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Conserved domains on  [gi|20981701|sp|Q14974|]
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RecName: Full=Importin subunit beta-1; AltName: Full=Importin-90; AltName: Full=Karyopherin subunit beta-1; AltName: Full=Nuclear factor p97; AltName: Full=Pore targeting complex 97 kDa subunit; Short=PTAC97

Protein Classification

importin beta family protein( domain architecture ID 707677)

importin beta family protein may function in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
2-871 0e+00

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 613.87  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701   2 ELITILEKTV-SPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRW 80
Cdd:COG5215   5 EFRCLGKNHVlSPDPNARLRAEAQLLELQSGDFEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHANDPELQKGCSQRW 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701  81 LAIDANARREVKNYVLQTLGTETYR-PSSASQCVAGIACAEIPVNQWPELIPQLVANVTNpNSTEHMKESTLEAIGYICQ 159
Cdd:COG5215  85 LGMRHESKEQVKGMALRALKSPEPRfCTMAAQLLAAIARMELPNSLWPGLMEEMVRNVGD-EQPVSGKCESLGICGYHCE 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 160 DIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQ 239
Cdd:COG5215 164 SEAPEDLIQMSNVILFAIVMGALKNETTSAVRLAALKALMDSLMFVQGNFCYEEERNYFMQVVCEATQGNDEELQHAAFG 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 240 NLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQgrpPEHTSKFyAKGAL 319
Cdd:COG5215 244 CLNKIMMLYYKFMQSYMENALAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEV---PAQNHGF-ARAAV 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 320 QYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEP 399
Cdd:COG5215 320 ADVLPELLSLLEKQGEDYYGDDWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGPCE 399

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 400 SQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAE 479
Cdd:COG5215 400 DCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHLVLEVSASLIGLMDCPFRSINCSWRKENLVD 479

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 480 aayEAADVADDQEEPatycLSSSFELIVQKLLETTDRPDgHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQ 559
Cdd:COG5215 480 ---HIAKAVREVESF----LAKFYLAILNALVKGTELAL-NESNLRVSLFSALGTLILICPDAVSDILAGFYDYTSKKLD 551

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 560 QVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKvQHQDALQISDVVMASLLRMFQSTAgSGGVQEDALMAVSTLVEVL 639
Cdd:COG5215 552 ECISVLGQILATEDQLLVEELQSNYIGVLEAIIRT-RRRDIEDVEDQLMELFIRILESTK-PTTAFGDVYTAISALSTSL 629

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 640 GGEFLKYMEAFKPFLGIGLkNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGD 719
Cdd:COG5215 630 EERFEQYASKFIPYLTRAL-NCTDRFVLNSAVGLVGDLANTLGTDFNIYADVLMSSLVQCLSSEATHRDLKPAILSVFGD 708

                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 720 IALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGlkgdqenVHPDVMLVQPRVEFILS 799
Cdd:COG5215 709 IALAIGANFESYLDMIMMLFQQASELDPHSDEVYVDDYRKNAVQLVNCAYVGIGDS-------SKNRVRSVLPYVISIFH 781

                       810       820       830       840       850       860       870
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20981701 800 FIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKA-KTLATWATKELRK 871
Cdd:COG5215 782 KIGMIAEDPNGSEAHTRAALGLIGDLAGMFPKGELKFGLDEDWVKDFLYGMMKKISSQQtKDSARWAAEQVKR 854
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
2-871 0e+00

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 613.87  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701   2 ELITILEKTV-SPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRW 80
Cdd:COG5215   5 EFRCLGKNHVlSPDPNARLRAEAQLLELQSGDFEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHANDPELQKGCSQRW 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701  81 LAIDANARREVKNYVLQTLGTETYR-PSSASQCVAGIACAEIPVNQWPELIPQLVANVTNpNSTEHMKESTLEAIGYICQ 159
Cdd:COG5215  85 LGMRHESKEQVKGMALRALKSPEPRfCTMAAQLLAAIARMELPNSLWPGLMEEMVRNVGD-EQPVSGKCESLGICGYHCE 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 160 DIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQ 239
Cdd:COG5215 164 SEAPEDLIQMSNVILFAIVMGALKNETTSAVRLAALKALMDSLMFVQGNFCYEEERNYFMQVVCEATQGNDEELQHAAFG 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 240 NLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQgrpPEHTSKFyAKGAL 319
Cdd:COG5215 244 CLNKIMMLYYKFMQSYMENALAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEV---PAQNHGF-ARAAV 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 320 QYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEP 399
Cdd:COG5215 320 ADVLPELLSLLEKQGEDYYGDDWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGPCE 399

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 400 SQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAE 479
Cdd:COG5215 400 DCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHLVLEVSASLIGLMDCPFRSINCSWRKENLVD 479

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 480 aayEAADVADDQEEPatycLSSSFELIVQKLLETTDRPDgHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQ 559
Cdd:COG5215 480 ---HIAKAVREVESF----LAKFYLAILNALVKGTELAL-NESNLRVSLFSALGTLILICPDAVSDILAGFYDYTSKKLD 551

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 560 QVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKvQHQDALQISDVVMASLLRMFQSTAgSGGVQEDALMAVSTLVEVL 639
Cdd:COG5215 552 ECISVLGQILATEDQLLVEELQSNYIGVLEAIIRT-RRRDIEDVEDQLMELFIRILESTK-PTTAFGDVYTAISALSTSL 629

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 640 GGEFLKYMEAFKPFLGIGLkNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGD 719
Cdd:COG5215 630 EERFEQYASKFIPYLTRAL-NCTDRFVLNSAVGLVGDLANTLGTDFNIYADVLMSSLVQCLSSEATHRDLKPAILSVFGD 708

                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 720 IALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGlkgdqenVHPDVMLVQPRVEFILS 799
Cdd:COG5215 709 IALAIGANFESYLDMIMMLFQQASELDPHSDEVYVDDYRKNAVQLVNCAYVGIGDS-------SKNRVRSVLPYVISIFH 781

                       810       820       830       840       850       860       870
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20981701 800 FIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKA-KTLATWATKELRK 871
Cdd:COG5215 782 KIGMIAEDPNGSEAHTRAALGLIGDLAGMFPKGELKFGLDEDWVKDFLYGMMKKISSQQtKDSARWAAEQVKR 854
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 380-435 9.22e-12

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 60.84  E-value: 9.22e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 20981701   380 WRYRDAAVMAFGCILEGpEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRI 435
Cdd:pfam13513   1 WRVREAAALALGSLAEG-GPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 21-101 8.63e-08

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 49.93  E-value: 8.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701     21 AQKFLERAavENLPTFLVELSRVLANPGNSQVaRVAAGLQIKNSLTSkdpdikaqyqqRWLAIDANARREVKNYVLQTLG 100
Cdd:smart00913   1 AEKQLEQF--QKSPGFWLLLLEILANSEDQYV-RQLAAITLKNKITR-----------RWSSLPEEEKEEIKNSLLELLL 66


                   .
gi 20981701    101 T 101
Cdd:smart00913  67 S 67
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
2-871 0e+00

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 613.87  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701   2 ELITILEKTV-SPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRW 80
Cdd:COG5215   5 EFRCLGKNHVlSPDPNARLRAEAQLLELQSGDFEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHANDPELQKGCSQRW 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701  81 LAIDANARREVKNYVLQTLGTETYR-PSSASQCVAGIACAEIPVNQWPELIPQLVANVTNpNSTEHMKESTLEAIGYICQ 159
Cdd:COG5215  85 LGMRHESKEQVKGMALRALKSPEPRfCTMAAQLLAAIARMELPNSLWPGLMEEMVRNVGD-EQPVSGKCESLGICGYHCE 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 160 DIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQ 239
Cdd:COG5215 164 SEAPEDLIQMSNVILFAIVMGALKNETTSAVRLAALKALMDSLMFVQGNFCYEEERNYFMQVVCEATQGNDEELQHAAFG 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 240 NLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQgrpPEHTSKFyAKGAL 319
Cdd:COG5215 244 CLNKIMMLYYKFMQSYMENALAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEV---PAQNHGF-ARAAV 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 320 QYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEP 399
Cdd:COG5215 320 ADVLPELLSLLEKQGEDYYGDDWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGPCE 399

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 400 SQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAE 479
Cdd:COG5215 400 DCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHLVLEVSASLIGLMDCPFRSINCSWRKENLVD 479

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 480 aayEAADVADDQEEPatycLSSSFELIVQKLLETTDRPDgHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQ 559
Cdd:COG5215 480 ---HIAKAVREVESF----LAKFYLAILNALVKGTELAL-NESNLRVSLFSALGTLILICPDAVSDILAGFYDYTSKKLD 551

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 560 QVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKvQHQDALQISDVVMASLLRMFQSTAgSGGVQEDALMAVSTLVEVL 639
Cdd:COG5215 552 ECISVLGQILATEDQLLVEELQSNYIGVLEAIIRT-RRRDIEDVEDQLMELFIRILESTK-PTTAFGDVYTAISALSTSL 629

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 640 GGEFLKYMEAFKPFLGIGLkNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGD 719
Cdd:COG5215 630 EERFEQYASKFIPYLTRAL-NCTDRFVLNSAVGLVGDLANTLGTDFNIYADVLMSSLVQCLSSEATHRDLKPAILSVFGD 708

                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 720 IALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGlkgdqenVHPDVMLVQPRVEFILS 799
Cdd:COG5215 709 IALAIGANFESYLDMIMMLFQQASELDPHSDEVYVDDYRKNAVQLVNCAYVGIGDS-------SKNRVRSVLPYVISIFH 781

                       810       820       830       840       850       860       870
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20981701 800 FIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKA-KTLATWATKELRK 871
Cdd:COG5215 782 KIGMIAEDPNGSEAHTRAALGLIGDLAGMFPKGELKFGLDEDWVKDFLYGMMKKISSQQtKDSARWAAEQVKR 854
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 380-435 9.22e-12

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 60.84  E-value: 9.22e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 20981701   380 WRYRDAAVMAFGCILEGpEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRI 435
Cdd:pfam13513   1 WRVREAAALALGSLAEG-GPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N pfam03810
Importin-beta N-terminal domain;
21-101 3.80e-11

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 59.56  E-value: 3.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701    21 AQKFLERAavENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKaqyqqrwLAIDANARREVKNYVLQTLG 100
Cdd:pfam03810   1 AEKQLEQF--EKSPGFWSKLLQILSNSENPLEVRQLAALYLKNLITRHWEEEK-------NSLPPEEKEQIKNNLLNLLG 71


                  .
gi 20981701   101 T 101
Cdd:pfam03810  72 S 72
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 21-101 8.63e-08

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 49.93  E-value: 8.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701     21 AQKFLERAavENLPTFLVELSRVLANPGNSQVaRVAAGLQIKNSLTSkdpdikaqyqqRWLAIDANARREVKNYVLQTLG 100
Cdd:smart00913   1 AEKQLEQF--QKSPGFWLLLLEILANSEDQYV-RQLAAITLKNKITR-----------RWSSLPEEEKEEIKNSLLELLL 66


                   .
gi 20981701    101 T 101
Cdd:smart00913  67 S 67
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 410-439 2.22e-04

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 39.05  E-value: 2.22e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 20981701   410 MPTLIELMKDPSVVVRDTAAWTVGRICELL 439
Cdd:pfam02985   2 LPLLLKLLNDPSPEVREAAAEALGELAEVL 31
HEAT COG1413
HEAT repeat [General function prediction only];
365-435 6.92e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.77  E-value: 6.92e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20981701 365 PHVLPFIKEHIKNPDWRYRDAAVMAFGCIleGPEPsqlkplviqAMPTLIELMKDPSVVVRDTAAWTVGRI 435
Cdd:COG1413  77 PEAVPALIAALKDEDPEVRRAAAEALGRL--GDPA---------AVPALLEALKDPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
365-478 1.17e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20981701 365 PHVLPFIKEHIKNPDWRYRDAAVMAFGCIleGPEpsqlkplviQAMPTLIELMKDPSVVVRDTAAWTVGRICEllpEAAI 444
Cdd:COG1413  46 PRAVPALLEALKDPDPEVRAAAAEALGRI--GDP---------EAVPALIAALKDEDPEVRRAAAEALGRLGD---PAAV 111

                        90       100       110
                ....*....|....*....|....*....|....
gi 20981701 445 NdvYLAPLLQclieglSAEPRVASNVCWAFSSLA 478
Cdd:COG1413 112 P--ALLEALK------DPDWEVRRAAARALGRLG 137
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 424-477 3.29e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.58  E-value: 3.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 20981701   424 VRDTAAWTVGRICELLPEAAINdvYLAPLLQCLIEGL-SAEPRVASNVCWAFSSL 477
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAP--AVPELLPALLPLLnDDSDLVREAAAWALGRL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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