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Conserved domains on  [gi|66392160|ref|NP_766616|]
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intermembrane lipid transfer protein VPS13A [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 139-371 2.00e-85

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


:

Pssm-ID: 465309  Cd Length: 234  Bit Score: 279.91  E-value: 2.00e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160    139 FTEKLVTQIIQNLQVQISSIHIRYEDDITNGDKPLSFGISLQNISLQTTDQYWIPCLHDNTEKLVRKLIRLDNLFAYWNV 218
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTSKIIHKLVELESLSVYWDT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160    219 NSE---MFYLNDYDESLKALKNGIVNENIVPEGYDFVFRPISASAKLQMNRRSDFDfSDPKINLAVDLHTIAIEFNKPQY 295
Cdd:pfam16908   81 DSEsleLLGDLDLEELLEKFKSLIASKSNKPPDHQYILKPVSGSAKLTLNKKGETE-TIPKIDLDLEFDEIGLTLDDRQY 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66392160    296 FSLMELLESIDMMTQNQPYRKFKPSVPLHLHAKEWWAYAIHSILEVNVcPSLRMWSWEHIRNHRYKMKRYREFYKK 371
Cdd:pfam16908  160 RDILSLLDSFHRFLRRQKYRKYRPKVSVKENPRAWWKYAINAVLEEIR-ERRRKWSWDYIKKRRDDRKEYIELYKK 234
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
4-2005 3.91e-79

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 293.71  E-value: 3.91e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160    4 ESVVVEVLNRFLGDYVVNLDESQLSLGIWKGAVALKNLVIKENALHELDVPFKVKVGHIGSLKLKIPWKNLYTQPVEAVL 83
Cdd:COG5043    3 EGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIYI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   84 EEIFLLIVPSSRiqydpIKEEKQLMETKQQELKRIEKAKQKVFDK------EKPREEKQDTFTEKLVTQIIQNLQVQISS 157
Cdd:COG5043   83 EDIYLLISPQAK-----NSLTREELPQSQQALKQRQLDSWEILREtleessSSPNISRKQSFIESLITKLIDNIQIYIED 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  158 IHIRYEDDITN-GDKPLSFGISLQNISLQTTDQYWIPCLHDNTEKLVRKLIRLDNLFAYWNVNSEMFYLNDYDESLKALK 236
Cdd:COG5043  158 IHLRFEDNLSAdLEGPYSFGLTLYSLRATSTDASWTEYFVSTDSSCIHKLITLDYFSIYWCEISPCITTEDIDSYLENFQ 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  237 NGIvnENIVPEGYDFVFRPISASAKLQMNRRSDFDFsdPKINLAVDLHTIAIEFNKPQYFSLMELLESIDMMTQNQPYRK 316
Cdd:COG5043  238 PMI--AEKSPAYNEYILKPVRGTAKVSINKLPTDEI--PRLRGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFLK 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  317 FKPSVPLHLHAKEWWAYAIHSILEvNVCPSLRMWSWEHIRNHRYKMKRYREFYKKKLTSKKPSPEILMSLEELEKTLDVF 396
Cdd:COG5043  314 YRPKSTPKEKPLEWFKYIILVVLD-SIHEKRYHWTWKYFKERCEDRRAYMKIIRKKYLNEQLSADLSKELEKRELTYDLI 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  397 NITIARQQAEVEAKKAGYKIYKegvkdPEDNAGWFGWLWtwsESNANQQQDVKPGILEEMLTPEEKSLLYEAIGYSETAV 476
Cdd:COG5043  393 KYRSRLFRSLAKRRNSIYLKPQ-----THKLQGWFSGLW---NGKPQAQDEDTLASTDKTAAELTDQEQKDFFSEIEPVG 464

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  477 DptLPKTFEALKFFVHLKSMSIVLRENHQKPELLNVVVEGLSTSvVQRpgaqaikfeTKIDSFHITGLP------DDFKK 550
Cdd:COG5043  465 Q--LYSDTVNLDVEVSIAKGSFVIQKHIRKINLISQRFENFKSK-FSL---------NKLDLFDGATNPelkpyrSIRNK 532

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  551 PHLLS-------SLDDTSLLQITFEINPLNETVAQRCTIEAEPLEIIYDARTVNSIVEFFRPP--KDVHLAQLTSVTLTK 621
Cdd:COG5043  533 PKVREseslqeiEEESRTHLFASFEDSKPDGKASSTLIIHLRTLVIFYNRVCILSVLKFFVPSrtKIEHVSEWVYSAAAT 612

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  622 LEEFRAKTATGLLYVIETQKVLDLRINVKASYVIVPQyGNFSPTSNLLLLDLGHLKVSSKRrslLPDVRPSEAS-LEDIM 700
Cdd:COG5043  613 VMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPE-DCTDPKSPTLFLDAGRISIHSQL---VEDAIIKKFReLQTLE 688

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  701 HRAYDSFDIQLTSIQLLYSRVGDNWKEARKLNvSTQHILIPMHVNVELSKAMVFMDIKMPKFKISGKLPLVSLRISDKKL 780
Cdd:COG5043  689 NLMYDRFTISLFNVRCLIGPDYEGKRELPKGK-CDYHILKELKLEINVEISILPKATNLPKIKVSGHMPHASLMFSDVQY 767

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  781 QGIMELLGSIPKPEPVTDVSAPARSFqiqASALPVSHISQklIPLLEQpvteddseeeffdapcspLEECPQVSCrdkct 860
Cdd:COG5043  768 KVIINLMSNILPTISVDEINGDYQQF---SSASLPPPFFD--IKDNFQ------------------IENHANEQT----- 819

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  861 rQKKLQKKDCVMNLIQLRMRFEVAEVSIQFYHLVgdcelPVLeMGALGLGTEAEFRTFDLKGSAFLKELWLKCPEYLDEN 940
Cdd:COG5043  820 -AAKFHAQQIFAFYFKVDYFICSGLDSRSENYLV-----PVL-RARLEFYFDLVARKFNLRVTSNSNDIVDKEFTYPSSL 892

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  941 KKPVY--LITTLDNTMEDLLTLEFMKVEKNApnLNSTYNNVLQLIKVNFSSLDIHLHTEALLNTMNYLNNILPELREKSA 1018
Cdd:COG5043  893 CDNLLsrSSPKPKNNFDDTVFIEYKSIDYDV--LDSVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFTSPNDEYM 970

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1019 -----SVSAAEPEDKGDIIKKLALKLPTNEdiITLqllaeLSCLQIFIQDQKQNiseikieglDSEMIMKPLVTEINAKL 1093
Cdd:COG5043  971 igedpELTRKISDVENIKIEDANVRLDNND--IFL-----YDCIQLFATVLSYG---------AFMHMEEREKFFLQLRL 1034

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1094 RNIIVLDSDKMAIYKKALY-ITGKEVFSFKMISYmdatagYAYTDMSVVDIRVHLTVGCIEVVFITkflySILAFIDNFQ 1172
Cdd:COG5043 1035 MDLELKNHEKSNNPDSTIVkIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGSLHFYFIE----SYFNFLSKFK 1104

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1173 AVKdalaeATVQAAEMAADGVKELARKSSRFALDVNIKAPVVLIPQSPVSQNVFVAdfgLITMKNIFVTVTETqsnipPV 1252
Cdd:COG5043 1105 RFK-----VSFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGERNCRMQ---LIIKPGSFYAFSKC-----PV 1171

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1253 IDLiTIKLSKMRL------YRSQFRNDTYQEVLDLLLPLNLEVIVERNLSWEwyKEVPCFNIKAQLKPMEFILSQEDLTt 1326
Cdd:COG5043 1172 VEK-NSKLSIFSCelrkgeFSTAVPSSGHHDVLLEELNIHLDLTIDANPTTG--ENAYVFKATGDLDPVILNLCQSQHL- 1247

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1327 vfqtlhgniwYGQDLS--APSSANKDPETMTSGVTSPPDHSPATVVTAAVVEVHPQASQAHTM-LNVSFQTDYLTMALY- 1402
Cdd:COG5043 1248 ----------ILLDLIdvVTTFFRIDSSFSTSENLPRELDSEFDRSGTPVKLKHSKKTVVETLdILFTFKLPKIRLNLYt 1317

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1403 ----SPGPDEASFTdvrdpSLELAEFKLE-NIISSLKIYTdDSTVFSFSVKNCILDDKRSHvmkaTPRMIGLTVGFDKKD 1477
Cdd:COG5043 1318 gtfgIHGGDLTGLH-----NILFFEIGLDyGFYSSGTVYA-EFSIASFRIEDVNPIKDVVF----LDVIEYSTNTHNLLV 1387

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1478 MVDIKYRKIKTFVVTDAVVQEMYVcaSVEFLMTVAHiFFDAYMTSTALETSVQTRTTRE-----APAQELGK--WEMNIL 1550
Cdd:COG5043 1388 NGCLEYDSQGRLLNLVLDIDKMFL--NLDYLYSIWS-IFVHWLRAYYSHLDYLVEQEYFnmgnpNQVACGEEsyKLYRIT 1464

                       1610      1620      1630      1640      1650      1660      1670      1680
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1551 IKNPEIVFVADMTRNDAPALVI-TTQCEICckgepTSNTVTAAIKDLQVRACPFLP-------VKRKGKVTTVLQPC-DL 1621
Cdd:COG5043 1465 IVDTTLVFVRDASDMNSYAIPFfFGQFLVT-----QQSIFTVTANNMGIFACKMSEtaninqlLDDFGIRFTISQHCsEK 1539

                       1690      1700      1710      1720      1730      1740      1750      1760
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1622 FYQATQLGRDPQMIDISVKSLTLkvSPVIINTIITITSAlYTTKETVPEENTSNiahlwDKKDTKNLKMWFLEESNESEK 1701
Cdd:COG5043 1540 IQIITTLDFDSLLLRISVNDFLL--LQTILRRIYNFIYA-LYDKETTDEELEKR-----TKDGQLALNPDFLAASVPTAQ 1611

                       1770      1780      1790      1800      1810      1820      1830      1840
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1702 VVPTNEVMPGGETLNLRIDSIFIVLEAGIGHRTVPMLLAKaCFSGESKNWLSLINLHCHLELEVHYYNEMFGVWEPLLEp 1781
Cdd:COG5043 1612 PSSVFGIRLCSEEFLINVDGIRLILISDLHDLPLLDINIK-PFQVDLKDWSTELNANASLELFMNFFNFSRSHWEPVLE- 1689

                       1850      1860      1870      1880      1890      1900      1910      1920
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1782 leidqtddfrPWNLGIKMKKKakeaivesdseaenykvpEYKTAISFYSRDQLNITLSKCGLVMLNNLVEAFTEaaTGSS 1861
Cdd:COG5043 1690 ----------PWKVGVHISRN------------------DSKTAVHVFSREIADIVLTPRLIATLHFIFTKLIS--TPFP 1739

                       1930      1940      1950      1960      1970      1980      1990      2000
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1862 SVFLRDlAPFMIFNSLGLTVSVSPsdSFSVLNVPLAKSYELKNDESLS---------MDYVRTKDNDHFNAMTSLSSKLF 1932
Cdd:COG5043 1740 IERKCD-APYRIVNYTQTAVSVWA--QFENAADSVECVRHLPNNTSTPwkfeewrqmQDVVSQDQDRVYIGVHVSNSKYE 1816

                       2010      2020      2030      2040      2050      2060      2070
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66392160 1933 FILLTPANHSvadkipltkvGRRLYTVRHRESGVERSIICQIDTVEGS-KKVTIRSPVQIKNHFSIPISVFEGD 2005
Cdd:COG5043 1817 SLRHVRVNRV----------GEHLLLISYPRDELKHYMVVDVRLGEDNiKHITLRSPLLIINETQTEIEVVFCD 1880
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 2758-2935 2.15e-67

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


:

Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 225.89  E-value: 2.15e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   2758 FEYFHISPIKLHLSVSLSSGRDEAKDSEQhgglipVHSLNLLLKSIGATLTDVQDVVFKLAFFELNYQFHTTSELQSEVI 2837
Cdd:pfam16909    4 FELLHLQPIKLHLSFSRSERVNLEESLEK------SNPLSFLLNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNRIQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   2838 RHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKIT 2917
Cdd:pfam16909   78 KHYSQQFLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKIT 157

                          170
                   ....*....|....*...
gi 66392160   2918 SAMAKGVAAMTMDEDYQQ 2935
Cdd:pfam16909  158 GSIGKGLAALTMDKQYQQ 175
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
2626-3090 3.49e-56

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 218.21  E-value: 3.49e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 2626 YNTSAHQSSFRIQIYRIQIQNQIHGAIFPFVFYP-IKPPRSVTMDSAPKPFTDVSIVMRSAGhsQISRIKYFKVLIQEMD 2704
Cdd:COG5043 2027 FIDSKAYQTFSWECAWVQIDNQLVLGIYPVILYPtEISQEEKEIENHLLPSRKFAVVKDSDS--AVTYDKYVTILLQELS 2104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 2705 LSLDLGFVYALADLVtKAEVTEKTEVEHFHKDVEAfeqeYEVVSSVDQSQVnLFEYFHISPIKLHLSVSlssgrdeaKDS 2784
Cdd:COG5043 2105 IELDEDLALAYLEKL-KFPGSKYMDDKKFDDEIEL----PDIIINKSGSNI-YFEFLHLQPTRLHISFS--------RSS 2170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 2785 EQHGGLIPV----HSLNLLLKSIGATLTDVQDVVFKLAFFELNYQFHTTSELQSEVIRHYSKQAIKQMYVLILGLDVLGN 2860
Cdd:COG5043 2171 ESSGEDGKVvpssNSYSDFYGMLAMTLGNINDAPVRLNSLLMDNARVSLPELFDLIASHYLQQVEYQIYKILGSADFLGN 2250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 2861 PFGLIREFSEGVEAFFYEPYQGAI--QGPEEFVEGMALGLKALVGGAVGGLAGAASKITSAMAKGVAAMTMDEDYQQKRR 2938
Cdd:COG5043 2251 PVGLFETVSSGVSDLFYEPYQGRFlvDNSQEWGIGIAKGGNSFIKKTIYGVSDSVSKFTGSISKGLSLVTSDPELQSSRR 2330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 2939 EA-MNKQPAGLREGITRGGKGLVSGFVSGITGIVTKPIKGAQKEGAAGFFKGVGKGLVGAVTRPTGGIIDMASSTFQGIK 3017
Cdd:COG5043 2331 LVrRRNRPKGSVYGVTAGATSLYDSTSSGEKGLALEPIIGAATNGASGFVKGLGKGILGLETKPLVGFLDLTSNDSEGIK 2410

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66392160 3018 RATETS---EVESLRPPRFFNEDGVIRPYRLRDGSGNQMLQVMENGRFAKYKYFTHVMINKTDMFmITRRGVLFVT 3090
Cdd:COG5043 2411 NTTTVLdyhDIPRLRLPRYVWDDGCVAPYDLRESQGQYWLKTLDAGKYPLDEYKFHDIINNVAVI-ISRDIHAIVT 2485
SHR-BD super family cl05933
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2202-2349 2.62e-23

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


The actual alignment was detected with superfamily member pfam06650:

Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 102.38  E-value: 2.62e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   2202 VAFHSPYWMVNKTNRMLQYKADG--------IHRKHPPNYTKPVLFSFqPNHFFNNNKVQLMVTDSELSDQFSIDTVGSH 2273
Cdd:pfam06650    3 VSIYSPYVILNKTGLPLIVRSKGnknkaagtLESHEGGRRLIPLMFSF-DTFDDRKNRALLRIGDSSWSKPFSFDAIGQT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   2274 GAI--RCKGLKMEYQVGVTINLSS--FNITRIVTFIPFYMIKNKSKYHISVAEEGSDKWLSLDLEQSIPF-WPENASNIL 2348
Cdd:pfam06650   82 NDVvlPSPNGQNEVYLGISVSEGRgkYKLTKIVTIAPRFIIKNKLPEDLEIREPGSSKIISLPPGELIPLhWLRNVEEKQ 161


                   .
gi 66392160   2349 L 2349
Cdd:pfam06650  162 L 162
 
Name Accession Description Interval E-value
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 139-371 2.00e-85

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 279.91  E-value: 2.00e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160    139 FTEKLVTQIIQNLQVQISSIHIRYEDDITNGDKPLSFGISLQNISLQTTDQYWIPCLHDNTEKLVRKLIRLDNLFAYWNV 218
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTSKIIHKLVELESLSVYWDT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160    219 NSE---MFYLNDYDESLKALKNGIVNENIVPEGYDFVFRPISASAKLQMNRRSDFDfSDPKINLAVDLHTIAIEFNKPQY 295
Cdd:pfam16908   81 DSEsleLLGDLDLEELLEKFKSLIASKSNKPPDHQYILKPVSGSAKLTLNKKGETE-TIPKIDLDLEFDEIGLTLDDRQY 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66392160    296 FSLMELLESIDMMTQNQPYRKFKPSVPLHLHAKEWWAYAIHSILEVNVcPSLRMWSWEHIRNHRYKMKRYREFYKK 371
Cdd:pfam16908  160 RDILSLLDSFHRFLRRQKYRKYRPKVSVKENPRAWWKYAINAVLEEIR-ERRRKWSWDYIKKRRDDRKEYIELYKK 234
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
4-2005 3.91e-79

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 293.71  E-value: 3.91e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160    4 ESVVVEVLNRFLGDYVVNLDESQLSLGIWKGAVALKNLVIKENALHELDVPFKVKVGHIGSLKLKIPWKNLYTQPVEAVL 83
Cdd:COG5043    3 EGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIYI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   84 EEIFLLIVPSSRiqydpIKEEKQLMETKQQELKRIEKAKQKVFDK------EKPREEKQDTFTEKLVTQIIQNLQVQISS 157
Cdd:COG5043   83 EDIYLLISPQAK-----NSLTREELPQSQQALKQRQLDSWEILREtleessSSPNISRKQSFIESLITKLIDNIQIYIED 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  158 IHIRYEDDITN-GDKPLSFGISLQNISLQTTDQYWIPCLHDNTEKLVRKLIRLDNLFAYWNVNSEMFYLNDYDESLKALK 236
Cdd:COG5043  158 IHLRFEDNLSAdLEGPYSFGLTLYSLRATSTDASWTEYFVSTDSSCIHKLITLDYFSIYWCEISPCITTEDIDSYLENFQ 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  237 NGIvnENIVPEGYDFVFRPISASAKLQMNRRSDFDFsdPKINLAVDLHTIAIEFNKPQYFSLMELLESIDMMTQNQPYRK 316
Cdd:COG5043  238 PMI--AEKSPAYNEYILKPVRGTAKVSINKLPTDEI--PRLRGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFLK 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  317 FKPSVPLHLHAKEWWAYAIHSILEvNVCPSLRMWSWEHIRNHRYKMKRYREFYKKKLTSKKPSPEILMSLEELEKTLDVF 396
Cdd:COG5043  314 YRPKSTPKEKPLEWFKYIILVVLD-SIHEKRYHWTWKYFKERCEDRRAYMKIIRKKYLNEQLSADLSKELEKRELTYDLI 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  397 NITIARQQAEVEAKKAGYKIYKegvkdPEDNAGWFGWLWtwsESNANQQQDVKPGILEEMLTPEEKSLLYEAIGYSETAV 476
Cdd:COG5043  393 KYRSRLFRSLAKRRNSIYLKPQ-----THKLQGWFSGLW---NGKPQAQDEDTLASTDKTAAELTDQEQKDFFSEIEPVG 464

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  477 DptLPKTFEALKFFVHLKSMSIVLRENHQKPELLNVVVEGLSTSvVQRpgaqaikfeTKIDSFHITGLP------DDFKK 550
Cdd:COG5043  465 Q--LYSDTVNLDVEVSIAKGSFVIQKHIRKINLISQRFENFKSK-FSL---------NKLDLFDGATNPelkpyrSIRNK 532

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  551 PHLLS-------SLDDTSLLQITFEINPLNETVAQRCTIEAEPLEIIYDARTVNSIVEFFRPP--KDVHLAQLTSVTLTK 621
Cdd:COG5043  533 PKVREseslqeiEEESRTHLFASFEDSKPDGKASSTLIIHLRTLVIFYNRVCILSVLKFFVPSrtKIEHVSEWVYSAAAT 612

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  622 LEEFRAKTATGLLYVIETQKVLDLRINVKASYVIVPQyGNFSPTSNLLLLDLGHLKVSSKRrslLPDVRPSEAS-LEDIM 700
Cdd:COG5043  613 VMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPE-DCTDPKSPTLFLDAGRISIHSQL---VEDAIIKKFReLQTLE 688

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  701 HRAYDSFDIQLTSIQLLYSRVGDNWKEARKLNvSTQHILIPMHVNVELSKAMVFMDIKMPKFKISGKLPLVSLRISDKKL 780
Cdd:COG5043  689 NLMYDRFTISLFNVRCLIGPDYEGKRELPKGK-CDYHILKELKLEINVEISILPKATNLPKIKVSGHMPHASLMFSDVQY 767

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  781 QGIMELLGSIPKPEPVTDVSAPARSFqiqASALPVSHISQklIPLLEQpvteddseeeffdapcspLEECPQVSCrdkct 860
Cdd:COG5043  768 KVIINLMSNILPTISVDEINGDYQQF---SSASLPPPFFD--IKDNFQ------------------IENHANEQT----- 819

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  861 rQKKLQKKDCVMNLIQLRMRFEVAEVSIQFYHLVgdcelPVLeMGALGLGTEAEFRTFDLKGSAFLKELWLKCPEYLDEN 940
Cdd:COG5043  820 -AAKFHAQQIFAFYFKVDYFICSGLDSRSENYLV-----PVL-RARLEFYFDLVARKFNLRVTSNSNDIVDKEFTYPSSL 892

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  941 KKPVY--LITTLDNTMEDLLTLEFMKVEKNApnLNSTYNNVLQLIKVNFSSLDIHLHTEALLNTMNYLNNILPELREKSA 1018
Cdd:COG5043  893 CDNLLsrSSPKPKNNFDDTVFIEYKSIDYDV--LDSVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFTSPNDEYM 970

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1019 -----SVSAAEPEDKGDIIKKLALKLPTNEdiITLqllaeLSCLQIFIQDQKQNiseikieglDSEMIMKPLVTEINAKL 1093
Cdd:COG5043  971 igedpELTRKISDVENIKIEDANVRLDNND--IFL-----YDCIQLFATVLSYG---------AFMHMEEREKFFLQLRL 1034

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1094 RNIIVLDSDKMAIYKKALY-ITGKEVFSFKMISYmdatagYAYTDMSVVDIRVHLTVGCIEVVFITkflySILAFIDNFQ 1172
Cdd:COG5043 1035 MDLELKNHEKSNNPDSTIVkIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGSLHFYFIE----SYFNFLSKFK 1104

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1173 AVKdalaeATVQAAEMAADGVKELARKSSRFALDVNIKAPVVLIPQSPVSQNVFVAdfgLITMKNIFVTVTETqsnipPV 1252
Cdd:COG5043 1105 RFK-----VSFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGERNCRMQ---LIIKPGSFYAFSKC-----PV 1171

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1253 IDLiTIKLSKMRL------YRSQFRNDTYQEVLDLLLPLNLEVIVERNLSWEwyKEVPCFNIKAQLKPMEFILSQEDLTt 1326
Cdd:COG5043 1172 VEK-NSKLSIFSCelrkgeFSTAVPSSGHHDVLLEELNIHLDLTIDANPTTG--ENAYVFKATGDLDPVILNLCQSQHL- 1247

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1327 vfqtlhgniwYGQDLS--APSSANKDPETMTSGVTSPPDHSPATVVTAAVVEVHPQASQAHTM-LNVSFQTDYLTMALY- 1402
Cdd:COG5043 1248 ----------ILLDLIdvVTTFFRIDSSFSTSENLPRELDSEFDRSGTPVKLKHSKKTVVETLdILFTFKLPKIRLNLYt 1317

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1403 ----SPGPDEASFTdvrdpSLELAEFKLE-NIISSLKIYTdDSTVFSFSVKNCILDDKRSHvmkaTPRMIGLTVGFDKKD 1477
Cdd:COG5043 1318 gtfgIHGGDLTGLH-----NILFFEIGLDyGFYSSGTVYA-EFSIASFRIEDVNPIKDVVF----LDVIEYSTNTHNLLV 1387

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1478 MVDIKYRKIKTFVVTDAVVQEMYVcaSVEFLMTVAHiFFDAYMTSTALETSVQTRTTRE-----APAQELGK--WEMNIL 1550
Cdd:COG5043 1388 NGCLEYDSQGRLLNLVLDIDKMFL--NLDYLYSIWS-IFVHWLRAYYSHLDYLVEQEYFnmgnpNQVACGEEsyKLYRIT 1464

                       1610      1620      1630      1640      1650      1660      1670      1680
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1551 IKNPEIVFVADMTRNDAPALVI-TTQCEICckgepTSNTVTAAIKDLQVRACPFLP-------VKRKGKVTTVLQPC-DL 1621
Cdd:COG5043 1465 IVDTTLVFVRDASDMNSYAIPFfFGQFLVT-----QQSIFTVTANNMGIFACKMSEtaninqlLDDFGIRFTISQHCsEK 1539

                       1690      1700      1710      1720      1730      1740      1750      1760
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1622 FYQATQLGRDPQMIDISVKSLTLkvSPVIINTIITITSAlYTTKETVPEENTSNiahlwDKKDTKNLKMWFLEESNESEK 1701
Cdd:COG5043 1540 IQIITTLDFDSLLLRISVNDFLL--LQTILRRIYNFIYA-LYDKETTDEELEKR-----TKDGQLALNPDFLAASVPTAQ 1611

                       1770      1780      1790      1800      1810      1820      1830      1840
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1702 VVPTNEVMPGGETLNLRIDSIFIVLEAGIGHRTVPMLLAKaCFSGESKNWLSLINLHCHLELEVHYYNEMFGVWEPLLEp 1781
Cdd:COG5043 1612 PSSVFGIRLCSEEFLINVDGIRLILISDLHDLPLLDINIK-PFQVDLKDWSTELNANASLELFMNFFNFSRSHWEPVLE- 1689

                       1850      1860      1870      1880      1890      1900      1910      1920
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1782 leidqtddfrPWNLGIKMKKKakeaivesdseaenykvpEYKTAISFYSRDQLNITLSKCGLVMLNNLVEAFTEaaTGSS 1861
Cdd:COG5043 1690 ----------PWKVGVHISRN------------------DSKTAVHVFSREIADIVLTPRLIATLHFIFTKLIS--TPFP 1739

                       1930      1940      1950      1960      1970      1980      1990      2000
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1862 SVFLRDlAPFMIFNSLGLTVSVSPsdSFSVLNVPLAKSYELKNDESLS---------MDYVRTKDNDHFNAMTSLSSKLF 1932
Cdd:COG5043 1740 IERKCD-APYRIVNYTQTAVSVWA--QFENAADSVECVRHLPNNTSTPwkfeewrqmQDVVSQDQDRVYIGVHVSNSKYE 1816

                       2010      2020      2030      2040      2050      2060      2070
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66392160 1933 FILLTPANHSvadkipltkvGRRLYTVRHRESGVERSIICQIDTVEGS-KKVTIRSPVQIKNHFSIPISVFEGD 2005
Cdd:COG5043 1817 SLRHVRVNRV----------GEHLLLISYPRDELKHYMVVDVRLGEDNiKHITLRSPLLIINETQTEIEVVFCD 1880
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 567-791 6.18e-69

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 232.79  E-value: 6.18e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160    567 FEINPLNETVAQRCTIEAEPLEIIYDARTVNSIVEFFRPPKDVH--LAQLTSVTLTKLEEFRAKTATGLLYVIETQKVLD 644
Cdd:pfam16910    1 FETNPLDGSADSRLTVKLRPLEIIYDPHFIEEVIDFFKPPESHLelIGALMAAAEATLEGIKEQTRAGLEYALEEHKTLD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160    645 LRINVKASYVIVPQY-------------GNFSPTSNlLLLDLGHLKVSSKRRSllpdvRPSEASLEDIMHRAYDSFDIQL 711
Cdd:pfam16910   81 LDIDLQAPLIIVPEDytskdspclildaGHISVTSD-LVDKSTIKEIKSKQSQ-----QYTEEDLKELESLMYDKFSLKL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160    712 TSIQLLYSRVGDNWKEARKLNVSTQ-HILIPMHVNVELSKAMVFMDIKMPKFKISGKLPLVSLRISDKKLQGIMELLG-S 789
Cdd:pfam16910  155 SDTQVLIGPSGEDWKEALTEDDSSPlHILEPINLDLTLEKSILPKAPRLPKFKVSGHLPSLHINFSDDKYKSLMRLIDvS 234


                   ..
gi 66392160    790 IP 791
Cdd:pfam16910  235 IP 236
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 2758-2935 2.15e-67

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 225.89  E-value: 2.15e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   2758 FEYFHISPIKLHLSVSLSSGRDEAKDSEQhgglipVHSLNLLLKSIGATLTDVQDVVFKLAFFELNYQFHTTSELQSEVI 2837
Cdd:pfam16909    4 FELLHLQPIKLHLSFSRSERVNLEESLEK------SNPLSFLLNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNRIQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   2838 RHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKIT 2917
Cdd:pfam16909   78 KHYSQQFLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKIT 157

                          170
                   ....*....|....*...
gi 66392160   2918 SAMAKGVAAMTMDEDYQQ 2935
Cdd:pfam16909  158 GSIGKGLAALTMDKQYQQ 175
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
2626-3090 3.49e-56

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 218.21  E-value: 3.49e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 2626 YNTSAHQSSFRIQIYRIQIQNQIHGAIFPFVFYP-IKPPRSVTMDSAPKPFTDVSIVMRSAGhsQISRIKYFKVLIQEMD 2704
Cdd:COG5043 2027 FIDSKAYQTFSWECAWVQIDNQLVLGIYPVILYPtEISQEEKEIENHLLPSRKFAVVKDSDS--AVTYDKYVTILLQELS 2104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 2705 LSLDLGFVYALADLVtKAEVTEKTEVEHFHKDVEAfeqeYEVVSSVDQSQVnLFEYFHISPIKLHLSVSlssgrdeaKDS 2784
Cdd:COG5043 2105 IELDEDLALAYLEKL-KFPGSKYMDDKKFDDEIEL----PDIIINKSGSNI-YFEFLHLQPTRLHISFS--------RSS 2170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 2785 EQHGGLIPV----HSLNLLLKSIGATLTDVQDVVFKLAFFELNYQFHTTSELQSEVIRHYSKQAIKQMYVLILGLDVLGN 2860
Cdd:COG5043 2171 ESSGEDGKVvpssNSYSDFYGMLAMTLGNINDAPVRLNSLLMDNARVSLPELFDLIASHYLQQVEYQIYKILGSADFLGN 2250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 2861 PFGLIREFSEGVEAFFYEPYQGAI--QGPEEFVEGMALGLKALVGGAVGGLAGAASKITSAMAKGVAAMTMDEDYQQKRR 2938
Cdd:COG5043 2251 PVGLFETVSSGVSDLFYEPYQGRFlvDNSQEWGIGIAKGGNSFIKKTIYGVSDSVSKFTGSISKGLSLVTSDPELQSSRR 2330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 2939 EA-MNKQPAGLREGITRGGKGLVSGFVSGITGIVTKPIKGAQKEGAAGFFKGVGKGLVGAVTRPTGGIIDMASSTFQGIK 3017
Cdd:COG5043 2331 LVrRRNRPKGSVYGVTAGATSLYDSTSSGEKGLALEPIIGAATNGASGFVKGLGKGILGLETKPLVGFLDLTSNDSEGIK 2410

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66392160 3018 RATETS---EVESLRPPRFFNEDGVIRPYRLRDGSGNQMLQVMENGRFAKYKYFTHVMINKTDMFmITRRGVLFVT 3090
Cdd:COG5043 2411 NTTTVLdyhDIPRLRLPRYVWDDGCVAPYDLRESQGQYWLKTLDAGKYPLDEYKFHDIINNVAVI-ISRDIHAIVT 2485
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2202-2349 2.62e-23

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 102.38  E-value: 2.62e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   2202 VAFHSPYWMVNKTNRMLQYKADG--------IHRKHPPNYTKPVLFSFqPNHFFNNNKVQLMVTDSELSDQFSIDTVGSH 2273
Cdd:pfam06650    3 VSIYSPYVILNKTGLPLIVRSKGnknkaagtLESHEGGRRLIPLMFSF-DTFDDRKNRALLRIGDSSWSKPFSFDAIGQT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   2274 GAI--RCKGLKMEYQVGVTINLSS--FNITRIVTFIPFYMIKNKSKYHISVAEEGSDKWLSLDLEQSIPF-WPENASNIL 2348
Cdd:pfam06650   82 NDVvlPSPNGQNEVYLGISVSEGRgkYKLTKIVTIAPRFIIKNKLPEDLEIREPGSSKIISLPPGELIPLhWLRNVEEKQ 161


                   .
gi 66392160   2349 L 2349
Cdd:pfam06650  162 L 162
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 2938-3017 5.31e-18

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 81.40  E-value: 5.31e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   2938 REAMNKQPAGLREGITRGGKGLVSGFVSGITGIVTKPIKGAQKEGAAGFFKGVGKGLVGAVTRPTGGIIDMASSTFQGIK 3017
Cdd:pfam09333    1 ISLYANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVR 80
 
Name Accession Description Interval E-value
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
 139-371 2.00e-85

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 279.91  E-value: 2.00e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160    139 FTEKLVTQIIQNLQVQISSIHIRYEDDITNGDKPLSFGISLQNISLQTTDQYWIPCLHDNTEKLVRKLIRLDNLFAYWNV 218
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTSKIIHKLVELESLSVYWDT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160    219 NSE---MFYLNDYDESLKALKNGIVNENIVPEGYDFVFRPISASAKLQMNRRSDFDfSDPKINLAVDLHTIAIEFNKPQY 295
Cdd:pfam16908   81 DSEsleLLGDLDLEELLEKFKSLIASKSNKPPDHQYILKPVSGSAKLTLNKKGETE-TIPKIDLDLEFDEIGLTLDDRQY 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66392160    296 FSLMELLESIDMMTQNQPYRKFKPSVPLHLHAKEWWAYAIHSILEVNVcPSLRMWSWEHIRNHRYKMKRYREFYKK 371
Cdd:pfam16908  160 RDILSLLDSFHRFLRRQKYRKYRPKVSVKENPRAWWKYAINAVLEEIR-ERRRKWSWDYIKKRRDDRKEYIELYKK 234
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
4-2005 3.91e-79

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 293.71  E-value: 3.91e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160    4 ESVVVEVLNRFLGDYVVNLDESQLSLGIWKGAVALKNLVIKENALHELDVPFKVKVGHIGSLKLKIPWKNLYTQPVEAVL 83
Cdd:COG5043    3 EGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEIYI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   84 EEIFLLIVPSSRiqydpIKEEKQLMETKQQELKRIEKAKQKVFDK------EKPREEKQDTFTEKLVTQIIQNLQVQISS 157
Cdd:COG5043   83 EDIYLLISPQAK-----NSLTREELPQSQQALKQRQLDSWEILREtleessSSPNISRKQSFIESLITKLIDNIQIYIED 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  158 IHIRYEDDITN-GDKPLSFGISLQNISLQTTDQYWIPCLHDNTEKLVRKLIRLDNLFAYWNVNSEMFYLNDYDESLKALK 236
Cdd:COG5043  158 IHLRFEDNLSAdLEGPYSFGLTLYSLRATSTDASWTEYFVSTDSSCIHKLITLDYFSIYWCEISPCITTEDIDSYLENFQ 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  237 NGIvnENIVPEGYDFVFRPISASAKLQMNRRSDFDFsdPKINLAVDLHTIAIEFNKPQYFSLMELLESIDMMTQNQPYRK 316
Cdd:COG5043  238 PMI--AEKSPAYNEYILKPVRGTAKVSINKLPTDEI--PRLRGQLSVEEFSISLSDHMYYSLLGVLDYLQVVMKQQKFLK 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  317 FKPSVPLHLHAKEWWAYAIHSILEvNVCPSLRMWSWEHIRNHRYKMKRYREFYKKKLTSKKPSPEILMSLEELEKTLDVF 396
Cdd:COG5043  314 YRPKSTPKEKPLEWFKYIILVVLD-SIHEKRYHWTWKYFKERCEDRRAYMKIIRKKYLNEQLSADLSKELEKRELTYDLI 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  397 NITIARQQAEVEAKKAGYKIYKegvkdPEDNAGWFGWLWtwsESNANQQQDVKPGILEEMLTPEEKSLLYEAIGYSETAV 476
Cdd:COG5043  393 KYRSRLFRSLAKRRNSIYLKPQ-----THKLQGWFSGLW---NGKPQAQDEDTLASTDKTAAELTDQEQKDFFSEIEPVG 464

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  477 DptLPKTFEALKFFVHLKSMSIVLRENHQKPELLNVVVEGLSTSvVQRpgaqaikfeTKIDSFHITGLP------DDFKK 550
Cdd:COG5043  465 Q--LYSDTVNLDVEVSIAKGSFVIQKHIRKINLISQRFENFKSK-FSL---------NKLDLFDGATNPelkpyrSIRNK 532

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  551 PHLLS-------SLDDTSLLQITFEINPLNETVAQRCTIEAEPLEIIYDARTVNSIVEFFRPP--KDVHLAQLTSVTLTK 621
Cdd:COG5043  533 PKVREseslqeiEEESRTHLFASFEDSKPDGKASSTLIIHLRTLVIFYNRVCILSVLKFFVPSrtKIEHVSEWVYSAAAT 612

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  622 LEEFRAKTATGLLYVIETQKVLDLRINVKASYVIVPQyGNFSPTSNLLLLDLGHLKVSSKRrslLPDVRPSEAS-LEDIM 700
Cdd:COG5043  613 VMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPE-DCTDPKSPTLFLDAGRISIHSQL---VEDAIIKKFReLQTLE 688

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  701 HRAYDSFDIQLTSIQLLYSRVGDNWKEARKLNvSTQHILIPMHVNVELSKAMVFMDIKMPKFKISGKLPLVSLRISDKKL 780
Cdd:COG5043  689 NLMYDRFTISLFNVRCLIGPDYEGKRELPKGK-CDYHILKELKLEINVEISILPKATNLPKIKVSGHMPHASLMFSDVQY 767

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  781 QGIMELLGSIPKPEPVTDVSAPARSFqiqASALPVSHISQklIPLLEQpvteddseeeffdapcspLEECPQVSCrdkct 860
Cdd:COG5043  768 KVIINLMSNILPTISVDEINGDYQQF---SSASLPPPFFD--IKDNFQ------------------IENHANEQT----- 819

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  861 rQKKLQKKDCVMNLIQLRMRFEVAEVSIQFYHLVgdcelPVLeMGALGLGTEAEFRTFDLKGSAFLKELWLKCPEYLDEN 940
Cdd:COG5043  820 -AAKFHAQQIFAFYFKVDYFICSGLDSRSENYLV-----PVL-RARLEFYFDLVARKFNLRVTSNSNDIVDKEFTYPSSL 892

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160  941 KKPVY--LITTLDNTMEDLLTLEFMKVEKNApnLNSTYNNVLQLIKVNFSSLDIHLHTEALLNTMNYLNNILPELREKSA 1018
Cdd:COG5043  893 CDNLLsrSSPKPKNNFDDTVFIEYKSIDYDV--LDSVYEEVDTTIAVVLSDLILNLEPTSFLTLIDFIRSTFTSPNDEYM 970

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1019 -----SVSAAEPEDKGDIIKKLALKLPTNEdiITLqllaeLSCLQIFIQDQKQNiseikieglDSEMIMKPLVTEINAKL 1093
Cdd:COG5043  971 igedpELTRKISDVENIKIEDANVRLDNND--IFL-----YDCIQLFATVLSYG---------AFMHMEEREKFFLQLRL 1034

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1094 RNIIVLDSDKMAIYKKALY-ITGKEVFSFKMISYmdatagYAYTDMSVVDIRVHLTVGCIEVVFITkflySILAFIDNFQ 1172
Cdd:COG5043 1035 MDLELKNHEKSNNPDSTIVkIDDNKLFIFKYESY------DIPDPITDCDCVLDISTGSLHFYFIE----SYFNFLSKFK 1104

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1173 AVKdalaeATVQAAEMAADGVKELARKSSRFALDVNIKAPVVLIPQSPVSQNVFVAdfgLITMKNIFVTVTETqsnipPV 1252
Cdd:COG5043 1105 RFK-----VSFSSIRYAAYYKAYGNKVSNNYKFELRIKHPIVQFPDVLGERNCRMQ---LIIKPGSFYAFSKC-----PV 1171

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1253 IDLiTIKLSKMRL------YRSQFRNDTYQEVLDLLLPLNLEVIVERNLSWEwyKEVPCFNIKAQLKPMEFILSQEDLTt 1326
Cdd:COG5043 1172 VEK-NSKLSIFSCelrkgeFSTAVPSSGHHDVLLEELNIHLDLTIDANPTTG--ENAYVFKATGDLDPVILNLCQSQHL- 1247

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1327 vfqtlhgniwYGQDLS--APSSANKDPETMTSGVTSPPDHSPATVVTAAVVEVHPQASQAHTM-LNVSFQTDYLTMALY- 1402
Cdd:COG5043 1248 ----------ILLDLIdvVTTFFRIDSSFSTSENLPRELDSEFDRSGTPVKLKHSKKTVVETLdILFTFKLPKIRLNLYt 1317

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1403 ----SPGPDEASFTdvrdpSLELAEFKLE-NIISSLKIYTdDSTVFSFSVKNCILDDKRSHvmkaTPRMIGLTVGFDKKD 1477
Cdd:COG5043 1318 gtfgIHGGDLTGLH-----NILFFEIGLDyGFYSSGTVYA-EFSIASFRIEDVNPIKDVVF----LDVIEYSTNTHNLLV 1387

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1478 MVDIKYRKIKTFVVTDAVVQEMYVcaSVEFLMTVAHiFFDAYMTSTALETSVQTRTTRE-----APAQELGK--WEMNIL 1550
Cdd:COG5043 1388 NGCLEYDSQGRLLNLVLDIDKMFL--NLDYLYSIWS-IFVHWLRAYYSHLDYLVEQEYFnmgnpNQVACGEEsyKLYRIT 1464

                       1610      1620      1630      1640      1650      1660      1670      1680
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1551 IKNPEIVFVADMTRNDAPALVI-TTQCEICckgepTSNTVTAAIKDLQVRACPFLP-------VKRKGKVTTVLQPC-DL 1621
Cdd:COG5043 1465 IVDTTLVFVRDASDMNSYAIPFfFGQFLVT-----QQSIFTVTANNMGIFACKMSEtaninqlLDDFGIRFTISQHCsEK 1539

                       1690      1700      1710      1720      1730      1740      1750      1760
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1622 FYQATQLGRDPQMIDISVKSLTLkvSPVIINTIITITSAlYTTKETVPEENTSNiahlwDKKDTKNLKMWFLEESNESEK 1701
Cdd:COG5043 1540 IQIITTLDFDSLLLRISVNDFLL--LQTILRRIYNFIYA-LYDKETTDEELEKR-----TKDGQLALNPDFLAASVPTAQ 1611

                       1770      1780      1790      1800      1810      1820      1830      1840
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1702 VVPTNEVMPGGETLNLRIDSIFIVLEAGIGHRTVPMLLAKaCFSGESKNWLSLINLHCHLELEVHYYNEMFGVWEPLLEp 1781
Cdd:COG5043 1612 PSSVFGIRLCSEEFLINVDGIRLILISDLHDLPLLDINIK-PFQVDLKDWSTELNANASLELFMNFFNFSRSHWEPVLE- 1689

                       1850      1860      1870      1880      1890      1900      1910      1920
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1782 leidqtddfrPWNLGIKMKKKakeaivesdseaenykvpEYKTAISFYSRDQLNITLSKCGLVMLNNLVEAFTEaaTGSS 1861
Cdd:COG5043 1690 ----------PWKVGVHISRN------------------DSKTAVHVFSREIADIVLTPRLIATLHFIFTKLIS--TPFP 1739

                       1930      1940      1950      1960      1970      1980      1990      2000
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 1862 SVFLRDlAPFMIFNSLGLTVSVSPsdSFSVLNVPLAKSYELKNDESLS---------MDYVRTKDNDHFNAMTSLSSKLF 1932
Cdd:COG5043 1740 IERKCD-APYRIVNYTQTAVSVWA--QFENAADSVECVRHLPNNTSTPwkfeewrqmQDVVSQDQDRVYIGVHVSNSKYE 1816

                       2010      2020      2030      2040      2050      2060      2070
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66392160 1933 FILLTPANHSvadkipltkvGRRLYTVRHRESGVERSIICQIDTVEGS-KKVTIRSPVQIKNHFSIPISVFEGD 2005
Cdd:COG5043 1817 SLRHVRVNRV----------GEHLLLISYPRDELKHYMVVDVRLGEDNiKHITLRSPLLIINETQTEIEVVFCD 1880
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 567-791 6.18e-69

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 232.79  E-value: 6.18e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160    567 FEINPLNETVAQRCTIEAEPLEIIYDARTVNSIVEFFRPPKDVH--LAQLTSVTLTKLEEFRAKTATGLLYVIETQKVLD 644
Cdd:pfam16910    1 FETNPLDGSADSRLTVKLRPLEIIYDPHFIEEVIDFFKPPESHLelIGALMAAAEATLEGIKEQTRAGLEYALEEHKTLD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160    645 LRINVKASYVIVPQY-------------GNFSPTSNlLLLDLGHLKVSSKRRSllpdvRPSEASLEDIMHRAYDSFDIQL 711
Cdd:pfam16910   81 LDIDLQAPLIIVPEDytskdspclildaGHISVTSD-LVDKSTIKEIKSKQSQ-----QYTEEDLKELESLMYDKFSLKL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160    712 TSIQLLYSRVGDNWKEARKLNVSTQ-HILIPMHVNVELSKAMVFMDIKMPKFKISGKLPLVSLRISDKKLQGIMELLG-S 789
Cdd:pfam16910  155 SDTQVLIGPSGEDWKEALTEDDSSPlHILEPINLDLTLEKSILPKAPRLPKFKVSGHLPSLHINFSDDKYKSLMRLIDvS 234


                   ..
gi 66392160    790 IP 791
Cdd:pfam16910  235 IP 236
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
 2758-2935 2.15e-67

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 225.89  E-value: 2.15e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   2758 FEYFHISPIKLHLSVSLSSGRDEAKDSEQhgglipVHSLNLLLKSIGATLTDVQDVVFKLAFFELNYQFHTTSELQSEVI 2837
Cdd:pfam16909    4 FELLHLQPIKLHLSFSRSERVNLEESLEK------SNPLSFLLNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNRIQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   2838 RHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGVEAFFYEPYQGAIQGPEEFVEGMALGLKALVGGAVGGLAGAASKIT 2917
Cdd:pfam16909   78 KHYSQQFLYQLYKILGSLDFLGNPVGLFNNISSGVKDFFYEPYQGLIQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKIT 157

                          170
                   ....*....|....*...
gi 66392160   2918 SAMAKGVAAMTMDEDYQQ 2935
Cdd:pfam16909  158 GSIGKGLAALTMDKQYQQ 175
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
2626-3090 3.49e-56

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 218.21  E-value: 3.49e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 2626 YNTSAHQSSFRIQIYRIQIQNQIHGAIFPFVFYP-IKPPRSVTMDSAPKPFTDVSIVMRSAGhsQISRIKYFKVLIQEMD 2704
Cdd:COG5043 2027 FIDSKAYQTFSWECAWVQIDNQLVLGIYPVILYPtEISQEEKEIENHLLPSRKFAVVKDSDS--AVTYDKYVTILLQELS 2104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 2705 LSLDLGFVYALADLVtKAEVTEKTEVEHFHKDVEAfeqeYEVVSSVDQSQVnLFEYFHISPIKLHLSVSlssgrdeaKDS 2784
Cdd:COG5043 2105 IELDEDLALAYLEKL-KFPGSKYMDDKKFDDEIEL----PDIIINKSGSNI-YFEFLHLQPTRLHISFS--------RSS 2170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 2785 EQHGGLIPV----HSLNLLLKSIGATLTDVQDVVFKLAFFELNYQFHTTSELQSEVIRHYSKQAIKQMYVLILGLDVLGN 2860
Cdd:COG5043 2171 ESSGEDGKVvpssNSYSDFYGMLAMTLGNINDAPVRLNSLLMDNARVSLPELFDLIASHYLQQVEYQIYKILGSADFLGN 2250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 2861 PFGLIREFSEGVEAFFYEPYQGAI--QGPEEFVEGMALGLKALVGGAVGGLAGAASKITSAMAKGVAAMTMDEDYQQKRR 2938
Cdd:COG5043 2251 PVGLFETVSSGVSDLFYEPYQGRFlvDNSQEWGIGIAKGGNSFIKKTIYGVSDSVSKFTGSISKGLSLVTSDPELQSSRR 2330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160 2939 EA-MNKQPAGLREGITRGGKGLVSGFVSGITGIVTKPIKGAQKEGAAGFFKGVGKGLVGAVTRPTGGIIDMASSTFQGIK 3017
Cdd:COG5043 2331 LVrRRNRPKGSVYGVTAGATSLYDSTSSGEKGLALEPIIGAATNGASGFVKGLGKGILGLETKPLVGFLDLTSNDSEGIK 2410

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66392160 3018 RATETS---EVESLRPPRFFNEDGVIRPYRLRDGSGNQMLQVMENGRFAKYKYFTHVMINKTDMFmITRRGVLFVT 3090
Cdd:COG5043 2411 NTTTVLdyhDIPRLRLPRYVWDDGCVAPYDLRESQGQYWLKTLDAGKYPLDEYKFHDIINNVAVI-ISRDIHAIVT 2485
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 3-117 1.95e-40

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 146.17  E-value: 1.95e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160      3 FESVVVEVLNRFLGDYVVNLDESQLSLGIWKGAVALKNLVIKENALHELDVPFKVKVGHIGSLKLKIPWKNLYTQPVEAV 82
Cdd:pfam12624    1 LESLVASLLNRYLGEYVENLDPDQLKVGLWSGDVVLENLKLKKEALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEPVVIE 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 66392160     83 LEEIFLLIVPSSR-IQYDPIKEEKQLMETKQQELKR 117
Cdd:pfam12624   81 IEDVYLLAVPKDEsEEYDEEEEEKRELAAKKEKLAA 116
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
 2202-2349 2.62e-23

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 102.38  E-value: 2.62e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   2202 VAFHSPYWMVNKTNRMLQYKADG--------IHRKHPPNYTKPVLFSFqPNHFFNNNKVQLMVTDSELSDQFSIDTVGSH 2273
Cdd:pfam06650    3 VSIYSPYVILNKTGLPLIVRSKGnknkaagtLESHEGGRRLIPLMFSF-DTFDDRKNRALLRIGDSSWSKPFSFDAIGQT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   2274 GAI--RCKGLKMEYQVGVTINLSS--FNITRIVTFIPFYMIKNKSKYHISVAEEGSDKWLSLDLEQSIPF-WPENASNIL 2348
Cdd:pfam06650   82 NDVvlPSPNGQNEVYLGISVSEGRgkYKLTKIVTIAPRFIIKNKLPEDLEIREPGSSKIISLPPGELIPLhWLRNVEEKQ 161


                   .
gi 66392160   2349 L 2349
Cdd:pfam06650  162 L 162
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 2938-3017 5.31e-18

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 81.40  E-value: 5.31e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   2938 REAMNKQPAGLREGITRGGKGLVSGFVSGITGIVTKPIKGAQKEGAAGFFKGVGKGLVGAVTRPTGGIIDMASSTFQGIK 3017
Cdd:pfam09333    1 ISLYANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVR 80
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
 1141-1265 2.90e-05

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 48.28  E-value: 2.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66392160   1141 VDIRVHLTVGCIEVVFITKFLYSILAFIdNFQAVKDALAEATVQAAEMAADGVKELAR--------KSSRFALDVNIKAP 1212
Cdd:pfam16910   10 ADSRLTVKLRPLEIIYDPHFIEEVIDFF-KPPESHLELIGALMAAAEATLEGIKEQTRagleyaleEHKTLDLDIDLQAP 88

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 66392160   1213 VVLIPQSPVSQ--NVFVADFGLITMKNIFVtvteTQSNIPPVIDLITIKLSKMRL 1265
Cdd:pfam16910   89 LIIVPEDYTSKdsPCLILDAGHISVTSDLV----DKSTIKEIKSKQSQQYTEEDL 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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