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Conserved domains on  [gi|73620907|sp|Q5H8B9|]
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RecName: Full=FRAS1-related extracellular matrix protein 3; AltName: Full=NV domain-containing protein 2; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Frem_N pfam19309
Frem protein N-terminal domain; This entry represents a presumed domain found at the ...
 61-261 1.62e-116

Frem protein N-terminal domain; This entry represents a presumed domain found at the N-terminus of Frem related proteins.


:

Pssm-ID: 466034  Cd Length: 202  Bit Score: 367.04  E-value: 1.62e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907     61 ILIANSGFQVPQGRSVWLNPLRDLVIRVQRGDQCKVTVLD---FPRLQGALSPHQFPCDFGAQQVKYTHFGSPSSTRTRI 137
Cdd:pfam19309    1 ILIANRGLRVPFGRSVWLDPLRDLVIQVQPGDRCEVTVLDndpLPQRPGALSPRRFPCDFGPREVQYTHFGSRSPSRDRV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    138 QLQVRYDAGNSTLVLPFTLQVNVVFPKLQLVARNRPLKVFKVLGCSHAIDRRVLNFASRS---RCRLTVLPHPGGpLPKY 214
Cdd:pfam19309   81 RLQLRYDAPTDTLVLPFTLEVEVVFSQLEIVTRNLPLTVEKLLGTSNPIDRRVLEFAYDPgteRCKVTVLPGAGG-LPRY 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 73620907    215 GLLVDTAGNPLSrghlADCEAFIQAGVRYQHTTTPSSPSRDYVPMLV 261
Cdd:pfam19309  160 GRLVNATGAPLM----VDCEAFLRAGVRYQHTATTSSPNRDYVPMVV 202
Cadherin_3 pfam16184
Cadherin-like;
407-513 6.88e-28

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 109.61  E-value: 6.88e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    407 TSEPFAFMVVVKSMNVLAPIASYRGGLVVFEGQARPLSDALsFQVSDKDNSKE-IKIVAVRGLQHGQLVVHGAP-AGCKN 484
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDL-LQAEDPDTPPEdLTYTVVQGPSHGHLALKGAPgLPVTN 79

                           90       100
                   ....*....|....*....|....*....
gi 73620907    485 FTLADLSAGRVVYQHDGSDSYSDNIILKM 513
Cdd:pfam16184   80 FTQADIDSGLVVYVHDGSESTSDGFTFQV 108
Cadherin_3 pfam16184
Cadherin-like;
1509-1615 4.39e-26

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 104.61  E-value: 4.39e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1509 HSESRIFRIFVTEQDNKKPTLTI-QALALQRGDNIVVTPSQLTVEDEDTPADFILFTITQIPIHGRILYNGS--RPVTTF 1585
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTnTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGApgLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 73620907   1586 TKKDLTKSLI-YCHDGSETSKDSFSFTVTDG 1615
Cdd:pfam16184   81 TQADIDSGLVvYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1278-1394 7.21e-26

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 103.84  E-value: 7.21e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1278 HTTHTTVPIAVILVDDEVPQLTINDGLEIETGHSEIITNHILKAIDLDSDNKSLSFVLHSEPQQGLLQRLRKPGGDAKhn 1357
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVT-- 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 73620907   1358 ltvgmNFTQDEIDRGLIHYIHTGQ-GEAVDLKFDVTDG 1394
Cdd:pfam16184   79 -----NFTQADIDSGLVVYVHDGSeSTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
804-913 2.89e-25

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 102.30  E-value: 2.89e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    804 NSVSGTFTVFLQPLNNQPPKV-INRGFAVLEGDSFILGRGELNVSDPDTNDDQIFFILVWGPQHGHLQYFKKYMVPGESF 882
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLtTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 73620907    883 MLADVINGSISYQNSRDQTDSDVIYLEVSDG 913
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1400-1507 3.09e-22

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 93.44  E-value: 3.09e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1400 DRYFYITIDNSNSAVPEIVSKR-VTLTEGNRMTLTTELLNTSDIHSPGEQLLYSITRAPSTGHLESSDQPGEPMASFTQL 1478
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNFTQA 83

                           90       100
                   ....*....|....*....|....*....
gi 73620907   1479 QLARNKISYVHISNDKIKlDHFELRVTGG 1507
Cdd:pfam16184   84 DIDSGLVVYVHDGSESTS-DGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1167-1276 1.53e-21

Cadherin-like;


:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 91.51  E-value: 1.53e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1167 SPKVLLPLTILPTNDEQPQLFTRE-FVVLEGMSRVIDTSLVNGVDADFPSDK-HFRLTVFPQHGQITQQLATGsKPIHSF 1244
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDlTYTVVQGPSHGHLALKGAPG-LPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 73620907   1245 TLQEIQEpSSIAYEHDDSESTEDSFEVWLSDG 1276
Cdd:pfam16184   81 TQADIDS-GLVVYVHDGSESTSDGFTFQVTDG 111
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1855-2121 9.78e-19

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 93.32  E-value: 9.78e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1855 AALEFPEMATVEIVDPEDE--STVYIPEAEYQLAEAVGEFLVPV-RRSGDTSQELTVICSTRPGSATGTipsvqlslSDY 1931
Cdd:TIGR00845  379 AARKAVSMHEVATDDEENDpvSKIFFEPGHYTCLENCGTVALTVvRRGGDLTNTVYVDYRTEDGTANAG--------SDY 450

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1932 VSRpednTSMLHFEKDESEKTCQVLIINDSLYEEEESFSIALSLP---------------TGGQLGAKFpTARVTILADr 1996
Cdd:TIGR00845  451 EFT----EGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLrvgsedgileanhvsAVAQLASPN-TATVTILDD- 524

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1997 eDEPAL-HFECSEYHAEESAGYVEVAVWR----RGTglsqassVIVRSRGTEEQAAEAGTDYIGVRQHLHFSPGVSVQRL 2071
Cdd:TIGR00845  525 -DHAGIfTFEEDVFHVSESIGIMEVKVLRtsgaRGT-------VIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTI 596

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 73620907   2072 RVTILDDlpqPAFEGPEMFELLLQMPTgaVIGEPNKTTVTINDSVTNCEE 2121
Cdd:TIGR00845  597 RVKIVDD---EEYEKNDTFFIELGEPR--WAKRGIKAALLLNETITDDDQ 641
Cadherin_3 super family cl28802
Cadherin-like;
1045-1163 2.26e-18

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 82.65  E-value: 2.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1045 RVLVEVTVLPVDNMAPKVLVRKPFIVYEGGKNLLTPQHVNIEDVDTSKDEILCTLTVQPSSGYLENLapapgsevSRAGN 1124
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALK--------GAPGL 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 73620907   1125 PISAFFVKDVRVGCINYVqsiHKGIEPGADQFTFYCSDG 1163
Cdd:pfam16184   76 PVTNFTQADIDSGLVVYV---HDGSESTSDGFTFQVTDG 111
Cadherin_3 super family cl28802
Cadherin-like;
1632-1744 3.46e-18

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 81.88  E-value: 3.46e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1632 VPQTVWIQISPFDDRLPQMGINRGataLKLLHTGHlgFLITNEYLQATHQGVPHRLLTYKVTRGPEHGYIVNAGLGNENT 1711
Cdd:pfam16184    3 VPFTFNITIIPVNDEAPVLTTNTG---LRLWEGSS--RPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPV 77

                           90       100       110
                   ....*....|....*....|....*....|...
gi 73620907   1712 HMFTQADIDEMRVYYIlNKGrGRATRDTFYFSV 1744
Cdd:pfam16184   78 TNFTQADIDSGLVVYV-HDG-SESTSDGFTFQV 108
Cadherin_3 super family cl28802
Cadherin-like;
518-575 1.42e-16

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 77.26  E-value: 1.42e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 73620907    518 HRVDFLFPITIVPVDDAAPVLTANMGLSVTEGQVVQISPFVLCATDIDSEDSAILFVL 575
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTV 58
Cadherin_3 super family cl28802
Cadherin-like;
677-800 2.33e-14

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 71.09  E-value: 2.33e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    677 SNQHFFTISIQPADTSQPQLSPETTLEMTVQGYQ-LTPFQqkyLQYTDQNSDEQNLWYTLLTRPtdadsnhqvQAGEIVL 755
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRpITPDL---LQAEDPDTPPEDLTYTVVQGP---------SHGHLAL 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 73620907    756 TDSPGRPIVHFTQTQVNHQKIAYrppqRNLGIVPRVVQFTYKVED 800
Cdd:pfam16184   70 KGAPGLPVTNFTQADIDSGLVVY----VHDGSESTSDGFTFQVTD 110
Calx-beta super family cl02522
Calx-beta domain;
1764-1850 1.05e-09

Calx-beta domain;


The actual alignment was detected with superfamily member smart00237:

Pssm-ID: 413355 [Multi-domain]  Cd Length: 90  Bit Score: 57.26  E-value: 1.05e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    1764 ISLEKEYYIVDEDSPFFEVTL-RRGYLGGTSVVSIGTKGDTAEENKDFKGkAPMLVQFSPGQSTATWRVGLIPDTKYETS 1842
Cdd:smart00237    4 VGFEQPVYTVSESDGEVEVCVvRTGGARGPVVVPYSTEDGTATAGSDYEP-VPGELTFPPGETEKEIRIKIIDDDIYEKD 82


                    ....*...
gi 73620907    1843 ETFQIILS 1850
Cdd:smart00237   83 ETFYVRLS 90
Cadherin_3 super family cl28802
Cadherin-like;
315-381 1.47e-08

Cadherin-like;


The actual alignment was detected with superfamily member pfam16184:

Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 54.53  E-value: 1.47e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 73620907    315 TALTPDVLAAEDSESDPDDLVFNILNvpeaPPGHhggqGYVVNTDDPlGLPVSFFTQKELRELKIAY 381
Cdd:pfam16184   35 RPITPDLLQAEDPDTPPEDLTYTVVQ----GPSH----GHLALKGAP-GLPVTNFTQADIDSGLVVY 92
 
Name Accession Description Interval E-value
Frem_N pfam19309
Frem protein N-terminal domain; This entry represents a presumed domain found at the ...
 61-261 1.62e-116

Frem protein N-terminal domain; This entry represents a presumed domain found at the N-terminus of Frem related proteins.


Pssm-ID: 466034  Cd Length: 202  Bit Score: 367.04  E-value: 1.62e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907     61 ILIANSGFQVPQGRSVWLNPLRDLVIRVQRGDQCKVTVLD---FPRLQGALSPHQFPCDFGAQQVKYTHFGSPSSTRTRI 137
Cdd:pfam19309    1 ILIANRGLRVPFGRSVWLDPLRDLVIQVQPGDRCEVTVLDndpLPQRPGALSPRRFPCDFGPREVQYTHFGSRSPSRDRV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    138 QLQVRYDAGNSTLVLPFTLQVNVVFPKLQLVARNRPLKVFKVLGCSHAIDRRVLNFASRS---RCRLTVLPHPGGpLPKY 214
Cdd:pfam19309   81 RLQLRYDAPTDTLVLPFTLEVEVVFSQLEIVTRNLPLTVEKLLGTSNPIDRRVLEFAYDPgteRCKVTVLPGAGG-LPRY 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 73620907    215 GLLVDTAGNPLSrghlADCEAFIQAGVRYQHTTTPSSPSRDYVPMLV 261
Cdd:pfam19309  160 GRLVNATGAPLM----VDCEAFLRAGVRYQHTATTSSPNRDYVPMVV 202
Cadherin_3 pfam16184
Cadherin-like;
407-513 6.88e-28

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 109.61  E-value: 6.88e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    407 TSEPFAFMVVVKSMNVLAPIASYRGGLVVFEGQARPLSDALsFQVSDKDNSKE-IKIVAVRGLQHGQLVVHGAP-AGCKN 484
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDL-LQAEDPDTPPEdLTYTVVQGPSHGHLALKGAPgLPVTN 79

                           90       100
                   ....*....|....*....|....*....
gi 73620907    485 FTLADLSAGRVVYQHDGSDSYSDNIILKM 513
Cdd:pfam16184   80 FTQADIDSGLVVYVHDGSESTSDGFTFQV 108
Cadherin_3 pfam16184
Cadherin-like;
1509-1615 4.39e-26

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 104.61  E-value: 4.39e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1509 HSESRIFRIFVTEQDNKKPTLTI-QALALQRGDNIVVTPSQLTVEDEDTPADFILFTITQIPIHGRILYNGS--RPVTTF 1585
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTnTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGApgLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 73620907   1586 TKKDLTKSLI-YCHDGSETSKDSFSFTVTDG 1615
Cdd:pfam16184   81 TQADIDSGLVvYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1278-1394 7.21e-26

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 103.84  E-value: 7.21e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1278 HTTHTTVPIAVILVDDEVPQLTINDGLEIETGHSEIITNHILKAIDLDSDNKSLSFVLHSEPQQGLLQRLRKPGGDAKhn 1357
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVT-- 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 73620907   1358 ltvgmNFTQDEIDRGLIHYIHTGQ-GEAVDLKFDVTDG 1394
Cdd:pfam16184   79 -----NFTQADIDSGLVVYVHDGSeSTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
804-913 2.89e-25

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 102.30  E-value: 2.89e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    804 NSVSGTFTVFLQPLNNQPPKV-INRGFAVLEGDSFILGRGELNVSDPDTNDDQIFFILVWGPQHGHLQYFKKYMVPGESF 882
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLtTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 73620907    883 MLADVINGSISYQNSRDQTDSDVIYLEVSDG 913
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1400-1507 3.09e-22

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 93.44  E-value: 3.09e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1400 DRYFYITIDNSNSAVPEIVSKR-VTLTEGNRMTLTTELLNTSDIHSPGEQLLYSITRAPSTGHLESSDQPGEPMASFTQL 1478
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNFTQA 83

                           90       100
                   ....*....|....*....|....*....
gi 73620907   1479 QLARNKISYVHISNDKIKlDHFELRVTGG 1507
Cdd:pfam16184   84 DIDSGLVVYVHDGSESTS-DGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1167-1276 1.53e-21

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 91.51  E-value: 1.53e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1167 SPKVLLPLTILPTNDEQPQLFTRE-FVVLEGMSRVIDTSLVNGVDADFPSDK-HFRLTVFPQHGQITQQLATGsKPIHSF 1244
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDlTYTVVQGPSHGHLALKGAPG-LPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 73620907   1245 TLQEIQEpSSIAYEHDDSESTEDSFEVWLSDG 1276
Cdd:pfam16184   81 TQADIDS-GLVVYVHDGSESTSDGFTFQVTDG 111
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1855-2121 9.78e-19

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 93.32  E-value: 9.78e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1855 AALEFPEMATVEIVDPEDE--STVYIPEAEYQLAEAVGEFLVPV-RRSGDTSQELTVICSTRPGSATGTipsvqlslSDY 1931
Cdd:TIGR00845  379 AARKAVSMHEVATDDEENDpvSKIFFEPGHYTCLENCGTVALTVvRRGGDLTNTVYVDYRTEDGTANAG--------SDY 450

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1932 VSRpednTSMLHFEKDESEKTCQVLIINDSLYEEEESFSIALSLP---------------TGGQLGAKFpTARVTILADr 1996
Cdd:TIGR00845  451 EFT----EGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLrvgsedgileanhvsAVAQLASPN-TATVTILDD- 524

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1997 eDEPAL-HFECSEYHAEESAGYVEVAVWR----RGTglsqassVIVRSRGTEEQAAEAGTDYIGVRQHLHFSPGVSVQRL 2071
Cdd:TIGR00845  525 -DHAGIfTFEEDVFHVSESIGIMEVKVLRtsgaRGT-------VIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTI 596

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 73620907   2072 RVTILDDlpqPAFEGPEMFELLLQMPTgaVIGEPNKTTVTINDSVTNCEE 2121
Cdd:TIGR00845  597 RVKIVDD---EEYEKNDTFFIELGEPR--WAKRGIKAALLLNETITDDDQ 641
Cadherin_3 pfam16184
Cadherin-like;
1045-1163 2.26e-18

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 82.65  E-value: 2.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1045 RVLVEVTVLPVDNMAPKVLVRKPFIVYEGGKNLLTPQHVNIEDVDTSKDEILCTLTVQPSSGYLENLapapgsevSRAGN 1124
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALK--------GAPGL 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 73620907   1125 PISAFFVKDVRVGCINYVqsiHKGIEPGADQFTFYCSDG 1163
Cdd:pfam16184   76 PVTNFTQADIDSGLVVYV---HDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1632-1744 3.46e-18

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 81.88  E-value: 3.46e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1632 VPQTVWIQISPFDDRLPQMGINRGataLKLLHTGHlgFLITNEYLQATHQGVPHRLLTYKVTRGPEHGYIVNAGLGNENT 1711
Cdd:pfam16184    3 VPFTFNITIIPVNDEAPVLTTNTG---LRLWEGSS--RPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPV 77

                           90       100       110
                   ....*....|....*....|....*....|...
gi 73620907   1712 HMFTQADIDEMRVYYIlNKGrGRATRDTFYFSV 1744
Cdd:pfam16184   78 TNFTQADIDSGLVVYV-HDG-SESTSDGFTFQV 108
Cadherin_3 pfam16184
Cadherin-like;
518-575 1.42e-16

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 77.26  E-value: 1.42e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 73620907    518 HRVDFLFPITIVPVDDAAPVLTANMGLSVTEGQVVQISPFVLCATDIDSEDSAILFVL 575
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTV 58
Cadherin_3 pfam16184
Cadherin-like;
677-800 2.33e-14

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 71.09  E-value: 2.33e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    677 SNQHFFTISIQPADTSQPQLSPETTLEMTVQGYQ-LTPFQqkyLQYTDQNSDEQNLWYTLLTRPtdadsnhqvQAGEIVL 755
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRpITPDL---LQAEDPDTPPEDLTYTVVQGP---------SHGHLAL 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 73620907    756 TDSPGRPIVHFTQTQVNHQKIAYrppqRNLGIVPRVVQFTYKVED 800
Cdd:pfam16184   70 KGAPGLPVTNFTQADIDSGLVVY----VHDGSESTSDGFTFQVTD 110
Calx-beta pfam03160
Calx-beta domain;
2004-2094 4.07e-13

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 66.89  E-value: 4.07e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   2004 FECSEYHAEESAGYVEVAVWRRGTGLSQASSVIVRsrgTEEQAAEAGTDYIGVRQHLHFSPGVSVQRLRVTILDDLpqpA 2083
Cdd:pfam03160    6 FEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYR---TEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDD---V 79

                           90
                   ....*....|.
gi 73620907   2084 FEGPEMFELLL 2094
Cdd:pfam03160   80 YEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1874-1974 8.10e-12

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 63.04  E-value: 8.10e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    1874 STVYIPEAEYQLAEAVGEFLVPVRRSGDTSQELTVICSTRPGSATGTipsvqlslSDYVSRPEDntsmLHFEKDESEKTC 1953
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAG--------SDYEPVPGE----LTFPPGETEKEI 69

                            90       100
                    ....*....|....*....|.
gi 73620907    1954 QVLIINDSLYEEEESFSIALS 1974
Cdd:smart00237   70 RIKIIDDDIYEKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1764-1850 1.05e-09

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 57.26  E-value: 1.05e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    1764 ISLEKEYYIVDEDSPFFEVTL-RRGYLGGTSVVSIGTKGDTAEENKDFKGkAPMLVQFSPGQSTATWRVGLIPDTKYETS 1842
Cdd:smart00237    4 VGFEQPVYTVSESDGEVEVCVvRTGGARGPVVVPYSTEDGTATAGSDYEP-VPGELTFPPGETEKEIRIKIIDDDIYEKD 82


                    ....*...
gi 73620907    1843 ETFQIILS 1850
Cdd:smart00237   83 ETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
1764-1850 1.22e-09

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 56.87  E-value: 1.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1764 ISLEKEYYIVDEDSPFFEVT--LRRGYLGGTSVVSIGTKGDTAEENKDFKGKAPMLVqFSPGQSTATWRVGLIPDTKYET 1841
Cdd:pfam03160    4 IGFEPPTYQVSENDGVAEVCvvRMSGTLRRTVVVPYRTEDGTATAGDDYEPVEGELV-FGPGETEKCINVTIIDDDVYEG 82


                   ....*....
gi 73620907   1842 SETFQIILS 1850
Cdd:pfam03160   83 DENFFVLLS 91
Cadherin_3 pfam16184
Cadherin-like;
315-381 1.47e-08

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 54.53  E-value: 1.47e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 73620907    315 TALTPDVLAAEDSESDPDDLVFNILNvpeaPPGHhggqGYVVNTDDPlGLPVSFFTQKELRELKIAY 381
Cdd:pfam16184   35 RPITPDLLQAEDPDTPPEDLTYTVVQ----GPSH----GHLALKGAP-GLPVTNFTQADIDSGLVVY 92
 
Name Accession Description Interval E-value
Frem_N pfam19309
Frem protein N-terminal domain; This entry represents a presumed domain found at the ...
 61-261 1.62e-116

Frem protein N-terminal domain; This entry represents a presumed domain found at the N-terminus of Frem related proteins.


Pssm-ID: 466034  Cd Length: 202  Bit Score: 367.04  E-value: 1.62e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907     61 ILIANSGFQVPQGRSVWLNPLRDLVIRVQRGDQCKVTVLD---FPRLQGALSPHQFPCDFGAQQVKYTHFGSPSSTRTRI 137
Cdd:pfam19309    1 ILIANRGLRVPFGRSVWLDPLRDLVIQVQPGDRCEVTVLDndpLPQRPGALSPRRFPCDFGPREVQYTHFGSRSPSRDRV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    138 QLQVRYDAGNSTLVLPFTLQVNVVFPKLQLVARNRPLKVFKVLGCSHAIDRRVLNFASRS---RCRLTVLPHPGGpLPKY 214
Cdd:pfam19309   81 RLQLRYDAPTDTLVLPFTLEVEVVFSQLEIVTRNLPLTVEKLLGTSNPIDRRVLEFAYDPgteRCKVTVLPGAGG-LPRY 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 73620907    215 GLLVDTAGNPLSrghlADCEAFIQAGVRYQHTTTPSSPSRDYVPMLV 261
Cdd:pfam19309  160 GRLVNATGAPLM----VDCEAFLRAGVRYQHTATTSSPNRDYVPMVV 202
Cadherin_3 pfam16184
Cadherin-like;
407-513 6.88e-28

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 109.61  E-value: 6.88e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    407 TSEPFAFMVVVKSMNVLAPIASYRGGLVVFEGQARPLSDALsFQVSDKDNSKE-IKIVAVRGLQHGQLVVHGAP-AGCKN 484
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDL-LQAEDPDTPPEdLTYTVVQGPSHGHLALKGAPgLPVTN 79

                           90       100
                   ....*....|....*....|....*....
gi 73620907    485 FTLADLSAGRVVYQHDGSDSYSDNIILKM 513
Cdd:pfam16184   80 FTQADIDSGLVVYVHDGSESTSDGFTFQV 108
Cadherin_3 pfam16184
Cadherin-like;
1509-1615 4.39e-26

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 104.61  E-value: 4.39e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1509 HSESRIFRIFVTEQDNKKPTLTI-QALALQRGDNIVVTPSQLTVEDEDTPADFILFTITQIPIHGRILYNGS--RPVTTF 1585
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTnTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGApgLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 73620907   1586 TKKDLTKSLI-YCHDGSETSKDSFSFTVTDG 1615
Cdd:pfam16184   81 TQADIDSGLVvYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1278-1394 7.21e-26

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 103.84  E-value: 7.21e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1278 HTTHTTVPIAVILVDDEVPQLTINDGLEIETGHSEIITNHILKAIDLDSDNKSLSFVLHSEPQQGLLQRLRKPGGDAKhn 1357
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVT-- 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 73620907   1358 ltvgmNFTQDEIDRGLIHYIHTGQ-GEAVDLKFDVTDG 1394
Cdd:pfam16184   79 -----NFTQADIDSGLVVYVHDGSeSTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
804-913 2.89e-25

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 102.30  E-value: 2.89e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    804 NSVSGTFTVFLQPLNNQPPKV-INRGFAVLEGDSFILGRGELNVSDPDTNDDQIFFILVWGPQHGHLQYFKKYMVPGESF 882
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLtTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 73620907    883 MLADVINGSISYQNSRDQTDSDVIYLEVSDG 913
Cdd:pfam16184   81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1400-1507 3.09e-22

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 93.44  E-value: 3.09e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1400 DRYFYITIDNSNSAVPEIVSKR-VTLTEGNRMTLTTELLNTSDIHSPGEQLLYSITRAPSTGHLESSDQPGEPMASFTQL 1478
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNFTQA 83

                           90       100
                   ....*....|....*....|....*....
gi 73620907   1479 QLARNKISYVHISNDKIKlDHFELRVTGG 1507
Cdd:pfam16184   84 DIDSGLVVYVHDGSESTS-DGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1167-1276 1.53e-21

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 91.51  E-value: 1.53e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1167 SPKVLLPLTILPTNDEQPQLFTRE-FVVLEGMSRVIDTSLVNGVDADFPSDK-HFRLTVFPQHGQITQQLATGsKPIHSF 1244
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTgLRLWEGSSRPITPDLLQAEDPDTPPEDlTYTVVQGPSHGHLALKGAPG-LPVTNF 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 73620907   1245 TLQEIQEpSSIAYEHDDSESTEDSFEVWLSDG 1276
Cdd:pfam16184   81 TQADIDS-GLVVYVHDGSESTSDGFTFQVTDG 111
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1855-2121 9.78e-19

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 93.32  E-value: 9.78e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1855 AALEFPEMATVEIVDPEDE--STVYIPEAEYQLAEAVGEFLVPV-RRSGDTSQELTVICSTRPGSATGTipsvqlslSDY 1931
Cdd:TIGR00845  379 AARKAVSMHEVATDDEENDpvSKIFFEPGHYTCLENCGTVALTVvRRGGDLTNTVYVDYRTEDGTANAG--------SDY 450

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1932 VSRpednTSMLHFEKDESEKTCQVLIINDSLYEEEESFSIALSLP---------------TGGQLGAKFpTARVTILADr 1996
Cdd:TIGR00845  451 EFT----EGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLrvgsedgileanhvsAVAQLASPN-TATVTILDD- 524

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1997 eDEPAL-HFECSEYHAEESAGYVEVAVWR----RGTglsqassVIVRSRGTEEQAAEAGTDYIGVRQHLHFSPGVSVQRL 2071
Cdd:TIGR00845  525 -DHAGIfTFEEDVFHVSESIGIMEVKVLRtsgaRGT-------VIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTI 596

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 73620907   2072 RVTILDDlpqPAFEGPEMFELLLQMPTgaVIGEPNKTTVTINDSVTNCEE 2121
Cdd:TIGR00845  597 RVKIVDD---EEYEKNDTFFIELGEPR--WAKRGIKAALLLNETITDDDQ 641
Cadherin_3 pfam16184
Cadherin-like;
1045-1163 2.26e-18

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 82.65  E-value: 2.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1045 RVLVEVTVLPVDNMAPKVLVRKPFIVYEGGKNLLTPQHVNIEDVDTSKDEILCTLTVQPSSGYLENLapapgsevSRAGN 1124
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALK--------GAPGL 75

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 73620907   1125 PISAFFVKDVRVGCINYVqsiHKGIEPGADQFTFYCSDG 1163
Cdd:pfam16184   76 PVTNFTQADIDSGLVVYV---HDGSESTSDGFTFQVTDG 111
Cadherin_3 pfam16184
Cadherin-like;
1632-1744 3.46e-18

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 81.88  E-value: 3.46e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1632 VPQTVWIQISPFDDRLPQMGINRGataLKLLHTGHlgFLITNEYLQATHQGVPHRLLTYKVTRGPEHGYIVNAGLGNENT 1711
Cdd:pfam16184    3 VPFTFNITIIPVNDEAPVLTTNTG---LRLWEGSS--RPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPV 77

                           90       100       110
                   ....*....|....*....|....*....|...
gi 73620907   1712 HMFTQADIDEMRVYYIlNKGrGRATRDTFYFSV 1744
Cdd:pfam16184   78 TNFTQADIDSGLVVYV-HDG-SESTSDGFTFQV 108
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1764-1976 8.17e-18

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 90.62  E-value: 8.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1764 ISLEKEYYIVDEDSPFFEVTLRR--GYLGGTSVVSIGTKGDTAEENKDFKGKAPMLVqFSPGQSTATWRVGLIPDTKYET 1841
Cdd:TIGR00845  402 IFFEPGHYTCLENCGTVALTVVRrgGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLV-FKPGETQKEFRIGIIDDDIFEE 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1842 SETFQIILSEP---------------GAAALEFPEMATVEIVDPEDESTVYIPEAEYQLAEAVGEFLVPVRRSGDTSQEL 1906
Cdd:TIGR00845  481 DEHFYVRLSNLrvgsedgileanhvsAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTV 560

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1907 TVICSTRPGSATGtipsvqlSLSDYvsrpEDNTSMLHFEKDESEKTCQVLIINDSLYEEEESFSIALSLP 1976
Cdd:TIGR00845  561 IVPYRTVEGTARG-------GGKDF----EDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEP 619
Cadherin_3 pfam16184
Cadherin-like;
518-575 1.42e-16

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 77.26  E-value: 1.42e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 73620907    518 HRVDFLFPITIVPVDDAAPVLTANMGLSVTEGQVVQISPFVLCATDIDSEDSAILFVL 575
Cdd:pfam16184    1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTV 58
Cadherin_3 pfam16184
Cadherin-like;
677-800 2.33e-14

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 71.09  E-value: 2.33e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    677 SNQHFFTISIQPADTSQPQLSPETTLEMTVQGYQ-LTPFQqkyLQYTDQNSDEQNLWYTLLTRPtdadsnhqvQAGEIVL 755
Cdd:pfam16184    2 SVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRpITPDL---LQAEDPDTPPEDLTYTVVQGP---------SHGHLAL 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 73620907    756 TDSPGRPIVHFTQTQVNHQKIAYrppqRNLGIVPRVVQFTYKVED 800
Cdd:pfam16184   70 KGAPGLPVTNFTQADIDSGLVVY----VHDGSESTSDGFTFQVTD 110
Calx-beta pfam03160
Calx-beta domain;
2004-2094 4.07e-13

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 66.89  E-value: 4.07e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   2004 FECSEYHAEESAGYVEVAVWRRGTGLSQASSVIVRsrgTEEQAAEAGTDYIGVRQHLHFSPGVSVQRLRVTILDDLpqpA 2083
Cdd:pfam03160    6 FEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYR---TEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDD---V 79

                           90
                   ....*....|.
gi 73620907   2084 FEGPEMFELLL 2094
Cdd:pfam03160   80 YEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1874-1974 8.10e-12

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 63.04  E-value: 8.10e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    1874 STVYIPEAEYQLAEAVGEFLVPVRRSGDTSQELTVICSTRPGSATGTipsvqlslSDYVSRPEDntsmLHFEKDESEKTC 1953
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAG--------SDYEPVPGE----LTFPPGETEKEI 69

                            90       100
                    ....*....|....*....|.
gi 73620907    1954 QVLIINDSLYEEEESFSIALS 1974
Cdd:smart00237   70 RIKIIDDDIYEKDETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
1874-1974 2.75e-11

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 61.50  E-value: 2.75e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1874 STVYIPEAEYQLAEAVGEFLVPV-RRSGDTSQELTVICSTRPGSATGTipsvqlslSDYVSRPEDntsmLHFEKDESEKT 1952
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVvRMSGTLRRTVVVPYRTEDGTATAG--------DDYEPVEGE----LVFGPGETEKC 69

                           90       100
                   ....*....|....*....|..
gi 73620907   1953 CQVLIINDSLYEEEESFSIALS 1974
Cdd:pfam03160   70 INVTIIDDDVYEGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2004-2095 4.59e-10

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 58.03  E-value: 4.59e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    2004 FECSEYHAEESAGYVEVAVWRRGtGLSQASSVIVRsrgTEEQAAEAGTDYIGVRQHLHFSPGVSVQRLRVTILDDlpqPA 2083
Cdd:smart00237    6 FEQPVYTVSESDGEVEVCVVRTG-GARGPVVVPYS---TEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDD---DI 78

                            90
                    ....*....|..
gi 73620907    2084 FEGPEMFELLLQ 2095
Cdd:smart00237   79 YEKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1764-1850 1.05e-09

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 57.26  E-value: 1.05e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907    1764 ISLEKEYYIVDEDSPFFEVTL-RRGYLGGTSVVSIGTKGDTAEENKDFKGkAPMLVQFSPGQSTATWRVGLIPDTKYETS 1842
Cdd:smart00237    4 VGFEQPVYTVSESDGEVEVCVvRTGGARGPVVVPYSTEDGTATAGSDYEP-VPGELTFPPGETEKEIRIKIIDDDIYEKD 82


                    ....*...
gi 73620907    1843 ETFQIILS 1850
Cdd:smart00237   83 ETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
1764-1850 1.22e-09

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 56.87  E-value: 1.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620907   1764 ISLEKEYYIVDEDSPFFEVT--LRRGYLGGTSVVSIGTKGDTAEENKDFKGKAPMLVqFSPGQSTATWRVGLIPDTKYET 1841
Cdd:pfam03160    4 IGFEPPTYQVSENDGVAEVCvvRMSGTLRRTVVVPYRTEDGTATAGDDYEPVEGELV-FGPGETEKCINVTIIDDDVYEG 82


                   ....*....
gi 73620907   1842 SETFQIILS 1850
Cdd:pfam03160   83 DENFFVLLS 91
Cadherin_3 pfam16184
Cadherin-like;
315-381 1.47e-08

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 54.53  E-value: 1.47e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 73620907    315 TALTPDVLAAEDSESDPDDLVFNILNvpeaPPGHhggqGYVVNTDDPlGLPVSFFTQKELRELKIAY 381
Cdd:pfam16184   35 RPITPDLLQAEDPDTPPEDLTYTVVQ----GPSH----GHLALKGAP-GLPVTNFTQADIDSGLVVY 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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