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Conserved domains on  [gi|17380150|sp|Q9UBF1|]
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RecName: Full=Melanoma-associated antigen C2; AltName: Full=Cancer/testis antigen 10; Short=CT10; AltName: Full=Hepatocellular carcinoma-associated antigen 587; AltName: Full=MAGE-C2 antigen; AltName: Full=MAGE-E1 antigen

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAGE super family cl03220
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 229-312 4.32e-05

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


The actual alignment was detected with superfamily member pfam01454:

Pssm-ID: 426270  Cd Length: 205  Bit Score: 44.18  E-value: 4.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380150   229 LLIIILSVIFIKGNCASEEVIWEVLNAVGV---YAGREHFVYGEPRELLTKVwVQGHYLEYREVPHSSP--PYYEFLWGP 303
Cdd:pfam01454 118 ILTVILSLILLSGGSISEQELLRYLRRLGIdtdGTKEIPPLNGNTDDLLKRL-VKQGYLVRTKEGASDDgeEIIEYRVGP 196


                  ....*....
gi 17380150   304 RAHSESIKK 312
Cdd:pfam01454 197 RAKVEFGPE 205
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 229-312 4.32e-05

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 44.18  E-value: 4.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380150   229 LLIIILSVIFIKGNCASEEVIWEVLNAVGV---YAGREHFVYGEPRELLTKVwVQGHYLEYREVPHSSP--PYYEFLWGP 303
Cdd:pfam01454 118 ILTVILSLILLSGGSISEQELLRYLRRLGIdtdGTKEIPPLNGNTDDLLKRL-VKQGYLVRTKEGASDDgeEIIEYRVGP 196


                  ....*....
gi 17380150   304 RAHSESIKK 312
Cdd:pfam01454 197 RAKVEFGPE 205
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 229-312 4.32e-05

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 44.18  E-value: 4.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380150   229 LLIIILSVIFIKGNCASEEVIWEVLNAVGV---YAGREHFVYGEPRELLTKVwVQGHYLEYREVPHSSP--PYYEFLWGP 303
Cdd:pfam01454 118 ILTVILSLILLSGGSISEQELLRYLRRLGIdtdGTKEIPPLNGNTDDLLKRL-VKQGYLVRTKEGASDDgeEIIEYRVGP 196


                  ....*....
gi 17380150   304 RAHSESIKK 312
Cdd:pfam01454 197 RAKVEFGPE 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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