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Conserved domains on  [gi|568931218|ref|XP_006538918|]
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leucine-rich repeat-containing protein 38 isoform X1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
201-333 1.85e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 1.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 201 DVRKLLVAGNRIQQIPEDFFIFHGdLVYLDFRNNSLRSLEEgTFSGSGKLAFLDLSYNNLTQLGAgAFRSAGRLVKLSLA 280
Cdd:COG4886  114 NLESLDLSGNQLTDLPEELANLTN-LKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLS 190

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568931218 281 NNHLAGVHEAaFESLESLQVLELNDNNLRSLNvAALDALPALRTVRLDGN-----PWL 333
Cdd:COG4886  191 NNQITDLPEP-LGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNqltdlPEL 246
LRRNT smart00013
Leucine rich repeat N-terminal domain;
171-202 2.38e-03

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 35.37  E-value: 2.38e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568931218   171 ACPAGCACTDPHtVDCRDRGLPSVPDPFPLDV 202
Cdd:smart00013   1 ACPAPCNCSGTA-VDCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
201-333 1.85e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 1.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 201 DVRKLLVAGNRIQQIPEDFFIFHGdLVYLDFRNNSLRSLEEgTFSGSGKLAFLDLSYNNLTQLGAgAFRSAGRLVKLSLA 280
Cdd:COG4886  114 NLESLDLSGNQLTDLPEELANLTN-LKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLS 190

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568931218 281 NNHLAGVHEAaFESLESLQVLELNDNNLRSLNvAALDALPALRTVRLDGN-----PWL 333
Cdd:COG4886  191 NNQITDLPEP-LGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNqltdlPEL 246
LRR_8 pfam13855
Leucine rich repeat;
273-331 5.64e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 5.64e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568931218  273 RLVKLSLANNHLAGVHEAAFESLESLQVLELNDNNLRSLNVAALDALPALRTVRLDGNP 331
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 189-330 4.81e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.28  E-value: 4.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 189 RGLPSVPdpfpLDVRKLLVAGNRI-----QQIPEDFfIFHGDLVYLDFRNNSL-----RSLEEGtFSGSGKLAFLDLSYN 258
Cdd:cd00116  130 KGLKDLP----PALEKLVLGRNRLegascEALAKAL-RANRDLKELNLANNGIgdagiRALAEG-LKANCNLEVLDLNNN 203

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568931218 259 NLTQLGAGAFrsagrlvklslannhlagvhEAAFESLESLQVLELNDNNLRSLNVAAL-DALPA----LRTVRLDGN 330
Cdd:cd00116  204 GLTDEGASAL--------------------AETLASLKSLEVLNLGDNNLTDAGAAALaSALLSpnisLLTLSLSCN 260
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
186-334 3.95e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 3.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 186 CRDR-GLPSVPDPFPLDVRKLLVAGNRIQQIPEDffiFHGDLVYLDFRNNSLRSLEEgTFSGSgkLAFLDLSYNNLTQLG 264
Cdd:PRK15370 184 RLKIlGLTTIPACIPEQITTLILDNNELKSLPEN---LQGNIKTLYANSNQLTSIPA-TLPDT--IQEMELSINRITELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 265 AgafRSAGRLVKLSLANNHLAGVHEAAFESLESLQVLelnDNNLRS-----------LNVA--ALDALPA-----LRTVR 326
Cdd:PRK15370 258 E---RLPSALQSLDLFHNKISCLPENLPEELRYLSVY---DNSIRTlpahlpsgithLNVQsnSLTALPEtlppgLKTLE 331


                 ....*...
gi 568931218 327 LDGNPWLC 334
Cdd:PRK15370 332 AGENALTS 339
LRRNT smart00013
Leucine rich repeat N-terminal domain;
171-202 2.38e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 35.37  E-value: 2.38e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568931218   171 ACPAGCACTDPHtVDCRDRGLPSVPDPFPLDV 202
Cdd:smart00013   1 ACPAPCNCSGTA-VDCSGRGLTEVPLDLPPDT 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 171-199 3.34e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 34.91  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|....*....
gi 568931218  171 ACPAGCACTDPHtVDCRDRGLPSVPDPFP 199
Cdd:pfam01462   1 ACPVPCHCSATV-VNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
201-333 1.85e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 1.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 201 DVRKLLVAGNRIQQIPEDFFIFHGdLVYLDFRNNSLRSLEEgTFSGSGKLAFLDLSYNNLTQLGAgAFRSAGRLVKLSLA 280
Cdd:COG4886  114 NLESLDLSGNQLTDLPEELANLTN-LKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLS 190

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568931218 281 NNHLAGVHEAaFESLESLQVLELNDNNLRSLNvAALDALPALRTVRLDGN-----PWL 333
Cdd:COG4886  191 NNQITDLPEP-LGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNqltdlPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
183-341 6.93e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 6.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 183 TVDCRDRGLPSVPDPF-PLD-VRKLLVAGNRIQQIPEDFFIFHGdLVYLDFRNNSLRSLEEgTFSGSGKLAFLDLSYNNL 260
Cdd:COG4886  163 SLDLSNNQLTDLPEELgNLTnLKELDLSNNQITDLPEPLGNLTN-LEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQL 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 261 TQLGAgaFRSAGRLVKLSLANNHLAGVHEAAfeSLESLQVLELNDNNLRSLNVAALDALPALRTVRLDGNPWLCDCDFAH 340
Cdd:COG4886  241 TDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316


                 .
gi 568931218 341 L 341
Cdd:COG4886  317 L 317
LRR_8 pfam13855
Leucine rich repeat;
273-331 5.64e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 5.64e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568931218  273 RLVKLSLANNHLAGVHEAAFESLESLQVLELNDNNLRSLNVAALDALPALRTVRLDGNP 331
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
202-260 4.67e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 4.67e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568931218  202 VRKLLVAGNRIQQIPEDFFIFHGDLVYLDFRNNSLRSLEEGTFSGSGKLAFLDLSYNNL 260
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
253-308 9.82e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 9.82e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568931218  253 LDLSYNNLTQLGAGAFRSAGRLVKLSLANNHLAGVHEAAFESLESLQVLELNDNNL 308
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
226-284 1.04e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.04e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568931218  226 LVYLDFRNNSLRSLEEGTFSGSGKLAFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNHL 284
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 189-330 4.81e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.28  E-value: 4.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 189 RGLPSVPdpfpLDVRKLLVAGNRI-----QQIPEDFfIFHGDLVYLDFRNNSL-----RSLEEGtFSGSGKLAFLDLSYN 258
Cdd:cd00116  130 KGLKDLP----PALEKLVLGRNRLegascEALAKAL-RANRDLKELNLANNGIgdagiRALAEG-LKANCNLEVLDLNNN 203

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568931218 259 NLTQLGAGAFrsagrlvklslannhlagvhEAAFESLESLQVLELNDNNLRSLNVAAL-DALPA----LRTVRLDGN 330
Cdd:cd00116  204 GLTDEGASAL--------------------AETLASLKSLEVLNLGDNNLTDAGAAALaSALLSpnisLLTLSLSCN 260
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 188-331 2.66e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 2.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 188 DRGLPSVPDpfpLDV-RKLLVA---GNRIQQIPEDFFIFHgdLVYLDFRNNSLRSLEEgtFSGSGKLAFLDLSYNNLT-- 261
Cdd:cd21340   11 DKNITKIDN---LSLcKNLKVLylyDNKITKIENLEFLTN--LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISvv 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 262 -----------------QLGAG---AF--RS----AGRLVKLSLANNHLAGVHEaaFESLESLQVLELNDNNLRSLN--V 313
Cdd:cd21340   84 eglenltnleelhienqRLPPGeklTFdpRSlaalSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelL 161

                        170
                 ....*....|....*...
gi 568931218 314 AALDALPALRTVRLDGNP 331
Cdd:cd21340  162 DLLSSWPSLRELDLTGNP 179
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
186-334 3.95e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 3.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 186 CRDR-GLPSVPDPFPLDVRKLLVAGNRIQQIPEDffiFHGDLVYLDFRNNSLRSLEEgTFSGSgkLAFLDLSYNNLTQLG 264
Cdd:PRK15370 184 RLKIlGLTTIPACIPEQITTLILDNNELKSLPEN---LQGNIKTLYANSNQLTSIPA-TLPDT--IQEMELSINRITELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 265 AgafRSAGRLVKLSLANNHLAGVHEAAFESLESLQVLelnDNNLRS-----------LNVA--ALDALPA-----LRTVR 326
Cdd:PRK15370 258 E---RLPSALQSLDLFHNKISCLPENLPEELRYLSVY---DNSIRTlpahlpsgithLNVQsnSLTALPEtlppgLKTLE 331


                 ....*...
gi 568931218 327 LDGNPWLC 334
Cdd:PRK15370 332 AGENALTS 339
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 226-308 2.24e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 226 LVYLDFRNNSLRSLE----EGTFSGSGKLAFLDLSYNNLTQLGAGAFRSA-----GRLVKLSLANNHLAG-----VHEAA 291
Cdd:cd00116  195 LEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTDAGAAALASAllspnISLLTLSLSCNDITDdgakdLAEVL 274

                         90
                 ....*....|....*..
gi 568931218 292 FESlESLQVLELNDNNL 308
Cdd:cd00116  275 AEK-ESLLELDLRGNKF 290
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 232-330 5.28e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 5.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 232 RNNSLRSLEEgtFSGSGKLAFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNHLAGVHEAAFESLESLQVLELNDNNLRSL 311
Cdd:PLN00113 461 RNKFFGGLPD--SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQ 538

                         90
                 ....*....|....*....
gi 568931218 312 NVAALDALPALRTVRLDGN 330
Cdd:PLN00113 539 IPASFSEMPVLSQLDLSQN 557
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 187-337 7.27e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 7.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 187 RDRGLPSVPDPFPLD-VRKLLVAGNRIQQ-IPEDFFIFhGDLVYLDFRNNSLRSLEEGTFSGSGKLAFLDLSYNNLTQLG 264
Cdd:PLN00113 461 RNKFFGGLPDSFGSKrLENLDLSRNQFSGaVPRKLGSL-SELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQI 539

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568931218 265 AGAFRSAGRLVKLSLANNHLAGVHEAAFESLESLQVLELNDNNLRSlNVAALDALPALRTVRLDGNPWLCDCD 337
Cdd:PLN00113 540 PASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHG-SLPSTGAFLAINASAVAGNIDLCGGD 611
PLN03150 PLN03150
hypothetical protein; Provisional
 229-334 7.97e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.73  E-value: 7.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 229 LDFRNNSLRSLEEGTFSGSGKLAFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNHLAGVHEAAFESLESLQVLELNDNNL 308
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502

                         90       100
                 ....*....|....*....|....*..
gi 568931218 309 RSLNVAALDALPALRTV-RLDGNPWLC 334
Cdd:PLN03150 503 SGRVPAALGGRLLHRASfNFTDNAGLC 529
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 297-338 1.23e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568931218  297 SLQVLELNDNNLRSLNvaALDALPALRTVRLDGNPWLCDCDF 338
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITDLSD 41
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 215-315 1.90e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.91  E-value: 1.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218  215 IPEDFFiFHGDLVYLDFrNNSLRSLEEGTFSGSGKLAFLDLSyNNLTQLGAGAFRSAGrLVKLSLANNhLAGVHEAAFES 294
Cdd:pfam13306   3 IGSYAF-YNCSLTSITI-PSSLTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNCS-LTSITIPSS-LTSIGEYAFSN 77

                          90       100
                  ....*....|....*....|.
gi 568931218  295 LESLQVLELNdNNLRSLNVAA 315
Cdd:pfam13306  78 CSNLKSITLP-SNLTSIGSYA 97
LRRNT smart00013
Leucine rich repeat N-terminal domain;
171-202 2.38e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 35.37  E-value: 2.38e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568931218   171 ACPAGCACTDPHtVDCRDRGLPSVPDPFPLDV 202
Cdd:smart00013   1 ACPAPCNCSGTA-VDCSGRGLTEVPLDLPPDT 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 171-199 3.34e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 34.91  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|....*....
gi 568931218  171 ACPAGCACTDPHtVDCRDRGLPSVPDPFP 199
Cdd:pfam01462   1 ACPVPCHCSATV-VNCSDRGLTAVPRDLP 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 214-308 4.90e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 4.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 214 QIPEDFFIFHGDLVYLDFRNNSLR-SLEEGTFSGsgkLAFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNHLAGVHEAAF 292
Cdd:PLN00113 108 PIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPN---LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSL 184

                         90
                 ....*....|....*.
gi 568931218 293 ESLESLQVLELNDNNL 308
Cdd:PLN00113 185 TNLTSLEFLTLASNQL 200
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 273-308 5.20e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 5.20e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568931218  273 RLVKLSLANNHLAGVheAAFESLESLQVLELNDNNL 308
Cdd:pfam12799   2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNK 35
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
233-331 7.18e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.38  E-value: 7.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 233 NNSLRSLEEGTFSGSGKLAFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNhlagvheAAFESLESLQVLELNDNNLRSLN 312
Cdd:COG4886   57 LRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLP 129

                         90
                 ....*....|....*....
gi 568931218 313 vAALDALPALRTVRLDGNP 331
Cdd:COG4886  130 -EELANLTNLKELDLSNNQ 147
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
203-380 7.37e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.38  E-value: 7.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 203 RKLLVAGNRIQQIPEdffIFH-GDLVYLDFRNNSLRSLEEgtFSGSGKLAFLDLSYNNLTQLGAGAFRSAGRLVKLSLAN 281
Cdd:COG4886  231 ETLDLSNNQLTDLPE---LGNlTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568931218 282 NHLAGVHEAAFESLESLQVLELNDNNLRS-------LNVAALDALPALRTVRLDGNPWLCDCDFAHLFSWIQENTSKLPK 354
Cdd:COG4886  306 LLLNLLELLILLLLLTTLLLLLLLLKGLLvtlttlaLSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385

                        170       180
                 ....*....|....*....|....*.
gi 568931218 355 ATKKMLLHNPMVIILQLQSLRSRLAV 380
Cdd:COG4886  386 LLTLLLLLLTTTAGVLLLTLALLDAV 411
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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