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Conserved domains on  [gi|17506815|ref|NP_492766|]
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Large ribosomal subunit protein uL10 [Caenorhabditis elegans]

Protein Classification

uL10 family ribosomal protein( domain architecture ID 11488073)

uL10 family ribosomal protein is an essential element of the ribosomal GTPase-associated center responsible for the interplay with translational factors during various stages of protein synthesis.

Gene Ontology:  GO:0003735|GO:0000027
PubMed:  24524803

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00135 PTZ00135
60S acidic ribosomal protein P0; Provisional
 1-312 1.39e-140

60S acidic ribosomal protein P0; Provisional


:

Pssm-ID: 240285 [Multi-domain]  Cd Length: 310  Bit Score: 399.39  E-value: 1.39e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815    1 MVREDRSTWKANYFTKLVELFEEYPKCLLVGVDNVGSKQMQEIRQAMRGHAEILMGKNTMIRKALRGHLGKNPSLEKLLP 80
Cdd:PTZ00135   1 MAKPEKKAKKKAYFEKLYELLEKYKKILIVSVDNVGSKQMQDIRRSLRGKAELLMGKNTLIRKALKQRLEELPELEKLLP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815   81 HIVENVGFVFTKEDLGEIRSKLLENRKGAPAKAGAIAPCDVKLPPQNTGMGPEKTSFFQALQIPTKIARGTIEILNDVHL 160
Cdd:PTZ00135  81 HVKGNVGFVFTKDDLFEVKPVILENKVPAPARAGVIAPIDVVIPAGPTGMDPSQTSFFQALGIATKIVKGQIEITNEVHL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815  161 IKEGDKVGASESALLNMLGVTPFSYGLVVRQVYDDGTLYTPEVLDMTTEELRKRFLSGVRNVASVSLAVNYPTLASVAHS 240
Cdd:PTZ00135 161 IKEGQKVGASQAVLLQKLNIKPFSYGLEVLSIYDNGSIYDAKVLDITDEDIVAKFQEGVQNVAAISLAAGYPTEASAPHS 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17506815  241 LANGLQNMLGVAAVTDVSFKEAETIKAFIADPSKFaaAAPAAAAAPAAAAPAAKKEEPKEESDDDMGFGLFD 312
Cdd:PTZ00135 241 ILNAFKNLAAIGLESGFTFPLAEKIKEALANPSAA--AAAAAAAAAAAAAAAAAPAEEEEEEEDDMGFGLFD 310
 
Name Accession Description Interval E-value
PTZ00135 PTZ00135
60S acidic ribosomal protein P0; Provisional
 1-312 1.39e-140

60S acidic ribosomal protein P0; Provisional


Pssm-ID: 240285 [Multi-domain]  Cd Length: 310  Bit Score: 399.39  E-value: 1.39e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815    1 MVREDRSTWKANYFTKLVELFEEYPKCLLVGVDNVGSKQMQEIRQAMRGHAEILMGKNTMIRKALRGHLGKNPSLEKLLP 80
Cdd:PTZ00135   1 MAKPEKKAKKKAYFEKLYELLEKYKKILIVSVDNVGSKQMQDIRRSLRGKAELLMGKNTLIRKALKQRLEELPELEKLLP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815   81 HIVENVGFVFTKEDLGEIRSKLLENRKGAPAKAGAIAPCDVKLPPQNTGMGPEKTSFFQALQIPTKIARGTIEILNDVHL 160
Cdd:PTZ00135  81 HVKGNVGFVFTKDDLFEVKPVILENKVPAPARAGVIAPIDVVIPAGPTGMDPSQTSFFQALGIATKIVKGQIEITNEVHL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815  161 IKEGDKVGASESALLNMLGVTPFSYGLVVRQVYDDGTLYTPEVLDMTTEELRKRFLSGVRNVASVSLAVNYPTLASVAHS 240
Cdd:PTZ00135 161 IKEGQKVGASQAVLLQKLNIKPFSYGLEVLSIYDNGSIYDAKVLDITDEDIVAKFQEGVQNVAAISLAAGYPTEASAPHS 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17506815  241 LANGLQNMLGVAAVTDVSFKEAETIKAFIADPSKFaaAAPAAAAAPAAAAPAAKKEEPKEESDDDMGFGLFD 312
Cdd:PTZ00135 241 ILNAFKNLAAIGLESGFTFPLAEKIKEALANPSAA--AAAAAAAAAAAAAAAAAPAEEEEEEEDDMGFGLFD 310
Ribosomal_P0_L10e cd05795
Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal ...
 9-182 5.48e-103

Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal protein P0 and the archaeal P0 homolog, L10e. P0 or L10e forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. The stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These eukaryotic and archaeal P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 240221 [Multi-domain]  Cd Length: 175  Bit Score: 298.72  E-value: 5.48e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815   9 WKANYFTKLVELFEEYPKCLLVGVDNVGSKQMQEIRQAMRGHAEILMGKNTMIRKALRGHLGKNPSLEKLLPHIVENVGF 88
Cdd:cd05795   2 WKKEYVEKLTELLKSYPKVLIVDADNVGSKQLQKIRRSLRGKAEILMGKNTLIRRALRNLGDENPELEKLLPYLKGNVGF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815  89 VFTKEDLGEIRSKLLENRKGAPAKAGAIAPCDVKLPPQNTGMGPEKTSFFQALQIPTKIARGTIEILNDVHLIKEGDKVG 168
Cdd:cd05795  82 IFTNGDPFEIRKILEENKVPAPAKPGAIAPCDVVVPAGPTGMPPGPTSFFQALGIPTKIEKGKIEIISDVVVVKKGEKVG 161

                       170
                ....*....|....
gi 17506815 169 ASESALLNMLGVTP 182
Cdd:cd05795 162 ASEATLLNKLNIKP 175
RL10P_insert pfam17777
Insertion domain in 60S ribosomal protein L10P; This domain is found in prokaryotic and ...
 111-180 7.73e-26

Insertion domain in 60S ribosomal protein L10P; This domain is found in prokaryotic and archaeal ribosomal L10 protein.


Pssm-ID: 465500 [Multi-domain]  Cd Length: 71  Bit Score: 97.66  E-value: 7.73e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17506815   111 AKAGAIAPCDVKLPPQNTGMGPEKT-SFFQALQIPTKIARGTIEILNDVHLIKEGDKVGASESALLNMLGV 180
Cdd:pfam17777   1 ARAGAIATEDVVLPAGPTGLAPGPIePQLRALGIPTKIKKGKIEITKDYTVCKEGEKLTPEQANLLKLLGI 71
RplJ COG0244
Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 ...
 1-113 8.77e-05

Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440014  Cd Length: 172  Bit Score: 42.36  E-value: 8.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815   1 MVREDrstwKANYFTKLVELFEEYPkcLLVGVDNVG--SKQMQEIRQAMRGH-AEILMGKNTMIRKALRGHlgknpSLEK 77
Cdd:COG0244   1 MTREE----KKAVVAELKEKLKEAQ--AVVLTDYRGltVAQMTELRRKLREAgVEYKVVKNTLARIALEGT-----GFEG 69

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 17506815  78 LLPHIVENVGFVFTKEDLgeirskllenrkGAPAKA 113
Cdd:COG0244  70 LDDLLKGPTAIAFSYEDP------------VAAAKV 93
 
Name Accession Description Interval E-value
PTZ00135 PTZ00135
60S acidic ribosomal protein P0; Provisional
 1-312 1.39e-140

60S acidic ribosomal protein P0; Provisional


Pssm-ID: 240285 [Multi-domain]  Cd Length: 310  Bit Score: 399.39  E-value: 1.39e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815    1 MVREDRSTWKANYFTKLVELFEEYPKCLLVGVDNVGSKQMQEIRQAMRGHAEILMGKNTMIRKALRGHLGKNPSLEKLLP 80
Cdd:PTZ00135   1 MAKPEKKAKKKAYFEKLYELLEKYKKILIVSVDNVGSKQMQDIRRSLRGKAELLMGKNTLIRKALKQRLEELPELEKLLP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815   81 HIVENVGFVFTKEDLGEIRSKLLENRKGAPAKAGAIAPCDVKLPPQNTGMGPEKTSFFQALQIPTKIARGTIEILNDVHL 160
Cdd:PTZ00135  81 HVKGNVGFVFTKDDLFEVKPVILENKVPAPARAGVIAPIDVVIPAGPTGMDPSQTSFFQALGIATKIVKGQIEITNEVHL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815  161 IKEGDKVGASESALLNMLGVTPFSYGLVVRQVYDDGTLYTPEVLDMTTEELRKRFLSGVRNVASVSLAVNYPTLASVAHS 240
Cdd:PTZ00135 161 IKEGQKVGASQAVLLQKLNIKPFSYGLEVLSIYDNGSIYDAKVLDITDEDIVAKFQEGVQNVAAISLAAGYPTEASAPHS 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17506815  241 LANGLQNMLGVAAVTDVSFKEAETIKAFIADPSKFaaAAPAAAAAPAAAAPAAKKEEPKEESDDDMGFGLFD 312
Cdd:PTZ00135 241 ILNAFKNLAAIGLESGFTFPLAEKIKEALANPSAA--AAAAAAAAAAAAAAAAAPAEEEEEEEDDMGFGLFD 310
Ribosomal_P0_L10e cd05795
Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal ...
 9-182 5.48e-103

Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal protein P0 and the archaeal P0 homolog, L10e. P0 or L10e forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. The stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These eukaryotic and archaeal P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 240221 [Multi-domain]  Cd Length: 175  Bit Score: 298.72  E-value: 5.48e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815   9 WKANYFTKLVELFEEYPKCLLVGVDNVGSKQMQEIRQAMRGHAEILMGKNTMIRKALRGHLGKNPSLEKLLPHIVENVGF 88
Cdd:cd05795   2 WKKEYVEKLTELLKSYPKVLIVDADNVGSKQLQKIRRSLRGKAEILMGKNTLIRRALRNLGDENPELEKLLPYLKGNVGF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815  89 VFTKEDLGEIRSKLLENRKGAPAKAGAIAPCDVKLPPQNTGMGPEKTSFFQALQIPTKIARGTIEILNDVHLIKEGDKVG 168
Cdd:cd05795  82 IFTNGDPFEIRKILEENKVPAPAKPGAIAPCDVVVPAGPTGMPPGPTSFFQALGIPTKIEKGKIEIISDVVVVKKGEKVG 161

                       170
                ....*....|....
gi 17506815 169 ASESALLNMLGVTP 182
Cdd:cd05795 162 ASEATLLNKLNIKP 175
PTZ00240 PTZ00240
60S ribosomal protein P0; Provisional
 7-261 7.33e-68

60S ribosomal protein P0; Provisional


Pssm-ID: 140267 [Multi-domain]  Cd Length: 323  Bit Score: 214.83  E-value: 7.33e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815    7 STWKANYFTKLVELFEEYPKCLLVGVDNVGSKQMQEIRQAMRGHAEILMGKNTMIRKALRGHL-GKNPSLE-KLLPHIVE 84
Cdd:PTZ00240   5 TTAKREYEERLVDCLTKYSCVLFVGMDNVRSQQVHDVRRALRGKAEFVMGKKTLQAKIVEKRAqAKKASAEaKLFNDQCE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815   85 -------NVGFVFTKEDLGEIRSKLLENRKGAPAKAGAIAPCDVKLPPQNTGMGPEKTSFFQALQIPTKIARGTIEILND 157
Cdd:PTZ00240  85 eknllsgNTGLIFTNNEVQEITSVLDSHRVKAPARVGAIAPCDVIVPAGSTGMEPTQTSFFQALNIATKIAKGMVEIVTE 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815  158 VHLIKEGDKVGASESALLNMLGVTPFSYGLVVRQVYDDGTLYTPEVLDMTTEELRKRFLSGVRNVASVSLAVNYPTLASV 237
Cdd:PTZ00240 165 KKVLSVGDKVDNSTATLLQKLNISPFYYQVEVLSVWDRGVLFTREDLSMTEDVVEKMLMEGLSNVAAMSLGAGIPTAATI 244

                        250       260
                 ....*....|....*....|....
gi 17506815  238 AHSLANGLQNMLGVAAVTDVSFKE 261
Cdd:PTZ00240 245 GPMLVDAFKNLLAVSVATSYEFEE 268
rplP0 PRK04019
acidic ribosomal protein P0; Validated
 9-270 7.44e-54

acidic ribosomal protein P0; Validated


Pssm-ID: 179712 [Multi-domain]  Cd Length: 330  Bit Score: 178.52  E-value: 7.44e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815    9 WKANYFTKLVELFEEYPKCLLVGVDNVGSKQMQEIRQAMRGHAEILMGKNTMIRKALRgHLGKnPSLEKLLPHIVENVGF 88
Cdd:PRK04019   7 WKKEEVEELKELIKSYPVVGIVDLEGIPARQLQEIRRKLRGKAELKVSKNTLIKRALE-EAGE-EDLEKLEDYLEGQVAL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815   89 VFTKEDLGEIrSKLLENRK-GAPAKAGAIAPCDVKLPPQNTGM--GPeKTSFFQALQIPTKIARGTIEILNDVHLIKEGD 165
Cdd:PRK04019  85 IFTNMNPFKL-YKLLEKSKtPAPAKPGDIAPEDIVVPAGPTGFppGP-ILSELQKLGIPARIQKGKIVIKKDTVVAKAGE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815  166 KVGASESALLNMLGVTPFSYGLVVRQVYDDGTLYTPEVLDMTTEELRKRFLSGVRNvaSVSLAVN--YPTLASVAHSLAN 243
Cdd:PRK04019 163 VISPELANVLQKLGIKPIEVGLDLKAAYEDGVIYTPEVLAIDEEKYRSDIQEAAQN--AFNLAVNaaYPTPETLETLIQK 240

                        250       260
                 ....*....|....*....|....*..
gi 17506815  244 GLQNMLGVAAvtDVSFKEAETIKAFIA 270
Cdd:PRK04019 241 AFREAKALAV--EAGIVTPETADDILS 265
Ribosomal_L10_P0 cd00379
Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in ...
 9-163 7.16e-32

Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in bacteria, P0 in eukaryotes, and L10e in archaea, as well as uncharacterized P0-like eukaryotic proteins. In all three kingdoms, L10 forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). Some eukaryotic P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 238222 [Multi-domain]  Cd Length: 155  Bit Score: 116.13  E-value: 7.16e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815   9 WKANYFTKLVELFEEYPKCLLVGVDNVGSKQMQEIRQAMRGH-AEILMGKNTMIRKALRGHlgknpSLEKLLPHIVENVG 87
Cdd:cd00379   2 KKEELVEELKELLKKYKSVVVVDYRGLTVAQLTELRKELRESgAKLKVGKNTLMRRALKGT-----GFEELKPLLKGPTA 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17506815  88 FVFTKEDLGEIRSKLLENRKG---APAKAGAIApCDVKLPPQNTGMGPEKTsffQALQIPTKIARGTIEILNDVHLIKE 163
Cdd:cd00379  77 LAFTNEDPVEVAKVLKDFAKEnkkLFAKGGVVA-GKVLDPAGVTALAKLPS---REELLAMLIGLLKAPIAKLARLLNA 151
RL10P_insert pfam17777
Insertion domain in 60S ribosomal protein L10P; This domain is found in prokaryotic and ...
 111-180 7.73e-26

Insertion domain in 60S ribosomal protein L10P; This domain is found in prokaryotic and archaeal ribosomal L10 protein.


Pssm-ID: 465500 [Multi-domain]  Cd Length: 71  Bit Score: 97.66  E-value: 7.73e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17506815   111 AKAGAIAPCDVKLPPQNTGMGPEKT-SFFQALQIPTKIARGTIEILNDVHLIKEGDKVGASESALLNMLGV 180
Cdd:pfam17777   1 ARAGAIATEDVVLPAGPTGLAPGPIePQLRALGIPTKIKKGKIEITKDYTVCKEGEKLTPEQANLLKLLGI 71
Ribosomal_L10 pfam00466
Ribosomal protein L10;
9-107 1.48e-22

Ribosomal protein L10;


Pssm-ID: 459822 [Multi-domain]  Cd Length: 99  Bit Score: 89.91  E-value: 1.48e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815     9 WKANYFTKLVELFEEYPKCLLVGVDNVGSKQMQEIRQAMRGH-AEILMGKNTMIRKALRGHlgknpSLEKLLPHIVENVG 87
Cdd:pfam00466   5 KKEELVEELKELLKEYKSVVVVDYRGLTVAQLTELRKKLRENgAELKVGKNTLMRRALEET-----GEEKLEDYLKGPTA 79

                          90       100
                  ....*....|....*....|
gi 17506815    88 FVFTKEDLGEIRSKLLENRK 107
Cdd:pfam00466  80 LLFTNEDPVAVAKVLEDFAK 99
Ribosomal_P0_like cd05796
Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized ...
 9-167 4.10e-20

Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be involved in mRNA decay. P0 forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. It occupies the L7/L12 stalk of the ribosome. The stalk is known to contain the binding site for elongation factors EF-G and EF-Tu; however, there is disagreement as to whether or not P0 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, P0 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). Some eukaryotic P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 240222 [Multi-domain]  Cd Length: 163  Bit Score: 85.32  E-value: 4.10e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815   9 WKANYFTKLVELFEEYPKCLLVGVDNVGSKQMQEIRQAMRgHAEILMGKNTMIRKALrghlGKNPS------LEKLLPHI 82
Cdd:cd05796   2 LKQKLVENIREAVDKYKYIYVFSVDNMRNNKLKDIRQEWK-DSRFFFGKNKVMQVAL----GRTPEdeykpnLHKLSKYL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815  83 VENVGFVFTKEDLGEIRSKLLENRKGAPAKAGAIAPCDVKLP----PQNTG-MGPEktsfFQALQIPTKIARGTIEILND 157
Cdd:cd05796  77 KGQVGLLFTNEPPEEVIEYFDSYSEPDFARAGSIATETVTLPegplEQFPHsMEPQ----LRKLGLPTKLKKGVITLEAD 152

                       170
                ....*....|
gi 17506815 158 VHLIKEGDKV 167
Cdd:cd05796 153 YVVCEEGKVL 162
Ribosomal_L10 cd05797
Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and ...
 10-116 6.44e-06

Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These bacteria and eukaryotic sequences have no additional C-terminal domain, present in other eukaryotic and archaeal orthologs.


Pssm-ID: 240223  Cd Length: 157  Bit Score: 45.57  E-value: 6.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815  10 KANYFTKLVELFEEYPkcLLVGVDNVG--SKQMQEIRQAMRGH-AEILMGKNTMIRKALrghlgKNPSLEKLLPHIVENV 86
Cdd:cd05797   5 KEEIVAELKEKLKEAK--SVVVADYRGltVAQLTELRKELREAgVKLKVVKNTLAKRAL-----EGTGFEDLDDLLKGPT 77

                        90       100       110
                ....*....|....*....|....*....|...
gi 17506815  87 GFVFTKEDLGEIRSKLLENRKGAPA---KAGAI 116
Cdd:cd05797  78 AIAFSEEDPVAAAKVLKDFAKENKKleiKGGVV 110
RplJ COG0244
Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 ...
 1-113 8.77e-05

Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440014  Cd Length: 172  Bit Score: 42.36  E-value: 8.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815   1 MVREDrstwKANYFTKLVELFEEYPkcLLVGVDNVG--SKQMQEIRQAMRGH-AEILMGKNTMIRKALRGHlgknpSLEK 77
Cdd:COG0244   1 MTREE----KKAVVAELKEKLKEAQ--AVVLTDYRGltVAQMTELRRKLREAgVEYKVVKNTLARIALEGT-----GFEG 69

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 17506815  78 LLPHIVENVGFVFTKEDLgeirskllenrkGAPAKA 113
Cdd:COG0244  70 LDDLLKGPTAIAFSYEDP------------VAAAKV 93
Ribosomal_60s pfam00428
60s Acidic ribosomal protein; This family includes archaebacterial L12, eukaryotic P0, P1 and ...
 231-311 1.20e-04

60s Acidic ribosomal protein; This family includes archaebacterial L12, eukaryotic P0, P1 and P2.


Pssm-ID: 459808  Cd Length: 87  Bit Score: 40.32  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815   231 YPTLASVAHSLANGLQNMLGVAAVTDVSFKEAETIKAFIADPSKFAAAAP------AAAAAPAAAAPAAKKEEPKEESDD 304
Cdd:pfam00428   1 EPTAANIKKVLKAAGVNVEAVRVKLFAKALEGKNIKELLANGGAKAAAAAaaaaaaAAAAAAAAAAEEKKKEEEEEESDD 80


                  ....*..
gi 17506815   305 DMGFGLF 311
Cdd:pfam00428  81 DMGFGLF 87
rplJ PRK00099
50S ribosomal protein L10; Reviewed
 1-116 5.52e-03

50S ribosomal protein L10; Reviewed


Pssm-ID: 234632  Cd Length: 172  Bit Score: 37.04  E-value: 5.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506815    1 MVREDrstwKANYFTKLVELFEEYPKCLLVGVDNVGSKQMQEIRQAMRGH-AEILMGKNTMIRKALrghlgKNPSLEKLL 79
Cdd:PRK00099   1 MNREE----KKEIVAELAEKLKKAQSAVVADYRGLTVAQMTELRKKLREAgVEYKVVKNTLARRAL-----EGTGFEGLD 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 17506815   80 PHIVENVGFVFTKEDLGEIrSKLLEN-RKGAPA---KAGAI 116
Cdd:PRK00099  72 DLLKGPTAIAFSYEDPVAA-AKVLKDfAKDNKKleiKGGAI 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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