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Conserved domains on  [gi|558134843|ref|XP_006091009|]
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T-lymphocyte activation antigen CD86 isoform X1 [Myotis lucifugus]

Protein Classification

IgV_CD86 domain-containing protein( domain architecture ID 11610713)

IgV_CD86 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CD86 cd16087
Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here ...
 50-158 1.43e-65

Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 86). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. The CTLA-4 and B7-2 monomers are both two-layer beta-sandwiches that display the chain topology characteristic of the immunoglobulin variable (V-type) domains present in antigen receptors. The front and back sheets of B7-2 are composed of AGFCC'C" and BED strands, respectively. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.


:

Pssm-ID: 409508  Cd Length: 108  Bit Score: 203.33  E-value: 1.43e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558134843  50 MKSQAYFNKIGDLPCHFTNPENISLDELVVFWQNQDKLVLYELFRGKENLQSVDANYKDRTSLDQDNWTLRLHNIQIKDK 129
Cdd:cd16087    1 LKIQAYFNETAYLPCQFKNPQNISLSELVVFWQDQKKLVLYELYLGKEKLDNVNSKYIGRTSFDQENWTLQLHNVQIKDQ 80

                         90       100
                 ....*....|....*....|....*....
gi 558134843 130 RLYQCFIYHRKNlQGMNLIHQNDIDLSVL 158
Cdd:cd16087   81 GTYQCFIHHKSP-KGLVLIHQMSSELSVI 108
 
Name Accession Description Interval E-value
IgV_CD86 cd16087
Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here ...
 50-158 1.43e-65

Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 86). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. The CTLA-4 and B7-2 monomers are both two-layer beta-sandwiches that display the chain topology characteristic of the immunoglobulin variable (V-type) domains present in antigen receptors. The front and back sheets of B7-2 are composed of AGFCC'C" and BED strands, respectively. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409508  Cd Length: 108  Bit Score: 203.33  E-value: 1.43e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558134843  50 MKSQAYFNKIGDLPCHFTNPENISLDELVVFWQNQDKLVLYELFRGKENLQSVDANYKDRTSLDQDNWTLRLHNIQIKDK 129
Cdd:cd16087    1 LKIQAYFNETAYLPCQFKNPQNISLSELVVFWQDQKKLVLYELYLGKEKLDNVNSKYIGRTSFDQENWTLQLHNVQIKDQ 80

                         90       100
                 ....*....|....*....|....*....
gi 558134843 130 RLYQCFIYHRKNlQGMNLIHQNDIDLSVL 158
Cdd:cd16087   81 GTYQCFIHHKSP-KGLVLIHQMSSELSVI 108
IGv smart00406
Immunoglobulin V-Type;
62-136 7.53e-07

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 46.61  E-value: 7.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558134843    62 LPCHFTNPENIsldELVVFWQNQDKLVLYELF--RGKENLQSVDANYKDRTSLDQDN----WTLRLHNIQIKDKRLYQCF 135
Cdd:smart00406   4 LSCKFSGSTFS---SYYVSWVRQPPGKGLEWLgyIGSNGSSYYQESYKGRFTISKDTskndVSLTISNLRVEDTGTYYCA 80


                   .
gi 558134843   136 I 136
Cdd:smart00406  81 V 81
 
Name Accession Description Interval E-value
IgV_CD86 cd16087
Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here ...
 50-158 1.43e-65

Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 86). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. The CTLA-4 and B7-2 monomers are both two-layer beta-sandwiches that display the chain topology characteristic of the immunoglobulin variable (V-type) domains present in antigen receptors. The front and back sheets of B7-2 are composed of AGFCC'C" and BED strands, respectively. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409508  Cd Length: 108  Bit Score: 203.33  E-value: 1.43e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558134843  50 MKSQAYFNKIGDLPCHFTNPENISLDELVVFWQNQDKLVLYELFRGKENLQSVDANYKDRTSLDQDNWTLRLHNIQIKDK 129
Cdd:cd16087    1 LKIQAYFNETAYLPCQFKNPQNISLSELVVFWQDQKKLVLYELYLGKEKLDNVNSKYIGRTSFDQENWTLQLHNVQIKDQ 80

                         90       100
                 ....*....|....*....|....*....
gi 558134843 130 RLYQCFIYHRKNlQGMNLIHQNDIDLSVL 158
Cdd:cd16087   81 GTYQCFIHHKSP-KGLVLIHQMSSELSVI 108
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 54-136 1.59e-08

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 52.22  E-value: 1.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558134843  54 AYFNKIGDLPCHFTNPENISLDELVVFWQ--NQDKLVlYELFRGKENLQSVDANYKDRTSLDQD-----NWTLRLHNIQI 126
Cdd:cd20934    9 ALVGTDATLRCSFSPEPGFSLAQLSVFWQltDTKQLV-HSFTESQDQGRDQGSAYANRTALFPDllaqgNASLRLQRVRV 87

                         90
                 ....*....|
gi 558134843 127 KDKRLYQCFI 136
Cdd:cd20934   88 ADEGSYTCFV 97
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 62-136 2.86e-08

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 51.23  E-value: 2.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558134843  62 LPCHFTNPEnisldELVVFWQNQD-KLVLYELFRGKENLQSVDANYKDRTSLDQD-----NWTLRLHNIQIKDKRLYQCF 135
Cdd:cd16091   17 LPCSFTPGS-----EVVIHWYKQDsDIKVHSYYYGKDQLESQDQRYRNRTSLFKDqisngNASLLLRRVQLQDEGRYKCY 91


                 .
gi 558134843 136 I 136
Cdd:cd16091   92 T 92
IgV_B7-H4 cd20984
Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the ...
 52-140 2.91e-08

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H4 (also known as B7-S1, B7x, or Vtcn1). B7-H4 is one of the B7 family of immune-regulatory ligands that act as negative regulators of T cell function; it contains one IgV domain and one IgC domain. The B7-family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. The binding of B7-H4 to unidentified receptors results in the inhibition of TCR-mediated T cell proliferation, cell-cycle progression and IL-2 production. As a co-inhibitory molecule, B7-H4 is widely expressed in tumor tissues and its expression is significantly associated with poor prognosis in human cancers such as glioma, pancreatic cancer, oral squamous cell carcinoma, renal cell carcinoma, and lung cancer.


Pssm-ID: 409576  Cd Length: 110  Bit Score: 51.45  E-value: 2.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558134843  52 SQAYFNKIGDLPCHFTnpENISLDELVVFWQNQ-DKLVLYELFRGKENLQSVDANYKDRTSLDQD-----NWTLRLHNIQ 125
Cdd:cd20984    7 LAGNIGEDGILSCTFT--PDIKLSDIVIQWLKEgDSGLVHEFKEGKDELSRQSPMFRGRTSLFADqvhvgNASLRLKNVQ 84

                         90
                 ....*....|....*
gi 558134843 126 IKDKRLYQCFIYHRK 140
Cdd:cd20984   85 LTDAGTYLCIISNSK 99
IgV_PDl1 cd20947
Immunoglobulin Variable (IgV) domain of Programmed death ligand 1 (PD-L1); The members here ...
 62-136 6.68e-07

Immunoglobulin Variable (IgV) domain of Programmed death ligand 1 (PD-L1); The members here are composed of the immunoglobulin variable (IgV) domain of Programmed death ligand 1 (PD-L1; also known as Cluster of Differentiation 274 (CD274)). PD-L1 is a cell-surface ligand that competes with PD-L2 for binding to the immunosuppressive receptor programmed death-1 (PD-1). PD-1 is a member of the B7 family that plays an important role in negatively regulating immune responses upon interaction with its two ligands, PD-L1 or PD-L2. Like PD-L2, PD-L1 interacts with PD-1 and suppresses T cell proliferation and cytokine production. The PD-1 receptor is expressed on the surface of activated T cells, while PD-L1 is expressed on cancer cells. When PD-1 and PD-L1 bind together, they form a molecular shield protecting tumor cells from being destroyed by the immune system. Thus, inhibiting the binding of PD-L1 to PD-1 with an antibody leads to killing of tumor cells by T cells. PD-1 inhibitors (such as Pembrolizumab, Nivolumab, and Cemiplimab) and PD-L1 inhibitors (such as Atezolizumab, Avelumab, and Durvalumab ) are an emerging class of immunotherapy that stimulate lymphocytes against tumor cells.


Pssm-ID: 409539  Cd Length: 110  Bit Score: 47.62  E-value: 6.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558134843  62 LPCHFTNPENISLDELVVFWQNQDKLVLyELFRGKENLQSVDANYKDRTSLDQD-----NWTLRLHNIQIKDKRLYQCFI 136
Cdd:cd20947   18 IECKFPVEKQLDLAALIVYWEMEDKNII-QFVHGEEDLKVQHSSYRQRARLLKDqlslgNAALQITDVKLQDAGVYRCMI 96
IGv smart00406
Immunoglobulin V-Type;
62-136 7.53e-07

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 46.61  E-value: 7.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558134843    62 LPCHFTNPENIsldELVVFWQNQDKLVLYELF--RGKENLQSVDANYKDRTSLDQDN----WTLRLHNIQIKDKRLYQCF 135
Cdd:smart00406   4 LSCKFSGSTFS---SYYVSWVRQPPGKGLEWLgyIGSNGSSYYQESYKGRFTISKDTskndVSLTISNLRVEDTGTYYCA 80


                   .
gi 558134843   136 I 136
Cdd:smart00406  81 V 81
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 61-135 2.47e-06

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 46.03  E-value: 2.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558134843  61 DLPCHFTnPEnISLDELVVFW-QNQDKLVLYeLFR-GKENLQSVDANYKDRTSLDQD-----NWTLRLHNIQIKDKRLYQ 133
Cdd:cd05713   19 ELPCHLS-PK-MSAEHMEVRWfRSQFSPVVH-LYRdGQDQEEEQMPEYRGRTELLKDaiaegSVALRIHNVRPSDEGQYT 95


                 ..
gi 558134843 134 CF 135
Cdd:cd05713   96 CF 97
IgV_CD80 cd16086
Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 80; The members here ...
 57-157 1.24e-05

Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 80; The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 80). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as cluster of differentiation 152/CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. CD80 contains two Ig-like domains, an amino-terminal immunoglobulin variable (IgV)-like domain characteristic of adhesion molecules and a membrane proximal immunoglobulin constant (IgC)-like domain similar to the constant domains of antigen receptors. Members of the Ig family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and Major Histocompatibility Complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, and the IgC domain is involved in oligomerization and molecular interactions.


Pssm-ID: 319335  Cd Length: 105  Bit Score: 43.59  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558134843  57 NKIGDLPCHFtnpeNISLDELV---VFWQNQDKLVLyELFRGKENlqsVDANYKDRTSLD-QDNWTLRLHNIQIKDKRLY 132
Cdd:cd16086    9 KEKALLSCDY----NVSVDELAqvrIYWQKDDKMVL-TIISGDVK---VWPEYKNRTLFDiTNNLSIVILALRLSDRGTY 80

                         90       100
                 ....*....|....*....|....*.
gi 558134843 133 QCFIyhRKNLQG-MNLIHQNDIDLSV 157
Cdd:cd16086   81 TCVV--QKKERGaYKREHLASVTLSV 104
IgV_B7-H2 cd20935
Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2); The members here are composed of ...
 62-137 5.19e-05

Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2); The members here are composed of the immunoglobulin variable (IgV) domain of B7-H2 (B7 homolog 2 also known as ICOSL (inducible T cell costimulator ligand) or CD275). B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS and acts as a costimulatory signal for T-cell proliferation and cytokine secretion. The interaction of ICOS with ICOSL (B7-H2) regulates T cell activation and expansion, is involved in T cell dependent B cell activation, and T-helper cell differentiation. It is a member of the B7 family of immune regulatory proteins and shares homology with other B7 ligands, such as B7-1, B7-2, B7-H1 (PD-L1), PD-L2, and B7-H3. The extracellular domains of B7 proteins contain two Ig-like domains and all members have short cytoplasmic domains. These ligands are typically expressed on antigen presenting cells (such as macrophages, B cells and dendritic cells) and have the ability to regulate T-cell proliferation and function. Tumor cells are also capable of expressing the B7 family members in order to evade immune surveillance.


Pssm-ID: 409529  Cd Length: 113  Bit Score: 42.16  E-value: 5.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558134843  62 LPCHFTNPENISLDELVVFWQ--NQDKLVLYELfRGKENLQSVDANYKDRT-----SLDQDNWTLRLHNIQIKDKRLYQC 134
Cdd:cd20935   13 LSCICPEGSRFDLNDLYVYWQisESETVVTYHL-PQNSSLENVDSHYRNRAllsldSMKQGDFSLRLFNVTPQDEQKFHC 91


                 ...
gi 558134843 135 FIY 137
Cdd:cd20935   92 LVF 94
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 68-140 7.47e-04

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 38.48  E-value: 7.47e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 558134843  68 NPENISLDELVVFWQ-NQDKLVLYELFRGKENLQSvdanYKDRTSLDQDNWTLRLHNIQIKDKRLYQCFIYHRK 140
Cdd:cd05775   16 TISSLQDDIDEIKWKkTKDKIVEWENNIGPTYFGS----FKDRVLLDKESGSLTIKNLTKEDSGTYELEITSTN 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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