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Conserved domains on  [gi|121954381|sp|Q16HH9|]
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RecName: Full=Mediator of RNA polymerase II transcription subunit 23; AltName: Full=Mediator complex subunit 23

Protein Classification

Med23 domain-containing protein( domain architecture ID 10569018)

Med23 domain-containing protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 3-1317 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


:

Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2283.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381     3 TDTQIIKLVEEIL-----CEKTNDYDYEGPMPDEaelqKRAEDGMKKFATVFAGMSQEVKENALRSCLIHVAGINHRNKV 77
Cdd:pfam11573    1 EVNQVKSIINEILkveiiEEAFSGFTSNLPDDEK----EKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381    78 RKHMQVLKDLVGKGIIPARLLCEQIMSSEKLVYQNQSFWIECFQVVRRVIGGVDYKGVREIMKCCKEKALSFPSGISSSI 157
Cdd:pfam11573   77 DFLFQLLEYAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEK 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   158 LPQMLELTEVIEHIFNRNACLLPAYFIINEIQKAdYQDT----HWRIANLIANFIEEFVIVAQMLSIIGHSSMLPIVEHS 233
Cdd:pfam11573  157 VPQLRALENVILYILDRNACLLPAYFIVNEIMKG-YPDAkmwpHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHS 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   234 SYADNLINPWKLDPTTLKLALRGNLPYEPELLQPQIKLLRFVLEQPYSRDMVCSMLNLQKTQKQKCMALEEQLVWLVMCA 313
Cdd:pfam11573  236 GYADHLTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQHKQRCKALEEQLVELMICA 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   314 MECSEKEPvhtvdgEISSHTQWVWLHLSSQLIYFVLFQFATFQNIVNTLHDKLAVSNLRRGRDHLMWVLLQYISGSIQRN 393
Cdd:pfam11573  316 MERSETEP------EDEPITHWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKN 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   394 SITNFLPILKLYDSLYPEKEPLPVPDYNNPLCTHQMAPTCIWIHLLKRAQSEHYNINRSIPTALKLHHEFLQHLVMPNNN 473
Cdd:pfam11573  390 PLSDFLPILKLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHLVLNNDS 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   474 ATLCMGSDYRLALLCNAYSTNPDYFSRPMAALIETILGNCKNPSAGGgstsaTQPLPTVPLSMSVLDSLTIHSKMSLIHS 553
Cdd:pfam11573  470 PNLAMGSDYRIALLCNAYSTNTEYFSRPMPALVETILGNSKSRSPGC-----NAPGPTTPLSMEFLDSLTVHSKMSLIHS 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   554 IVTHMIKQAQSKTTVPntnnMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSAAWGILYTLLEMFSYRMHHIQPH 633
Cdd:pfam11573  545 IVTHVIKFAQSKSSVA----LAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPH 620

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   634 YRVQLLSHLHSLASVPHTNQMQLHSCVESTALRLITGLGSVEVQAQMSRYVTEQKAPgnIVSAESEELNRALILTLARSM 713
Cdd:pfam11573  621 YRVQLLSHLHSLANVPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTF--LVSQESEELNRALILTLARAI 698

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   714 QITGTGNDPQSttWCKELLNSIMQNTPHTWSQHTLQCFPPVLNDLVVQHNVPKENKQLLKKSVDEEYRNWTSMSNENDII 793
Cdd:pfam11573  699 HITGTGTDSES--WCKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDII 776

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   794 GHFgtaGTPGTPPLFLCLLFKMIVETDTISPVAYKILERIGARALSAHLRKLCDYLVFEVSNSGDGAHVNKCVDTINDMI 873
Cdd:pfam11573  777 AHF---SVPGTPPLFLCLLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMI 853

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   874 WKYNIITIDRLVLCLSLRTLEGNEAQVSFCIIQLLLLKTSEFRNRLQEFVSINSPEHWKQNNWHERHLAFHQKFPEKFTP 953
Cdd:pfam11573  854 WKYNIVTIDRLVLCLALRPQEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAP 933

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   954 DE-----SVSHPSLPVYFGNVCLRFLPVLDITIHRYLEVPaAMSKTLDVLLDHLGPLYKFHDRPITYLYNTLHYYERMLR 1028
Cdd:pfam11573  934 EGvaeydSSSNPYLPTYFGNVCLRFLPVLDIVIHRALELP-PVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLR 1012

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381  1029 DRPQLKKRLVGTVIGSLKDVRPDNWAVTEQYQSYMSKK-DDAVNWMPDlNYYIYLVRRMQDTIDGTN--IFPGTDWRFNE 1105
Cdd:pfam11573 1013 DRPDLKRKLVSAIIGSLKDCRPPGWALTEAYEKYHQKSsDEQLIWLPE-DYYMKLIDRMVDTMDGKTppPFPAKDWRFNE 1091

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381  1106 FPNPPAHALYVTCVELLGLPVGPQGVANSLIDVVVKGYPVIPSQSVHNWINTIGLIMAALPESYWGVIYERLREVISCPQ 1185
Cdd:pfam11573 1092 FPNPGAHALYVTCVELMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPE 1171

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381  1186 MTDWLHRQSPFELFNFKIVREAMLEKNYVVILAIAQSILHHSGIGQISTVTEHIKENFKPIIKTEYQLIYLCHLVGPFLN 1265
Cdd:pfam11573 1172 LTNWTYPCSPFELFNFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQ 1251

                         1290      1300      1310      1320      1330
                   ....*....|....*....|....*....|....*....|....*....|..
gi 121954381  1266 RLCAERSRAVSDITLILYELLEQVDKAQpsLALKYMDPICDLLYHIKYMFIG 1317
Cdd:pfam11573 1252 RFRAERERGVLDITKLLYELLEQVDKEG--VELRYMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 3-1317 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2283.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381     3 TDTQIIKLVEEIL-----CEKTNDYDYEGPMPDEaelqKRAEDGMKKFATVFAGMSQEVKENALRSCLIHVAGINHRNKV 77
Cdd:pfam11573    1 EVNQVKSIINEILkveiiEEAFSGFTSNLPDDEK----EKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381    78 RKHMQVLKDLVGKGIIPARLLCEQIMSSEKLVYQNQSFWIECFQVVRRVIGGVDYKGVREIMKCCKEKALSFPSGISSSI 157
Cdd:pfam11573   77 DFLFQLLEYAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEK 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   158 LPQMLELTEVIEHIFNRNACLLPAYFIINEIQKAdYQDT----HWRIANLIANFIEEFVIVAQMLSIIGHSSMLPIVEHS 233
Cdd:pfam11573  157 VPQLRALENVILYILDRNACLLPAYFIVNEIMKG-YPDAkmwpHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHS 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   234 SYADNLINPWKLDPTTLKLALRGNLPYEPELLQPQIKLLRFVLEQPYSRDMVCSMLNLQKTQKQKCMALEEQLVWLVMCA 313
Cdd:pfam11573  236 GYADHLTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQHKQRCKALEEQLVELMICA 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   314 MECSEKEPvhtvdgEISSHTQWVWLHLSSQLIYFVLFQFATFQNIVNTLHDKLAVSNLRRGRDHLMWVLLQYISGSIQRN 393
Cdd:pfam11573  316 MERSETEP------EDEPITHWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKN 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   394 SITNFLPILKLYDSLYPEKEPLPVPDYNNPLCTHQMAPTCIWIHLLKRAQSEHYNINRSIPTALKLHHEFLQHLVMPNNN 473
Cdd:pfam11573  390 PLSDFLPILKLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHLVLNNDS 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   474 ATLCMGSDYRLALLCNAYSTNPDYFSRPMAALIETILGNCKNPSAGGgstsaTQPLPTVPLSMSVLDSLTIHSKMSLIHS 553
Cdd:pfam11573  470 PNLAMGSDYRIALLCNAYSTNTEYFSRPMPALVETILGNSKSRSPGC-----NAPGPTTPLSMEFLDSLTVHSKMSLIHS 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   554 IVTHMIKQAQSKTTVPntnnMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSAAWGILYTLLEMFSYRMHHIQPH 633
Cdd:pfam11573  545 IVTHVIKFAQSKSSVA----LAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPH 620

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   634 YRVQLLSHLHSLASVPHTNQMQLHSCVESTALRLITGLGSVEVQAQMSRYVTEQKAPgnIVSAESEELNRALILTLARSM 713
Cdd:pfam11573  621 YRVQLLSHLHSLANVPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTF--LVSQESEELNRALILTLARAI 698

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   714 QITGTGNDPQSttWCKELLNSIMQNTPHTWSQHTLQCFPPVLNDLVVQHNVPKENKQLLKKSVDEEYRNWTSMSNENDII 793
Cdd:pfam11573  699 HITGTGTDSES--WCKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDII 776

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   794 GHFgtaGTPGTPPLFLCLLFKMIVETDTISPVAYKILERIGARALSAHLRKLCDYLVFEVSNSGDGAHVNKCVDTINDMI 873
Cdd:pfam11573  777 AHF---SVPGTPPLFLCLLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMI 853

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   874 WKYNIITIDRLVLCLSLRTLEGNEAQVSFCIIQLLLLKTSEFRNRLQEFVSINSPEHWKQNNWHERHLAFHQKFPEKFTP 953
Cdd:pfam11573  854 WKYNIVTIDRLVLCLALRPQEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAP 933

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   954 DE-----SVSHPSLPVYFGNVCLRFLPVLDITIHRYLEVPaAMSKTLDVLLDHLGPLYKFHDRPITYLYNTLHYYERMLR 1028
Cdd:pfam11573  934 EGvaeydSSSNPYLPTYFGNVCLRFLPVLDIVIHRALELP-PVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLR 1012

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381  1029 DRPQLKKRLVGTVIGSLKDVRPDNWAVTEQYQSYMSKK-DDAVNWMPDlNYYIYLVRRMQDTIDGTN--IFPGTDWRFNE 1105
Cdd:pfam11573 1013 DRPDLKRKLVSAIIGSLKDCRPPGWALTEAYEKYHQKSsDEQLIWLPE-DYYMKLIDRMVDTMDGKTppPFPAKDWRFNE 1091

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381  1106 FPNPPAHALYVTCVELLGLPVGPQGVANSLIDVVVKGYPVIPSQSVHNWINTIGLIMAALPESYWGVIYERLREVISCPQ 1185
Cdd:pfam11573 1092 FPNPGAHALYVTCVELMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPE 1171

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381  1186 MTDWLHRQSPFELFNFKIVREAMLEKNYVVILAIAQSILHHSGIGQISTVTEHIKENFKPIIKTEYQLIYLCHLVGPFLN 1265
Cdd:pfam11573 1172 LTNWTYPCSPFELFNFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQ 1251

                         1290      1300      1310      1320      1330
                   ....*....|....*....|....*....|....*....|....*....|..
gi 121954381  1266 RLCAERSRAVSDITLILYELLEQVDKAQpsLALKYMDPICDLLYHIKYMFIG 1317
Cdd:pfam11573 1252 RFRAERERGVLDITKLLYELLEQVDKEG--VELRYMDPICDLLYHIKYMFVG 1301
 
Name Accession Description Interval E-value
Med23 pfam11573
Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator ...
 3-1317 0e+00

Mediator complex subunit 23; Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.


Pssm-ID: 463299  Cd Length: 1301  Bit Score: 2283.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381     3 TDTQIIKLVEEIL-----CEKTNDYDYEGPMPDEaelqKRAEDGMKKFATVFAGMSQEVKENALRSCLIHVAGINHRNKV 77
Cdd:pfam11573    1 EVNQVKSIINEILkveiiEEAFSGFTSNLPDDEK----EKTAILRKQFNNMMSKMSEEEKESLVKELIKLVHHVAEKNRL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381    78 RKHMQVLKDLVGKGIIPARLLCEQIMSSEKLVYQNQSFWIECFQVVRRVIGGVDYKGVREIMKCCKEKALSFPSGISSSI 157
Cdd:pfam11573   77 DFLFQLLEYAVQKGIISARLVCEGLIMSEKLVLCNRLFWQECFKLIRKIIPGVDYKGVREILKYCLEKARRLPYSLSPEK 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   158 LPQMLELTEVIEHIFNRNACLLPAYFIINEIQKAdYQDT----HWRIANLIANFIEEFVIVAQMLSIIGHSSMLPIVEHS 233
Cdd:pfam11573  157 VPQLRALENVILYILDRNACLLPAYFIVNEIMKG-YPDAkmwpHWRLAELLSNFVESFRPIAQMVSIIGRSFMLPVVEHS 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   234 SYADNLINPWKLDPTTLKLALRGNLPYEPELLQPQIKLLRFVLEQPYSRDMVCSMLNLQKTQKQKCMALEEQLVWLVMCA 313
Cdd:pfam11573  236 GYADHLTSPWKLDPATLKFQLKGNLPYRPELLEPQTYLLRYVLEQPYSRDMVCSMLGLQKQHKQRCKALEEQLVELMICA 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   314 MECSEKEPvhtvdgEISSHTQWVWLHLSSQLIYFVLFQFATFQNIVNTLHDKLAVSNLRRGRDHLMWVLLQYISGSIQRN 393
Cdd:pfam11573  316 MERSETEP------EDEPITHWLWLHLSSQLIYFVLFQFASFPNIVKSLHEKLAGRDLTRGRDHLMWVLLQFISGSIQKN 389

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   394 SITNFLPILKLYDSLYPEKEPLPVPDYNNPLCTHQMAPTCIWIHLLKRAQSEHYNINRSIPTALKLHHEFLQHLVMPNNN 473
Cdd:pfam11573  390 PLSDFLPILKLYDLLYPEKEPLPVPDYNKPLCTHQMAATCIWIHLLKKAQDENQKLQRPIPDTLKSHHEFLQHLVLNNDS 469

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   474 ATLCMGSDYRLALLCNAYSTNPDYFSRPMAALIETILGNCKNPSAGGgstsaTQPLPTVPLSMSVLDSLTIHSKMSLIHS 553
Cdd:pfam11573  470 PNLAMGSDYRIALLCNAYSTNTEYFSRPMPALVETILGNSKSRSPGC-----NAPGPTTPLSMEFLDSLTVHSKMSLIHS 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   554 IVTHMIKQAQSKTTVPntnnMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSAAWGILYTLLEMFSYRMHHIQPH 633
Cdd:pfam11573  545 IVTHVIKFAQSKSSVA----LAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSQAWGILHTLLEMFSYRMHHIQPH 620

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   634 YRVQLLSHLHSLASVPHTNQMQLHSCVESTALRLITGLGSVEVQAQMSRYVTEQKAPgnIVSAESEELNRALILTLARSM 713
Cdd:pfam11573  621 YRVQLLSHLHSLANVPQTNQTQLHLCVESTALRLITGLGSSEVQPQLSRFLNEPKTF--LVSQESEELNRALILTLARAI 698

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   714 QITGTGNDPQSttWCKELLNSIMQNTPHTWSQHTLQCFPPVLNDLVVQHNVPKENKQLLKKSVDEEYRNWTSMSNENDII 793
Cdd:pfam11573  699 HITGTGTDSES--WCKELLETIMQNTPHGWPQHTLSCFPPWLLEFFKQNNVPKENKQQLKKNVEEEYRKWTSMTNENDII 776

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   794 GHFgtaGTPGTPPLFLCLLFKMIVETDTISPVAYKILERIGARALSAHLRKLCDYLVFEVSNSGDGAHVNKCVDTINDMI 873
Cdd:pfam11573  777 AHF---SVPGTPPLFLCLLWKMLLETDRITPIAYKVLERIGARALSAHLRKFCDYLVFEFTNSCGGQHVNKCADALNDMI 853

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   874 WKYNIITIDRLVLCLSLRTLEGNEAQVSFCIIQLLLLKTSEFRNRLQEFVSINSPEHWKQNNWHERHLAFHQKFPEKFTP 953
Cdd:pfam11573  854 WKYNIVTIDRLVLCLALRPQEGNEAQVCFFIIQLLLLKTTEFRNRVQDFVKENSPEHWKQPNWHEKHLAYHRKFPEKFAP 933

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381   954 DE-----SVSHPSLPVYFGNVCLRFLPVLDITIHRYLEVPaAMSKTLDVLLDHLGPLYKFHDRPITYLYNTLHYYERMLR 1028
Cdd:pfam11573  934 EGvaeydSSSNPYLPTYFGNVCLRFLPVLDIVIHRALELP-PVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLR 1012

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381  1029 DRPQLKKRLVGTVIGSLKDVRPDNWAVTEQYQSYMSKK-DDAVNWMPDlNYYIYLVRRMQDTIDGTN--IFPGTDWRFNE 1105
Cdd:pfam11573 1013 DRPDLKRKLVSAIIGSLKDCRPPGWALTEAYEKYHQKSsDEQLIWLPE-DYYMKLIDRMVDTMDGKTppPFPAKDWRFNE 1091

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381  1106 FPNPPAHALYVTCVELLGLPVGPQGVANSLIDVVVKGYPVIPSQSVHNWINTIGLIMAALPESYWGVIYERLREVISCPQ 1185
Cdd:pfam11573 1092 FPNPGAHALYVTCVELMALPVSPETVANALIDVVQKGYHLIPRNQIHLWINAIGLILTALPESYWSVLHDRIVEVLSNPE 1171

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121954381  1186 MTDWLHRQSPFELFNFKIVREAMLEKNYVVILAIAQSILHHSGIGQISTVTEHIKENFKPIIKTEYQLIYLCHLVGPFLN 1265
Cdd:pfam11573 1172 LTNWTYPCSPFELFNFDNYHESLLENRASYILALAHAVWHHAGIGQLNPFPQFVKEKLLPHVKTEEQLLYLCHLVGPFLQ 1251

                         1290      1300      1310      1320      1330
                   ....*....|....*....|....*....|....*....|....*....|..
gi 121954381  1266 RLCAERSRAVSDITLILYELLEQVDKAQpsLALKYMDPICDLLYHIKYMFIG 1317
Cdd:pfam11573 1252 RFRAERERGVLDITKLLYELLEQVDKEG--VELRYMDPICDLLYHIKYMFVG 1301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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