NCBI Conserved Domain Search

Conserved domains on [gi|121583711|ref|NP_666462|]

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olfactory receptor 1123 [Mus musculus]

Protein Classification

olfactory receptor( domain architecture ID 11607024)

olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 10, subfamily A olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

38-314

6.28e-172

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 477.72 E-value: 6.28e-172

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  38 WILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFI 117
Cdd:cd15225    1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 118 LMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPV 197
Cdd:cd15225   81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 198 LKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKP 277
Cdd:cd15225  161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 121583711 278 NQSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15225  241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

Name

Accession

Description

Interval

E-value

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

38-314

6.28e-172

Pssm-ID: 320353 Cd Length: 277 Bit Score: 477.72 E-value: 6.28e-172

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  38 WILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFI 117
Cdd:cd15225    1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 118 LMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPV 197
Cdd:cd15225   81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 198 LKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKP 277
Cdd:cd15225  161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 121583711 278 NQSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15225  241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

44-319

1.10e-42

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 148.42 E-value: 1.10e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711   44 FLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILMLGGT 123
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  124 ECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLKLACG 203
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  204 DTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPK--PNQSE 281
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRfgHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 121583711  282 ITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRKLLS 319
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

Name

Accession

Description

Interval

E-value

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

38-314

6.28e-172

Pssm-ID: 320353 Cd Length: 277 Bit Score: 477.72 E-value: 6.28e-172

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  38 WILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFI 117
Cdd:cd15225    1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 118 LMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPV 197
Cdd:cd15225   81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 198 LKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKP 277
Cdd:cd15225  161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 121583711 278 NQSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15225  241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

39-307

3.61e-137

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 389.54 E-value: 3.61e-137

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd13954    2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd13954   82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd13954  162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSS 241

                        250       260
                 ....*....|....*....|....*....
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd13954  242 YSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

39-307

4.74e-122

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 351.04 E-value: 4.74e-122

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15230    2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15230   82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15230  162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241

                        250       260
                 ....*....|....*....|....*....
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15230  242 YSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

40-314

7.99e-120

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 345.79 E-value: 7.99e-120

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  40 LFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILM 119
Cdd:cd15231    3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 120 LGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLK 199
Cdd:cd15231   83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 200 LACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPNQ 279
Cdd:cd15231  163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 121583711 280 SEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15231  243 SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

39-307

2.41e-119

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 344.26 E-value: 2.41e-119

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15237    2 LLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15237   82 ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15237  162 KLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHST 241

                        250       260
                 ....*....|....*....|....*....
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15237  242 HSPDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

39-307

1.44e-117

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 339.85 E-value: 1.44e-117

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15911    2 LLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15911   82 SLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15911  162 KLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTN 241

                        250       260
                 ....*....|....*....|....*....
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15911  242 TSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

24-318

8.61e-117

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 338.95 E-value: 8.61e-117

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  24 EFILLGFSDVPNLQWILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKG 103
Cdd:cd15943    1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 104 NISILACATQMCFILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCG 183
Cdd:cd15943   81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 184 SNRINHFICDIPPVLKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVL 263
Cdd:cd15943  161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 121583711 264 FYGTAGITYLQPKPNQSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRKLL 318
Cdd:cd15943  241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

39-314

1.64e-115

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 334.90 E-value: 1.64e-115

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15421    2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15421   82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15421  162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15421  242 HSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

39-316

1.84e-114

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 332.30 E-value: 1.84e-114

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15417    2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15417   82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15417  162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRK 316
Cdd:cd15417  242 HSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

38-307

4.45e-114

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 331.12 E-value: 4.45e-114

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  38 WILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFI 117
Cdd:cd15918    1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 118 LMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPV 197
Cdd:cd15918   81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 198 LKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKP 277
Cdd:cd15918  161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 121583711 278 NQSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15918  241 SHSASKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

40-314

9.25e-114

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 330.33 E-value: 9.25e-114

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  40 LFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILM 119
Cdd:cd15229    3 LFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 120 LGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLK 199
Cdd:cd15229   83 FAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLP 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 200 LACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPNQ 279
Cdd:cd15229  163 LSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSAS 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 121583711 280 SEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15229  243 SSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

39-307

1.18e-113

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 329.83 E-value: 1.18e-113

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15912    2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15912   82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15912  162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241

                        250       260
                 ....*....|....*....|....*....
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15912  242 SSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

39-307

1.69e-113

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 329.58 E-value: 1.69e-113

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15947    2 PLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15947   82 WLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15947  162 KLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSS 241

                        250       260
                 ....*....|....*....|....*....
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15947  242 YSQDQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

41-307

1.05e-112

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 327.49 E-value: 1.05e-112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  41 FGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILML 120
Cdd:cd15227    4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 121 GGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLKL 200
Cdd:cd15227   84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 201 ACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPNQS 280
Cdd:cd15227  164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243

                        250       260
                 ....*....|....*....|....*..
gi 121583711 281 EITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15227  244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

37-314

7.65e-112

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 325.72 E-value: 7.65e-112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  37 QWILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCF 116
Cdd:cd15235    1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 117 ILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPP 196
Cdd:cd15235   81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 197 VLKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPK 276
Cdd:cd15235  161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121583711 277 PNQSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15235  241 SSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

39-316

1.38e-110

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 322.34 E-value: 1.38e-110

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15411    2 PLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15411   82 ALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15411  162 KLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRK 316
Cdd:cd15411  242 YSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

25-310

4.99e-110

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 321.19 E-value: 4.99e-110

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  25 FILLGFSDVPNLQWILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGN 104
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 105 ISILACATQMCFILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGS 184
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 185 NRINHFICDIPPVLKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLF 264
Cdd:cd15408  161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 121583711 265 YGTAGITYLQPKPNQSEITGKLLSLFYTILIPTLNPIIYTLRNKDI 310
Cdd:cd15408  241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEV 286

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

25-318

5.03e-109

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 319.22 E-value: 5.03e-109

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  25 FILLGFSDVPNLQWILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGN 104
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 105 ISILACATQMCFILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGS 184
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 185 NRINHFICDIPPVLKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLF 264
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121583711 265 YGTAGITYLQPKPNQSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRKLL 318
Cdd:cd15410  241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

39-307

5.16e-106

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 310.31 E-value: 5.16e-106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15431    2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWIS-----VIPVVIGQtyqifsLPFCGSNRINHFICD 193
Cdd:cd15431   82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSaflltVIPVLTMP------LHFCGPNVINHFFCE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 194 IPPVLKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYL 273
Cdd:cd15431  156 VQALLKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYL 235

                        250       260       270
                 ....*....|....*....|....*....|....
gi 121583711 274 QPKPNQSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15431  236 RPQSKSSSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

40-314

9.68e-106

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 310.10 E-value: 9.68e-106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  40 LFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILM 119
Cdd:cd15429    3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 120 LGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLK 199
Cdd:cd15429   83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 200 LACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPNQ 279
Cdd:cd15429  163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 121583711 280 SEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15429  243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

40-314

3.81e-105

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 308.49 E-value: 3.81e-105

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  40 LFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILM 119
Cdd:cd15420    3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 120 LGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLK 199
Cdd:cd15420   83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 200 LACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPNQ 279
Cdd:cd15420  163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 121583711 280 SEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15420  243 SAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

39-314

6.61e-105

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 307.87 E-value: 6.61e-105

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15432    2 VLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15432   82 GLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15432  162 KLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSN 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15432  242 SSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

39-316

1.07e-104

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 307.31 E-value: 1.07e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15419    2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15419   82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15419  162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAV 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRK 316
Cdd:cd15419  242 SSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

25-316

2.60e-103

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 304.36 E-value: 2.60e-103

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  25 FILLGFSDVPNLQWILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGN 104
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 105 ISILACATQMCFILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGS 184
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 185 NRINHFICDIPPVLKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLF 264
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 121583711 265 YGTAGITYLQPKPNQSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRK 316
Cdd:cd15945  241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

39-307

4.32e-103

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 303.14 E-value: 4.32e-103

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15430    2 LLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15430   82 AMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15430  162 KLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSK 241

                        250       260
                 ....*....|....*....|....*....
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15430  242 NAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

40-307

3.30e-102

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 300.74 E-value: 3.30e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  40 LFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILM 119
Cdd:cd15224    3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 120 LGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLK 199
Cdd:cd15224   83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 200 LACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPNQ 279
Cdd:cd15224  163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAIS 242

                        250       260
                 ....*....|....*....|....*...
gi 121583711 280 SEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15224  243 SFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

39-314

4.50e-102

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 300.84 E-value: 4.50e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15434    2 ILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15434   82 GLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15434  162 KLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15434  242 VSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

39-314

3.72e-100

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 296.03 E-value: 3.72e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15234    2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15234   82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15234  162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15234  242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

39-316

1.97e-99

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 294.23 E-value: 1.97e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15413    2 PLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15413   82 TFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15413  162 ALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRK 316
Cdd:cd15413  242 HSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

39-314

4.82e-99

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 293.18 E-value: 4.82e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15424    2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15424   82 SLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15424  162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSG 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15424  242 STPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

39-316

6.27e-99

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 292.73 E-value: 6.27e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15416    2 ILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15416   82 TFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15416  162 KLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRK 316
Cdd:cd15416  242 YSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

39-307

9.31e-99

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 291.90 E-value: 9.31e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15915    2 FLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15915   82 FLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSIL-KLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKP 277
Cdd:cd15915  162 KLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLlKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSS 241

                        250       260       270
                 ....*....|....*....|....*....|
gi 121583711 278 NQSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15915  242 GDSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

39-307

1.17e-98

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 291.85 E-value: 1.17e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15232    2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15232   82 WSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15232  162 LLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSS 241

                        250       260
                 ....*....|....*....|....*....
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15232  242 YSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

29-318

5.63e-98

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 290.81 E-value: 5.63e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  29 GFSDVPNLQWILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISIL 108
Cdd:cd15406    1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 109 ACATQMCFILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRIN 188
Cdd:cd15406   81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 189 HFICDIPPVLKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTA 268
Cdd:cd15406  161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 121583711 269 GITYLQPKPNQSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRKLL 318
Cdd:cd15406  241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

25-318

1.30e-97

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 290.15 E-value: 1.30e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  25 FILLGFSDVPNLQWILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGN 104
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 105 ISILACATQMCFILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGS 184
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 185 NRINHFICDIPPVLKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLF 264
Cdd:cd15944  161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121583711 265 YGTAGITYLQPKPNQSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRKLL 318
Cdd:cd15944  241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

39-316

6.40e-95

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 282.76 E-value: 6.40e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15409    2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15409   82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15409  162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRK 316
Cdd:cd15409  242 YALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

39-307

2.08e-94

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 281.18 E-value: 2.08e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15914    2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15914   82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15914  162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKS 241

                        250       260
                 ....*....|....*....|....*....
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15914  242 YSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

40-316

1.09e-92

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 276.99 E-value: 1.09e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  40 LFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILM 119
Cdd:cd15415    3 LFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 120 LGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLK 199
Cdd:cd15415   83 FVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 200 LACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPNQ 279
Cdd:cd15415  163 LSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQY 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 121583711 280 SEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRK 316
Cdd:cd15415  243 SLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

39-316

2.63e-92

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 275.82 E-value: 2.63e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15412    2 LLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15412   82 ALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15412  162 KLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSE 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRK 316
Cdd:cd15412  242 ESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

39-307

1.69e-91

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 273.42 E-value: 1.69e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15913    2 LLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWIS-----VIPVVIgqtyqIFSLPFCGSNRINHFICD 193
Cdd:cd15913   82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCgflwfLIPVVL-----ISQLPFCGPNIIDHFLCD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 194 IPPVLKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYL 273
Cdd:cd15913  157 PGPLLALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYV 236

                        250       260       270
                 ....*....|....*....|....*....|....
gi 121583711 274 QPKPNQSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15913  237 SPGSGNSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

39-320

2.80e-91

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 273.53 E-value: 2.80e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15414    2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15414   82 LFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15414  162 SLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSS 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRKLLSK 320
Cdd:cd15414  242 SSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRR 283

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

38-307

1.42e-90

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 271.01 E-value: 1.42e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  38 WILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFI 117
Cdd:cd15939    1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 118 LMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPV 197
Cdd:cd15939   81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 198 LKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSiLKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKP 277
Cdd:cd15939  161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVT 239

                        250       260       270
                 ....*....|....*....|....*....|
gi 121583711 278 NQSEitGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15939  240 TFPI--DKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

40-307

7.48e-90

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 269.07 E-value: 7.48e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  40 LFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILM 119
Cdd:cd15226    3 LFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 120 LGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLK 199
Cdd:cd15226   83 FGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 200 LACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAkGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPNQ 279
Cdd:cd15226  163 LACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSG-GSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                        250       260
                 ....*....|....*....|....*...
gi 121583711 280 SeiTGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15226  242 P--VDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

40-314

1.06e-88

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 266.65 E-value: 1.06e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  40 LFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILM 119
Cdd:cd15428    3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 120 LGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLK 199
Cdd:cd15428   83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 200 LACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPNQ 279
Cdd:cd15428  163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSST 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 121583711 280 SEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15428  243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

38-314

8.86e-87

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 261.97 E-value: 8.86e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  38 WILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFI 117
Cdd:cd15405    1 IPLFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 118 LMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPV 197
Cdd:cd15405   81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 198 LKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKP 277
Cdd:cd15405  161 LQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 121583711 278 NQSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15405  241 VGSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

39-314

9.46e-87

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 261.60 E-value: 9.46e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15228    2 ILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15228   82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPn 278
Cdd:cd15228  162 KLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP- 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 121583711 279 qSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15228  241 -SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

40-316

2.06e-86

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 260.82 E-value: 2.06e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  40 LFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILM 119
Cdd:cd15407    3 LFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 120 LGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLK 199
Cdd:cd15407   83 FATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 200 LACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPNQ 279
Cdd:cd15407  163 LSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSH 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 121583711 280 SEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRK 316
Cdd:cd15407  243 SMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

37-317

2.72e-86

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 260.87 E-value: 2.72e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  37 QWILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCF 116
Cdd:cd15418    1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 117 ILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPP 196
Cdd:cd15418   81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 197 VLKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPK 276
Cdd:cd15418  161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 121583711 277 PNQSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRKL 317
Cdd:cd15418  241 SSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

39-307

4.81e-86

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 259.68 E-value: 4.81e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15940    2 AFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15940   82 LFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSaKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15940  162 KLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRST-EGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTS 240

                        250       260
                 ....*....|....*....|....*....
gi 121583711 279 QSEitGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15940  241 FSE--DKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

39-307

2.61e-85

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 257.79 E-value: 2.61e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15946    2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15946   82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15946  162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241

                        250       260
                 ....*....|....*....|....*....
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15946  242 YSPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

40-314

2.69e-85

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 258.15 E-value: 2.69e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  40 LFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGN-ISILACATQMCFIL 118
Cdd:cd15916    3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGGKvISFGGCVAQLYFFH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15916   83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQpkPN 278
Cdd:cd15916  163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLR--PG 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15916  241 SKEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

39-314

7.45e-85

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 257.03 E-value: 7.45e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15433    2 VLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15433   82 ALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15433  162 KLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHR 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15433  242 YSQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

39-314

1.09e-83

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 253.92 E-value: 1.09e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15236    2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15236   82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15236  162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15236  242 NSSDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

39-314

2.19e-80

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 245.47 E-value: 2.19e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15233    2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15233   82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPN 278
Cdd:cd15233  162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15233  242 YSSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

40-307

1.37e-75

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 232.99 E-value: 1.37e-75

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  40 LFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILM 119
Cdd:cd15936    3 LFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 120 LGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLK 199
Cdd:cd15936   83 TGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 200 LACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYcKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAgiTYLQPKPNQ 279
Cdd:cd15936  163 LACTDTFLLELLMVSNSGLVTLLIFFILLISY-TVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPC--IYIYARPFQ 239

                        250       260
                 ....*....|....*....|....*...
gi 121583711 280 SEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15936  240 TFPMDKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

40-307

2.11e-74

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 229.76 E-value: 2.11e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  40 LFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILM 119
Cdd:cd15938    3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 120 LGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLK 199
Cdd:cd15938   83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 200 LACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIicsILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPNQ 279
Cdd:cd15938  163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239

                        250       260
                 ....*....|....*....|....*...
gi 121583711 280 SeiTGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15938  240 P--VDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

39-314

2.95e-73

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 227.42 E-value: 2.95e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQT-PMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGN-ISILACATQMCF 116
Cdd:cd15941    2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSGRtISFEGCVVQLYA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 117 ILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPP 196
Cdd:cd15941   82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 197 VLKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPK 276
Cdd:cd15941  162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121583711 277 PNQSeiTGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15941  242 SSQA--GAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

40-314

5.72e-73

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 226.55 E-value: 5.72e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  40 LFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILM 119
Cdd:cd15942    3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 120 LGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLK 199
Cdd:cd15942   83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 200 LACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLqpKPNQ 279
Cdd:cd15942  163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYL--RPGS 240

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 121583711 280 SEITGKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15942  241 QDPLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

39-307

2.00e-72

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 225.03 E-value: 2.00e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPAL-QTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFI 117
Cdd:cd15935    2 LLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 118 LMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPV 197
Cdd:cd15935   82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 198 LKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYcKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKP 277
Cdd:cd15935  162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSY-GIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 121583711 278 NQSeiTGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15935  241 SSS--VDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

39-307

3.54e-70

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 219.22 E-value: 3.54e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15937    2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVL 198
Cdd:cd15937   82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSiLKLSSAKGRTKAFSTCSSHLIVVVLFYGTAgiTYLQPKPN 278
Cdd:cd15937  162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPA--IYIYARPF 238

                        250       260
                 ....*....|....*....|....*....
gi 121583711 279 QSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd15937  239 RSFPMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

44-314

2.77e-68

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 214.46 E-value: 2.77e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  44 FLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILMLGGT 123
Cdd:cd15223    7 FLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 124 ECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLKLACG 203
Cdd:cd15223   87 ESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 204 DTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTA---GITYLQPKPNQS 280
Cdd:cd15223  167 DTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVlvsSLTYRFGKTIPP 246

                        250       260       270
                 ....*....|....*....|....*....|....
gi 121583711 281 EITgKLLSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15223  247 DVH-VLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

44-310

3.16e-59

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 191.35 E-value: 3.16e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  44 FLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILMLGGT 123
Cdd:cd15917    7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 124 ECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLKLACG 203
Cdd:cd15917   87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 204 DTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYL-----QPKPN 278
Cdd:cd15917  167 DTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLthrfgHHVPP 246

                        250       260       270
                 ....*....|....*....|....*....|..
gi 121583711 279 QSEItgkLLSLFYTILIPTLNPIIYTLRNKDI 310
Cdd:cd15917  247 HVHI---LLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

38-310

5.49e-57

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 185.31 E-value: 5.49e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  38 WILFgIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFI 117
Cdd:cd15950    2 WIAI-PFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 118 LMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPV 197
Cdd:cd15950   81 HSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 198 LKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFY--GTAGI---TY 272
Cdd:cd15950  161 VKLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYipGLLSIytqRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121583711 273 LQPKPNQSEItgkLLSLFYTILIPTLNPIIYTLRNKDI 310
Cdd:cd15950  241 GQGVPPHTQV---LLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

44-310

1.03e-56

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 184.80 E-value: 1.03e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  44 FLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILMLGGT 123
Cdd:cd15221    7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 124 ECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLKLACG 203
Cdd:cd15221   87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 204 DTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPK-----PN 278
Cdd:cd15221  167 DITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRfgrhiPR 246

                        250       260       270
                 ....*....|....*....|....*....|..
gi 121583711 279 QSEItgkLLSLFYTILIPTLNPIIYTLRNKDI 310
Cdd:cd15221  247 HVHI---LLANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

38-310

2.38e-56

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 183.74 E-value: 2.38e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  38 WILFgIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFI 117
Cdd:cd15952    2 WIGF-PFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 118 LMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPV 197
Cdd:cd15952   81 HTFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 198 LKLACGDTFVNEIAVYVVAMVFVmVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYL---- 273
Cdd:cd15952  161 AKLACASIRINIIYGLFAISVLV-LDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLthrf 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121583711 274 -QPKPNQSEItgkLLSLFYTILIPTLNPIIYTLRNKDI 310
Cdd:cd15952  240 gHNIPRYIHI---LLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

38-310

2.25e-55

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 181.16 E-value: 2.25e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  38 WILFgIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFI 117
Cdd:cd15222    2 WISI-PFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 118 LMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNH----RICTQLVAACWISVIPVVIgqtyQIFSLPFCGSNRINHFICD 193
Cdd:cd15222   81 HTFSFMESSVLLAMAFDRFVAICNPLRYASILTNsriaKIGLAIVLRSVLLLLPLPF----LLKRLPFCHSNVLSHSYCL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 194 IPPVLKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTA-GITY 272
Cdd:cd15222  157 HQDVMKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMiGLSM 236

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 121583711 273 L-QPKPNQSEITGKLLSLFYTILIPTLNPIIYTLRNKDI 310
Cdd:cd15222  237 VhRFGKHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

44-310

2.26e-53

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 176.30 E-value: 2.26e-53

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  44 FLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILMLGGT 123
Cdd:cd15953    7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 124 ECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLKLACG 203
Cdd:cd15953   87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 204 DTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYL-----QPKPN 278
Cdd:cd15953  167 DTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLthrfgQGIAP 246

                        250       260       270
                 ....*....|....*....|....*....|..
gi 121583711 279 QSEItgkLLSLFYTILIPTLNPIIYTLRNKDI 310
Cdd:cd15953  247 HIHI---ILANLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

38-310

5.23e-51

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 170.22 E-value: 5.23e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  38 WILFgIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFI 117
Cdd:cd15951    2 WISI-PFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 118 LMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPV 197
Cdd:cd15951   81 HSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 198 LKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYL---- 273
Cdd:cd15951  161 VKLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLthrf 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121583711 274 -QPKPNQSEItgkLLSLFYTILIPTLNPIIYTLRNKDI 310
Cdd:cd15951  241 gHNVPPHVHI---LIANVYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

44-310

5.43e-47

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 159.68 E-value: 5.43e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  44 FLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILMLGGT 123
Cdd:cd15948    8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 124 ECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLKLACG 203
Cdd:cd15948   88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 204 DTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPNQ--SE 281
Cdd:cd15948  168 DTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHRFARhvAP 247

                        250       260
                 ....*....|....*....|....*....
gi 121583711 282 ITGKLLSLFYTILIPTLNPIIYTLRNKDI 310
Cdd:cd15948  248 HVHILLANFYLLFPPMMNPIVYGVKTKQI 276

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

44-319

1.10e-42

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 148.42 E-value: 1.10e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711   44 FLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILMLGGT 123
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  124 ECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLKLACG 203
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  204 DTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPK--PNQSE 281
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRfgHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 121583711  282 ITGKLLSLFYTILIPTLNPIIYTLRNKDIMAALRKLLS 319
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

44-310

3.86e-41

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 144.62 E-value: 3.86e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  44 FLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILMLGGT 123
Cdd:cd15956    7 FCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 124 ECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPVLKLACG 203
Cdd:cd15956   87 ESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 204 DTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPK--PNQSE 281
Cdd:cd15956  167 ATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRfgHSVPS 246

                        250       260
                 ....*....|....*....|....*....
gi 121583711 282 ITGKLLSLFYTILIPTLNPIIYTLRNKDI 310
Cdd:cd15956  247 AAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

38-310

4.25e-41

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 144.20 E-value: 4.25e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  38 WILFGiFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFI 117
Cdd:cd15954    2 WISIP-FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 118 LMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFICDIPPV 197
Cdd:cd15954   81 HTFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 198 LKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKP 277
Cdd:cd15954  161 VKLACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 121583711 278 NQSEITGK---LLSLFYTILIPTLNPIIYTLRNKDI 310
Cdd:cd15954  241 GGHHITPHihiIMANLYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

25-310

1.90e-39

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 140.30 E-value: 1.90e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  25 FILLGFSDVPNLQWILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGN 104
Cdd:cd15949    4 FILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 105 ISILACATQMCFILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGS 184
Cdd:cd15949   84 IPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 185 NRINHFICDIPPVLKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLF 264
Cdd:cd15949  164 NIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAILAF 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 121583711 265 YGTAGITYLQPK--PNQSEITGKLLSLFYTILIPTLNPIIYTLRNKDI 310
Cdd:cd15949  244 YVPIAVSSLIHRfgQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQI 291

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

44-310

3.46e-36

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 131.43 E-value: 3.46e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  44 FLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILMLGGT 123
Cdd:cd15955    7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 124 ECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLV------AACWISVIPVVIGQTYQIFSlpfcgSNRINHFICDIPPV 197
Cdd:cd15955   87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGvlvvvrAVVLIIPCPLLIKLRLHHFR-----STVISHSYCEHMAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 198 LKLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPK- 276
Cdd:cd15955  162 VKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRf 241

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 121583711 277 -PNQSEITGKLLSLFYTILIPTLNPIIYTLRNKDI 310
Cdd:cd15955  242 gHHVAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

55-303

1.73e-31

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 118.55 E-value: 1.73e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711   55 NSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGN-ISILACATQMCFILMLGGTECLLLTAMAY 133
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWpFGSALCKIVGALFVVNGYASILLLTAISI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  134 DRYVAICNPLHYSLVMNHRICTQLVAACW-----ISVIPVVIGQTYQifslpfcgSNRINHFICDIPPVLKLACgdtfVN 208
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWvlallLSLPPLLFGWTLT--------VPEGNVTVCFIDFPEDLSK----PV 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  209 EIAVYVVAMVFVmVPFMLIIFSYCKIICSILKLSSAKGR-------TKAFSTCSSHLIVVVLFYGTAGITYLQ----PKP 277
Cdd:pfam00001 150 SYTLLISVLGFL-LPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLdslaLDC 228

                         250       260
                  ....*....|....*....|....*...
gi 121583711  278 NQSEITGKLLSL--FYTILIPTLNPIIY 303
Cdd:pfam00001 229 ELSRLLDKALSVtlWLAYVNSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

40-307

5.87e-19

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 85.03 E-value: 5.87e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  40 LFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILM 119
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 120 LGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWI-SVIpvvigqtyqIFSLPFCGSNRINHFICDIPPvl 198
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLlSLL---------LALPPLLGWGVYDYGGYCCCC-- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 kLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICsILKLSSAKGRTKAFSTCSSH------------LIVVVLFY- 265
Cdd:cd00637  150 -LCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFR-KLRRHRRRIRSSSSNSSRRRrrrrerkvtktlLIVVVVFLl 227

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 121583711 266 ------GTAGITYLQPKPNQSEITGKLLSLFYTILIPTLNPIIYTLRN 307
Cdd:cd00637  228 cwlpyfILLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

39-314

1.03e-12

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 66.82 E-value: 1.03e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIpvvigqtyqIFSLPFCGSNRINHFICDIPpvl 198
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSL---------LISLPPLVGWRDETQPSVVD--- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 klaCGDTFVNEIAVYVVAMVFV-MVPFMLIIFSYCKIicsilkLSSAKGRTKAFSTCSshLIVVVL------FYGTAGIT 271
Cdd:cd14967  149 ---CECEFTPNKIYVLVSSVISfFIPLLIMIVLYARI------FRVARRELKAAKTLA--IIVGAFllcwlpFFIIYLVS 217

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 121583711 272 YLQPKPNQSEITgkllsLFYTILIP----TLNPIIYTLRNKDIMAAL 314
Cdd:cd14967  218 AFCPPDCVPPIL-----YAVFFWLGylnsALNPIIYALFNRDFRRAF 259

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

115-314

2.29e-07

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 51.49 E-value: 2.29e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 115 CFILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFIcdi 194
Cdd:cd14968   76 CLVLVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNNGAPLESGCGEGGI--- 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 195 ppvlklACGdtFVNEIA----VYVVAMVFVMVPFMLIIFSYCKIICSILK--------LSSAKGRT---KAFSTCSSHLI 259
Cdd:cd14968  153 ------QCL--FEEVIPmdymVYFNFFACVLVPLLIMLVIYLRIFRVIRKqlrqieslLRSRRSRStlqKEVKAAKSLAI 224

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 121583711 260 VVVLF-------YGTAGITYLQP---KPNQSEITGKLLSLFYTIliptLNPIIYTLRNKDIMAAL 314
Cdd:cd14968  225 ILFLFalcwlplHIINCITLFCPeckVPKILTYIAILLSHANSA----VNPIVYAYRIRKFRQTF 285

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

110-314

4.38e-07

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 50.45 E-value: 4.38e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 110 CATQMCFILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACW-----ISVIPVVIGQTYQIFSLPFCGs 184
Cdd:cd15104   73 CLLRMCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWlysglIGFLPLISPQFQQTSYKGKCS- 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 185 nrinhficdippvlklaCGDTFVNEIAVYVVAMVFVMVpFMLIIFSYCKIIC-------SILKLSSAKGR---------- 247
Cdd:cd15104  152 -----------------FFAAFHPRVLLVLSCMVFFPA-LLLFVFCYCDILKiarvhsrAIYKVEHALARqihprrtlsd 213

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 248 TKAFSTCSSHLIVVVLFYGTAGITYLQPKPNQSEITGKLLSLFYTILI---PTLNPIIYTLRNKDIMAAL 314
Cdd:cd15104  214 FKAARTVAVLIGCFLLSWLPFQITGLVQALCDECKLYDVLEDYLWLLGlcnSLLNPWIYAFWQKEVRRAL 283

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

43-253

1.35e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 49.28 E-value: 1.35e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  43 IFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKG-NISILACATQMCFILMLG 121
Cdd:cd14979    6 IYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPwAFGDGGCKLYYFLFEACT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 122 GTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIpvvigqtyqIFSLPFCGSNRINH--FICDIPPVLK 199
Cdd:cd14979   86 YATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSI---------LCAIPILFLMGIQYlnGPLPGPVPDS 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 121583711 200 LACG---DTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFST 253
Cdd:cd14979  157 AVCTlvvDRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSMRNIKKGTRAQGT 213

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

108-305

8.42e-06

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 46.39 E-value: 8.42e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 108 LACATQMCFILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWIsvIPVVIGQTYQIFSLPFCGSNRI 187
Cdd:cd15055   71 TFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWF--VSALYSSVLLYDNLNQPGLIRY 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 188 NHFICDIPpvlklacgdTFVNEIAVYVVAMVFVMVPFMLIIFSYCKI----------ICSILKLSSAKGRTKAFSTCSSH 257
Cdd:cd15055  149 NSCYGECV---------VVVNFIWGVVDLVLTFILPCTVMIVLYMRIfvvarsqaraIRSHTAQVSLEGSSKKVSKKSER 219

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121583711 258 -------LIVVVL-------FYGTAGITYLQPKPNQSEItgkLLSLFYtiLIPTLNPIIYTL 305
Cdd:cd15055  220 kaaktlgIVVGVFllcwlpyYIVSLVDPYISTPSSVFDV---LIWLGY--FNSCLNPLIYAL 276

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

64-309

2.22e-05

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 45.31 E-value: 2.22e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  64 TDPALQTPMYFFLSNFSFVEICYVTVTIPRML---VDLCTqkgniSILACATQMCFILMLGGTECLLLTAMAYDRYVAIC 140
Cdd:cd15069   27 TNSTLQTPTNYFLVSLAAADVAVGLFAIPFAItisLGFCT-----DFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIK 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 141 NPLHYSLVMNHRICTQLVAACWisVIPVVIGQTyqifslPFCGSNR--INHFICDIPPVLKLACGDTFVNEIAVYVVAMV 218
Cdd:cd15069  102 VPLRYKSLVTGKRARGVIAVLW--VLAFGIGLT------PFLGWNKamSATNNSTNPADHGTNHSCCLISCLFENVVPMS 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 219 F---------VMVPFMLIIFSYCKII---CSILKLSSAKGRT-----KAFSTCSSHLIVVVLF-------YGTAGITYLQ 274
Cdd:cd15069  174 YmvyfnffgcVLPPLLIMLVIYIKIFlvaCRQLQRTELMDHSrttlqREIHAAKSLAIIVGIFalcwlpvHILNCITLFQ 253

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 121583711 275 P-----KPNQSEITGKLLSLFYTIliptLNPIIYTLRNKD 309
Cdd:cd15069  254 PefsksKPKWAMNVAILLSHANSV----VNPIVYAYRNRD 289

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

110-163

5.51e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 44.27 E-value: 5.51e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121583711 110 CATQMCFILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWI 163
Cdd:cd15312   73 CKIHSSLDMMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWS 126

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

43-242

6.38e-05

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 43.73 E-value: 6.38e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  43 IFLIMYLTILMcNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILMLGG 122
Cdd:cd14969    7 LSLIGVLGVVL-NGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 123 TECLLLTAMAYDRYVAICNPLHYSLVMNHRICTqLVAACWISVIpvvigqtyqIFSL-PFCGSNRInhficdIPPVLKLA 201
Cdd:cd14969   86 VSISTLAALAFERYLVIVRPLKAFRLSKRRALI-LIAFIWLYGL---------FWALpPLFGWSSY------VPEGGGTS 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 121583711 202 CG----DTFVNEIAVYVVAMVFV-MVPFMLIIFSYCKIICSILKLS 242
Cdd:cd14969  150 CSvdwySKDPNSLSYIVSLFVFCfFLPLAIIIFCYYKIYRTLRKMS 195

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

109-234

6.50e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 43.77 E-value: 6.50e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 109 ACATQMCFILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWisVIPVVIGQTyQIFSLPFCGSNRIN 188
Cdd:cd15068   70 GCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICW--VLSFAIGLT-PMLGWNNCGQPKEG 146

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 121583711 189 HFICDIPPVLKLAC--GDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKI 234
Cdd:cd15068  147 KNHSQGCGEGQVAClfEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRI 194

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

42-314

7.34e-05

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 43.82 E-value: 7.34e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  42 GIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSN---------FSFVEIC---YVTVTIPRMLVDLctqkgnisILA 109
Cdd:cd14972    3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANlaaadllagIAFVFTFlsvLLVSLTPSPATWL--------LRK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 110 CATQMCFILMLGGtecllLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACW-ISVIpvvigqtyqIFSLPFCGSNRIN 188
Cdd:cd14972   75 GSLVLSLLASAYS-----LLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWvWSVL---------LALLPVLGWNCVL 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 189 hfiCDIPPVLKLACGDTfvneIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSS--------AKGRTKAFSTCSSHLIV 260
Cdd:cd14972  141 ---CDQESCSPLGPGLP----KSYLVLILVFFFIALVIIVFLYVRIFWCLWRHANaiaarqeaAVPAQPSTSRKLAKTVV 213

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 121583711 261 VVLFY-------GTAGITYLQPKPNQSEITGKL-LSLFYTILIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd14972  214 IVLGVflvcwlpLLILLVLDVLCPSVCDIQAVFyYFLVLALLNSAINPIIYAFRLKEMRRAV 275

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

128-238

2.72e-04

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 41.82 E-value: 2.72e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 128 LTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWisVIPVVIgqtyqifSLPFCGSNRINHFICDIP-PVLKLACGDTF 206
Cdd:cd14993   91 LVAISIDRYLAICYPLKARRVSTKRRARIIIVAIW--VIAIII-------MLPLLVVYELEEIISSEPgTITIYICTEDW 161

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 121583711 207 VNEI--AVYVVAMVFVM--VPFMLIIFSYCKIICSI 238
Cdd:cd14993  162 PSPElrKAYNVALFVVLyvLPLLIISVAYSLIGRRL 197

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

40-238

3.39e-04

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 41.79 E-value: 3.39e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  40 LFGIFLIMYLTI-LMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTvTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15079    2 LLGFIYIFLGIVsLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMI-KMPIFIYNSFYEGWALGPLGCQIYAFLGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHySLVMNHRICTQLVAACWISVIPVVIgqtyqifsLPFC-GSNRInhficdIPPV 197
Cdd:cd15079   81 LSGIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWAL--------LPLLfGWGRY------VPEG 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 121583711 198 LKLACGDTFVNE-------IAVYVVAMVFvmVPFMLIIFSYCKIICSI 238
Cdd:cd15079  146 FLTSCSFDYLTRdwntrsfVATIFVFAYV--IPLIIIIYCYSFIVKAV 191

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

39-238

9.69e-04

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 40.39 E-value: 9.69e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIF-LIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFI 117
Cdd:cd15083    1 YVLGIFiLIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 118 LMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIGqtyqifslPFCGSNRInhficdIPPV 197
Cdd:cd15083   81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLP--------PLFGWSRY------VLEG 146

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 121583711 198 LKLACG------DTFVNEIAVYVVAMVFVMvPFMLIIFSYCKIICSI 238
Cdd:cd15083  147 LLTSCSfdylsrDDANRSYVICLLIFGFVL-PLLIIIYCYSFIFRAV 192

7tmA_GPR151

cd15002

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...

78-264

1.08e-03

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320133 [Multi-domain] Cd Length: 280 Bit Score: 40.09 E-value: 1.08e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  78 NFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTqL 157
Cdd:cd15002   42 NLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITA-V 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 158 VAACWISVIPVVIGQtyqifsLPFCGSNRINH---FICDIPPVLKlacgdtFVNEIAVYVVAMVFVMVPFMLIIFSYCKI 234
Cdd:cd15002  121 VASIWVPACLLPLPQ------WLFRTVKQSEGvylCILCIPPLAH------EFMSAFVKLYPLFVFCLPLTFALFYFWRA 188

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 121583711 235 ICSiLKLSSAKG---RTKAFSTCSSH--LIVVVLF 264
Cdd:cd15002  189 YGQ-CQRRGTKTqnlRNQIRSRKLTHmlLSVVLAF 222

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

38-308

2.20e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 39.12 E-value: 2.20e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  38 WILFGIFLIMYLTIlMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVD-LCTQKGNISILACATQMCF 116
Cdd:cd15305    2 WPALLILIIIILTI-GGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAiLYDYAWPLPRYLCPIWISL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 117 ILMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISVIPVVIgqtyqifSLPFCGSNRINHFICDIPP 196
Cdd:cd15305   81 DVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISM-------PIPVIGLQDDEKVFVNGTC 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 197 VLKlacgdtfvNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSS----HLIVVVLFYGTAGITY 272
Cdd:cd15305  154 VLN--------DENFVLIGSFVAFFIPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIvfflFLIMWCPFFITNILSV 225

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 121583711 273 LQPKPNQSEITGKLLSLFYTI--LIPTLNPIIYTLRNK 308
Cdd:cd15305  226 LCKEACDQKLMEELLNVFVWVgyVSSGINPLVYTLFNK 263

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

128-309

2.41e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 39.02 E-value: 2.41e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 128 LTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWISvipvvigqTYQIFSLPFCGSNRINHFICDIPPVLKLACGDTFV 207
Cdd:cd15063   91 LCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVL--------SFVICFPPLVGWNDGKDGIMDYSGSSSLPCTCELT 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 208 NEiAVYVV--AMVFVMVPFMLIIFSYCKIicsilkLSSAKGRTKAFSTCSSHLIVVVLFYGTAGITYLQPKPNQSEITGK 285
Cdd:cd15063  163 NG-RGYVIysALGSFYIPMLVMLFFYFRI------YRAARMETKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCEDCIPPL 235

                        170       180
                 ....*....|....*....|....*.
gi 121583711 286 LLSLFYTI--LIPTLNPIIYTLRNKD 309
Cdd:cd15063  236 LFSVFFWLgyCNSALNPCIYALFSRD 261

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

39-240

2.80e-03

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 38.88 E-value: 2.80e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  39 ILFGIFLIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15061    1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWisVIPVVigqtyqIFSLPFCGSNRinHFICDIppvl 198
Cdd:cd15061   81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVW--VISLL------ITSPPLVGPSW--HGRRGL---- 146

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 121583711 199 klacGDTFVNEIAVYVV--AMVFVMVPFMLIIFSYCKIICSILK 240
Cdd:cd15061  147 ----GSCYYTYDKGYRIysSMGSFFLPLLLMLFVYLRIFRVIAK 186

7tmA_5-HT6

cd15054

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...

38-162

3.23e-03

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320182 [Multi-domain] Cd Length: 267 Bit Score: 38.63 E-value: 3.23e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  38 WILFGIFLIMYLTIlMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPRMLVDLCTQKGNISILACATQMCFI 117
Cdd:cd15054    2 WVAAFLCLIILLTV-AGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 121583711 118 LMLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACW 162
Cdd:cd15054   81 VMCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAW 125

7tmA_Gal1_R

cd15098

galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...

128-264

3.36e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320226 [Multi-domain] Cd Length: 282 Bit Score: 38.55 E-value: 3.36e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 128 LTAMAYDRYVAICNPLHYSLVMNHRicTQLVAACWISVIPVVIGQTYQIFSLPFCGSNRINHFIC--DIPPvlklacgdt 205
Cdd:cd15098   93 LVAMSVDRYIAVVHSRTSSSLRTRR--NALLGVLVIWVLSLAMASPVAVHQDLVHHWTASNQTFCweNWPE--------- 161

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 121583711 206 fVNEIAVYVVaMVFV---MVPFMLIIFSYCKII---CSILKLSSAKGRTKAFSTCSSHLIVVVLF 264
Cdd:cd15098  162 -KQQKPVYVV-CTFVfgyLLPLLLITFCYAKVLnhlHKKLKNMSKKSERSKKKTAQTVLVVVVVF 224

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

45-314

4.31e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 38.37 E-value: 4.31e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  45 LIMYLTILMCNSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIP-RMLVDLCTQKGNISILACATQMCFILMLGGT 123
Cdd:cd15304    8 VIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLFSTA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 124 ECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWisVIPVVIGQTYQIFSLPfcgsnrinhficDIPPVLKLAcG 203
Cdd:cd15304   88 SIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVW--TISVGISMPIPVFGLQ------------DDSKVFKEG-S 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 204 DTFVNEIAVYVVAMVFVMVPFMLIIFSYCKIICSILKLSSAKGRTKAFSTCSSHLIVVVL--FYGTAGITYLQPKPNQSE 281
Cdd:cd15304  153 CLLADENFVLIGSFVAFFIPLTIMVITYFLTIKSLQQSISNEQKASKVLGIVFFLFVVMWcpFFITNVMAVICKESCNEV 232

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 121583711 282 ITGKLLSLFYTI--LIPTLNPIIYTLRNKDIMAAL 314
Cdd:cd15304  233 VIGGLLNVFVWIgyLSSAVNPLVYTLFNKTYRSAF 267

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

43-308

4.33e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 38.22 E-value: 4.33e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711  43 IFLIMYLTILMC----NSTIVLITRTDPALQTPMYFFLSNFSFVEICYVTVTIPrmLVDLCTQKGNISILACATQMCFIL 118
Cdd:cd15070    2 TYISIEILIGLCavvgNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 119 MLGGTECLLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACWisVIPVVIGQTyqifslPFCGSNRINHFICDIPPVL 198
Cdd:cd15070   80 VFTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCW--LVSFLVGLT------PMFGWNRKPSLESVNTTPL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121583711 199 KLACGDTFVNEIAVYVVAMVFVMVPFMLIIFSYCKI---ICSIL--KLSSAKGRT----KAFSTCSSHLIVVVLFYGT-- 267
Cdd:cd15070  152 QCQFTSVMRMDYMVYFSFFTWILIPLVIMCALYVDIfyiIRNKLsqNATGFRETGafygREFKTAKSLALVLFLFAVCwl 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 121583711 268 -----AGITYLQPKPNQSEItgkLLSLFYTILIPTLNPIIYTLRNK 308
Cdd:cd15070  232 plsiiNCVVYFNPKVPKIAL---YLGILLSHANSMMNPIVYACKIK 274

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

126-171

8.58e-03

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 37.36 E-value: 8.58e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 121583711 126 LLLTAMAYDRYVAICNPLHYSLVMNHRICTQLVAACW-----ISVIPVVIG 171
Cdd:cd15066   88 LHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWispalISFLPIFLG 138

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01