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Conserved domains on  [gi|81873736|sp|Q8BGV3|]
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RecName: Full=Tumor-associated calcium signal transducer 2; AltName: Full=Cell surface glycoprotein Trop-2; Flags: Precursor

Protein Classification

TY domain-containing protein( domain architecture ID 11082431)

TY domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 67-139 1.07e-11

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 59.24  E-value: 1.07e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81873736    67 CLLLKARMSARKSGRslvmpsehaiLDNDGLYDPECDDKGRFKARQC-NQTSVCWCVNSVGVRR--TDKGDQSLRC 139
Cdd:pfam00086   1 CERERARALEQAASG----------RPASGLYIPNCDEDGFYKPVQChGSTGYCWCVDPEGQEIpgTRTRGGDPDC 66
 
Name Accession Description Interval E-value
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 67-139 1.07e-11

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 59.24  E-value: 1.07e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81873736    67 CLLLKARMSARKSGRslvmpsehaiLDNDGLYDPECDDKGRFKARQC-NQTSVCWCVNSVGVRR--TDKGDQSLRC 139
Cdd:pfam00086   1 CERERARALEQAASG----------RPASGLYIPNCDEDGFYKPVQChGSTGYCWCVDPEGQEIpgTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 66-139 3.02e-11

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 58.24  E-value: 3.02e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81873736  66 KCLLLKARMSARKSGRSlvmpsehaildNDGLYDPECDDKGRFKARQCN-QTSVCWCVNSVGVR--RTDKGDQSLRC 139
Cdd:cd00191   1 PCERERASALESLAGPK-----------LSGLYVPQCDEDGNYEPVQCHgSTGYCWCVDPDGEEipGTRTRGGPPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 100-141 1.51e-06

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 44.29  E-value: 1.51e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 81873736    100 PECDDKGRFKARQCNQTS-VCWCVNSVGVR--RTDKGDQSLRCDE 141
Cdd:smart00211   2 PQCDEDGNYEPVQCDGSSgQCWCVDATGREipGTRTEGGDPDCPS 46
 
Name Accession Description Interval E-value
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 67-139 1.07e-11

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 59.24  E-value: 1.07e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 81873736    67 CLLLKARMSARKSGRslvmpsehaiLDNDGLYDPECDDKGRFKARQC-NQTSVCWCVNSVGVRR--TDKGDQSLRC 139
Cdd:pfam00086   1 CERERARALEQAASG----------RPASGLYIPNCDEDGFYKPVQChGSTGYCWCVDPEGQEIpgTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 66-139 3.02e-11

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 58.24  E-value: 3.02e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 81873736  66 KCLLLKARMSARKSGRSlvmpsehaildNDGLYDPECDDKGRFKARQCN-QTSVCWCVNSVGVR--RTDKGDQSLRC 139
Cdd:cd00191   1 PCERERASALESLAGPK-----------LSGLYVPQCDEDGNYEPVQCHgSTGYCWCVDPDGEEipGTRTRGGPPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 100-141 1.51e-06

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 44.29  E-value: 1.51e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 81873736    100 PECDDKGRFKARQCNQTS-VCWCVNSVGVR--RTDKGDQSLRCDE 141
Cdd:smart00211   2 PQCDEDGNYEPVQCDGSSgQCWCVDATGREipGTRTEGGDPDCPS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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