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Conserved domains on  [gi|21703962|ref|NP_663463|]
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peroxisomal ATPase PEX6 [Mus musculus]

Protein Classification

CDC48 family AAA ATPase( domain architecture ID 1001098)

CDC48 family AAA ATPase is involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus; similar to yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDC48 super family cl36852
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 467-978 7.58e-98

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


The actual alignment was detected with superfamily member TIGR01243:

Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 324.55  E-value: 7.58e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLGRDRDGL-GE- 544
Cdd:TIGR01243 215 VLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVtGEv 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   545 DARVAATLRHLLldeDALSRCPPLMVVATTSRVQDLPTDVQTA--FPHELEVPVLSEAQRLSILQALTAHLPLGQEVNLP 622
Cdd:TIGR01243 295 EKRVVAQLLTLM---DGLKGRGRVIVIGATNRPDALDPALRRPgrFDREIVIRVPDKRARKEILKVHTRNMPLAEDVDLD 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   623 QLARRCAGFVVGDLYALLTHTCRAACTRIRASGSAGGLSEEDEGDLcVAGFPLLAEDFGQALDQLQTAHSQAVGApRIPS 702
Cdd:TIGR01243 372 KLAEVTHGFVGADLAALAKEAAMAALRRFIREGKINFEAEEIPAEV-LKELKVTMKDFMEALKMVEPSAIREVLV-EVPN 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   703 VSWHDVGGLQDVKKEILETIQLPLEHPEL--LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVG 780
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIfeKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVG 529

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   781 QSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSgGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALL 860
Cdd:TIGR01243 530 ESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALL 608

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   861 RPGRFDKLVFVGASEDRAsQLRVLSAITRKFKLEASVSLANvLDCCPPQLTGADLYSLCSDAMMTALKRRVRD-----LE 935
Cdd:TIGR01243 609 RPGRFDRLILVPPPDEEA-RKEIFKIHTRSMPLAEDVDLEE-LAEMTEGYTGADIEAVCREAAMAALRESIGSpakekLE 686

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 21703962   936 EGLELRSSALLLTMEDLLQAAARLQPSVSEQELLRYKRIQRKF 978
Cdd:TIGR01243 687 VGEEEFLKDLKVEMRHFLEALKKVKPSVSKEDMLRYERLAKEL 729
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 467-978 7.58e-98

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 324.55  E-value: 7.58e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLGRDRDGL-GE- 544
Cdd:TIGR01243 215 VLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVtGEv 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   545 DARVAATLRHLLldeDALSRCPPLMVVATTSRVQDLPTDVQTA--FPHELEVPVLSEAQRLSILQALTAHLPLGQEVNLP 622
Cdd:TIGR01243 295 EKRVVAQLLTLM---DGLKGRGRVIVIGATNRPDALDPALRRPgrFDREIVIRVPDKRARKEILKVHTRNMPLAEDVDLD 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   623 QLARRCAGFVVGDLYALLTHTCRAACTRIRASGSAGGLSEEDEGDLcVAGFPLLAEDFGQALDQLQTAHSQAVGApRIPS 702
Cdd:TIGR01243 372 KLAEVTHGFVGADLAALAKEAAMAALRRFIREGKINFEAEEIPAEV-LKELKVTMKDFMEALKMVEPSAIREVLV-EVPN 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   703 VSWHDVGGLQDVKKEILETIQLPLEHPEL--LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVG 780
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIfeKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVG 529

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   781 QSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSgGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALL 860
Cdd:TIGR01243 530 ESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALL 608

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   861 RPGRFDKLVFVGASEDRAsQLRVLSAITRKFKLEASVSLANvLDCCPPQLTGADLYSLCSDAMMTALKRRVRD-----LE 935
Cdd:TIGR01243 609 RPGRFDRLILVPPPDEEA-RKEIFKIHTRSMPLAEDVDLEE-LAEMTEGYTGADIEAVCREAAMAALRESIGSpakekLE 686

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 21703962   936 EGLELRSSALLLTMEDLLQAAARLQPSVSEQELLRYKRIQRKF 978
Cdd:TIGR01243 687 VGEEEFLKDLKVEMRHFLEALKKVKPSVSKEDMLRYERLAKEL 729
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 697-965 1.72e-90

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 291.52  E-value: 1.72e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 697 APRIPSVSWHDVGGLQDVKKEILETIQLPLEHPELLSLGLRRSGLLL--HGPPGTGKTLLAKAVATECSLTFLSVKGPEL 774
Cdd:COG1222  69 PAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVllYGPPGTGKTLLAKAVAGELGAPFIRVRGSEL 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 775 INMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVmDRVVSQLLAELDGLHSTQDVFVIGATNRPDL 854
Cdd:COG1222 149 VSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEV-QRTVNQLLAELDGFESRGDVLIIAATNRPDL 227

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 855 LDPALLRPGRFDKLVFVGASeDRASQLRVLSAITRKFKLEASV---SLANVLDccppQLTGADLYSLCSDAMMTALKRRV 931
Cdd:COG1222 228 LDPALLRPGRFDRVIEVPLP-DEEAREEILKIHLRDMPLADDVdldKLAKLTE----GFSGADLKAIVTEAGMFAIREGR 302

                       250       260       270
                ....*....|....*....|....*....|....
gi 21703962 932 RDleeglelrssallLTMEDLLQAAARLQPSVSE 965
Cdd:COG1222 303 DT-------------VTMEDLEKAIEKVKKKTET 323
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 714-871 7.92e-86

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 272.46  E-value: 7.92e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 714 VKKEILETIQLPLEHPEL-LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFAR 792
Cdd:cd19527   1 VKKEILDTIQLPLEHPELfSSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 793 ARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHST-QDVFVIGATNRPDLLDPALLRPGRFDKLVFV 871
Cdd:cd19527  81 ARDAKPCVIFFDELDSLAPSRGNSGDSGGVMDRVVSQLLAELDGMSSSgQDVFVIGATNRPDLLDPALLRPGRFDKLLYL 160
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 701-955 2.33e-64

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 222.40  E-value: 2.33e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  701 PSVSWHDVGGLQDVKKEILETIQLPLEHPELLSLG--LRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMY 778
Cdd:PRK03992 126 PNVTYEDIGGLEEQIREVREAVELPLKKPELFEEVgiEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKF 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  779 VGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGgvmDRVVS----QLLAELDGLHSTQDVFVIGATNRPDL 854
Cdd:PRK03992 206 IGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSG---DREVQrtlmQLLAEMDGFDPRGNVKIIAATNRIDI 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  855 LDPALLRPGRFDKLVFVGASeDRASQLRVLSAITRKFKLEASV---SLANVLDccppQLTGADLYSLCSDAMMTALKRRv 931
Cdd:PRK03992 283 LDPAILRPGRFDRIIEVPLP-DEEGRLEILKIHTRKMNLADDVdleELAELTE----GASGADLKAICTEAGMFAIRDD- 356

                        250       260
                 ....*....|....*....|....
gi 21703962  932 RDleeglelrssalLLTMEDLLQA 955
Cdd:PRK03992 357 RT------------EVTMEDFLKA 368
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 744-872 9.96e-53

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 180.10  E-value: 9.96e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   744 HGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSggVM 823
Cdd:pfam00004   4 YGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDS--ES 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 21703962   824 DRVVSQLLAELDGL-HSTQDVFVIGATNRPDLLDPALLrpGRFDKLVFVG 872
Cdd:pfam00004  82 RRVVNQLLTELDGFtSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 744-875 8.06e-17

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 78.57  E-value: 8.06e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962    744 HGPPGTGKTLLAKAVATECSLTFLSVK-----------------GPELINMYVGQSEENVREVFARARAAAPCIIFFDEL 806
Cdd:smart00382   8 VGPPGSGKTTLARALARELGPPGGGVIyidgedileevldqlllIIVGGKKASGSGELRLRLALALARKLKPDVLILDEI 87

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21703962    807 DSLApsrgrsgDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPgRFDKLVFVGASE 875
Cdd:smart00382  88 TSLL-------DAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 467-978 7.58e-98

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 324.55  E-value: 7.58e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLGRDRDGL-GE- 544
Cdd:TIGR01243 215 VLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVtGEv 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   545 DARVAATLRHLLldeDALSRCPPLMVVATTSRVQDLPTDVQTA--FPHELEVPVLSEAQRLSILQALTAHLPLGQEVNLP 622
Cdd:TIGR01243 295 EKRVVAQLLTLM---DGLKGRGRVIVIGATNRPDALDPALRRPgrFDREIVIRVPDKRARKEILKVHTRNMPLAEDVDLD 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   623 QLARRCAGFVVGDLYALLTHTCRAACTRIRASGSAGGLSEEDEGDLcVAGFPLLAEDFGQALDQLQTAHSQAVGApRIPS 702
Cdd:TIGR01243 372 KLAEVTHGFVGADLAALAKEAAMAALRRFIREGKINFEAEEIPAEV-LKELKVTMKDFMEALKMVEPSAIREVLV-EVPN 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   703 VSWHDVGGLQDVKKEILETIQLPLEHPEL--LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVG 780
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIfeKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVG 529

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   781 QSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSgGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALL 860
Cdd:TIGR01243 530 ESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALL 608

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   861 RPGRFDKLVFVGASEDRAsQLRVLSAITRKFKLEASVSLANvLDCCPPQLTGADLYSLCSDAMMTALKRRVRD-----LE 935
Cdd:TIGR01243 609 RPGRFDRLILVPPPDEEA-RKEIFKIHTRSMPLAEDVDLEE-LAEMTEGYTGADIEAVCREAAMAALRESIGSpakekLE 686

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 21703962   936 EGLELRSSALLLTMEDLLQAAARLQPSVSEQELLRYKRIQRKF 978
Cdd:TIGR01243 687 VGEEEFLKDLKVEMRHFLEALKKVKPSVSKEDMLRYERLAKEL 729
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 697-965 1.72e-90

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 291.52  E-value: 1.72e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 697 APRIPSVSWHDVGGLQDVKKEILETIQLPLEHPELLSLGLRRSGLLL--HGPPGTGKTLLAKAVATECSLTFLSVKGPEL 774
Cdd:COG1222  69 PAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVllYGPPGTGKTLLAKAVAGELGAPFIRVRGSEL 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 775 INMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVmDRVVSQLLAELDGLHSTQDVFVIGATNRPDL 854
Cdd:COG1222 149 VSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEV-QRTVNQLLAELDGFESRGDVLIIAATNRPDL 227

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 855 LDPALLRPGRFDKLVFVGASeDRASQLRVLSAITRKFKLEASV---SLANVLDccppQLTGADLYSLCSDAMMTALKRRV 931
Cdd:COG1222 228 LDPALLRPGRFDRVIEVPLP-DEEAREEILKIHLRDMPLADDVdldKLAKLTE----GFSGADLKAIVTEAGMFAIREGR 302

                       250       260       270
                ....*....|....*....|....*....|....
gi 21703962 932 RDleeglelrssallLTMEDLLQAAARLQPSVSE 965
Cdd:COG1222 303 DT-------------VTMEDLEKAIEKVKKKTET 323
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 714-871 7.92e-86

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 272.46  E-value: 7.92e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 714 VKKEILETIQLPLEHPEL-LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFAR 792
Cdd:cd19527   1 VKKEILDTIQLPLEHPELfSSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 793 ARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHST-QDVFVIGATNRPDLLDPALLRPGRFDKLVFV 871
Cdd:cd19527  81 ARDAKPCVIFFDELDSLAPSRGNSGDSGGVMDRVVSQLLAELDGMSSSgQDVFVIGATNRPDLLDPALLRPGRFDKLLYL 160
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 714-871 1.56e-75

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 244.50  E-value: 1.56e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 714 VKKEILETIQLPLEHPELLSLGLRRSGL--LLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFA 791
Cdd:cd19511   1 VKRELKEAVEWPLKHPDAFKRLGIRPPKgvLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 792 RARAAAPCIIFFDELDSLAPSRGRSgDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFV 871
Cdd:cd19511  81 KARQAAPCIIFFDEIDSLAPRRGQS-DSSGVTDRVVSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLDKLIYV 159
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 714-871 1.72e-73

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 239.33  E-value: 1.72e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 714 VKKEILETIQLPLEHPELLSL--GLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFA 791
Cdd:cd19528   1 VKRELQELVQYPVEHPDKFLKfgMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 792 RARAAAPCIIFFDELDSLAPSRGRS-GDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVF 870
Cdd:cd19528  81 KARAAAPCVLFFDELDSIAKARGGNiGDAGGAADRVINQILTEMDGMNTKKNVFIIGATNRPDIIDPAILRPGRLDQLIY 160


                .
gi 21703962 871 V 871
Cdd:cd19528 161 I 161
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 540-958 5.50e-66

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 227.49  E-value: 5.50e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 540 DGLGEDARVAATLRHLLLDEDALSRCPPLMVVATTSRVQDLPTDVQTAFPHELEVPVLSEAQRLSILQALTAHLPLGQEV 619
Cdd:COG0464   1 LAELLALAVALALALLLLDDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 620 NLPQLARRCAGFVVGDLYALLTHTCRAACTRIRASGSAGGLSEEDEGDLCVAGFPLLAEDFGQALDQLQTAHSQAvgapr 699
Cdd:COG0464  81 LLAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAI----- 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 700 ipsvsWHDVGGLQDVKKEILETIQLPLEHPELLSLGLRRSGLLL--HGPPGTGKTLLAKAVATECSLTFLSVKGPELINM 777
Cdd:COG0464 156 -----LDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLllYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSK 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 778 YVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDsgGVMDRVVSQLLAELDGLHStqDVFVIGATNRPDLLDP 857
Cdd:COG0464 231 YVGETEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGD--GVGRRVVNTLLTEMEELRS--DVVVIAATNRPDLLDP 306

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 858 ALLRpgRFDKLVFVGASeDRASQLRVLSAITRKFKLEASVSLANVLDCCpPQLTGADLYSLCSDAMMTAlkrrvrdleeg 937
Cdd:COG0464 307 ALLR--RFDEIIFFPLP-DAEERLEIFRIHLRKRPLDEDVDLEELAEAT-EGLSGADIRNVVRRAALQA----------- 371

                       410       420
                ....*....|....*....|.
gi 21703962 938 leLRSSALLLTMEDLLQAAAR 958
Cdd:COG0464 372 --LRLGREPVTTEDLLEALER 390
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 714-871 2.06e-64

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 214.28  E-value: 2.06e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 714 VKKEILETIQLPLEHPELLSLGLRRSGL--LLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFA 791
Cdd:cd19529   1 VKQELKEAVEWPLLKPEVFKRLGIRPPKgiLLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 792 RARAAAPCIIFFDELDSLAPSRGRSGDSgGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFV 871
Cdd:cd19529  81 KARQVAPCVIFFDEIDSIAPRRGTTGDS-GVTERVVNQLLTELDGLEEMNGVVVIAATNRPDIIDPALLRAGRFDRLIYI 159
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 701-955 2.33e-64

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 222.40  E-value: 2.33e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  701 PSVSWHDVGGLQDVKKEILETIQLPLEHPELLSLG--LRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMY 778
Cdd:PRK03992 126 PNVTYEDIGGLEEQIREVREAVELPLKKPELFEEVgiEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKF 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  779 VGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGgvmDRVVS----QLLAELDGLHSTQDVFVIGATNRPDL 854
Cdd:PRK03992 206 IGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSG---DREVQrtlmQLLAEMDGFDPRGNVKIIAATNRIDI 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  855 LDPALLRPGRFDKLVFVGASeDRASQLRVLSAITRKFKLEASV---SLANVLDccppQLTGADLYSLCSDAMMTALKRRv 931
Cdd:PRK03992 283 LDPAILRPGRFDRIIEVPLP-DEEGRLEILKIHTRKMNLADDVdleELAELTE----GASGADLKAICTEAGMFAIRDD- 356

                        250       260
                 ....*....|....*....|....
gi 21703962  932 RDleeglelrssalLLTMEDLLQA 955
Cdd:PRK03992 357 RT------------EVTMEDFLKA 368
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 714-870 4.05e-63

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 210.36  E-value: 4.05e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 714 VKKEILETIQLPLEHPE--LLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFA 791
Cdd:cd19526   1 VKKALEETIEWPSKYPKifASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21703962 792 RARAAAPCIIFFDELDSLAPSRGRsgDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVF 870
Cdd:cd19526  81 RAQSAKPCILFFDEFDSIAPKRGH--DSTGVTDRVVNQLLTQLDGVEGLDGVYVLAATSRPDLIDPALLRPGRLDKLVY 157
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 699-962 2.94e-60

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 219.78  E-value: 2.94e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   699 RIPSVSWHDVGGLQDVKKEILETIQLPLEHPE--LLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELIN 776
Cdd:TIGR01243 171 KVPKVTYEDIGGLKEAKEKIREMVELPMKHPElfEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMS 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   777 MYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSgdSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLD 856
Cdd:TIGR01243 251 KYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEV--TGEVEKRVVAQLLTLMDGLKGRGRVIVIGATNRPDALD 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   857 PALLRPGRFDKLVFVGASEDRASQlRVLSAITRKFKLEASVSLANVLDCCpPQLTGADLYSLCSDAMMTALKRRVRDLEE 936
Cdd:TIGR01243 329 PALRRPGRFDREIVIRVPDKRARK-EILKVHTRNMPLAEDVDLDKLAEVT-HGFVGADLAALAKEAAMAALRRFIREGKI 406

                         250       260       270
                  ....*....|....*....|....*....|..
gi 21703962   937 GLELRS------SALLLTMEDLLQAAARLQPS 962
Cdd:TIGR01243 407 NFEAEEipaevlKELKVTMKDFMEALKMVEPS 438
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
 701-955 2.94e-60

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 210.04  E-value: 2.94e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   701 PSVSWHDVGGLQDVKKEILETIQLPLEHPELLSLG--LRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMY 778
Cdd:TIGR01242 117 PNVSYEDIGGLEEQIREIREAVELPLKHPELFEEVgiEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVRKY 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   779 VGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGG-VMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDP 857
Cdd:TIGR01242 197 IGEGARLVREIFELAKEKAPSIIFIDEIDAIAAKRTDSGTSGDrEVQRTLMQLLAELDGFDPRGNVKVIAATNRPDILDP 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   858 ALLRPGRFDKLVFVGASEDRAsQLRVLSAITRKFKLEASVSL---ANVLDCCppqlTGADLYSLCSDAMMTALKRRVRdl 934
Cdd:TIGR01242 277 ALLRPGRFDRIIEVPLPDFEG-RLEILKIHTRKMKLAEDVDLeaiAKMTEGA----SGADLKAICTEAGMFAIREERD-- 349

                         250       260
                  ....*....|....*....|.
gi 21703962   935 eeglelrssalLLTMEDLLQA 955
Cdd:TIGR01242 350 -----------YVTMDDFIKA 359
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 711-871 4.83e-60

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 201.95  E-value: 4.83e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 711 LQDVKKEILETIQLPLEHPELLSLGLRRSGL--LLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVRE 788
Cdd:cd19530   1 LDHVREELTMSILRPIKRPDIYKALGIDLPTgvLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 789 VFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVmdRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKL 868
Cdd:cd19530  81 VFQRARASAPCVIFFDEVDALVPKRGDGGSWASE--RVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLRPGRLDKT 158


                ...
gi 21703962 869 VFV 871
Cdd:cd19530 159 LYV 161
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 707-869 1.35e-59

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 200.98  E-value: 1.35e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 707 DVGGLQDVKKEILETIQLPLEHPELLSLGLRRSG--LLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEE 784
Cdd:cd19503   1 DIGGLDEQIASLKELIELPLKYPELFRALGLKPPrgVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 785 NVREVFARARAAAPCIIFFDELDSLAPSRGRsgDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGR 864
Cdd:cd19503  81 NLREIFEEARSHAPSIIFIDEIDALAPKREE--DQREVERRVVAQLLTLMDGMSSRGKVVVIAATNRPDAIDPALRRPGR 158


                ....*
gi 21703962 865 FDKLV 869
Cdd:cd19503 159 FDREV 163
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 704-869 1.20e-55

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 190.24  E-value: 1.20e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 704 SWHDVGGLQDVKKEILETIQLPLEHPELLSLG--LRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQ 781
Cdd:cd19502   1 TYEDIGGLDEQIREIREVVELPLKHPELFEELgiEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 782 SEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGgvmDRVVS----QLLAELDGLHSTQDVFVIGATNRPDLLDP 857
Cdd:cd19502  81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRFDSGTGG---DREVQrtmlELLNQLDGFDPRGNIKVIMATNRPDILDP 157

                       170
                ....*....|..
gi 21703962 858 ALLRPGRFDKLV 869
Cdd:cd19502 158 ALLRPGRFDRKI 169
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 714-871 9.00e-54

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 184.41  E-value: 9.00e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 714 VKKEILETIQLPLEHPELLSLGLRRSGLLL-HGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFAR 792
Cdd:cd19481   1 LKASLREAVEAPRRGSRLRRYGLGLPKGILlYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFER 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21703962 793 ARAAAPCIIFFDELDSLAPSRGRSGDSgGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFV 871
Cdd:cd19481  81 ARRLAPCILFIDEIDAIGRKRDSSGES-GELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALLRPGRFDEVIEF 158
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 707-872 7.66e-53

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 181.87  E-value: 7.66e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 707 DVGGLQDVKKEILETIQLPLEHPE--LLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEE 784
Cdd:cd19519   1 DIGGCRKQLAQIREMVELPLRHPElfKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 785 NVREVFARARAAAPCIIFFDELDSLAPSRGRSgdSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGR 864
Cdd:cd19519  81 NLRKAFEEAEKNAPAIIFIDEIDAIAPKREKT--HGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGR 158


                ....*...
gi 21703962 865 FDKLVFVG 872
Cdd:cd19519 159 FDREIDIG 166
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 744-872 9.96e-53

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 180.10  E-value: 9.96e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   744 HGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSggVM 823
Cdd:pfam00004   4 YGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDS--ES 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 21703962   824 DRVVSQLLAELDGL-HSTQDVFVIGATNRPDLLDPALLrpGRFDKLVFVG 872
Cdd:pfam00004  82 RRVVNQLLTELDGFtSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 703-871 6.94e-51

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 176.65  E-value: 6.94e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 703 VSWHDVGGLQDVKKEILETIQLpLEHPELLSLGLRRSG--LLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVG 780
Cdd:cd19501   1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTKLGAKIPkgVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 781 QSEENVREVFARARAAAPCIIFFDELDSLAPSRGR-SGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPAL 859
Cdd:cd19501  80 VGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAgLGGGHDEREQTLNQLLVEMDGFESNTGVIVIAATNRPDVLDPAL 159

                       170
                ....*....|..
gi 21703962 860 LRPGRFDKLVFV 871
Cdd:cd19501 160 LRPGRFDRQVYV 171
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
 701-942 4.97e-50

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 184.80  E-value: 4.97e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   701 PSVSWHDVGGLQDVKKEILETIQLpLEHPE--LLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMY 778
Cdd:TIGR01241  50 PKVTFKDVAGIDEAKEELMEIVDF-LKNPSkfTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   779 VGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRsGDSGG--VMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLD 856
Cdd:TIGR01241 129 VGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGA-GLGGGndEREQTLNQLLVEMDGFGTNTGVIVIAATNRPDVLD 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   857 PALLRPGRFDKLVFVGASE--DRASQLRVLSaitRKFKLEASVSLANVLDCCpPQLTGADLYSLCSDAMMTALKR----- 929
Cdd:TIGR01241 208 PALLRPGRFDRQVVVDLPDikGREEILKVHA---KNKKLAPDVDLKAVARRT-PGFSGADLANLLNEAALLAARKnktei 283

                         250       260
                  ....*....|....*....|
gi 21703962   930 RVRDLEE-------GLELRS 942
Cdd:TIGR01241 284 TMNDIEEaidrviaGPEKKS 303
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 701-937 3.61e-48

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 176.88  E-value: 3.61e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  701 PSVSWHDVGGLQDVKKEILETIQLPLEHPELLSLGL--RRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMY 778
Cdd:PTZ00454 140 PDVTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGidPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKY 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  779 VGQSEENVREVFARARAAAPCIIFFDELDSLAPSR--GRSGDSGGVmDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLD 856
Cdd:PTZ00454 220 LGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRfdAQTGADREV-QRILLELLNQMDGFDQTTNVKVIMATNRADTLD 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  857 PALLRPGRFD-KLVFvgASEDRASQLRVLSAITRKFKLEASVSLANVLDcCPPQLTGADLYSLCSDAMMTALK--RRV-- 931
Cdd:PTZ00454 299 PALLRPGRLDrKIEF--PLPDRRQKRLIFQTITSKMNLSEEVDLEDFVS-RPEKISAADIAAICQEAGMQAVRknRYVil 375


                 ....*..
gi 21703962  932 -RDLEEG 937
Cdd:PTZ00454 376 pKDFEKG 382
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 699-939 2.58e-46

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 172.65  E-value: 2.58e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  699 RIPSVSWHDVGGLQDVKKEILETIQLPLEHPEL--LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELIN 776
Cdd:PTZ00361 176 KAPLESYADIGGLEQQIQEIKEAVELPLTHPELydDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQ 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  777 MYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSgDSGGVMD--RVVSQLLAELDGLHSTQDVFVIGATNRPDL 854
Cdd:PTZ00361 256 KYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDA-TSGGEKEiqRTMLELLNQLDGFDSRGDVKVIMATNRIES 334

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  855 LDPALLRPGRFD-KLVFvgASEDRASQLRVLSAITRKFKLEASVSLANVLDcCPPQLTGADLYSLCSDAMMTALK-RRVR 932
Cdd:PTZ00361 335 LDPALIRPGRIDrKIEF--PNPDEKTKRRIFEIHTSKMTLAEDVDLEEFIM-AKDELSGADIKAICTEAGLLALReRRMK 411

                        250
                 ....*....|.
gi 21703962  933 ----DLEEGLE 939
Cdd:PTZ00361 412 vtqaDFRKAKE 422
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
745-945 1.11e-44

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 170.99  E-value: 1.11e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 745 GPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGdsGGVMD 824
Cdd:COG0465 182 GPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGL--GGGHD 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 825 ---RVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGA--SEDRASQLRVLsaiTRKFKLEASVSL 899
Cdd:COG0465 260 ereQTLNQLLVEMDGFEGNEGVIVIAATNRPDVLDPALLRPGRFDRQVVVDLpdVKGREAILKVH---ARKKPLAPDVDL 336

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21703962 900 aNVLDCCPPQLTGADLYSLCSDAmmtAL------KRRV--RDLEE-------GLELRSSAL 945
Cdd:COG0465 337 -EVIARRTPGFSGADLANLVNEA---ALlaarrnKKAVtmEDFEEaidrviaGPERKSRVI 393
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 707-867 2.22e-44

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 157.95  E-value: 2.22e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 707 DVGGLQDVKKEILETIQLPLEHPELLSLGLRRSGL--LLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEE 784
Cdd:cd19518   1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVEPPRgvLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 785 NVREVFARARAAAPCIIFFDELDSLAPSrgRSGDSGGVMDRVVSQLLAELDGL----HSTQDVFVIGATNRPDLLDPALL 860
Cdd:cd19518  81 KIRELFDQAISNAPCIVFIDEIDAITPK--RESAQREMERRIVSQLLTCMDELnnekTAGGPVLVIGATNRPDSLDPALR 158


                ....*..
gi 21703962 861 RPGRFDK 867
Cdd:cd19518 159 RAGRFDR 165
ftsH CHL00176
cell division protein; Validated
 703-930 3.44e-44

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 170.62  E-value: 3.44e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  703 VSWHDVGGLQDVKKEiLETIQLPLEHPELLSLGLRRSGL--LLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVG 780
Cdd:CHL00176 180 ITFRDIAGIEEAKEE-FEEVVSFLKKPERFTAVGAKIPKgvLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVG 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  781 QSEENVREVFARARAAAPCIIFFDELDSLAPSRGrSGDSGGVMDR--VVSQLLAELDGLHSTQDVFVIGATNRPDLLDPA 858
Cdd:CHL00176 259 VGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRG-AGIGGGNDEReqTLNQLLTEMDGFKGNKGVIVIAATNRVDILDAA 337

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21703962  859 LLRPGRFDKLVFVGASeDRASQLRVLSAITRKFKLEASVSLAnVLDCCPPQLTGADLYSLCSDAMMTALKRR 930
Cdd:CHL00176 338 LLRPGRFDRQITVSLP-DREGRLDILKVHARNKKLSPDVSLE-LIARRTPGFSGADLANLLNEAAILTARRK 407
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
744-960 6.11e-44

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 159.66  E-value: 6.11e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 744 HGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARaAAPCIIFFDELDSLAPSRGRSGDSGGvM 823
Cdd:COG1223  41 YGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETARNLRKLFDFAR-RAPCVIFFDEFDAIAKDRGDQNDVGE-V 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 824 DRVVSQLLAELDGLHStqDVFVIGATNRPDLLDPALLRpgRFD-KLVFVgaSEDRASQLRVLSAITRKFKLEASVSLANV 902
Cdd:COG1223 119 KRVVNALLQELDGLPS--GSVVIAATNHPELLDSALWR--RFDeVIEFP--LPDKEERKEILELNLKKFPLPFELDLKKL 192

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21703962 903 LDCCPPqLTGADLyslcSDAMMTALKRRVRDLEEglelrssalLLTMEDLLQAAARLQ 960
Cdd:COG1223 193 AKKLEG-LSGADI----EKVLKTALKKAILEDRE---------KVTKEDLEEALKQRK 236
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
704-936 6.61e-44

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 169.83  E-value: 6.61e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  704 SWHDVGGLQDVKKEILETIQLpLEHPE--LLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQ 781
Cdd:PRK10733 150 TFADVAGCDEAKEEVAELVEY-LREPSrfQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGV 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  782 SEENVREVFARARAAAPCIIFFDELDSLAPSRGrSGDSGGVMDR--VVSQLLAELDGLHSTQDVFVIGATNRPDLLDPAL 859
Cdd:PRK10733 229 GASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRG-AGLGGGHDEReqTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPAL 307

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21703962  860 LRPGRFDKLVFVGASEDRASQlRVLSAITRKFKLEASVSlANVLDCCPPQLTGADLYSLCSDAMMTALK--RRVRDLEE 936
Cdd:PRK10733 308 LRPGRFDRQVVVGLPDVRGRE-QILKVHMRRVPLAPDID-AAIIARGTPGFSGADLANLVNEAALFAARgnKRVVSMVE 384
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 708-871 1.16e-41

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 150.20  E-value: 1.16e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 708 VGGLQDVKKEILETIQLPLEHPEL-LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENV 786
Cdd:cd19509   1 IAGLDDAKEALKEAVILPSLRPDLfPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 787 REVFARARAAAPCIIFFDELDSLAPSRGrSGDSGGVMdRVVSQLLAELDGL--HSTQDVFVIGATNRPDLLDPALLRpgR 864
Cdd:cd19509  81 RALFALARELQPSIIFIDEIDSLLSERG-SGEHEASR-RVKTEFLVQMDGVlnKPEDRVLVLGATNRPWELDEAFLR--R 156


                ....*..
gi 21703962 865 FDKLVFV 871
Cdd:cd19509 157 FEKRIYI 163
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 707-867 2.86e-39

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 143.42  E-value: 2.86e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 707 DVGGLQDVKKEILETIQLPLEHPE--LLSLGLRRSGLLLHGPPGTGKTLLAKAVATECS-----LTFLSVKGPELINMYV 779
Cdd:cd19517   1 DIGGLSHYINQLKEMVFFPLLYPEvfAKFKITPPRGVLFHGPPGTGKTLMARALAAECSkggqkVSFFMRKGADCLSKWV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 780 GQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSggVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPAL 859
Cdd:cd19517  81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQ--IHASIVSTLLALMDGLDNRGQVVVIGATNRPDALDPAL 158


                ....*...
gi 21703962 860 LRPGRFDK 867
Cdd:cd19517 159 RRPGRFDR 166
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 744-866 3.98e-38

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 140.32  E-value: 3.98e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 744 HGPPGTGKTLLAKAVATecsltFLS------VKGPELINMYVGQSEENVREVFARARA--------AAPCIIFFDELDSL 809
Cdd:cd19504  41 YGPPGTGKTLMARQIGK-----MLNarepkiVNGPEILNKYVGESEANIRKLFADAEEeqrrlganSGLHIIIFDEIDAI 115

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 21703962 810 APSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFD 866
Cdd:cd19504 116 CKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRKDLIDEALLRPGRLE 172
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 701-871 9.57e-36

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 133.45  E-value: 9.57e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 701 PSVSWHDVGGLQDVKKEILETIQLPLEHPEL-LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYV 779
Cdd:cd19521   2 PNVKWEDVAGLEGAKEALKEAVILPVKFPHLfTGNRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWM 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 780 GQSEENVREVFARARAAAPCIIFFDELDSLAPSRGrSGDSGGVMdRVVSQLLAELDGL-HSTQDVFVIGATNRPDLLDPA 858
Cdd:cd19521  82 GESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRG-EGESEASR-RIKTELLVQMNGVgNDSQGVLVLGATNIPWQLDSA 159

                       170
                ....*....|...
gi 21703962 859 LLRpgRFDKLVFV 871
Cdd:cd19521 160 IRR--RFEKRIYI 170
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 707-871 3.15e-33

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 126.25  E-value: 3.15e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 707 DVGGLQDVKKEILETIQLPLEHPELLSLGLRR-SGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEEN 785
Cdd:cd19522   1 DIADLEEAKKLLEEAVVLPMWMPEFFKGIRRPwKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 786 VREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMdRVVSQLLAELDGLHSTQD-------VFVIGATNRPDLLDPA 858
Cdd:cd19522  81 VRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASR-RVKSELLVQMDGVGGASEnddpskmVMVLAATNFPWDIDEA 159

                       170
                ....*....|...
gi 21703962 859 LLRpgRFDKLVFV 871
Cdd:cd19522 160 LRR--RLEKRIYI 170
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 701-871 7.87e-33

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 125.49  E-value: 7.87e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 701 PSVSWHDVGGLQDVKKEILETIQLPLEHPEL-LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYV 779
Cdd:cd19525  17 PPINWADIAGLEFAKKTIKEIVVWPMLRPDIfTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWV 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 780 GQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGvmDRVVSQLLAELDGLHSTQD--VFVIGATNRPDLLDP 857
Cdd:cd19525  97 GEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESS--RRIKTEFLVQLDGATTSSEdrILVVGATNRPQEIDE 174

                       170
                ....*....|....
gi 21703962 858 ALLRpgRFDKLVFV 871
Cdd:cd19525 175 AARR--RLVKRLYI 186
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 707-865 2.85e-32

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 123.30  E-value: 2.85e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 707 DVGGLQDVKKEILETIQLPLEHPELLSLGLRRSGLL---LHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSE 783
Cdd:cd19520   1 DIGGLDEVITELKELVILPLQRPELFDNSRLLQPPKgvlLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 784 ENVREVFARARAAAPCIIFFDELDSLAPSRgRSGDSgGVMDRVVSQLLAELDGLHSTQD--VFVIGATNRPDLLDPALLR 861
Cdd:cd19520  81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQR-SSTDH-EATAMMKAEFMSLWDGLSTDGNcrVIVMGATNRPQDLDEAILR 158


                ....*.
gi 21703962 862 --PGRF 865
Cdd:cd19520 159 rmPKRF 164
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 707-871 4.43e-32

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 122.65  E-value: 4.43e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 707 DVGGLQDVKKEILETIQLPLEHPEL-LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEEN 785
Cdd:cd19524   1 DIAGQDLAKQALQEMVILPSLRPELfTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 786 VREVFARARAAAPCIIFFDELDSLAPSRgRSGDSGGVMdRVVSQLLAELDGLHSTQD--VFVIGATNRPDLLDPALLRpg 863
Cdd:cd19524  81 VRALFAVARELQPSIIFIDEVDSLLSER-SEGEHEASR-RLKTEFLIEFDGVQSNGDdrVLVMGATNRPQELDDAVLR-- 156


                ....*...
gi 21703962 864 RFDKLVFV 871
Cdd:cd19524 157 RFTKRVYV 164
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 467-581 2.07e-28

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 111.99  E-value: 2.07e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLGRDRDGLGEDA 546
Cdd:cd19481  29 ILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFERARRLAPCILFIDEIDAIGRKRDSSGESG 108

                        90       100       110
                ....*....|....*....|....*....|....*
gi 21703962 547 RVAATLRHLLLDEDALSRCPPLMVVATTSRVQDLP 581
Cdd:cd19481 109 ELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLD 143
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 744-872 3.25e-25

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 102.61  E-value: 3.25e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 744 HGPPGTGKTLLAKAVATEC---SLTFLSVKGPELINMYVGQSEEN---VREVFARARAAAPCIIFFDELDSLAPsrgrsg 817
Cdd:cd00009  25 YGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFGhflVRLLFELAEKAKPGVLFIDEIDSLSR------ 98

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 21703962 818 dsgGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVG 872
Cdd:cd00009  99 ---GAQNALLRVLETLNDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRIVIP 150
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 745-871 4.19e-23

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 96.67  E-value: 4.19e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 745 GPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSgGVMD 824
Cdd:cd19507  38 GIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRLRQMIQTAEAIAPCVLWIDEIEKGFSNADSKGDS-GTSS 116

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 21703962 825 RVVSQLLAELDglHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFV 871
Cdd:cd19507 117 RVLGTFLTWLQ--EKKKPVFVVATANNVQSLPPELLRKGRFDEIFFV 161
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 467-596 3.32e-22

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 93.04  E-value: 3.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLG--RDRDGLGE 544
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAgsRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 21703962   545 DARVAATLRHLLldEDALSRCPPLMVVATTSRVQDLPTDVQTAFPHELEVPV 596
Cdd:pfam00004  81 SRRVVNQLLTEL--DGFTSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 427-647 1.30e-20

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 95.36  E-value: 1.30e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 427 RSPPWDSLS-PPGLEALVNELCAILKPH---LQPGGtlLTGTSCVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLca 502
Cdd:COG0464 152 REAILDDLGgLEEVKEELRELVALPLKRpelREEYG--LPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDL-- 227

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 503 dSSRAV---ETKLQATFSRARRCRPAVLLLTAVDLLGRDRDGLGEdaRVAATLRHLLLDE-DALSrcPPLMVVATTSRVQ 578
Cdd:COG0464 228 -VSKYVgetEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGD--GVGRRVVNTLLTEmEELR--SDVVVIAATNRPD 302

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21703962 579 DLPTDVQTAFPHELEVPVLSEAQRLSILQALTAHLPLGQEVNLPQLARRCAGFVVGDLYALLTHTCRAA 647
Cdd:COG0464 303 LLDPALLRRFDEIIFFPLPDAEERLEIFRIHLRKRPLDEDVDLEELAEATEGLSGADIRNVVRRAALQA 371
ycf46 CHL00195
Ycf46; Provisional
 745-872 1.09e-18

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 90.46  E-value: 1.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  745 GPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSgGVMD 824
Cdd:CHL00195 266 GIQGTGKSLTAKAIANDWQLPLLRLDVGKLFGGIVGESESRMRQMIRIAEALSPCILWIDEIDKAFSNSESKGDS-GTTN 344

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 21703962  825 RVVSQLLAELDglHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVG 872
Cdd:CHL00195 345 RVLATFITWLS--EKKSPVFVVATANNIDLLPLEILRKGRFDEIFFLD 390
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
467-636 1.16e-18

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 86.48  E-value: 1.16e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLcaDSSRAVET--KLQATFSRARRcRPAVLLLTAVDLLGRDRDGLGE 544
Cdd:COG1223  38 ILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSL--IGSYLGETarNLRKLFDFARR-APCVIFFDEFDAIAKDRGDQND 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 545 DARVAATLRHLLLDEDALSRcpPLMVVATTSRVQDLPTDVQTAFPHELEVPVLSEAQRLSILQALTAHLPLGQEVNLPQL 624
Cdd:COG1223 115 VGEVKRVVNALLQELDGLPS--GSVVIAATNHPELLDSALWRRFDEVIEFPLPDKEERKEILELNLKKFPLPFELDLKKL 192

                       170
                ....*....|..
gi 21703962 625 ARRCAGFVVGDL 636
Cdd:COG1223 193 AKKLEGLSGADI 204
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 438-641 1.52e-17

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 85.06  E-value: 1.52e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 438 GLEALVNELC-AILKPHLQPG-----GTLLTGTscVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLcadSSRAV--- 508
Cdd:COG1222  82 GLDEQIEEIReAVELPLKNPElfrkyGIEPPKG--VLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSEL---VSKYIgeg 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 509 ETKLQATFSRARRCRPAVLLLTAVDLLGRDRDGLGEDARVAATLRHLLLDEDALSRCPPLMVVATTSRVQDLptDvqTA- 587
Cdd:COG1222 157 ARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEVQRTVNQLLAELDGFESRGDVLIIAATNRPDLL--D--PAl 232

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21703962 588 -----FPHELEVPVLSEAQRLSILQALTAHLPLGQEVNLPQLARRCAGFVVGDLYALLT 641
Cdd:COG1222 233 lrpgrFDRVIEVPLPDEEAREEILKIHLRDMPLADDVDLDKLAKLTEGFSGADLKAIVT 291
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 707-871 2.00e-17

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 80.70  E-value: 2.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 707 DVGGLQDVKKEILETIQLPLEHPEL-LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEEN 785
Cdd:cd19523   1 DIAGLGALKAAIKEEVLWPLLRPDAfSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 786 VREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGvmdRVVSQLLAELDG-LHSTQD-VFVIGATNRPDLLDPALLRpg 863
Cdd:cd19523  81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASPVG---RLQVELLAQLDGvLGSGEDgVLVVCTTSKPEEIDESLRR-- 155


                ....*...
gi 21703962 864 RFDKLVFV 871
Cdd:cd19523 156 YFSKRLLV 163
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 744-875 8.06e-17

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 78.57  E-value: 8.06e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962    744 HGPPGTGKTLLAKAVATECSLTFLSVK-----------------GPELINMYVGQSEENVREVFARARAAAPCIIFFDEL 806
Cdd:smart00382   8 VGPPGSGKTTLARALARELGPPGGGVIyidgedileevldqlllIIVGGKKASGSGELRLRLALALARKLKPDVLILDEI 87

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21703962    807 DSLApsrgrsgDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPgRFDKLVFVGASE 875
Cdd:smart00382  88 TSLL-------DAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 744-871 9.67e-13

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 66.61  E-value: 9.67e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 744 HGPPGTGKTLLAKAVATECSLTFLsvkgpeLINMY-VGQSEENVREVFARARAAApcIIFFDELDSLAPSR---GRSGDS 819
Cdd:cd19510  29 YGPPGTGKSSFIAALAGELDYDIC------DLNLSeVVLTDDRLNHLLNTAPKQS--IILLEDIDAAFESRehnKKNPSA 100

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 21703962 820 GGVMDRV-VSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFV 871
Cdd:cd19510 101 YGGLSRVtFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 467-580 4.91e-11

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 62.31  E-value: 4.91e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLG--RDRDGLGE 544
Cdd:cd19503  37 VLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEKNLREIFEEARSHAPSIIFIDEIDALApkREEDQREV 116

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21703962 545 DARVAATLRHLLldeDALSRCPPLMVVATTSRVQDL 580
Cdd:cd19503 117 ERRVVAQLLTLM---DGMSSRGKVVVIAATNRPDAI 149
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 438-592 1.24e-09

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 58.18  E-value: 1.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 438 GLEALVNELCA-ILKPHLQPGGTLLTGT---SCVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQ 513
Cdd:cd19518   4 GMDSTLKELCElLIHPILPPEYFQHLGVeppRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEEKIR 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 514 ATFSRARRCRPAVLLLTAVDLLGRDRDGLGEDA--RVAAtlrHLLLDEDALSRCP----PLMVVATTSRVQDLPTDVQTA 587
Cdd:cd19518  84 ELFDQAISNAPCIVFIDEIDAITPKRESAQREMerRIVS---QLLTCMDELNNEKtaggPVLVIGATNRPDSLDPALRRA 160


                ....*..
gi 21703962 588 --FPHEL 592
Cdd:cd19518 161 grFDREI 167
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 438-594 2.83e-09

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 57.05  E-value: 2.83e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 438 GLEALVNEL-----CAILKPHLQPGGTLLTGTSCVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLC----ADSSRAV 508
Cdd:cd19520   4 GLDEVITELkelviLPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTdkwyGESQKLV 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 509 EtklqATFSRARRCRPAVLLLTAVDLLGRDRDglGEDARVAATLRHLL------LDEDALSRcppLMVVATTSRVQDLPT 582
Cdd:cd19520  84 A----AVFSLASKLQPSIIFIDEIDSFLRQRS--STDHEATAMMKAEFmslwdgLSTDGNCR---VIVMGATNRPQDLDE 154

                       170
                ....*....|..
gi 21703962 583 DVQTAFPHELEV 594
Cdd:cd19520 155 AILRRMPKRFHI 166
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 744-859 3.18e-09

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 57.84  E-value: 3.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 744 HGPPGTGKTLLAKAVATECSL---------TFLSVKGPELINMYVGQSEENVREVFARARAAAP---CIIF--FDELDSL 809
Cdd:cd19508  58 HGPPGTGKTSLCKALAQKLSIrlssryrygQLIEINSHSLFSKWFSESGKLVTKMFQKIQELIDdkdALVFvlIDEVESL 137

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 21703962 810 APSRG--RSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPAL 859
Cdd:cd19508 138 AAARSasSSGTEPSDAIRVVNAVLTQIDRIKRYHNNVILLTSNLLEKIDVAF 189
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
457-640 1.25e-08

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 58.89  E-value: 1.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  457 GGTLLTGtscVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLG 536
Cdd:PRK10733 181 GGKIPKG---VLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVG 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  537 RDRD---GLGEDARvAATLRHLLLDEDALSRCPPLMVVATTSRVQDL-PTDVQTA-FPHELEVPVLSEAQRLSILQALTA 611
Cdd:PRK10733 258 RQRGaglGGGHDER-EQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLdPALLRPGrFDRQVVVGLPDVRGREQILKVHMR 336

                        170       180
                 ....*....|....*....|....*....
gi 21703962  612 HLPLGQEVNLPQLARRCAGFVVGDLYALL 640
Cdd:PRK10733 337 RVPLAPDIDAAIIARGTPGFSGADLANLV 365
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 448-576 1.79e-08

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 54.80  E-value: 1.79e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 448 AILKPHLQPGGTLLTGTSC---VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSL----CADSSRAVETklqaTFSRAR 520
Cdd:cd19530  11 SILRPIKRPDIYKALGIDLptgVLLYGPPGCGKTLLAKAVANESGANFISVKGPELlnkyVGESERAVRQ----VFQRAR 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21703962 521 RCRPAVLLLTAVDLLGRDRDGlGEDARVAATLRHLLLDEDALSRCPPLMVVATTSR 576
Cdd:cd19530  87 ASAPCVIFFDEVDALVPKRGD-GGSWASERVVNQLLTEMDGLEERSNVFVIAATNR 141
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 467-576 6.02e-08

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 53.06  E-value: 6.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSL----CADSSRAVetklQATFSRARRCRPAVLLLTAVDLLGRDR--- 539
Cdd:cd19511  30 VLLYGPPGCGKTLLAKALASEAGLNFISVKGPELfskyVGESERAV----REIFQKARQAAPCIIFFDEIDSLAPRRgqs 105

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 21703962 540 DGLGEDARVAATlrhLLLDEDALSRCPPLMVVATTSR 576
Cdd:cd19511 106 DSSGVTDRVVSQ---LLTELDGIESLKGVVVIAATNR 139
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 449-580 1.03e-07

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 52.35  E-value: 1.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 449 ILKPHLQPGgtLLTGTSCVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLL 528
Cdd:cd19509  19 SLRPDLFPG--LRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIVRALFALARELQPSIIF 96

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 21703962 529 LTAVDLLGRDRDglGEDARVAATLRHLLLDE-DALSRCPP--LMVVATTSRVQDL 580
Cdd:cd19509  97 IDEIDSLLSERG--SGEHEASRRVKTEFLVQmDGVLNKPEdrVLVLGATNRPWEL 149
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 745-869 1.47e-07

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 51.99  E-value: 1.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 745 GPPGTGKTLLAKAVATECSLTFLSV--------------KGPELINMYVGQSEENVREVFARARAAAPCIIFFD---ELD 807
Cdd:cd19505  19 GSIETGRSYLIKSLAANSYVPLIRIslnkllynkpdfgnDDWIDGMLILKESLHRLNLQFELAKAMSPCIIWIPnihELN 98

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21703962 808 SLAPSRGRSGDSGGVMDRVVSqLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLV 869
Cdd:cd19505  99 VNRSTQNLEEDPKLLLGLLLN-YLSRDFEKSSTRNILVIASTHIPQKVDPALIAPNRLDTCI 159
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 467-580 2.01e-07

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 52.30  E-value: 2.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVD-LLGRDRDGLGED 545
Cdd:cd19525  58 ILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDsLLSQRGEGEHES 137

                        90       100       110
                ....*....|....*....|....*....|....*
gi 21703962 546 ARVAATLRHLLLDEDALSRCPPLMVVATTSRVQDL 580
Cdd:cd19525 138 SRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEI 172
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 449-594 2.74e-07

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 51.42  E-value: 2.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 449 ILKPHLQPGGTLLTGTscVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLL 528
Cdd:cd19523  20 LLRPDAFSGLLRLPRS--ILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKILQASFLAARCRQPSVLF 97

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21703962 529 LTAVDLLGRDRDglGEDARVAATLRHLLLDEDALSRCPP--LMVVATTSRVQDLPTDVQTAFPHELEV 594
Cdd:cd19523  98 ISDLDALLSSQD--DEASPVGRLQVELLAQLDGVLGSGEdgVLVVCTTSKPEEIDESLRRYFSKRLLV 163
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 465-595 3.66e-07

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 50.61  E-value: 3.66e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 465 SCVLLQGPPGSGKTTAVTA---ACSRLGLHLLKVPCSSLCA---DSSRAVETKLQATFSRARRCRPAVLLLTAVDLLGRD 538
Cdd:cd00009  20 KNLLLYGPPGTGKTTLARAianELFRPGAPFLYLNASDLLEglvVAELFGHFLVRLLFELAEKAKPGVLFIDEIDSLSRG 99

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21703962 539 RDglgedarvAATLRHLLLDEDALSRCPPLMVVATTSR--VQDLPTDVQTAFPHELEVP 595
Cdd:cd00009 100 AQ--------NALLRVLETLNDLRIDRENVRVIGATNRplLGDLDRALYDRLDIRIVIP 150
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 745-854 1.07e-06

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 52.54  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   745 GPPGTGKTLLAKAVATE-CSLTFLS------VKGPELINMYVGQSEENVREVFARARAAapcIIFFDELDSLAPSRGRSG 817
Cdd:TIGR03922 319 GPPGTGKTTIARVVAKIyCGLGVLRkplvreVSRADLIGQYIGESEAKTNEIIDSALGG---VLFLDEAYTLVETGYGQK 395

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 21703962   818 DSGGVMdrVVSQLLAELDglHSTQDVFVIGATNRPDL 854
Cdd:TIGR03922 396 DPFGLE--AIDTLLARME--NDRDRLVVIGAGYRKDL 428
ftsH CHL00176
cell division protein; Validated
 467-640 1.10e-06

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 52.74  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  467 VLLQGPPGSGKTTAVTAACSRLGlhllkVPCSSLCADSSRAVETKLQAT-----FSRARRCRPAVLLLTAVDLLGRDRD- 540
Cdd:CHL00176 219 VLLVGPPGTGKTLLAKAIAGEAE-----VPFFSISGSEFVEMFVGVGAArvrdlFKKAKENSPCIVFIDEIDAVGRQRGa 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  541 --GLGEDARvAATLRHLLLDEDALSRCPPLMVVATTSRVqdlptDVQTA-------FPHELEVPVLSEAQRLSILQALTA 611
Cdd:CHL00176 294 giGGGNDER-EQTLNQLLTEMDGFKGNKGVIVIAATNRV-----DILDAallrpgrFDRQITVSLPDREGRLDILKVHAR 367

                        170       180
                 ....*....|....*....|....*....
gi 21703962  612 HLPLGQEVNLPQLARRCAGFVVGDLYALL 640
Cdd:CHL00176 368 NKKLSPDVSLELIARRTPGFSGADLANLL 396
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 467-576 1.15e-06

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 49.35  E-value: 1.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLG--RDRDGLGE 544
Cdd:cd19526  30 ILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFSRAQSAKPCILFFDEFDSIApkRGHDSTGV 109

                        90       100       110
                ....*....|....*....|....*....|..
gi 21703962 545 DARVaatLRHLLLDEDALSRCPPLMVVATTSR 576
Cdd:cd19526 110 TDRV---VNQLLTQLDGVEGLDGVYVLAATSR 138
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 467-576 1.98e-06

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 48.65  E-value: 1.98e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLGRDRDGLGEDA 546
Cdd:cd19529  30 ILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFRKARQVAPCVIFFDEIDSIAPRRGTTGDSG 109

                        90       100       110
                ....*....|....*....|....*....|
gi 21703962 547 RVAATLRHLLLDEDALSRCPPLMVVATTSR 576
Cdd:cd19529 110 VTERVVNQLLTELDGLEEMNGVVVIAATNR 139
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 744-869 1.28e-05

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 45.98  E-value: 1.28e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 744 HGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYvGQSEENVREVFARARAAAP-CIIFFDELDSLAPSRGRSGDSGGV 822
Cdd:cd19512  28 YGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMG-REGVTAIHKVFDWANTSRRgLLLFVDEADAFLRKRSTEKISEDL 106

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 21703962 823 mdRVVSQLLAELDGLHSTQDVFVIgATNRPDLLDPALlrPGRFDKLV 869
Cdd:cd19512 107 --RAALNAFLYRTGEQSNKFMLVL-ASNQPEQFDWAI--NDRIDEMV 148
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 467-580 1.38e-05

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 46.56  E-value: 1.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLC----ADSSRAVetklQATFSRARRCRPAVLLLTAVDLLG--RDRD 540
Cdd:cd19502  40 VLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVqkyiGEGARLV----RELFEMAREKAPSIIFIDEIDAIGakRFDS 115

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 21703962 541 GLGEDARVAATLRHLLLDEDALSRCPPLMVVATTSRVQDL 580
Cdd:cd19502 116 GTGGDREVQRTMLELLNQLDGFDPRGNIKVIMATNRPDIL 155
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 467-593 1.47e-05

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 46.52  E-value: 1.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLGRDRDGLGEDA 546
Cdd:cd19522  36 VLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHE 115

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 21703962 547 RVAATLRHLLLDEDALSRCPP-------LMVVATTsrvqDLPTDVQTAFPHELE 593
Cdd:cd19522 116 ASRRVKSELLVQMDGVGGASEnddpskmVMVLAAT----NFPWDIDEALRRRLE 165
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 467-576 3.13e-05

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 45.19  E-value: 3.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLGRDRDGLGEDA 546
Cdd:cd19528  30 VLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARAAAPCVLFFDELDSIAKARGGNIGDA 109

                        90       100       110
                ....*....|....*....|....*....|..
gi 21703962 547 RVAA--TLRHLLLDEDALSRCPPLMVVATTSR 576
Cdd:cd19528 110 GGAAdrVINQILTEMDGMNTKKNVFIIGATNR 141
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 467-606 1.68e-04

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 43.06  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   467 VLLQGPPGSGKTT-----AVTAACSRL---GLHLLKVPCSSL----------------CADSSRAVETKLQATFSRARRc 522
Cdd:pfam05729   3 VILQGEAGSGKTTllqklALLWAQGKLpqgFDFVFFLPCRELsrsgnarsladllfsqWPEPAAPVSEVWAVILELPER- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   523 rpAVLLLTAVDLLGRDRDGLGEDARVAATLRHLLldEDALSRCPPLMVVATTSRVQDLPTDVQTafPHELEVPVLSEAQR 602
Cdd:pfam05729  82 --LLLILDGLDELVSDLGQLDGPCPVLTLLSSLL--RKKLLPGASLLLTVRPDALRDLRRGLEE--PRYLEVRGFSESDR 155


                  ....
gi 21703962   603 LSIL 606
Cdd:pfam05729 156 KQYV 159
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 744-805 1.74e-04

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 45.05  E-value: 1.74e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21703962 744 HGPPGTGKTLLAKAVATECSLTF--LS-----VKgpelinmyvgqseeNVREVFARARAAA----PCIIFFDE 805
Cdd:COG2256  55 WGPPGTGKTTLARLIANATDAEFvaLSavtsgVK--------------DIREVIEEARERRaygrRTILFVDE 113
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 467-580 2.67e-04

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 42.53  E-value: 2.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVD-LLGRDRDGLGED 545
Cdd:cd19524  36 LLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDsLLSERSEGEHEA 115

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 21703962 546 ARVAATlrHLLLDEDALSRCPP--LMVVATTSRVQDL 580
Cdd:cd19524 116 SRRLKT--EFLIEFDGVQSNGDdrVLVMGATNRPQEL 150
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 449-576 2.74e-04

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 42.50  E-value: 2.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 449 ILKPHLQPGGtlLTGTSCVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLL 528
Cdd:cd19527  13 LEHPELFSSG--LRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKARDAKPCVIF 90

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 21703962 529 LTAVDLLGRDRDGLGEDARVAATLRHLLLDE-DALSRCPP-LMVVATTSR 576
Cdd:cd19527  91 FDELDSLAPSRGNSGDSGGVMDRVVSQLLAElDGMSSSGQdVFVIGATNR 140
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 467-577 2.91e-04

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 42.42  E-value: 2.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLGRDRDGL-GE- 544
Cdd:cd19519  37 ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDEIDAIAPKREKThGEv 116

                        90       100       110
                ....*....|....*....|....*....|...
gi 21703962 545 DARVAATLRHLLldeDALSRCPPLMVVATTSRV 577
Cdd:cd19519 117 ERRIVSQLLTLM---DGLKQRAHVIVMAATNRP 146
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 467-627 3.85e-04

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 43.98  E-value: 3.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLGRDR-DG-LGE 544
Cdd:PTZ00454 182 VLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRfDAqTGA 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962  545 DARVAATLRHLLLDEDALSRCPPLMVVATTSRVQDLptDVQTAFPHEL----EVPVLSEAQRLSILQALTAHLPLGQEVN 620
Cdd:PTZ00454 262 DREVQRILLELLNQMDGFDQTTNVKVIMATNRADTL--DPALLRPGRLdrkiEFPLPDRRQKRLIFQTITSKMNLSEEVD 339


                 ....*..
gi 21703962  621 LPQLARR 627
Cdd:PTZ00454 340 LEDFVSR 346
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 745-805 6.58e-04

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 43.15  E-value: 6.58e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21703962  745 GPPGTGKTLLAKAVATECSLTFLSVKGpelinmyVGQSEENVREVFARARAAA----PCIIFFDE 805
Cdd:PRK13342  43 GPPGTGKTTLARIIAGATDAPFEALSA-------VTSGVKDLREVIEEARQRRsagrRTILFIDE 100
ycf2 CHL00206
Ycf2; Provisional
 839-939 1.62e-03

Ycf2; Provisional


Pssm-ID: 214396 [Multi-domain]  Cd Length: 2281  Bit Score: 42.59  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   839 STQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGAS--EDRASQLRVLSAiTRKFKLEASVSLANVLDCCPPQLTGADLY 916
Cdd:CHL00206 1769 STRNILVIASTHIPQKVDPALIAPNKLNTCIKIRRLliPQQRKHFFTLSY-TRGFHLEKKMFHTNGFGSITMGSNARDLV 1847

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 21703962   917 SL----------------CSDAMMTALKRRVRDLEEGLE 939
Cdd:CHL00206 1848 ALtnealsisitqkksiiDTNTIRSALHRQTWDLRSQVR 1886
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 467-581 1.80e-03

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 40.04  E-value: 1.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 467 VLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVD--LLGRDRDGLGE 544
Cdd:cd19507  34 LLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRLRQMIQTAEAIAPCVLWIDEIEkgFSNADSKGDSG 113

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 21703962 545 DA-RVAATLRHLLLDEDAlsrcpPLMVVATTSRVQDLP 581
Cdd:cd19507 114 TSsRVLGTFLTWLQEKKK-----PVFVVATANNVQSLP 146
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 459-580 2.36e-03

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 40.51  E-value: 2.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 459 TLLTGTSCVLLQGPPGSGKTTAVTAACSRLGL---------HLLKVPCSSLCA----DSSRAVeTKLQATFSRARRCRPA 525
Cdd:cd19508  47 NLITWNRLVLLHGPPGTGKTSLCKALAQKLSIrlssryrygQLIEINSHSLFSkwfsESGKLV-TKMFQKIQELIDDKDA 125

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21703962 526 V--LLLTAVDLLGRDRDGLG-----EDA-RVAATlrhLLLDEDALSRCPPLMVVATTSRVQDL 580
Cdd:cd19508 126 LvfVLIDEVESLAAARSASSsgtepSDAiRVVNA---VLTQIDRIKRYHNNVILLTSNLLEKI 185
DEXXQc_Upf1-like cd17934
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ...
 467-509 2.77e-03

DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438708 [Multi-domain]  Cd Length: 121  Bit Score: 38.76  E-value: 2.77e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 21703962 467 VLLQGPPGSGKTTAVTAACsrlgLHLLKVPCSS---LCADSSRAVE 509
Cdd:cd17934   2 SLIQGPPGTGKTTTIAAIV----LQLLKGLRGKrvlVTAQSNVAVD 43
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 466-580 3.70e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 38.89  E-value: 3.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962    466 CVLLQGPPGSGKTTAVTAACSRLGLHLLKVpcSSLCADSSRAV-------------------ETKLQATFSRARRCRPAV 526
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPGGGV--IYIDGEDILEEvldqllliivggkkasgsgELRLRLALALARKLKPDV 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 21703962    527 LLLTAVDLLGRDRDGLGEDARVAATLRHLLLDEDalsrcpPLMVVATTSRVQDL 580
Cdd:smart00382  82 LILDEITSLLDAEQEALLLLLEELRLLLLLKSEK------NLTVILTTNDEKDL 129
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 745-865 5.97e-03

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 38.04  E-value: 5.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962   745 GPPGTGKTLLAKAVAtecslTFLSVKGPELINMYVGQSEENV---REVFARA---------RAAA-PCIIFFDELDSLAP 811
Cdd:pfam07728   6 GPPGTGKTELAERLA-----AALSNRPVFYVQLTRDTTEEDLfgrRNIDPGGaswvdgplvRAAReGEIAVLDEINRANP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21703962   812 SrgrsgdsggVMDRVVSQL------LAELDGL--HSTQDVFVIGATNRPDL----LDPALLRpgRF 865
Cdd:pfam07728  81 D---------VLNSLLSLLderrllLPDGGELvkAAPDGFRLIATMNPLDRglneLSPALRS--RF 135
AAA_11 pfam13086
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 468-508 6.66e-03

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.


Pssm-ID: 404072 [Multi-domain]  Cd Length: 248  Bit Score: 39.25  E-value: 6.66e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 21703962   468 LLQGPPGSGKTTAVTAACSRLGLHLLKVPCSS----LCADSSRAV 508
Cdd:pfam13086  17 LIQGPPGTGKTTTIVELIRQLLSYPATSAAAGprilVCAPSNAAV 61
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 452-547 8.20e-03

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 38.30  E-value: 8.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703962 452 PHLQPGGTllTGTSCVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTA 531
Cdd:cd19521  30 PHLFTGNR--KPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESEKLVKQLFAMARENKPSIIFIDE 107

                        90
                ....*....|....*..
gi 21703962 532 VD-LLGRDRDGLGEDAR 547
Cdd:cd19521 108 VDsLCGTRGEGESEASR 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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