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Conserved domains on  [gi|675628959|ref|XP_008942943|]
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PREDICTED: heterochromatin protein 1-binding protein 3, partial [Merops nubicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
H15 cd00073
linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, ...
 155-246 9.53e-24

linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated proteins that bind to the exterior of nucleosomes and dramatically stabilize the highly condensed states of chromatin fibers; stabilization of higher order folding occurs through electrostatic neutralization of the linker DNA segments, through a highly positively charged carboxy- terminal domain known as the AKP helix (Ala, Lys, Pro); thought to be involved in specific protein-protein and protein-DNA interactions and play a role in suppressing core histone tail domain acetylation in the chromatin fiber


:

Pssm-ID: 238028 [Multi-domain]  Cd Length: 88  Bit Score: 92.30  E-value: 9.53e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675628959 155 ATSRPKMDAILTEAIRACFQKSGASVVAIRKYIIHKYPSLeLERRGYLLKQALKRELERGIIRQVKGKGASGSFVVvsnA 234
Cdd:cd00073    1 PPSHPPYSEMVTEAIKALKERKGSSLQAIKKYIEAKYKVD-DENFNKLLKLALKKGVAKGKLVQVKGTGASGSFKL---S 76

                         90
                 ....*....|..
gi 675628959 235 GKTVPKARDRKK 246
Cdd:cd00073   77 KKKKKKKKPAKK 88
PHA03325 super family cl25859
nuclear-egress-membrane-like protein; Provisional
 45-163 2.67e-03

nuclear-egress-membrane-like protein; Provisional


The actual alignment was detected with superfamily member PHA03325:

Pssm-ID: 223044  Cd Length: 418  Bit Score: 39.10  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675628959  45 VNSSSRETPPKSKPAEGEEVKADAEVTSEESASVGEEQES-ETLPAASTEPE----QPKEPENEGKEETKSSEETKKDEK 119
Cdd:PHA03325 264 LNSSLPTSAPKRRSRRAGAMRAAAGETADLADDDGSEHSDpEPLPASLPPPPvrrpRVKHPEAGKEEPDGARNAEAKEPA 343

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 675628959 120 DQSKEKEKKVKKTIP---AWATLSASQLARAQKQTQMAATSRPKMDA 163
Cdd:PHA03325 344 QPATSTSSKGSSSAQnkdSGSTGPGSSLAAASSFLEDDDFGSPPLDL 390
 
Name Accession Description Interval E-value
H15 cd00073
linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, ...
 155-246 9.53e-24

linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated proteins that bind to the exterior of nucleosomes and dramatically stabilize the highly condensed states of chromatin fibers; stabilization of higher order folding occurs through electrostatic neutralization of the linker DNA segments, through a highly positively charged carboxy- terminal domain known as the AKP helix (Ala, Lys, Pro); thought to be involved in specific protein-protein and protein-DNA interactions and play a role in suppressing core histone tail domain acetylation in the chromatin fiber


Pssm-ID: 238028 [Multi-domain]  Cd Length: 88  Bit Score: 92.30  E-value: 9.53e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675628959 155 ATSRPKMDAILTEAIRACFQKSGASVVAIRKYIIHKYPSLeLERRGYLLKQALKRELERGIIRQVKGKGASGSFVVvsnA 234
Cdd:cd00073    1 PPSHPPYSEMVTEAIKALKERKGSSLQAIKKYIEAKYKVD-DENFNKLLKLALKKGVAKGKLVQVKGTGASGSFKL---S 76

                         90
                 ....*....|..
gi 675628959 235 GKTVPKARDRKK 246
Cdd:cd00073   77 KKKKKKKKPAKK 88
Linker_histone pfam00538
linker histone H1 and H5 family; Linker histone H1 is an essential component of chromatin ...
 158-228 1.43e-22

linker histone H1 and H5 family; Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures Histone H1 is replaced by histone H5 in some cell types.


Pssm-ID: 459846 [Multi-domain]  Cd Length: 71  Bit Score: 88.74  E-value: 1.43e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 675628959  158 RPKMDAILTEAIRACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELERGIIRQVKGKGASGSF 228
Cdd:pfam00538   1 HPPYSDMIKEAIKALKERKGSSRQAIKKYIKANYKVGDVAKFNSLLKRALKKGVEKGTLVQPKGTGASGSF 71
H15 smart00526
Domain in histone families 1 and 5;
155-221 1.04e-14

Domain in histone families 1 and 5;


Pssm-ID: 197772 [Multi-domain]  Cd Length: 66  Bit Score: 67.60  E-value: 1.04e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 675628959   155 ATSRPKMDAILTEAIRACFQKSGASVVAIRKYIIHKYPSLElERRGYLLKQALKRELERGIIRQVKG 221
Cdd:smart00526   1 PPSHPPYSEMIVEAISALKERKGSSLQAIKKYIEANYKVLP-NNFRKLLKLALKRLVASGKLVQVKG 66
PHA03325 PHA03325
nuclear-egress-membrane-like protein; Provisional
 45-163 2.67e-03

nuclear-egress-membrane-like protein; Provisional


Pssm-ID: 223044  Cd Length: 418  Bit Score: 39.10  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675628959  45 VNSSSRETPPKSKPAEGEEVKADAEVTSEESASVGEEQES-ETLPAASTEPE----QPKEPENEGKEETKSSEETKKDEK 119
Cdd:PHA03325 264 LNSSLPTSAPKRRSRRAGAMRAAAGETADLADDDGSEHSDpEPLPASLPPPPvrrpRVKHPEAGKEEPDGARNAEAKEPA 343

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 675628959 120 DQSKEKEKKVKKTIP---AWATLSASQLARAQKQTQMAATSRPKMDA 163
Cdd:PHA03325 344 QPATSTSSKGSSSAQnkdSGSTGPGSSLAAASSFLEDDDFGSPPLDL 390
 
Name Accession Description Interval E-value
H15 cd00073
linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, ...
 155-246 9.53e-24

linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated proteins that bind to the exterior of nucleosomes and dramatically stabilize the highly condensed states of chromatin fibers; stabilization of higher order folding occurs through electrostatic neutralization of the linker DNA segments, through a highly positively charged carboxy- terminal domain known as the AKP helix (Ala, Lys, Pro); thought to be involved in specific protein-protein and protein-DNA interactions and play a role in suppressing core histone tail domain acetylation in the chromatin fiber


Pssm-ID: 238028 [Multi-domain]  Cd Length: 88  Bit Score: 92.30  E-value: 9.53e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675628959 155 ATSRPKMDAILTEAIRACFQKSGASVVAIRKYIIHKYPSLeLERRGYLLKQALKRELERGIIRQVKGKGASGSFVVvsnA 234
Cdd:cd00073    1 PPSHPPYSEMVTEAIKALKERKGSSLQAIKKYIEAKYKVD-DENFNKLLKLALKKGVAKGKLVQVKGTGASGSFKL---S 76

                         90
                 ....*....|..
gi 675628959 235 GKTVPKARDRKK 246
Cdd:cd00073   77 KKKKKKKKPAKK 88
Linker_histone pfam00538
linker histone H1 and H5 family; Linker histone H1 is an essential component of chromatin ...
 158-228 1.43e-22

linker histone H1 and H5 family; Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures Histone H1 is replaced by histone H5 in some cell types.


Pssm-ID: 459846 [Multi-domain]  Cd Length: 71  Bit Score: 88.74  E-value: 1.43e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 675628959  158 RPKMDAILTEAIRACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELERGIIRQVKGKGASGSF 228
Cdd:pfam00538   1 HPPYSDMIKEAIKALKERKGSSRQAIKKYIKANYKVGDVAKFNSLLKRALKKGVEKGTLVQPKGTGASGSF 71
H15 smart00526
Domain in histone families 1 and 5;
155-221 1.04e-14

Domain in histone families 1 and 5;


Pssm-ID: 197772 [Multi-domain]  Cd Length: 66  Bit Score: 67.60  E-value: 1.04e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 675628959   155 ATSRPKMDAILTEAIRACFQKSGASVVAIRKYIIHKYPSLElERRGYLLKQALKRELERGIIRQVKG 221
Cdd:smart00526   1 PPSHPPYSEMIVEAISALKERKGSSLQAIKKYIEANYKVLP-NNFRKLLKLALKRLVASGKLVQVKG 66
PHA03325 PHA03325
nuclear-egress-membrane-like protein; Provisional
 45-163 2.67e-03

nuclear-egress-membrane-like protein; Provisional


Pssm-ID: 223044  Cd Length: 418  Bit Score: 39.10  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675628959  45 VNSSSRETPPKSKPAEGEEVKADAEVTSEESASVGEEQES-ETLPAASTEPE----QPKEPENEGKEETKSSEETKKDEK 119
Cdd:PHA03325 264 LNSSLPTSAPKRRSRRAGAMRAAAGETADLADDDGSEHSDpEPLPASLPPPPvrrpRVKHPEAGKEEPDGARNAEAKEPA 343

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 675628959 120 DQSKEKEKKVKKTIP---AWATLSASQLARAQKQTQMAATSRPKMDA 163
Cdd:PHA03325 344 QPATSTSSKGSSSAQnkdSGSTGPGSSLAAASSFLEDDDFGSPPLDL 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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