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.35  E-value: 1.81e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 688532955    254 ANSYLGFSLDSGKMLTKRGQLTIVAGAPRANHS---GAVVLL 292
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVY 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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