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Conserved domains on  [gi|11387071|sp|O88816|]
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RecName: Full=Serotonin N-acetyltransferase; Short=Serotonin acetylase; AltName: Full=Aralkylamine N-acetyltransferase; Short=AA-NAT

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006981)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
35-182 1.95e-13

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 64.72  E-value: 1.95e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387071  35 FRCLTPEDATSAFEIEREAFisVSGTCPLYLDEIRHFLTLcpELSLGWFEEGCLVAFIIGSLWDkerltqesltlHRPGG 114
Cdd:COG3153   1 IRPATPEDAEAIAALLRAAF--GPGREAELVDRLREDPAA--GLSLVAEDDGEIVGHVALSPVD-----------IDGEG 65

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 11387071 115 RTAHLHVLAVHRTFRQQGKGSVLLW---RYLHHLGsqpaVRRAVLMCEDALVPFYEKFGFQAVGPCAITVG 182
Cdd:COG3153  66 PALLLGPLAVDPEYRGQGIGRALMRaalEAARERG----ARAVVLLGDPSLLPFYERFGFRPAGELGLTLG 132
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
35-182 1.95e-13

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 64.72  E-value: 1.95e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387071  35 FRCLTPEDATSAFEIEREAFisVSGTCPLYLDEIRHFLTLcpELSLGWFEEGCLVAFIIGSLWDkerltqesltlHRPGG 114
Cdd:COG3153   1 IRPATPEDAEAIAALLRAAF--GPGREAELVDRLREDPAA--GLSLVAEDDGEIVGHVALSPVD-----------IDGEG 65

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 11387071 115 RTAHLHVLAVHRTFRQQGKGSVLLW---RYLHHLGsqpaVRRAVLMCEDALVPFYEKFGFQAVGPCAITVG 182
Cdd:COG3153  66 PALLLGPLAVDPEYRGQGIGRALMRaalEAARERG----ARAVVLLGDPSLLPFYERFGFRPAGELGLTLG 132
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 45-171 5.12e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 57.53  E-value: 5.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387071    45 SAFEIEREAFISVSGTCPLylDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLWDKErltqesltlhrpgGRTAHLHVLAV 124
Cdd:pfam00583   3 ALYELLSEEFPEPWPDEPL--DLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDE-------------PPVGEIEGLAV 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 11387071   125 HRTFRQQGKGSVLLWRYLHHLGSQPAVRR--AVLMCEDALVPFYEKFGF 171
Cdd:pfam00583  68 APEYRGKGIGTALLQALLEWARERGCERIflEVAADNLAAIALYEKLGF 116
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 42-175 4.69e-04

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 38.85  E-value: 4.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387071    42 DATSAFEIEREAFisvsgTCPLYLDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLwdkerltqeslTLHrpggrTAHLHV 121
Cdd:TIGR01575   1 DLKAVLEIEAAAF-----AFPWTEAQFAEELANYHLCYLLARIGGKVVGYAGVQI-----------VLD-----EAHILN 59

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 11387071   122 LAVHRTFRQQGKGSVLLwRYLHHLGSQPAVRRAVL---MCEDALVPFYEKFGFQAVG 175
Cdd:TIGR01575  60 IAVKPEYQGQGIGRALL-RELIDEAKGRGVNEIFLevrVSNIAAQALYKKLGFNEIA 115
PTZ00330 PTZ00330
acetyltransferase; Provisional
 111-173 5.52e-03

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 35.97  E-value: 5.52e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 11387071  111 RPGGRTAHLHVLAVHRTFRQQGKGSVLLWRyLHHLGSQPAVRRAVLMCEDALVPFYEKFGFQA 173
Cdd:PTZ00330  77 RGGKCVGHIEDVVVDPSYRGQGLGRALISD-LCEIARSSGCYKVILDCTEDMVAFYKKLGFRA 138
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
35-182 1.95e-13

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 64.72  E-value: 1.95e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387071  35 FRCLTPEDATSAFEIEREAFisVSGTCPLYLDEIRHFLTLcpELSLGWFEEGCLVAFIIGSLWDkerltqesltlHRPGG 114
Cdd:COG3153   1 IRPATPEDAEAIAALLRAAF--GPGREAELVDRLREDPAA--GLSLVAEDDGEIVGHVALSPVD-----------IDGEG 65

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 11387071 115 RTAHLHVLAVHRTFRQQGKGSVLLW---RYLHHLGsqpaVRRAVLMCEDALVPFYEKFGFQAVGPCAITVG 182
Cdd:COG3153  66 PALLLGPLAVDPEYRGQGIGRALMRaalEAARERG----ARAVVLLGDPSLLPFYERFGFRPAGELGLTLG 132
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 45-171 5.12e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 57.53  E-value: 5.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387071    45 SAFEIEREAFISVSGTCPLylDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLWDKErltqesltlhrpgGRTAHLHVLAV 124
Cdd:pfam00583   3 ALYELLSEEFPEPWPDEPL--DLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDE-------------PPVGEIEGLAV 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 11387071   125 HRTFRQQGKGSVLLWRYLHHLGSQPAVRR--AVLMCEDALVPFYEKFGF 171
Cdd:pfam00583  68 APEYRGKGIGTALLQALLEWARERGCERIflEVAADNLAAIALYEKLGF 116
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
40-176 1.49e-07

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 48.64  E-value: 1.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387071  40 PEDATSAFEIEREAFISVSGTCP-LYLDEI----RHFLtlcpelslgWFEEGCLVAfiigslwdkerltqeSLTLHRPGG 114
Cdd:COG2153   1 AEELYDALALRREVFVVEQGVPPyLELDGKdedaRHLL---------AYDDGELVA---------------TARLLPPGD 56

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 11387071 115 RTAHLHVLAVHRTFRQQGKGSVLLWRYLHHLGSQPAvRRAVLMCEDALVPFYEKFGFQAVGP 176
Cdd:COG2153  57 GEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGA-RRIVLSAQAHAVGFYEKLGFVPVGE 117
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 111-175 2.38e-07

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 46.96  E-value: 2.38e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 11387071 111 RPGGRTAHLHVLAVHRTFRQQGKGSVLLwRYLHHLGSQPAVRRAVLMCED---ALVPFYEKFGFQAVG 175
Cdd:COG0456   8 VDGGDEAEIEDLAVDPEYRGRGIGRALL-EAALERARERGARRLRLEVREdneAAIALYEKLGFEEVG 74
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 115-176 4.98e-07

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 46.88  E-value: 4.98e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 11387071   115 RTAHLHVLAVHRTFRQQGKGSVLLWRYLHHLGSQPAVRRAVLMCED-ALVPFYEKFGFQAVGP 176
Cdd:pfam13673  50 DRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTVNASpYAVPFYEKLGFRATGP 112
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 109-176 1.12e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 46.14  E-value: 1.12e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 11387071 109 LHRPGGRTAHLHVLAVHRTFRQQGKGSVLLwRYLHHLGSQPAVRRAVLMCEDALVPFYEKFGFQAVGP 176
Cdd:COG1246  45 LHPLDEDLAELRSLAVHPDYRGRGIGRRLL-EALLAEARELGLKRLFLLTTSAAIHFYEKLGFEEIDK 111
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 109-172 1.78e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 44.37  E-value: 1.78e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 11387071   109 LHRPGGRTAHLHVLAVHRTFRQQGKGSVLLwRYLHHLGSQPAVRRAVLMCEDALVPFYEKFGFQ 172
Cdd:pfam13508  21 LPLDDEGALAELRLAVHPEYRGQGIGRALL-EAAEAAAKEGGIKLLELETTNRAAAFYEKLGFE 83
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
34-175 3.96e-06

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 44.99  E-value: 3.96e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387071  34 EFRCLTPEDATSAFEIEREAFISVSGT---CPLYLDEIRHFLTLCPELSLGWF---EEGCLVAFIIGSLWDKerltqesl 107
Cdd:COG1247   3 TIRPATPEDAPAIAAIYNEAIAEGTATfetEPPSEEEREAWFAAILAPGRPVLvaeEDGEVVGFASLGPFRP-------- 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 11387071 108 tlhRPGGRTAHLHVLAVHRTFRQQGKGSVLLWRYLHHLGSQPaVRRAVLMCED---ALVPFYEKFGFQAVG 175
Cdd:COG1247  75 ---RPAYRGTAEESIYVDPDARGRGIGRALLEALIERARARG-YRRLVAVVLAdneASIALYEKLGFEEVG 141
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 107-175 5.07e-05

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 41.58  E-value: 5.07e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 11387071 107 LTLHRPGGRTAHLHVLAVHRTFRQQGKGSVLL---WRYLHHLGsqpaVRRAVLMCED---ALVPFYEKFGFQAVG 175
Cdd:COG0454  49 AGLRRLDDKVLELKRLYVLPEYRGKGIGKALLealLEWARERG----CTALELDTLDgnpAAIRFYERLGFKEIE 119
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 42-175 4.69e-04

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 38.85  E-value: 4.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11387071    42 DATSAFEIEREAFisvsgTCPLYLDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLwdkerltqeslTLHrpggrTAHLHV 121
Cdd:TIGR01575   1 DLKAVLEIEAAAF-----AFPWTEAQFAEELANYHLCYLLARIGGKVVGYAGVQI-----------VLD-----EAHILN 59

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 11387071   122 LAVHRTFRQQGKGSVLLwRYLHHLGSQPAVRRAVL---MCEDALVPFYEKFGFQAVG 175
Cdd:TIGR01575  60 IAVKPEYQGQGIGRALL-RELIDEAKGRGVNEIFLevrVSNIAAQALYKKLGFNEIA 115
PTZ00330 PTZ00330
acetyltransferase; Provisional
 111-173 5.52e-03

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 35.97  E-value: 5.52e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 11387071  111 RPGGRTAHLHVLAVHRTFRQQGKGSVLLWRyLHHLGSQPAVRRAVLMCEDALVPFYEKFGFQA 173
Cdd:PTZ00330  77 RGGKCVGHIEDVVVDPSYRGQGLGRALISD-LCEIARSSGCYKVILDCTEDMVAFYKKLGFRA 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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