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Conserved domains on  [gi|597928052|ref|XP_007318370|]
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hypothetical protein SERLADRAFT_356043 [Serpula lacrymans var. lacrymans S7.9]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 33-183 1.76e-49

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410228  Cd Length: 150  Bit Score: 163.54  E-value: 1.76e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052  33 EASTQYRNWRY-SPAKLANVRASLNTAAVTAIRTKFEVDEPgsssTVSFLDADEEQLLVKLYISKIPQLCGHFRFPEEVE 111
Cdd:cd20524    1 HTSTQRKHWIFsSEEELAELRAEANEKAREKLKESLKEEDA----EPKFLTPEEELLLVRYYEKKLLEFCRAFKLPDSVL 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 597928052 112 ATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNPITLESYTTHIP--RTSPSDVLDLEFLVAQSLGFEF 183
Cdd:cd20524   77 ATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKesEKTAEIILEYELLLLQGLNFHL 150
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 186-313 4.33e-26

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410229  Cd Length: 126  Bit Score: 101.22  E-value: 4.33e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052 186 WHAHRALWGIWLDLQSLLDAP-ADRPEEIYNTALGRVRSSRLTDVELIYTPPQIALACLSLASP---DLALQWANSKFAs 261
Cdd:cd20525    1 HHPYRPLEGFLLDLKTRLPDLkAENLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAASeagIDVEEYLSEKLP- 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 597928052 262 ptsspTSTPSPTSSALQTIVEAIKLVITQFGKPPDIESVREVDRRLRLCKNP 313
Cdd:cd20525   80 -----GSEESEELEKLLEIIREIKKLVKKYEGPPDKEEVKALDKKLKKCRNP 126
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 33-183 1.76e-49

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 163.54  E-value: 1.76e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052  33 EASTQYRNWRY-SPAKLANVRASLNTAAVTAIRTKFEVDEPgsssTVSFLDADEEQLLVKLYISKIPQLCGHFRFPEEVE 111
Cdd:cd20524    1 HTSTQRKHWIFsSEEELAELRAEANEKAREKLKESLKEEDA----EPKFLTPEEELLLVRYYEKKLLEFCRAFKLPDSVL 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 597928052 112 ATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNPITLESYTTHIP--RTSPSDVLDLEFLVAQSLGFEF 183
Cdd:cd20524   77 ATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKesEKTAEIILEYELLLLQGLNFHL 150
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 32-324 1.34e-45

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 158.46  E-value: 1.34e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052   32 YEASTQYRNWRYSPA-KLANVRASLNTAavtaIRTKFEVDEPGSSSTVSFLDADEEQLLVKLYISKIPQLCGHFR--FPE 108
Cdd:TIGR00569   1 YRNSSQKRHWTFTSEeQLQEKRADANAK----FREAHEEEEKVLEAKPIFLTPEEELDLVKYYEKRLLDFCSAFKptMPT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052  109 EVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNPITLESYTTHIPRT---SPSDVLDLEFLVAQSLGFEFAI 185
Cdd:TIGR00569  77 SVVGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFNVSIDQFVGNLKETplkALEQVLEYELLLIQQLNFHLIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052  186 WHAHRALWGIWLDLQSLLDAPADrPEEIYNTALGRVRSSRLTDVELIYTPPQIALACLSLASPDLALqwaNSKFASPTSS 265
Cdd:TIGR00569 157 HNPYRPLEGFLIDIKTRLPGLEN-PEYLRKHADKFLNRTLLTDAYLLYTPSQIALAAILHTASRAGL---NMESYLTEQL 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 597928052  266 PTSTPSPTSSALQTIVEAIKLVITQFgKPPDIESVREVDRRLRLCKNPEKVIGSKAYVA 324
Cdd:TIGR00569 233 SVPGNREELPQLIDIMRELRILVKKY-EEPRSEKVAALKKKLDECHSIEENLSSVKIRK 290
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 81-260 2.62e-26

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 106.74  E-value: 2.62e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052  81 LDADEEQLLVKLYISKIPQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNP--ITLESY-- 156
Cdd:COG5333   36 LTLEKELNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPrdISIESFea 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052 157 ---TTHIPRTSPSDVLDLEFLVAQSLGFEFAIWHAHRALWGIWLDLQSLLdapadrPEEIYNTALGRVRSSRLTDVELIY 233
Cdd:COG5333  116 rdlWSEEPKSSRERILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEKD------KYKLLQIAWKIINDALRTDLCLLY 189

                        170       180
                 ....*....|....*....|....*...
gi 597928052 234 TPPQIALACLSLASPDLALQ-WANSKFA 260
Cdd:COG5333  190 PPHIIALAALLIACEVLGMPiIKLLDFV 217
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 186-313 4.33e-26

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410229  Cd Length: 126  Bit Score: 101.22  E-value: 4.33e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052 186 WHAHRALWGIWLDLQSLLDAP-ADRPEEIYNTALGRVRSSRLTDVELIYTPPQIALACLSLASP---DLALQWANSKFAs 261
Cdd:cd20525    1 HHPYRPLEGFLLDLKTRLPDLkAENLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAASeagIDVEEYLSEKLP- 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 597928052 262 ptsspTSTPSPTSSALQTIVEAIKLVITQFGKPPDIESVREVDRRLRLCKNP 313
Cdd:cd20525   80 -----GSEESEELEKLLEIIREIKKLVKKYEGPPDKEEVKALDKKLKKCRNP 126
Cyclin_C_2 pfam16899
Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family ...
 187-259 7.63e-25

Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family corresponds with the C-terminal domain of some cyclins including cyclin C and cyclin H.


Pssm-ID: 465303  Cd Length: 98  Bit Score: 96.84  E-value: 7.63e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 597928052  187 HAHRALWGIWLDLQSLLDAPADRPEEIYNTALGRVRSSRLTDVELIYTPPQIALACLSLASPDLALQWANSKF 259
Cdd:pfam16899   1 HPFRPLEGFLLDLKTRPPLLEDRIESLYKRAREILKSALLTDAYFLYTPSQIALAALLLADSPLAEFYLTEKF 73
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 97-177 5.33e-13

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 63.77  E-value: 5.33e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052    97 IPQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNPITLESYTTHIPRTSPSDVLDLEFLVA 176
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFTEEEILRMERLLL 82


                   .
gi 597928052   177 Q 177
Cdd:smart00385  83 E 83
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 99-182 1.26e-04

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 41.35  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052   99 QLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTN-NPITLESYTTHIPRT-SPSDVLDLEFLVA 176
Cdd:pfam00134  40 EVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEiYPPTVEDLVYITDNAyTREEILRMERLIL 119


                  ....*.
gi 597928052  177 QSLGFE 182
Cdd:pfam00134 120 ETLNFD 125
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 33-183 1.76e-49

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 163.54  E-value: 1.76e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052  33 EASTQYRNWRY-SPAKLANVRASLNTAAVTAIRTKFEVDEPgsssTVSFLDADEEQLLVKLYISKIPQLCGHFRFPEEVE 111
Cdd:cd20524    1 HTSTQRKHWIFsSEEELAELRAEANEKAREKLKESLKEEDA----EPKFLTPEEELLLVRYYEKKLLEFCRAFKLPDSVL 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 597928052 112 ATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNPITLESYTTHIP--RTSPSDVLDLEFLVAQSLGFEF 183
Cdd:cd20524   77 ATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKesEKTAEIILEYELLLLQGLNFHL 150
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 32-324 1.34e-45

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 158.46  E-value: 1.34e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052   32 YEASTQYRNWRYSPA-KLANVRASLNTAavtaIRTKFEVDEPGSSSTVSFLDADEEQLLVKLYISKIPQLCGHFR--FPE 108
Cdd:TIGR00569   1 YRNSSQKRHWTFTSEeQLQEKRADANAK----FREAHEEEEKVLEAKPIFLTPEEELDLVKYYEKRLLDFCSAFKptMPT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052  109 EVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNPITLESYTTHIPRT---SPSDVLDLEFLVAQSLGFEFAI 185
Cdd:TIGR00569  77 SVVGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFNVSIDQFVGNLKETplkALEQVLEYELLLIQQLNFHLIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052  186 WHAHRALWGIWLDLQSLLDAPADrPEEIYNTALGRVRSSRLTDVELIYTPPQIALACLSLASPDLALqwaNSKFASPTSS 265
Cdd:TIGR00569 157 HNPYRPLEGFLIDIKTRLPGLEN-PEYLRKHADKFLNRTLLTDAYLLYTPSQIALAAILHTASRAGL---NMESYLTEQL 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 597928052  266 PTSTPSPTSSALQTIVEAIKLVITQFgKPPDIESVREVDRRLRLCKNPEKVIGSKAYVA 324
Cdd:TIGR00569 233 SVPGNREELPQLIDIMRELRILVKKY-EEPRSEKVAALKKKLDECHSIEENLSSVKIRK 290
CYCLIN_AcCycH_rpt1 cd20585
first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH ...
 32-182 2.34e-27

first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410288  Cd Length: 170  Bit Score: 106.07  E-value: 2.34e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052  32 YEASTQYRNWRYSPAKLANVRASLNTAAVTAIR----TKFEVD---------EPGSSSTVSF-----LDADEEQLLVKLY 93
Cdd:cd20585    2 FATSTHRQRWIFTPQDLTEKREAANQRAVDALQqcgaTRVEAQaagslgggaEVGGSNGKAAklpepLSADEELLMLKYY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052  94 ISKIPQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNPITLESYTTHIPRTsPSDVLDLEF 173
Cdd:cd20585   82 EQKIQEVCRALRLPNKIQATALLYFKRFYLQWSVMEHDPKRIMLTCIYLACKVEEYHVSAEELGKGIQQD-HQLILKNEL 160


                 ....*....
gi 597928052 174 LVAQSLGFE 182
Cdd:cd20585  161 ALLQGLNFD 169
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 81-260 2.62e-26

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 106.74  E-value: 2.62e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052  81 LDADEEQLLVKLYISKIPQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNP--ITLESY-- 156
Cdd:COG5333   36 LTLEKELNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPrdISIESFea 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052 157 ---TTHIPRTSPSDVLDLEFLVAQSLGFEFAIWHAHRALWGIWLDLQSLLdapadrPEEIYNTALGRVRSSRLTDVELIY 233
Cdd:COG5333  116 rdlWSEEPKSSRERILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEKD------KYKLLQIAWKIINDALRTDLCLLY 189

                        170       180
                 ....*....|....*....|....*...
gi 597928052 234 TPPQIALACLSLASPDLALQ-WANSKFA 260
Cdd:COG5333  190 PPHIIALAALLIACEVLGMPiIKLLDFV 217
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 186-313 4.33e-26

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410229  Cd Length: 126  Bit Score: 101.22  E-value: 4.33e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052 186 WHAHRALWGIWLDLQSLLDAP-ADRPEEIYNTALGRVRSSRLTDVELIYTPPQIALACLSLASP---DLALQWANSKFAs 261
Cdd:cd20525    1 HHPYRPLEGFLLDLKTRLPDLkAENLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAASeagIDVEEYLSEKLP- 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 597928052 262 ptsspTSTPSPTSSALQTIVEAIKLVITQFGKPPDIESVREVDRRLRLCKNP 313
Cdd:cd20525   80 -----GSEESEELEKLLEIIREIKKLVKKYEGPPDKEEVKALDKKLKKCRNP 126
Cyclin_C_2 pfam16899
Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family ...
 187-259 7.63e-25

Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family corresponds with the C-terminal domain of some cyclins including cyclin C and cyclin H.


Pssm-ID: 465303  Cd Length: 98  Bit Score: 96.84  E-value: 7.63e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 597928052  187 HAHRALWGIWLDLQSLLDAPADRPEEIYNTALGRVRSSRLTDVELIYTPPQIALACLSLASPDLALQWANSKF 259
Cdd:pfam16899   1 HPFRPLEGFLLDLKTRPPLLEDRIESLYKRAREILKSALLTDAYFLYTPSQIALAALLLADSPLAEFYLTEKF 73
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 97-177 5.33e-13

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 63.77  E-value: 5.33e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052    97 IPQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNPITLESYTTHIPRTSPSDVLDLEFLVA 176
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFTEEEILRMERLLL 82


                   .
gi 597928052   177 Q 177
Cdd:smart00385  83 E 83
CYCLIN_CCNC_rpt1 cd20513
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 90-179 5.91e-12

first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410217 [Multi-domain]  Cd Length: 101  Bit Score: 61.46  E-value: 5.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052  90 VKLYISK-IPQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNPI---TLESYTTHIPR--- 162
Cdd:cd20513    1 LHIFFANfIQALGERLKLRQRVIATAIVYFKRFYARNSFKDIDPRLVAPTCLYLASKVEECPSharLIVAEAKVLKTkfs 80

                         90       100
                 ....*....|....*....|.
gi 597928052 163 ----TSPSDVLDLEFLVAQSL 179
Cdd:cd20513   81 yefpYRVNDILECEFYLLEAL 101
CYCLIN_AcCycH_rpt2 cd20586
second cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; ...
 186-313 4.39e-10

second cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410289 [Multi-domain]  Cd Length: 132  Bit Score: 57.05  E-value: 4.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052 186 WHAHRALWGIWLDLQSLLDApADRPE-----EIYNTALGRVRSSRLTDVELIYTPPQIALACLSLASPDL-ALQWANSKF 259
Cdd:cd20586    1 YAPYRALEGFVQDLEEFLAA-GSGPDsqglqELRKAALAAVDKLMLTDAPLLYPPGQLALAALRSANKAKgGVDFDRYLE 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 597928052 260 ASPTSSPTSTPSPTSSALQTIVEAIKLVITQfGKPPDIESVREVDRRLRLCKNP 313
Cdd:cd20586   80 RVAARAASKMPDDPAAALTAVLDEIEYLVSE-GARPEVAEVKEIDRKLKECRAP 132
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 94-172 1.23e-09

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 54.34  E-value: 1.23e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 597928052  94 ISKIPQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNPITLESYTTHIpRTSPSDVLDLE 172
Cdd:cd00043    3 VDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVS-GVSEKELRKAE 80
CYCLIN_ScCTK2-like_rpt1 cd20547
first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar ...
 97-183 1.42e-08

first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar proteins; CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTK2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410250 [Multi-domain]  Cd Length: 110  Bit Score: 52.35  E-value: 1.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052  97 IPQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNP-----ITLESYT-THIPRTSPSD--- 167
Cdd:cd20547    9 ISQLCKKLKFPRRTLGTAMLLYQRFHLFNPFTDSSNYEVALACLFLASKIEDTQkkskdILAASYNlRHPDKISVDDqml 88

                         90       100
                 ....*....|....*....|..
gi 597928052 168 ------VLDLEFLVAQSLGFEF 183
Cdd:cd20547   89 eefrkaILGLERLLLETICFDF 110
CYCLIN_AtCycC_rpt1 cd20571
first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; ...
 85-181 9.66e-07

first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; Plant CycCs are the cognate cyclin partners of cyclin-dependent kinase CDK8. They may be involved in cell cycle control. CycCs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410274 [Multi-domain]  Cd Length: 107  Bit Score: 46.77  E-value: 9.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052  85 EEQLLVKLYISK-IPQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNPITLESYTTHIPRT 163
Cdd:cd20571    1 EDVKLIKIHMSNyIKKLAQHIKVRQRVVATAITYFRRVYTRKSFTEYDPRLVAPTCLYLASKAEESTVQAKLLVFYMKRL 80

                         90       100
                 ....*....|....*....|....*.
gi 597928052 164 SPS--------DVLDLEFLVAQSLGF 181
Cdd:cd20571   81 YADeyhryeikDILEMEMKLLEALDY 106
CYCLIN_CCNT1_rpt1 cd20595
first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor ...
 113-182 6.81e-06

first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor essential for HIV-1 replication in CD4 T cells and macrophages. It is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). CCNT1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410298 [Multi-domain]  Cd Length: 138  Bit Score: 45.43  E-value: 6.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052 113 TAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNPITLESY--TTH--------IPRT-------SPSDVLDLEFLV 175
Cdd:cd20595   52 TAIVYMHRFYMIQSFTQFHRNSVAPAALFLAAKVEEQPKKLEHVikVAHtclhpqesLPDTrseaylqQVQDLVILESII 131


                 ....*..
gi 597928052 176 AQSLGFE 182
Cdd:cd20595  132 LQTLGFE 138
CYCLIN_CCNT2_rpt1 cd20596
first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit ...
 113-182 1.15e-05

first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). CCNT2 contains two cyclin boxs. The model responds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410299 [Multi-domain]  Cd Length: 139  Bit Score: 44.65  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052 113 TAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNPITLESY--TTHI---PRTSPSD------------VLDLEFLV 175
Cdd:cd20596   53 TAIVYMHRFYMHHSFTKFHRNIISPTALFLAAKVEEQPRKLEHVikVAHAclnPLEPQLDtksdaylqqaqeLVILETIM 132


                 ....*..
gi 597928052 176 AQSLGFE 182
Cdd:cd20596  133 LQTLGFE 139
CYCLIN_SpCG1C-like_rpt1 cd20545
first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar ...
 97-146 1.86e-05

first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410248 [Multi-domain]  Cd Length: 116  Bit Score: 43.57  E-value: 1.86e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 597928052  97 IPQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKT 146
Cdd:cd20545   12 IIRVGSRLKLPQTTLFTAATYFHRFYMRNSLKKYHYYEIAATCLFLATKV 61
CYCLIN_CCNT_rpt1 cd20538
first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, ...
 113-182 9.35e-05

first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, cyclin-T1 (CCNT1) and cyclin-T2 (CCNT2), both of which are regulatory subunits of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410241 [Multi-domain]  Cd Length: 137  Bit Score: 41.99  E-value: 9.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052 113 TAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNPITLESY--TTH--IPRTSPS-------------DVLDLEFLV 175
Cdd:cd20538   51 TAIVYMHRFYMFHSFTKFHRNSIAAAALFLAAKVEEQPRKLEHVikVAHacLHRGEPDldtkseaylqqaqELVINENIL 130


                 ....*..
gi 597928052 176 AQSLGFE 182
Cdd:cd20538  131 LQTLGFE 137
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 99-182 1.26e-04

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 41.35  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052   99 QLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTN-NPITLESYTTHIPRT-SPSDVLDLEFLVA 176
Cdd:pfam00134  40 EVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEiYPPTVEDLVYITDNAyTREEILRMERLIL 119


                  ....*.
gi 597928052  177 QSLGFE 182
Cdd:pfam00134 120 ETLNFD 125
CYCLIN_CCNK_rpt1 cd20530
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ...
 80-182 1.38e-03

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410233 [Multi-domain]  Cd Length: 115  Bit Score: 37.98  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597928052  80 FLDADEEQLLVKLYISKIPQLCGHFRFPEEVEATAISYLKRFYLKNTVMDwHPKNVMLTA-LFLASKTTNNPITL----- 153
Cdd:cd20530    1 GIDPETEARYRREGARFIQDVGTKLGLPYDTIATGIVYFHRFYMFHSFKD-FDRYVTAACcLFLAGKVEETPKKCkdiik 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 597928052 154 -------ESYTTHIPRTSPSDVLDLEFLVAQSLGFE 182
Cdd:cd20530   80 tarsllnDKQFAQFGDDPKEEVMVLERILLQTIKFD 115
CYCLIN_AcCycT_rpt1 cd20587
first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; ...
 81-155 4.67e-03

first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; CycTs associate with their partner cyclin-dependent kinases (CDKs) to trigger their kinase activity. CycTs show high sequence similarity with metazoan cyclin-K (CCNK). CycTs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410290 [Multi-domain]  Cd Length: 124  Bit Score: 36.73  E-value: 4.67e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 597928052  81 LDADEEQLLVKLYISKIPQLCGHFRFPEEVEATAISYLKRFYLKNTVMDWHPKNVMLTALFLASKTTNNPITLES 155
Cdd:cd20587    3 IDLKKETYLRKSYCTFLQDLGMRLKVPQVTIATAIVFCHRFFLRQSHAKNDRQTIATVCMFLAGKVEETPRPLKD 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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