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Conserved domains on  [gi|116242790|sp|O43173|]
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RecName: Full=Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase; AltName: Full=Alpha-2,8-sialyltransferase 8C; AltName: Full=Alpha-2,8-sialyltransferase III; AltName: Full=ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3; AltName: Full=Sialyltransferase 8C; Short=SIAT8-C; AltName: Full=Sialyltransferase St8Sia III; Short=ST8SiaIII

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 92-376 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467698  Cd Length: 284  Bit Score: 568.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790  92 FNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGIL 171
Cdd:cd23970    1 FNKTALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDYSSHKYVFSISPNLRSLLPEVSPFQNKHYNTCAVVGNSGIL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 172 TGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFH 251
Cdd:cd23970   81 TNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 252 TSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPnTR 331
Cdd:cd23970  161 TSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDP-TG 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 116242790 332 EDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTL 376
Cdd:cd23970  240 TPLPYHYYDKKGTKFTTKWQESHQLPAEFVLLYKMHGAGVLKLTL 284
 
Name Accession Description Interval E-value
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 92-376 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 568.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790  92 FNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGIL 171
Cdd:cd23970    1 FNKTALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDYSSHKYVFSISPNLRSLLPEVSPFQNKHYNTCAVVGNSGIL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 172 TGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFH 251
Cdd:cd23970   81 TNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 252 TSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPnTR 331
Cdd:cd23970  161 TSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDP-TG 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 116242790 332 EDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTL 376
Cdd:cd23970  240 TPLPYHYYDKKGTKFTTKWQESHQLPAEFVLLYKMHGAGVLKLTL 284
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 115-371 6.87e-82

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 250.60  E-value: 6.87e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790  115 SLTKNSVRIGQLMHYdySSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPT 194
Cdd:pfam00777   1 FLTKENFPLGEWIRY--SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790  195 EAFQRDVGRKTNLTTFNP-SILEKYYNNLLTIQDRNNFFLSLKKLDG--AILWIPAFFFHTSATVTRTLVDFFVEHRGQL 271
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFSHPRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790  272 ---KVQLAWPgNIMQHVNRYW-KNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFgfdpNTREDLPYHYYDKKGTKFt 347
Cdd:pfam00777 159 dpdKVLFLHP-DFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF----LDSRGNSHHYYDNVLMKK- 232

                         250       260
                  ....*....|....*....|....
gi 116242790  348 TKWQESHQLPAEFQLLYRMHGEGL 371
Cdd:pfam00777 233 GGFYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 92-376 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 568.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790  92 FNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGIL 171
Cdd:cd23970    1 FNKTALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDYSSHKYVFSISPNLRSLLPEVSPFQNKHYNTCAVVGNSGIL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 172 TGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFH 251
Cdd:cd23970   81 TNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 252 TSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPnTR 331
Cdd:cd23970  161 TSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDP-TG 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 116242790 332 EDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTL 376
Cdd:cd23970  240 TPLPYHYYDKKGTKFTTKWQESHQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 95-376 1.80e-103

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 306.50  E-value: 1.80e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790  95 TAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDysSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGS 174
Cdd:cd23963    1 TALDKFRKELERLLNTRKLFLTQKNTPLGDVLYYSY--FKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 175 QCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSA 254
Cdd:cd23963   79 GCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKRRYNSLKKNRDRDKFLNRLKEYNGSILWYPKFSFKSST 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 255 TVTRTLVDFFVEHRGQLKVQLAWPgNIMQHVNRYWKNKHLsPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTReDL 334
Cdd:cd23963  159 NLLLKAARALKKNGLNLTVVYSNP-EHFLAVQKFWKRRGL-EKRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGR-PV 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 116242790 335 PYHYYDKKGTKFTTKWqesHQLPAEFQLLYRMHGEGLTKLTL 376
Cdd:cd23963  236 PYHYYDDLSPSTKNKV---HNMPEEFKLLRELHKKGVLKLHT 274
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 95-375 4.60e-92

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 277.37  E-value: 4.60e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790  95 TAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVfSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGS 174
Cdd:cd23969    1 TEVLRMRKWILKFFDPEKDISVLKSQVKPGDRMHYEIDRHKTV-NITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 175 QCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSA 254
Cdd:cd23969   80 GCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPHAYGDLVNATDKEKFVERLRQLGDSILWIPAFVSKGGE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 255 TVTRTLVDFFVEHRgqLKVQLAWPGNIMQH-VNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREd 333
Cdd:cd23969  160 EHVQWTNEIILKHK--LNVKTAYPPLRLNHaIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRA- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 116242790 334 LPYHYYDKKGTKFTTKwqeSHQLPAEFQLLYRMHGEGLTKLT 375
Cdd:cd23969  237 VKYHYYDNRKYLTTAR---PHKMPEEFRALRSLHQRGALRLH 275
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 115-371 6.87e-82

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 250.60  E-value: 6.87e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790  115 SLTKNSVRIGQLMHYdySSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPT 194
Cdd:pfam00777   1 FLTKENFPLGEWIRY--SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790  195 EAFQRDVGRKTNLTTFNP-SILEKYYNNLLTIQDRNNFFLSLKKLDG--AILWIPAFFFHTSATVTRTLVDFFVEHRGQL 271
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFSHPRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790  272 ---KVQLAWPgNIMQHVNRYW-KNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFgfdpNTREDLPYHYYDKKGTKFt 347
Cdd:pfam00777 159 dpdKVLFLHP-DFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF----LDSRGNSHHYYDNVLMKK- 232

                         250       260
                  ....*....|....*....|....
gi 116242790  348 TKWQESHQLPAEFQLLYRMHGEGL 371
Cdd:pfam00777 233 GGFYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 101-375 3.75e-80

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 247.17  E-value: 3.75e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 101 RQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKyVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEI 180
Cdd:cd23988    7 RKDILRFLDAERDVSVVKSSFKPGDVIHYVLDRRR-TLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 181 DKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTL 260
Cdd:cd23988   86 DSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 261 VDFFVEHrgQLKVQLAWPGNIMQHVNR-YWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREdLPYHYY 339
Cdd:cd23988  166 NALILKN--KLKVRTAYPSLRLIHAVRgYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNP-VKYHYY 242

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116242790 340 DKKGTKFTTKwQESHQLPAEFQLLYRMHGEGLTKLT 375
Cdd:cd23988  243 DDLKYRYFSN-AGPHRMPLEFKTLNVLHNRGALKLT 277
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 95-376 2.69e-79

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 244.85  E-value: 2.69e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790  95 TAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKyVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGS 174
Cdd:cd23987    1 TLSLKIRKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDS-TMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 175 QCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSA 254
Cdd:cd23987   80 GCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 255 TVTRTLVDFFVEHRgqLKVQLAWPGNIMQHVNR-YWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREd 333
Cdd:cd23987  160 ERVEWVNDLILKHH--INVRTAYPSLRLLHAVRgYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNP- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 116242790 334 LPYHYYDKKGTKFTTKwQESHQLPAEFQLLYRMHGEGLTKLTL 376
Cdd:cd23987  237 VKYHYYDSLKYGYTSQ-ASPHTMPLEFKALKNLHQQGALKLTV 278
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 95-376 7.93e-75

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 233.30  E-value: 7.93e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790  95 TAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSShKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGS 174
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGER-KKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 175 QCGQEIDKSDFVFRCNFAPTEaFQRDVGRKTNLTTFNPSILEKYYNNLLtiQDRNNFFLSLKKLDGAILWIPAFFFHT-- 252
Cdd:cd23971   80 SCGREIDSADFVIRCNLPPLN-DSKDVGSKTNLVTANPSILREKFHNLK--KRRRPFVERMKVYGNALLLLPAFSYTSnt 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 253 --SATVTRTLVDFfvehRGQLKVQLAWPgNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNT 330
Cdd:cd23971  157 epSLRALYTLEDF----GSPQKVLFFNP-EYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDG 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 116242790 331 ReDLPYHYYDKKGTKFTTkwqesHQLPAEFQLLYRMHGEGLTKLTL 376
Cdd:cd23971  232 N-PISHHYYDNVLPKKGV-----HAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 101-374 2.04e-61

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 198.82  E-value: 2.04e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 101 RQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKyVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEI 180
Cdd:cd23991    7 RSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKK-KILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSCGAEI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 181 DKSDFVFRCNFAPTEA-FQRDVGRKTNLTTFNPSILEKYYNNLLtiQDRNNFFLSLKKLDGAILWIPAFFFH----TSAT 255
Cdd:cd23991   86 DQADFVFRCNLPPTGGnISKDVGSKTNLVTANPSIISIKYAKLN--ERRKPFLETVSVYGDAFLLLPAFSYRsntaLSFK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 256 VTRTLVDFfvehRGQLKVQLAWPgNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGfdpNTREDLP 335
Cdd:cd23991  164 VYYTLEDF----KAKQKVIFFHP-IYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFS---KNTEGKP 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 116242790 336 --YHYYDKKGTKfttkwQESHQLPAEFQLLYRMHGEGLTKL 374
Cdd:cd23991  236 isHHYYDNQLPK-----PGFHSMPKEFYQLLQLHSKGILKL 271
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 114-376 2.73e-55

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 182.72  E-value: 2.73e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 114 FSLTKNSVRIGQLMHYDYSSHkYVFSISNNFRSLLPDVSPImNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAP 193
Cdd:cd23989   20 FAVTKHNSPLGKNLWFDGEFL-HSHTVDNETYSLFPQDTPL-QLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPP 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 194 -TEAFQRDVGRKTNLTTFNPSILEKYYNNLLtiQDRNNFFLSLKKLDGAILWIPAFFFHT----SATVTRTLVDFFVEHr 268
Cdd:cd23989   98 lSREYTDDVGTKTQLVTANPSIIDKRFQNLL--WSRKSFVESMKVYGRSYIYMPAFSMKTgtdpSLRVYYTLADVGANQ- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 269 gqlKVQLAWPgNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREdLPYHYYDK--KGTKF 346
Cdd:cd23989  175 ---TVLFANP-NFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERT-ISHHYYDNvlPDSGF 249

                        250       260       270
                 ....*....|....*....|....*....|
gi 116242790 347 ttkwqesHQLPAEFQLLYRMHGEGLTKLTL 376
Cdd:cd23989  250 -------HAMPEEFLQLWHLHKSGVLRMQL 272
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 162-366 9.27e-52

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 171.01  E-value: 9.27e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNlltiqdRNNFFLSLKKLDGA 241
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRG------PRCGCHPLPLEEEV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 242 ILWIPAFFFHTSatvtrtlVDFFVEHRGQLKVQLAWP---GNIMQHVNRYWKNKHL----SPKRLSTGILMYTLASAICE 314
Cdd:cd19952   75 VLILSRAAAADF-------KRLKRRKKRHDNAVLLLTdpaPDLLSYVRKRLEKLGLksffGGNAPSSGLLAVLLALQLCD 147

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 116242790 315 EIHLYGFWPfgfDPNTREDLPYHYYDKKGTKFTTKwqeSHQLPAEFQLLYRM 366
Cdd:cd19952  148 SVDLYGFGV---DSGHAPKVPYHYYDLVEAEEGTA---VHSFDLEAELLRAL 193
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 109-374 4.63e-42

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 148.45  E-value: 4.63e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 109 DVIKNFSLTKNSVRIGQLMHYDYSSHKyVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFR 188
Cdd:cd23990   15 NAPSFLFTTQKNTPLGTKLKYEVDTSG-IYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFR 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 189 CNFAP-TEAFQRDVGRKTNLTTFNPSILEKYYNNLLtiQDRNNFFLSLKKLDGAILWIPAFF----FHTSATVTRTLVDF 263
Cdd:cd23990   94 CNLPPiSEKYVRDVGVKTDVVTINPSIITERFHKLE--KWRRPFYEVLQVYENASVVLPAFYntrnTDVSIRVKYVLDDF 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 264 fvehRGQLKVQLAWPgNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREdLPYHYYD--K 341
Cdd:cd23990  172 ----ESQQAVYYFHP-QYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIF-ITHHYYDnvK 245

                        250       260       270
                 ....*....|....*....|....*....|...
gi 116242790 342 KGTKFttkwqesHQLPAEFQLLYRMHGEGLTKL 374
Cdd:cd23990  246 PRPGF-------HAMPSEIFNFLHMHSRGILRV 271
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 162-374 1.26e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 104.65  E-value: 1.26e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPsilEKYYNNLLT--IQDRNN--FFLSLKK 237
Cdd:cd23964   85 CAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFP---ESLHNSLLKhvPQDKDTkyLFIPFKI 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 238 LDgaILWIpafffhTSATVTRTLVDF----------FVEHRGQLKVQLAWPGNImqhvnRYWKNKHL-SPK--RLSTGIL 304
Cdd:cd23964  162 RD--YDYL------DAVLSGKPVPDGcdkgkrppplFGPKLNATNVRLLHPDFI-----RYLFNRWLnSSTsyRPTTGAL 228

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 305 MYTLASAICEEIHLYGfwpFGFDPNtredLPYHYYDKKGTKFTTKWQeSHQLPAEFQLLYRMHGEGLTKL 374
Cdd:cd23964  229 MLLTALHTCDQVSVYG---FGYDPR----FSLHYYDKTFVKFTVFYA-NHDFTNERKLWRKLHEEGIINL 290
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 162-374 4.11e-23

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 97.35  E-value: 4.11e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTnltTFNPSILEKYynnlLTIQDRNNFFL-SLKKLDg 240
Cdd:cd23966   80 CAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKT---THHFMYPESA----VDLDPGVHLVLvPFKVLD- 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 241 aILWIPAFFfhTSATVTRTlvdfFVEHRGQL-----KVQLAWPGnIMQHVNRYWKNKHLS-PkrlSTGILMYTLASAICE 314
Cdd:cd23966  152 -LQWLISAL--TTGEITRT----YTPVKRFIkadkdKVLVINPA-FIKYVHDNWTEHHGRyP---STGFLALIFALHICD 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 315 EIHLYGfwpFGFDPNTREDlpyHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKL 374
Cdd:cd23966  221 EVSVFG---FGADSKGNWH---HYWEKNRSAGAFRKTGVHDADFESDIIKKLAKEGKIRV 274
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 162-374 5.27e-22

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 95.20  E-value: 5.27e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILekyYNNLLTIqdRNNFFLSL-KKLDG 240
Cdd:cd23974   87 CAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTL---MNSLRAY--AGVGFNGPpQSKET 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 241 AILWIPAF---FFHTSATVTRTLVD-----------FFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPK-----RLST 301
Cdd:cd23974  162 RYIFLPDHdrdYLLVKAALTHTPIDrgrdkskrpskYFGKDVTAEKFKIYHPDFIRYLRNRFLWSPILNTKqrdiyRPST 241

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 116242790 302 GILMYTLASAICEEIHLYGFW-PfgfDPNTREDlpyHYYDKKGTKFTtkWQESHQLPAEFQLLYRMHGEGLTKL 374
Cdd:cd23974  242 GAVMLLAALHTCDQVSAYGFMtP---DYGKYSD---HYYDKTYHKVV--FYANHDLRLEMQLWQKLHKAGLIKL 307
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 157-367 1.16e-21

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 93.10  E-value: 1.16e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 157 KHYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKyynnlltiqDRNNFFLSLK 236
Cdd:cd23968   43 KRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQILSK---------PEFNFLTDPL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 237 KLDGAIL-WIPAFFFHTSATVTRTlVDF-----FVEHRGQL---KVQLAWPG------NIMQHVNRYWKNKHlSPkrlST 301
Cdd:cd23968  114 YRNVTLLvWDPSSYNVNLEKWYKK-PDFdffpnYIKYRRRHpeePFYLIDPRflwrlwDILQEYTPEKIKPN-PP---SS 188

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116242790 302 GILMYTLASAICEEIHLYGFWpfgfdPNTREDLPYHYYDKKGTKFTTK--WqesHQLPAEFQLLYRMH 367
Cdd:cd23968  189 GFIGIVLMLHLCDWVDVYEYV-----PSVRQTDRCHYYDVEKDLACTLgaW---HPLAAEKLLVRHLN 248
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 162-345 3.23e-20

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 87.73  E-value: 3.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNL-------TTFNPsilEKYYNNLLTIqdrnnfFLS 234
Cdd:cd23967    5 CVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFrmfypesAFRDP---EEYDSDWLLV------LVP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 235 LKKLDgaILWIPAFFfhtsATVTRTLVDFFVEhrgqlKVQLAWPGN----------IMQ----HVNRYWKNKHLSPKRLS 300
Cdd:cd23967   76 FKSMD--LLWLQAVI----KGKKPNGKGGFWK-----KIATSVPKPpkkirilnpyILQeaafDLIGLPMNGKQGKNVPT 144

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 116242790 301 TGILMYTLASAICEEIHLYGfwpFGFDPNtREDLPYHYYDKKGTK 345
Cdd:cd23967  145 TGIIAIVMALHYCDEVDIAG---FGYDPS-DPNAPLHYYDSLTMK 185
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 127-374 3.70e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 87.11  E-value: 3.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 127 MHYDYSSHKYVFS-ISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKT 205
Cdd:cd23973   50 MGLNYTLVKEVVElIPKPKEQQLLALSPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRT 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 206 NLTTFNP-SIL-------EKYYNNLLTIQDRNNFFLSLKKLDGAilWIPAFFFHTS----ATVTRTLVDFFVEHRGQLKV 273
Cdd:cd23973  130 SFYVHTAhSITsslmilqKRGFKNIPQDKDIKYILFPEGPRDYQ--WLEALLKNKTipsgAYYGRRPRSYFSGDFTEDKY 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 274 QLAWPgNIMQHV-NRYWKNKHLSPK-----RLSTGILMYTLASAICEEIHLYGFWPFGFdpntrEDLPYHYYDKKGTKft 347
Cdd:cd23973  208 LVLHP-DFLRYVkNRFLRSKTLKGKywaiyRPTTGAFLLLTALHLCDTVSAYGFITEDY-----RKYPDHYYDKKKTK-- 279

                        250       260
                 ....*....|....*....|....*..
gi 116242790 348 TKWQESHQLPAEFQLLYRMHGEGLTKL 374
Cdd:cd23973  280 LVFYINHDFRLEKKLWKRLHDEKIIKL 306
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 162-366 1.29e-18

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 83.17  E-value: 1.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNP------SILEKYYNNLLTiqdrnnfFLSL 235
Cdd:cd23982    5 CVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPesaqfdPGIENDPDTLLV-------LVPF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 236 KKLDgaILWI-----------------PAFFFHTSATVTRTLVDFFVEHrgqlkvqlawPGNIMQHVNRYWKNKHlspkR 298
Cdd:cd23982   78 KPLD--FYWLyeilsnekrvrkgfwkqPPRIWDANPKQIRILNPYYTYV----------AATKLLQVPGQRKKKQ----K 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116242790 299 LSTGILMYTLASAICEEIHLYGF-WPFGFDPNTredlPYHYYDKKGTKFTTKWQesHQLPAEFQLLYRM 366
Cdd:cd23982  142 PTTGLLAITLALHLCDEVHIAGFgYPDNGNSNQ----PIHYYNQITLKSMANSG--HNLNAEAQAIQRL 204
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 162-345 2.77e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 82.68  E-value: 2.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNpsilekyYNNLLTIQDRNNFFLSLKK-LDG 240
Cdd:cd23965    4 CALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVS-------HSSLPRLLRNAILLLAGTRaPTV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 241 AILWIPAFFFHTS-ATVTRTL---------VDFFVEHRGQlkvqlawpgniMQHVNRYW-----KNKHLSPKRLSTGilM 305
Cdd:cd23965   77 VVFWGPETKMNKDgAGKYNLLrslskkypdVEFYSLTPEK-----------MDYADELFeketgKSRIKSGTWLSTG--W 143

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 116242790 306 YTLASA--ICEEIHLYGFWPFGF-DPNTREDLPYHYYDKKGTK 345
Cdd:cd23965  144 FTMLLAldVCDEIKVYGMVPENYcREHPNSKVPYHYYEPGGLK 186
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 162-321 4.95e-17

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 80.31  E-value: 4.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIqdrnnfFLSLKKLDga 241
Cdd:cd23980   84 CAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMI------LVPFKTLD-- 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 242 ILWIpafffhTSATVTRTLVDFFVEHRGQLKVQ----LAWPGNIMQHVNRYWKNKHlsPKRLSTGILMYTLASAICEEIH 317
Cdd:cd23980  156 LEWV------ISATTTGTISHTYVPVPRKIKVKkekiLIYHPAFIKYVFDRWLQGH--GRYPSTGILSVIFSLHVCDEVD 227


                 ....
gi 116242790 318 LYGF 321
Cdd:cd23980  228 LYGF 231
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 158-344 1.31e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 78.37  E-value: 1.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 158 HYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKyynnllTIQDRNNfFLSLKK 237
Cdd:cd23976   14 HCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQR------ILRNRNE-LLNVSQ 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 238 LDGAILWIPAFFFHTSAtvtrtlvdffvehRGQLKVQLAWPGNIMQHVNRYW------------------KNKHLSPKRL 299
Cdd:cd23976   87 GTVFIFWGPSNYMRRDG-------------KGLVYNNLQLMNQILPKLKVYTitrhkmlqfdelfkretgKDRKISNTWL 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 116242790 300 STGILMYTLASAICEEIHLYGFWPFGF--DPNTREdLPYHYYDKKGT 344
Cdd:cd23976  154 STGWFTMIIALELCDRINVYGMVPPDFcrDPNHPS-VPYHYYEPSGP 199
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 157-341 5.53e-15

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 74.36  E-value: 5.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 157 KHYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNpsilekyyNNLLTIQDRNnfFL--S 234
Cdd:cd23985   43 GPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLIN--------SQLVTTEKHK--FLkdS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 235 LKKLDGAILWIPAFFfhtSATVT----RTLVDFFVEHRGQ-----------LKVQLAWP-GNIMQHVNrywkNKHLSPKR 298
Cdd:cd23985  113 LYNEGILIVWDPAPY---HSDIPewykNPDYNFFENYKTYrrlnpnqpfyiLHPQMQWElWDIIQENS----PEEIQPNP 185

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 116242790 299 LSTGILMYTLASAICEEIHLYGFWpfgfdPNTREDLPYHYYDK 341
Cdd:cd23985  186 PSSGMLGIILMMTLCDQVDVYEFL-----PSKRKTDVCHYYQK 223
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 162-374 7.01e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 74.47  E-value: 7.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEkyyNNLltIQDRNNFFLSLKK---- 237
Cdd:cd23972   85 CAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMK---NSL--ISYWNLGFTRTPQgqdl 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 238 --------------LDGAILWIPAFFFHTSAtvTRTLVDFFVEHRGQlKVQLAWPGNIMQHVNRYWKNKHLSPK-----R 298
Cdd:cd23972  160 qyifipsdirdyvmLRSAILGVPVPEGLDKG--DRPHKYFGPEASAK-KFKLLHPDFISYLTDRFLKSKLLNTHyghlyM 236

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 116242790 299 LSTGILMYTLASAICEEIHLYGFwpfgFDPNTREdLPYHYYDKKgtKFTTKWQESHQLPAEFQLLYRMHGEGLTKL 374
Cdd:cd23972  237 PSTGALMLLTALHTCDQVSAYGF----ITSNYWK-FSDHYYERK--KKPLVFYANHDMLLEAALWRRLHKAGILQL 305
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 162-321 8.04e-15

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 74.14  E-value: 8.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLltiqdrnNFFL-SLKKLDg 240
Cdd:cd23979   83 CAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANV-------SFVLvPFKTLD- 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 241 aILWIPAFFFHTSATVTRTLVDFFVEHRGQlKVQLAWPGnIMQHVNRYWKNKHlsPKRLSTGILMYTLASAICEEIHLYG 320
Cdd:cd23979  155 -LLWITSALSTGQIRFTYAPVKQFLRVDKD-KVQIYNPA-FFKYIHDRWTEHH--GRYPSTGMLVLFFALHVCDEVNVYG 229


                 .
gi 116242790 321 F 321
Cdd:cd23979  230 F 230
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 162-341 3.12e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 71.43  E-value: 3.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLT----TFNPSILEKYynnlltiqdrnNFFLSLKK 237
Cdd:cd23977    4 CAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRvvshTSVPLLLRNQ-----------GYFFQQSR 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 238 LDGAILWIPafffhtSATVTRtlVDFFVEHRGQLKVQLAWPG--------NIMQHV-----NRYWKNKHLSPKRLSTGIL 304
Cdd:cd23977   73 DTKYVIWGP------ERNMDR--DGGGKTYRALLTLAKMYPHlqvytlteEKMAYCdgvfqNETGKNRMKSGSFLSTGWF 144

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 116242790 305 MYTLASAICEEIHLYGFWPFGFDPN-TREDLPYHYYDK 341
Cdd:cd23977  145 TMILALELCEEILVYGMVSDSYCRNkNHSSVPYHYYEK 182
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 160-340 9.74e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 69.96  E-value: 9.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 160 NICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEkyynnlLTIQDRNNFFlslKKLD 239
Cdd:cd23975    2 DLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVP------LLLKNPDYFF---KETN 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 240 GAI--LWIPAFFFHTSAT-VTRTLVDFFVEHRGQLKVQLAWPGNiMQHVNRYWK-----NKHLSPKRLSTGILMYTLASA 311
Cdd:cd23975   73 ETIyvIWGPFRNMRKDGKgIVYNMLKKAVESYPQAKIYVTTEKR-MSYCDTVFKketgkDRVQSGSYLSTGWFTLILAMD 151

                        170       180       190
                 ....*....|....*....|....*....|
gi 116242790 312 ICEEIHLYGFWPFGF-DPNTREDLPYHYYD 340
Cdd:cd23975  152 ACYGIHVYGMINDTYcKTEGYRKVPYHYYE 181
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 162-343 1.72e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 69.11  E-value: 1.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSilekyynNLLTIQDRNNFFLSLKKLDGA 241
Cdd:cd23978    4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHS-------SVYRVLRRPQEFLNRTPETTL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 242 ILWIP-----------AFFFHTSATVTRTLVDFFVehrgqlkvqlAWPGNIMQHVNRYW----KNKHLSPKRLSTGILMY 306
Cdd:cd23978   77 IFWGPpnkmqkdgksnLFRIIQRASMTFPNMSAFV----------VSPRRMRQFDDLFRgetgRDRKKSHSWLSTGWFTM 146

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 116242790 307 TLASAICEEIHLYGFWPFGF--DPNTREDLPYHYYDKKG 343
Cdd:cd23978  147 VIAVELCDNVHVYGMVPPNYcsKRPTPKKMPYHYYEPKG 185
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 159-344 1.28e-11

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 64.47  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 159 YNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEK----------YYNNLLTIQDR 228
Cdd:cd23986   49 FRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNpnhhfidsslYKDVILVAWDP 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 229 NNFFLSLKKldgailWI--PAFFFHTSatvtrtlvdfFVEHRGQLKVQlawPGNIMqHVNRYWK---------NKHLSPK 297
Cdd:cd23986  129 APYSANLHK------WYkkPDYNLFTP----------YVQYRKRNPNQ---PFYIL-HPKFIWQlwdiiqentQEKIQPN 188

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 116242790 298 RLSTGILMYTLASAICEEIHLYGFWpfgfdPNTRE-DL-PYH--YYDKKGT 344
Cdd:cd23986  189 PPSSGFIGILIMMSMCREVHVYEYI-----PSVRQtDLcHYHerYYDAACT 234
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 162-363 1.74e-11

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 62.84  E-value: 1.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNP-SIL---EKYYNNLLTIqdrnnfFLSLKK 237
Cdd:cd23984    5 CVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPeSIFsdpSHYDPNTTVV------LIPFKP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 238 LDGAILW---------------IPAFFFHTSATVTRTLVDFFVEHRGQlkvqlawpgNIMQHVNRYWKNKhlSPKRLSTG 302
Cdd:cd23984   79 HDLRWLLdllmgkkvsakgfwkKPALNLIYKPNQIRILNPFILRIAAY---------ELLHFPKRFPKEK--KPKHPTTG 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116242790 303 ILMYTLASAICEEIHLYGfwpFGFDPNTREDlPYHYYDKKgTKFTTKWQESHQLPAEFQLL 363
Cdd:cd23984  148 IIAITLALHICNEVHIAG---FKYDFSNLNS-TLHYYGNE-TMSVMTKNEYHNISAEQKFL 203
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 162-366 1.95e-11

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 62.83  E-value: 1.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNL-TTF---NPSILEKYYNNLLTIQdrnnffLSLKK 237
Cdd:cd23983    5 CVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIrMTYpegAPKSEQEYDPTSLFVA------VLFKS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 238 LDGAIL-----------WIPAFFFHTSATVT-------RTLVDFFVEHRGQLKVQLAWPgnimQHVNRYWKNKHlsPkrl 299
Cdd:cd23983   79 VDFAWLkamvkkeplsfWSRLFFWKEVADSIplkpsqfRILNPLIIKETALDILQYPEP----QSRLWGWDKNV--P--- 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116242790 300 STGILMYTLASAICEEIHLYGfwpFGFDPNtREDLPYHYYDKKGTKfTTKWQESHQLPAEFQLLYRM 366
Cdd:cd23983  150 TLGVTAVVLATHLCDEVSLAG---FGYDLS-QPHAPLHYYDSVCMA-AMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 162-366 1.03e-10

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 60.71  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 162 CAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNP----SILEKYYNNLLTIqdrnnfFLSLKK 237
Cdd:cd23981    5 CIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPegaiQKPEQYEKDSLFV------LAGFKW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116242790 238 LDgaILWIPAF-----------FFHTSATVT-------RTLVDFFVEHRGQLKVQLAWPGNIMQHVNrywknkhlSPkrl 299
Cdd:cd23981   79 QD--FKWLKYIvykekvsasdgFWKSVATRVprepheiRILNPYFIQEAAFSFIGLPFNNGLMGRGN--------IP--- 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116242790 300 STGILMYTLASAICEEIHLYGfwpFGFDPNTrEDLPYHYYDK-KGTKFTTKWqeSHQLPAEFQLLYRM 366
Cdd:cd23981  146 TLGSVAITMALHNCDEVAVAG---FGYDMNT-PNAPLHYYETiKMSAIKESW--THNIQREKEFLRKL 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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