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Conserved domains on  [gi|23097256|ref|NP_690854|]
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ribonucleases P/MRP protein subunit POP1 isoform 1 [Mus musculus]

Protein Classification

ribonucleases P/MRP protein subunit POP1( domain architecture ID 10536688)

ribonucleases P/MRP protein subunit POP1 is a component of both ribonuclease P and MRP ribonuclease, which cleave tRNA molecules by their 5'-ends and pre-rRNA sequences, respectively

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
POPLD pfam08170
POPLD (NUC188) domain; This domain is found in POP1-like nucleolar proteins.
 647-738 1.15e-40

POPLD (NUC188) domain; This domain is found in POP1-like nucleolar proteins.


:

Pssm-ID: 462391  Cd Length: 92  Bit Score: 144.62  E-value: 1.15e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097256    647 GWDVLIPKGWGMAFWIPFIYRGARVGGLKEATVHSQYRRSPNIPGDFPDCRAGVLFAEDQAKDLLEKYRRRPPAKRPNYV 726
Cdd:pfam08170    1 GWDLILPWGWALPFWYSLVYRGVRVGGLRERRQLAFESGKPYFPDDYPDTEAGWEEELERKKELEEKWFRKPPAKRVNYL 80

                           90
                   ....*....|..
gi 23097256    727 KLGTLAPFCCPW 738
Cdd:pfam08170   81 KGEIGSPFACDW 92
POP1 pfam06978
Ribonucleases P/MRP protein subunit POP1; This family represents a conserved region ...
 107-257 5.62e-39

Ribonucleases P/MRP protein subunit POP1; This family represents a conserved region approximately 150 residues long located towards the N-terminus of the POP1 subunit that is common to both the RNase MRP and RNase P ribonucleoproteins (EC:3.1.26.5). These RNA-containing enzymes generate mature tRNA molecules by cleaving their 5' ends.


:

Pssm-ID: 429227  Cd Length: 211  Bit Score: 144.34  E-value: 5.62e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097256    107 FAQARAAEISAMLKAV--TQKSSNSLVFQTLPRHMRRRAMSHNVKRLPRRL-----QEMAK------------------- 160
Cdd:pfam06978    1 FVKSREFEIKALENAMkkSKNASSTRAFQSLPRSLRRRTASHNVKRVPKRLrnralREMAEdntptvtsrkrkkkgltgr 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097256    161 ---------------------KEAEKAAHQKKEHSKNKCH--KARRCHINR---------TLEFNRRQQKNIWLETHIWH 208
Cdd:pfam06978   81 kryrletakkllrlaakkkamKALALPEKKDKDNEAPKLNnvRGSYDKIGKnklatppkgRIKYRKRQRNKTWLPTHLWH 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 23097256    209 AKRFHMVKKWGYCLGERPTAKSHRACYRAMT-NLCLLQDLSYYCCLELKG 257
Cdd:pfam06978  161 AKRAHMTKPWGFAIPLTPTQKCYRPTHRAAGsRGAVAWDTSYMSTIILEG 210
 
Name Accession Description Interval E-value
POPLD pfam08170
POPLD (NUC188) domain; This domain is found in POP1-like nucleolar proteins.
 647-738 1.15e-40

POPLD (NUC188) domain; This domain is found in POP1-like nucleolar proteins.


Pssm-ID: 462391  Cd Length: 92  Bit Score: 144.62  E-value: 1.15e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097256    647 GWDVLIPKGWGMAFWIPFIYRGARVGGLKEATVHSQYRRSPNIPGDFPDCRAGVLFAEDQAKDLLEKYRRRPPAKRPNYV 726
Cdd:pfam08170    1 GWDLILPWGWALPFWYSLVYRGVRVGGLRERRQLAFESGKPYFPDDYPDTEAGWEEELERKKELEEKWFRKPPAKRVNYL 80

                           90
                   ....*....|..
gi 23097256    727 KLGTLAPFCCPW 738
Cdd:pfam08170   81 KGEIGSPFACDW 92
POP1 pfam06978
Ribonucleases P/MRP protein subunit POP1; This family represents a conserved region ...
 107-257 5.62e-39

Ribonucleases P/MRP protein subunit POP1; This family represents a conserved region approximately 150 residues long located towards the N-terminus of the POP1 subunit that is common to both the RNase MRP and RNase P ribonucleoproteins (EC:3.1.26.5). These RNA-containing enzymes generate mature tRNA molecules by cleaving their 5' ends.


Pssm-ID: 429227  Cd Length: 211  Bit Score: 144.34  E-value: 5.62e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097256    107 FAQARAAEISAMLKAV--TQKSSNSLVFQTLPRHMRRRAMSHNVKRLPRRL-----QEMAK------------------- 160
Cdd:pfam06978    1 FVKSREFEIKALENAMkkSKNASSTRAFQSLPRSLRRRTASHNVKRVPKRLrnralREMAEdntptvtsrkrkkkgltgr 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097256    161 ---------------------KEAEKAAHQKKEHSKNKCH--KARRCHINR---------TLEFNRRQQKNIWLETHIWH 208
Cdd:pfam06978   81 kryrletakkllrlaakkkamKALALPEKKDKDNEAPKLNnvRGSYDKIGKnklatppkgRIKYRKRQRNKTWLPTHLWH 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 23097256    209 AKRFHMVKKWGYCLGERPTAKSHRACYRAMT-NLCLLQDLSYYCCLELKG 257
Cdd:pfam06978  161 AKRAHMTKPWGFAIPLTPTQKCYRPTHRAAGsRGAVAWDTSYMSTIILEG 210
 
Name Accession Description Interval E-value
POPLD pfam08170
POPLD (NUC188) domain; This domain is found in POP1-like nucleolar proteins.
 647-738 1.15e-40

POPLD (NUC188) domain; This domain is found in POP1-like nucleolar proteins.


Pssm-ID: 462391  Cd Length: 92  Bit Score: 144.62  E-value: 1.15e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097256    647 GWDVLIPKGWGMAFWIPFIYRGARVGGLKEATVHSQYRRSPNIPGDFPDCRAGVLFAEDQAKDLLEKYRRRPPAKRPNYV 726
Cdd:pfam08170    1 GWDLILPWGWALPFWYSLVYRGVRVGGLRERRQLAFESGKPYFPDDYPDTEAGWEEELERKKELEEKWFRKPPAKRVNYL 80

                           90
                   ....*....|..
gi 23097256    727 KLGTLAPFCCPW 738
Cdd:pfam08170   81 KGEIGSPFACDW 92
POP1 pfam06978
Ribonucleases P/MRP protein subunit POP1; This family represents a conserved region ...
 107-257 5.62e-39

Ribonucleases P/MRP protein subunit POP1; This family represents a conserved region approximately 150 residues long located towards the N-terminus of the POP1 subunit that is common to both the RNase MRP and RNase P ribonucleoproteins (EC:3.1.26.5). These RNA-containing enzymes generate mature tRNA molecules by cleaving their 5' ends.


Pssm-ID: 429227  Cd Length: 211  Bit Score: 144.34  E-value: 5.62e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097256    107 FAQARAAEISAMLKAV--TQKSSNSLVFQTLPRHMRRRAMSHNVKRLPRRL-----QEMAK------------------- 160
Cdd:pfam06978    1 FVKSREFEIKALENAMkkSKNASSTRAFQSLPRSLRRRTASHNVKRVPKRLrnralREMAEdntptvtsrkrkkkgltgr 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097256    161 ---------------------KEAEKAAHQKKEHSKNKCH--KARRCHINR---------TLEFNRRQQKNIWLETHIWH 208
Cdd:pfam06978   81 kryrletakkllrlaakkkamKALALPEKKDKDNEAPKLNnvRGSYDKIGKnklatppkgRIKYRKRQRNKTWLPTHLWH 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 23097256    209 AKRFHMVKKWGYCLGERPTAKSHRACYRAMT-NLCLLQDLSYYCCLELKG 257
Cdd:pfam06978  161 AKRAHMTKPWGFAIPLTPTQKCYRPTHRAAGsRGAVAWDTSYMSTIILEG 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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