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Conserved domains on  [gi|530416197|ref|XP_005258805|]
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trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X3 [Homo sapiens]

Protein Classification

-; -; Gfo/Idh/MocA family oxidoreductase; Gfo/Idh/MocA family oxidoreductase( domain architecture ID 11430574)

-; -; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; Gfo/Idh/MocA family oxidoreductase belonging to the NAD(P)(+)-binding Rossmann-fold superfamily catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to biliverdin reductase A (BLVRA)

CATH:  3.40.50.720
Gene Ontology:  GO:0016491|GO:0016651
PubMed:  26749496

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
13-135 9.54e-21

Predicted dehydrogenase [General function prediction only];


:

Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 87.67  E-value: 9.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416197  13 WTRFFPASEALRSVLAQGTLGDLRVARAEFGKNLIHVP---RAVDRAQAGGALLDIGIYCVQFTSMVFgGQKPEKISVVG 89
Cdd:COG0673  123 NRRFDPAVRAARELIDSGAIGEIRSVRARFGHPRPAGPadwRFDPELAGGGALLDLGIHDIDLARWLL-GSEPESVSATG 201

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530416197  90 RR---HETGVDDTVTVLLQYPGEVHGSFTCSITVQ---LSNTASVSGTKGMV 135
Cdd:COG0673  202 GRlvpDRVEVDDTAAATLRFANGAVATLEASWVAPggeRDERLEVYGTKGTL 253
 
Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
13-135 9.54e-21

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 87.67  E-value: 9.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416197  13 WTRFFPASEALRSVLAQGTLGDLRVARAEFGKNLIHVP---RAVDRAQAGGALLDIGIYCVQFTSMVFgGQKPEKISVVG 89
Cdd:COG0673  123 NRRFDPAVRAARELIDSGAIGEIRSVRARFGHPRPAGPadwRFDPELAGGGALLDLGIHDIDLARWLL-GSEPESVSATG 201

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530416197  90 RR---HETGVDDTVTVLLQYPGEVHGSFTCSITVQ---LSNTASVSGTKGMV 135
Cdd:COG0673  202 GRlvpDRVEVDDTAAATLRFANGAVATLEASWVAPggeRDERLEVYGTKGTL 253
GFO_IDH_MocA_C pfam02894
Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or ...
 24-133 2.74e-04

Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 427044  Cd Length: 203  Bit Score: 40.48  E-value: 2.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416197   24 RSVLAQGTLGDLRVARAefgkNLIHVPRA--------VDRAQAGGALLDIGIY---CVQFtsmVFGgqkPEKISVVGRRH 92
Cdd:pfam02894   1 KELIENGVLGEVVMVTV----HTRDPFRPpqefkrwrVDPEKSGGALYDLGIHtidLLIY---LFG---EPPSVVAVYAS 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 530416197   93 EtgvdDTVTVLLQYPGEVHGSF---TCSITVQLSNTASVSGTKG 133
Cdd:pfam02894  71 E----DTAFATLEFKNGAVGTLetsGGSIVEANGHRISIHGTKG 110
 
Name Accession Description Interval E-value
MviM COG0673
Predicted dehydrogenase [General function prediction only];
13-135 9.54e-21

Predicted dehydrogenase [General function prediction only];


Pssm-ID: 440437 [Multi-domain]  Cd Length: 295  Bit Score: 87.67  E-value: 9.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416197  13 WTRFFPASEALRSVLAQGTLGDLRVARAEFGKNLIHVP---RAVDRAQAGGALLDIGIYCVQFTSMVFgGQKPEKISVVG 89
Cdd:COG0673  123 NRRFDPAVRAARELIDSGAIGEIRSVRARFGHPRPAGPadwRFDPELAGGGALLDLGIHDIDLARWLL-GSEPESVSATG 201

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530416197  90 RR---HETGVDDTVTVLLQYPGEVHGSFTCSITVQ---LSNTASVSGTKGMV 135
Cdd:COG0673  202 GRlvpDRVEVDDTAAATLRFANGAVATLEASWVAPggeRDERLEVYGTKGTL 253
GFO_IDH_MocA_C pfam02894
Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or ...
 24-133 2.74e-04

Oxidoreductase family, C-terminal alpha/beta domain; This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.


Pssm-ID: 427044  Cd Length: 203  Bit Score: 40.48  E-value: 2.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416197   24 RSVLAQGTLGDLRVARAefgkNLIHVPRA--------VDRAQAGGALLDIGIY---CVQFtsmVFGgqkPEKISVVGRRH 92
Cdd:pfam02894   1 KELIENGVLGEVVMVTV----HTRDPFRPpqefkrwrVDPEKSGGALYDLGIHtidLLIY---LFG---EPPSVVAVYAS 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 530416197   93 EtgvdDTVTVLLQYPGEVHGSF---TCSITVQLSNTASVSGTKG 133
Cdd:pfam02894  71 E----DTAFATLEFKNGAVGTLetsGGSIVEANGHRISIHGTKG 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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