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Conserved domains on  [gi|18250284|ref|NP_083849|]
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isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor [Mus musculus]

Protein Classification

NAD-dependent isocitrate dehydrogenase( domain architecture ID 10015520)

NAD-dependent isocitrate dehydrogenase converts isocitrate to 2-oxoglutarate in an NAD-dependent manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 29-362 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


:

Pssm-ID: 272942  Cd Length: 333  Bit Score: 587.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284    29 GGVQTVTLIPGDGIGPEISASVMKIFDAAKAPIQWEERNVTAiQGPGgKWMIPPEAKESMDKNKMGLKGPLKTPIAAG-H 107
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSP-QTDG-KTEIPDEAVESIKRNKVALKGPLETPIGKGgH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   108 PSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEEASKRIAEFAFEYA 187
Cdd:TIGR00175  79 RSLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   188 RNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLI 267
Cdd:TIGR00175 159 RKNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   268 GGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDGKSLTKDLGG 347
Cdd:TIGR00175 239 GGPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGG 318

                         330
                  ....*....|....*
gi 18250284   348 NAKCSDFTEEICRRV 362
Cdd:TIGR00175 319 TATTSDFTEAVIKRL 333
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 29-362 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 587.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284    29 GGVQTVTLIPGDGIGPEISASVMKIFDAAKAPIQWEERNVTAiQGPGgKWMIPPEAKESMDKNKMGLKGPLKTPIAAG-H 107
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSP-QTDG-KTEIPDEAVESIKRNKVALKGPLETPIGKGgH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   108 PSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEEASKRIAEFAFEYA 187
Cdd:TIGR00175  79 RSLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   188 RNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLI 267
Cdd:TIGR00175 159 RKNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   268 GGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDGKSLTKDLGG 347
Cdd:TIGR00175 239 GGPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGG 318

                         330
                  ....*....|....*
gi 18250284   348 NAKCSDFTEEICRRV 362
Cdd:TIGR00175 319 TATTSDFTEAVIKRL 333
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 1-359 7.44e-172

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 483.23  E-value: 7.44e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284    1 MAGSAWVSKVSRLLGAFHNTKQVTRGF--AGGVQTVTLIPGDGIGPEISASVMKIFDAAKAPIQWEERNVTAIQGPGGKW 78
Cdd:PLN00118   9 LLGNRLAQILGASSSSSGAFSSSARAFssSSTPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGTTVDPRTGS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   79 MIPPEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEH 158
Cdd:PLN00118  89 FLTWESLESVRRNKVGLKGPMATPIGKGHRSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEH 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  159 VIVDGVVQSIKLITEEASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLN 238
Cdd:PLN00118 169 QVVRGVVESLKIITRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMM 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  239 MVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHM 318
Cdd:PLN00118 249 LVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHL 328

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 18250284  319 GLFDHAAKIEAACFATIKDGKSLTKDLGGNAKCSDFTEEIC 359
Cdd:PLN00118 329 KLNEQAEQIHNAILNTIAEGKYRTADLGGSSTTTDFTKAIC 369
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
33-358 2.31e-157

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 445.59  E-value: 2.31e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284    33 TVTLIPGDGIGPEISASVMKIFDAA--KAP--IQWEERNVTAIQGPGGKWMIPPEAKESMDKNKMGLKGPLKTPIA--AG 106
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAAleKAPleFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWdpAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   107 HPSMNLL--LRKTFDLYANVRPCVSI--EGYKTPY----TDVNIVTIRENTEGEYSGIEHVIVDG---VVQSIKLITEEA 175
Cdd:pfam00180  81 VRPENGLlaLRKELGLFANLRPAKVFppLGDASPLknevEGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   176 SKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLY 255
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   256 GDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRH-MGLFDHAAKIEAACFAT 334
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKV 320

                         330       340
                  ....*....|....*....|....*..
gi 18250284   335 IKDGKsLTKDLGGNA---KCSDFTEEI 358
Cdd:pfam00180 321 LESGI-RTGDLAGSAtyvSTSEFGEAV 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 33-362 1.77e-152

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 432.90  E-value: 1.77e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  33 TVTLIPGDGIGPEISASVMKIFDAAKA----PIQWEERNVtaiqgpGGKW------MIPPEAKESMDKNKMGLKGPLKTP 102
Cdd:COG0473   3 KIAVLPGDGIGPEVVAAALKVLEAAAErfglDFEFEEADI------GGAAydktgtPLPDETLEALRKADAILLGAVGGP 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284 103 IAAGHP---SMNLLLRKTFDLYANVRPCVSIEGYKTPY-----TDVNIVTIRENTEGEYSGIEHVIVDG----VVQSIKL 170
Cdd:COG0473  77 KWDDGVrpeSGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRV 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284 171 ITEEASKRIAEFAFEYARNnHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLV 250
Cdd:COG0473 157 YTRKGIERIARYAFELARK-RRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIV 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284 251 MPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAA 330
Cdd:COG0473 236 TENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAA 315

                       330       340       350
                ....*....|....*....|....*....|..
gi 18250284 331 CFATIKDGKsLTKDLGGNAKCSDFTEEICRRV 362
Cdd:COG0473 316 VEKVLAEGV-RTPDLGGKAGTSEMGDAIIAAL 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
33-365 2.20e-106

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 315.52  E-value: 2.20e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   33 TVTLIPGDGIGPEISASVMKIFDAAkapiqweERNVTAIQGPGGK-------WMIPPEAKESMDKNKMGLKGPLKTpiAA 105
Cdd:NF040626   3 KITVIPGDGIGKEVMEAALYVLDAL-------DLNFDFIEAEAGRecfkkngTTIPEETIKIAKKSDATLFGAVTS--TP 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  106 GHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEEASKRIAEFAFE 185
Cdd:NF040626  74 GQKSPIITLRKELDLYANLRPIKSYEGINCLFKDLDFLIVRENTEGLYSGLEEEYTEEKAIAERVITRKASERICKFAFE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  186 YARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAG 265
Cdd:NF040626 154 YAIKLGRKKVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNLFGDILSDEAAG 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  266 LIGGLGVTPSGNIGANGvAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDGKSLTKDL 345
Cdd:NF040626 234 LVGGLGLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALEKVLREGKVVTPDL 312

                        330       340
                 ....*....|....*....|
gi 18250284  346 GGNAKCSDFTEEICRRVKDL 365
Cdd:NF040626 313 GGNAKTMEMANEIKKKIEEL 332
AksF_Meth NF040619
homoisocitrate dehydrogenase;
34-358 8.08e-82

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 252.76  E-value: 8.08e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   34 VTLIPGDGIGPEISASVMKIFDaakapiqwEERNVTAIQGPGG-------KWMIPPEAKESMDKNKMGLKGPLKTPIAAG 106
Cdd:NF040619   4 ICVIEGDGIGKEVIPETVRVLK--------ELGDFEFIKGEAGlecfkkyGDAIPEETIEKAKECDAILFGAVTTPKPTE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  107 HPSMN-----LLLRKTFDLYANVRPcVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDG-VVQSIKLITEEASKRIA 180
Cdd:NF040619  76 LKNKNykspiLTLRKELDLYANVRP-INNFGDGQDVKNIDFVIIRENTEGLYVGREYYDEENeIAIAERIISKKGSERII 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  181 EFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKD--IKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDI 258
Cdd:NF040619 155 KFAFEYAKKNNRKKVSCIHKANVLRVTDGLFLEIFNEIKKKYKNfnIEADDYLVDATAMYLIKNPEMFDVIVTTNLFGDI 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  259 LSDLCAGLIGGLGVTPSGNIGANgVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDG 338
Cdd:NF040619 235 LSDEASGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDLIREAVKKCLENG 313

                        330       340
                 ....*....|....*....|
gi 18250284  339 KsLTKDLGGNAKCSDFTEEI 358
Cdd:NF040619 314 K-VTPDLGGNLKTKEVTDKI 332
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 29-362 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 587.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284    29 GGVQTVTLIPGDGIGPEISASVMKIFDAAKAPIQWEERNVTAiQGPGgKWMIPPEAKESMDKNKMGLKGPLKTPIAAG-H 107
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSP-QTDG-KTEIPDEAVESIKRNKVALKGPLETPIGKGgH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   108 PSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEEASKRIAEFAFEYA 187
Cdd:TIGR00175  79 RSLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   188 RNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLI 267
Cdd:TIGR00175 159 RKNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   268 GGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDGKSLTKDLGG 347
Cdd:TIGR00175 239 GGPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGG 318

                         330
                  ....*....|....*
gi 18250284   348 NAKCSDFTEEICRRV 362
Cdd:TIGR00175 319 TATTSDFTEAVIKRL 333
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 1-359 7.44e-172

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 483.23  E-value: 7.44e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284    1 MAGSAWVSKVSRLLGAFHNTKQVTRGF--AGGVQTVTLIPGDGIGPEISASVMKIFDAAKAPIQWEERNVTAIQGPGGKW 78
Cdd:PLN00118   9 LLGNRLAQILGASSSSSGAFSSSARAFssSSTPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGTTVDPRTGS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   79 MIPPEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEH 158
Cdd:PLN00118  89 FLTWESLESVRRNKVGLKGPMATPIGKGHRSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEH 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  159 VIVDGVVQSIKLITEEASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLN 238
Cdd:PLN00118 169 QVVRGVVESLKIITRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMM 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  239 MVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHM 318
Cdd:PLN00118 249 LVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHL 328

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 18250284  319 GLFDHAAKIEAACFATIKDGKSLTKDLGGNAKCSDFTEEIC 359
Cdd:PLN00118 329 KLNEQAEQIHNAILNTIAEGKYRTADLGGSSTTTDFTKAIC 369
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
33-358 2.31e-157

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 445.59  E-value: 2.31e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284    33 TVTLIPGDGIGPEISASVMKIFDAA--KAP--IQWEERNVTAIQGPGGKWMIPPEAKESMDKNKMGLKGPLKTPIA--AG 106
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAAleKAPleFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWdpAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   107 HPSMNLL--LRKTFDLYANVRPCVSI--EGYKTPY----TDVNIVTIRENTEGEYSGIEHVIVDG---VVQSIKLITEEA 175
Cdd:pfam00180  81 VRPENGLlaLRKELGLFANLRPAKVFppLGDASPLknevEGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   176 SKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLY 255
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   256 GDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRH-MGLFDHAAKIEAACFAT 334
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKV 320

                         330       340
                  ....*....|....*....|....*..
gi 18250284   335 IKDGKsLTKDLGGNA---KCSDFTEEI 358
Cdd:pfam00180 321 LESGI-RTGDLAGSAtyvSTSEFGEAV 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 33-362 1.77e-152

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 432.90  E-value: 1.77e-152
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  33 TVTLIPGDGIGPEISASVMKIFDAAKA----PIQWEERNVtaiqgpGGKW------MIPPEAKESMDKNKMGLKGPLKTP 102
Cdd:COG0473   3 KIAVLPGDGIGPEVVAAALKVLEAAAErfglDFEFEEADI------GGAAydktgtPLPDETLEALRKADAILLGAVGGP 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284 103 IAAGHP---SMNLLLRKTFDLYANVRPCVSIEGYKTPY-----TDVNIVTIRENTEGEYSGIEHVIVDG----VVQSIKL 170
Cdd:COG0473  77 KWDDGVrpeSGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRV 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284 171 ITEEASKRIAEFAFEYARNnHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLV 250
Cdd:COG0473 157 YTRKGIERIARYAFELARK-RRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIV 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284 251 MPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAA 330
Cdd:COG0473 236 TENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAA 315

                       330       340       350
                ....*....|....*....|....*....|..
gi 18250284 331 CFATIKDGKsLTKDLGGNAKCSDFTEEICRRV 362
Cdd:COG0473 316 VEKVLAEGV-RTPDLGGKAGTSEMGDAIIAAL 346
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 32-362 1.57e-132

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 382.14  E-value: 1.57e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   32 QTVTLIPGDGIGPEISASVMKIFDAAKAPIQWE--ERNVTAIQGPGGkwMIPPEAKESMDKNKMGLKGPLKTPIAAGHPS 109
Cdd:PRK08997   3 QTITVIPGDGIGPSIIDATLKILDKLGCDFEYEfaDAGLTALEKHGE--LLPQRTLDLIEKNKIALKGPLTTPVGEGFTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  110 MNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGI-EHVIVDG-VVQSIKLITEEASKRIAEFAFEYA 187
Cdd:PRK08997  81 INVTLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGEgQTVSEDGeTAEATSIITRKGAERIVRFAYELA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  188 RNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLI 267
Cdd:PRK08997 161 RKEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  268 GGLGVTPSGNIGANGvAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDGKSLTKDLGG 347
Cdd:PRK08997 241 GGLGMAPGANIGRDA-AIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTRDLGG 319

                        330
                 ....*....|....*
gi 18250284  348 NAKCSDFTEEICRRV 362
Cdd:PRK08997 320 THGTTDFTQAVIDRL 334
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
34-338 2.38e-130

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 381.93  E-value: 2.38e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   34 VTLIPGDGIGPEISASVMKIFDAAKAPIQWEER----NVTAIQGPGGkwmIPPEAKESMDKNKMGLKGPLKTPIAAGHPS 109
Cdd:PRK09222   7 ITVAYGDGIGPEIMEAVLKILEAAGAPLEIETIeigeKVYKKGWTSG---ISPSAWESIRRTKVLLKAPITTPQGGGYKS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  110 MNLLLRKTFDLYANVRPCVSIEGY-KTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEEASKRIAEFAFEYAR 188
Cdd:PRK09222  84 LNVTLRKTLGLYANVRPCVSYHPFvETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPGSEKIIRYAFEYAR 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  189 NNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIG 268
Cdd:PRK09222 164 ANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISG 243

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  269 GLGVTPSGNIGaNGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDG 338
Cdd:PRK09222 244 SVGLAGSANIG-EEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKTLEDG 312
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 29-360 5.92e-128

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 371.50  E-value: 5.92e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   29 GGVQTVTLIPGDGIGPEISASVMKIFDAAKAPIQWEERNVTaiqgpGGKWMIPPEAKESMDKNKMGLKGPLKTPIAAGHP 108
Cdd:PLN00123  28 GAPRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVH-----GDMKKVPEEVLESIRRNKVCLKGGLATPVGGGVS 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  109 SMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEEASKRIAEFAFEYAR 188
Cdd:PLN00123 103 SLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAY 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  189 NNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIG 268
Cdd:PLN00123 183 LNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAG 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  269 GLGVTPSGNIGAnGVAIFESVHGTA----PDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDGKSLTKD 344
Cdd:PLN00123 263 GTGVMPGGNVGA-DHAVFEQGASAGnvgnEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYRTKD 341

                        330
                 ....*....|....*.
gi 18250284  345 LGGNAKCSDFTEEICR 360
Cdd:PLN00123 342 LGGSSTTQEVVDAVIA 357
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 34-358 1.53e-106

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 315.55  E-value: 1.53e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284    34 VTLIPGDGIGPEISASVMKIFDAAKAPIQWE--ERNVTAIQGPGGKwmIPPEAKESMDKNKMGLKGPLKTPIAAGHPSMN 111
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILNKLGLEIEFIefEAGDEALKKYGSA--LPEDTLEEIRKADAILFGAVTTPANPGYKSVI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   112 LLLRKTFDLYANVRPCVSIEGYKTPY-TDVNIVTIRENTEGEYSGIEHVIVDGVVqSIKLITEEASKRIAEFAFEYARNN 190
Cdd:TIGR02088  79 VTLRKELDLYANVRPAKSLPGIPDLYpNGKDIVIVRENTEGLYAGFEFGFSDRAI-AIRVITREGSERIARFAFNLAKER 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   191 hRSNVTAVHKANIMRMSDGLFLQKCREVAENcKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGL 270
Cdd:TIGR02088 158 -NRKVTCVHKANVLKGTDGLFREVCREIAKR-YGVEYRDMYVDSAAMNLVKDPWRFDVIVTTNMFGDILSDLASALAGSL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   271 GVTPSGNIGaNGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDGKsLTKDLGGNAK 350
Cdd:TIGR02088 236 GLAPSANIG-DRKALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGKLVWEAVEYYIIEGK-KTPDLGGTAK 313


                  ....*...
gi 18250284   351 CSDFTEEI 358
Cdd:TIGR02088 314 TKEVGDEI 321
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
33-365 2.20e-106

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 315.52  E-value: 2.20e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   33 TVTLIPGDGIGPEISASVMKIFDAAkapiqweERNVTAIQGPGGK-------WMIPPEAKESMDKNKMGLKGPLKTpiAA 105
Cdd:NF040626   3 KITVIPGDGIGKEVMEAALYVLDAL-------DLNFDFIEAEAGRecfkkngTTIPEETIKIAKKSDATLFGAVTS--TP 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  106 GHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEEASKRIAEFAFE 185
Cdd:NF040626  74 GQKSPIITLRKELDLYANLRPIKSYEGINCLFKDLDFLIVRENTEGLYSGLEEEYTEEKAIAERVITRKASERICKFAFE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  186 YARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAG 265
Cdd:NF040626 154 YAIKLGRKKVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNLFGDILSDEAAG 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  266 LIGGLGVTPSGNIGANGvAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDGKSLTKDL 345
Cdd:NF040626 234 LVGGLGLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALEKVLREGKVVTPDL 312

                        330       340
                 ....*....|....*....|
gi 18250284  346 GGNAKCSDFTEEICRRVKDL 365
Cdd:NF040626 313 GGNAKTMEMANEIKKKIEEL 332
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 34-362 2.73e-103

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 307.45  E-value: 2.73e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   34 VTLIPGDGIGPEISASVMKIFDAAKAPIQ--WEERNVTAIQGPGGKwmIPPEAKESMDKNKMGLKGplktpiAAGHPSMN 111
Cdd:PRK14025   4 ICVIEGDGIGKEVVPAALHVLEATGLPFEfvYAEAGDEVFEKTGKA--LPEETIEAAKEADAVLFG------AAGETAAD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  112 LL--LRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEEASKRIAEFAFEYARN 189
Cdd:PRK14025  76 VIvkLRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASERIFRFAFEMAKR 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  190 NH----RSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAG 265
Cdd:PRK14025 156 RKkmgkEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAG 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  266 LIGGLGVTPSGNIGaNGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDGKSlTKDL 345
Cdd:PRK14025 236 LVGGLGLAPSANIG-DKYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGLT-TPDL 313

                        330
                 ....*....|....*..
gi 18250284  346 GGNAKCSDFTEEICRRV 362
Cdd:PRK14025 314 GGNLSTMEMAEEVAKRV 330
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 37-364 7.15e-90

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 275.84  E-value: 7.15e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  37 IPGDGIGPEISASVMKIFDAA--KA-----PIQWEE-------RNVTaiqgpgGKWmIPPEAKESMDKNKMGLKGPLKTP 102
Cdd:COG0538  24 IEGDGIGPEITRAIWKVIDAAveKAyggkrDIEWKEvdagekaRDET------GDW-LPDETAEAIKEYGVGIKGPLTTP 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284 103 IAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTP---YTDVNIVTIRENTEGEYSGIE--------------------HV 159
Cdd:COG0538  97 VGGGWRSLNVTIRQILDLYVCRRPVRYFKGVPSPvkhPEKVDIVIFRENTEDIYAGIEwkagspealkliffledemgVT 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284 160 IVD-----GVVqsIKLITEEASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAEN------------C 222
Cdd:COG0538 177 VIRfpedsGIG--IKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEEefgdkfitegpwE 254

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284 223 KDIKFNE----MYLDTVCLNMVQD----PSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAP 294
Cdd:COG0538 255 KYKGPKPagkiVYKDRIADDMLQQillrPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDGGAEFEATHGTAP 334

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18250284 295 DIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDGKsLTKDL-----GGNA-KCSDFTEEICRRVKD 364
Cdd:COG0538 335 KYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGK-VTYDLarlmeGATElSTSEFGDAIIENLDK 409
AksF_Meth NF040619
homoisocitrate dehydrogenase;
34-358 8.08e-82

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 252.76  E-value: 8.08e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   34 VTLIPGDGIGPEISASVMKIFDaakapiqwEERNVTAIQGPGG-------KWMIPPEAKESMDKNKMGLKGPLKTPIAAG 106
Cdd:NF040619   4 ICVIEGDGIGKEVIPETVRVLK--------ELGDFEFIKGEAGlecfkkyGDAIPEETIEKAKECDAILFGAVTTPKPTE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  107 HPSMN-----LLLRKTFDLYANVRPcVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDG-VVQSIKLITEEASKRIA 180
Cdd:NF040619  76 LKNKNykspiLTLRKELDLYANVRP-INNFGDGQDVKNIDFVIIRENTEGLYVGREYYDEENeIAIAERIISKKGSERII 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  181 EFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKD--IKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDI 258
Cdd:NF040619 155 KFAFEYAKKNNRKKVSCIHKANVLRVTDGLFLEIFNEIKKKYKNfnIEADDYLVDATAMYLIKNPEMFDVIVTTNLFGDI 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  259 LSDLCAGLIGGLGVTPSGNIGANgVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDG 338
Cdd:NF040619 235 LSDEASGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDLIREAVKKCLENG 313

                        330       340
                 ....*....|....*....|
gi 18250284  339 KsLTKDLGGNAKCSDFTEEI 358
Cdd:NF040619 314 K-VTPDLGGNLKTKEVTDKI 332
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 34-365 1.12e-80

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 250.40  E-value: 1.12e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   34 VTLIPGDGIGPEISASVMKIFDAAKA----PIQWEERNV--TAIQGPGGkwMIPPE----AKESmDKNKMGLKGPLK--T 101
Cdd:PRK00772   5 IAVLPGDGIGPEVMAEAVKVLDAVAEkfgfDFEFEEALVggAAIDAHGV--PLPEEtleaCRAA-DAVLLGAVGGPKwdN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  102 PIAAGHPSMNLL-LRKTFDLYANVRPCVSIEGYKTPYT-------DVNIVTIRENTEGEYSG----IEHVIVDGVVQSIK 169
Cdd:PRK00772  82 LPPDVRPERGLLaLRKELGLFANLRPAKLYPGLADASPlkpeivaGLDILIVRELTGGIYFGeprgREGLGGEERAFDTM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  170 LITEEASKRIAEFAFEYARNnhRSN-VTAVHKANIMRmSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDV 248
Cdd:PRK00772 162 VYTREEIERIARVAFELARK--RRKkVTSVDKANVLE-SSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  249 LVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRH-MGLFDHAAKI 327
Cdd:PRK00772 239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEEAADAI 318

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 18250284  328 EAACFATIKDGKsLTKDL---GGNAKCSDFTEEICRRVKDL 365
Cdd:PRK00772 319 EAAVEKVLAQGY-RTADIaegGGKVSTSEMGDAILAALAEG 358
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 37-358 2.53e-70

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 225.71  E-value: 2.53e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   37 IPGDGIGPEISASVMKIFDAA-------KAPIQWEE----RNVTAIQGPGgKWMiPPEAKESMDKNKMGLKGPLKTPIAA 105
Cdd:PRK07006  25 IEGDGIGPDITPAMLKVVDAAvekaykgERKISWMEiyagEKATKVYGED-VWL-PEETLDLIREYRVAIKGPLTTPVGG 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  106 GHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT---DVNIVTIRENTEGEYSGIEHVI----VDGVVQ------------ 166
Cdd:PRK07006 103 GIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKrpeDTDMVIFRENSEDIYAGIEWKAgsaeAKKVIKflqeemgvkkir 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  167 -------SIKLITEEASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAEN------------------ 221
Cdd:PRK07006 183 fpetsgiGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEEefgdelidggpwdkiknp 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  222 --CKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGaNGVAIFESVHGTAPDIAGK 299
Cdd:PRK07006 263 etGKEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIN-DGHAIFEATHGTAPKYAGL 341

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18250284  300 DMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKdGKSLTKDL-----GGN-AKCSDFTEEI 358
Cdd:PRK07006 342 DKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIA-SKTVTYDFarlmeGATeVKCSEFGDAL 405
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 34-362 1.06e-68

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 219.71  E-value: 1.06e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284    34 VTLIPGDGIGPEISASVMKIFDAAKapiqwEERNVTAIQGPGGKW----------MIPPEAKESMDKNK---MGLKG-PL 99
Cdd:TIGR02089   6 IAAIPGDGIGKEVVAAALQVLEAAA-----KRHGGFSLHFTEFPWscdyykehgkMMPEDGLEKLKKFDaifLGAVGwPA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   100 KTPiaaGHPSMNLLL---RKTFDLYANVRPCVSIEGYKTPY-----TDVNIVTIRENTEGEYSGIEHVIVDG----VVQS 167
Cdd:TIGR02089  81 LVP---DHISLWGLLlkiRREFDQYANVRPAKLLPGVTSPLrncgpGDFDFVVVRENSEGEYSGVGGRIHRGtdeeVATQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   168 IKLITEEASKRIAEFAFEYARNnHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFD 247
Cdd:TIGR02089 158 NAIFTRKGVERIMRFAFELAQK-RRKHLTSATKSNGIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFD 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   248 VLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVA--IFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAA 325
Cdd:TIGR02089 237 VIVASNLFGDILSDLGAALMGSLGVAPSANINPEGKFpsMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHLGEKEAGA 316

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 18250284   326 KIEAACFATIKDGkSLTKDLGGNAKCSDFTEEICRRV 362
Cdd:TIGR02089 317 KIMDAIERVTAAG-ILTPDVGGKATTSEVTEAVCNAL 352
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 34-362 1.08e-67

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 216.88  E-value: 1.08e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284    34 VTLIPGDGIGPEISASVMKIFDA-AKAP---IQWEERNV--TAIQGPGGKwmIPPEAKESMDKNKMGLKGPLKTP----- 102
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAvAERFglkFEFEEHLIggAAIDATGQP--LPEETLKGCKEADAVLLGAVGGPkwdnl 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   103 IAAGHPSMNLL-LRKTFDLYANVRPCVSIEGY------KTPYTD-VNIVTIRENTEGEY----SGIEhviVDGVVQSIKL 170
Cdd:TIGR00169  80 PRDQRPEQGLLkLRKSLDLFANLRPAKVFPGLedlsplKEEIAKgVDFVVVRELTGGIYfgepKGRE---GEGEAWDTEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   171 ITEEASKRIAEFAFEYARNnHRSNVTAVHKANIMRMSDgLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLV 250
Cdd:TIGR00169 157 YTVPEIERIARVAFEMARK-RRKKVTSVDKANVLESSR-LWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   251 MPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRH-MGLFDHAAKIEA 329
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYsFNLEEAADAIEA 314

                         330       340       350
                  ....*....|....*....|....*....|...
gi 18250284   330 ACFATIKDGKSlTKDLGGNAKCSDFTEEICRRV 362
Cdd:TIGR00169 315 AVKKVLAEGYR-TPDLGSSATTAVGTAEMGEEL 346
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 37-362 2.05e-67

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 215.95  E-value: 2.05e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   37 IPGDGIGPEISASVMKIFDAAKAP---IQWEERNVTAiqgpgGKWM-----IPPEAKESMDKNKMGLKGplktpiAAGHP 108
Cdd:PRK03437  10 IPGDGIGPEVVAEALKVLDAVAAGgpgVETTEYDLGA-----RRYLrtgetLPDSVLAELRQHDAILLG------AIGDP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  109 SM-------NLLLRKTFDL--YANVRPCVSIEGYKTPYT---DVNIVTIRENTEGEYSGIEHVIVDG----VVQSIKLIT 172
Cdd:PRK03437  79 SVpsgvlerGLLLKLRFALdhYVNLRPSKLYPGVTSPLAgpgDIDFVVVREGTEGPYTGNGGALRVGtpheVATEVSVNT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  173 EEASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMP 252
Cdd:PRK03437 159 AFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVTD 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  253 NLYGDILSDLCAGLIGGLGVTPSGNIGANGVA--IFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAA 330
Cdd:PRK03437 239 NLFGDIITDLAAAVTGGIGLAASGNINPTGTNpsMFEPVHGSAPDIAGQGIADPTAAILSVALLLDHLGEEDAAARIEAA 318

                        330       340       350
                 ....*....|....*....|....*....|..
gi 18250284  331 cfatikdgksLTKDLGGNAKCSDFTEEICRRV 362
Cdd:PRK03437 319 ----------VEADLAERGKMGRSTAEVGDRI 340
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
37-345 9.66e-66

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 213.92  E-value: 9.66e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   37 IPGDGIGPEISASVMKIFDAAKAPIQWEERNVtaiqgpggKWM---------------IPPEAKESMDKNKMGLKGPLKT 101
Cdd:PRK06451  29 VEGDGIGPEITHAAMKVINKAVEKAYGSDREI--------KWVevlagdkaekltgnrFPKESEELIEKYRVLLKGPLET 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  102 PIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTD---VNIVTIRENTEGEYSGIEHV------------------- 159
Cdd:PRK06451 101 PIGKGWKSINVAIRLMLDLYANIRPVKYIPGIESPLKNpekIDLIIFRENTDDLYRGIEYPydseeakkirdflrkelgv 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  160 -IVDGVVQSIKLITEEASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAEN------CKDIKFNEMYL 232
Cdd:PRK06451 181 eVEDDTGIGIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAYEVALKefrdyvVTEEEVTKNYN 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  233 -----------DTVCLNMVQD----PSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGvAIFESVHGTAPDIA 297
Cdd:PRK06451 261 gvppsgkviinDRIADNMFQQiiirPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTG-GMFEAIHGTAPKYA 339

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 18250284  298 GKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDgKSLTKDL 345
Cdd:PRK06451 340 GKNVANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQ-KKVTQDL 386
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 33-365 2.46e-59

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 195.33  E-value: 2.46e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   33 TVTLIPGDGIGPEISASVMKIFDAAkAPIQweernvtaiqgpGG--------KW----------MIPPEAKESMDKNKMG 94
Cdd:PRK08194   5 KIAVIPGDGVGKEVVPAAVRVLKAV-AEVH------------GGlkfeftefPWsceyylehgeMMPEDGLEQLKQFDAI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   95 LKGPLKTP-IAAGHPSM-NLLL--RKTFDLYANVRPCVSIEGYKTPYT---DVNIVTIRENTEGEYSGIEHVIVDG---- 163
Cdd:PRK08194  72 FLGAVGNPkLVPDHISLwGLLIkiRREFEQVINIRPAKQLRGIKSPLAnpkDFDLLVVRENSEGEYSEVGGRIHRGedei 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  164 VVQSiKLITEEASKRIAEFAFEYARNnHRSNVTAVHKAN----IMRMSDGLFlqkcREVAENCKDIKFNEMYLDTVCLNM 239
Cdd:PRK08194 152 AIQN-AVFTRKGTERAMRYAFELAAK-RRKHVTSATKSNgivhSMPFWDEVF----QEVGKDYPEIETDSQHIDALAAFF 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  240 VQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGV--AIFESVHGTAPDIAGKDMANPTALLLSAVMMLRH 317
Cdd:PRK08194 226 VTRPEEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNGKypSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDH 305

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 18250284  318 MGLFDHAAKIEAACFATIKDGkSLTKDLGGNAKCSDFTEEICRRVKDL 365
Cdd:PRK08194 306 FGEEELGSHLLDVIEDVTEDG-IKTPDIGGRATTDEVTDEIISRLKKL 352
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
34-361 1.08e-45

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 162.58  E-value: 1.08e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   34 VTLIPGDGIGPEISASVMKIFDAAKAPIQWEERNVT---------AIQGPGGKWMIPPEAKESMDKNKMGLKGPLKTPIA 104
Cdd:PRK07362  31 IPFIRGDGTGVDIWPATQKVLDAAVAKAYGGERKINwfkvyagdeACDLYGTYQYLPEDTLEAIREYGVAIKGPLTTPIG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  105 AGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT---DVNIVTIRENTEGEYSGIE------------------------ 157
Cdd:PRK07362 111 GGIRSLNVALRQIFDLYSCVRPCRYYAGTPSPHKnpeKLDVIVYRENTEDIYMGIEweagdeigdklikhlneevipasp 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  158 ----HVIVDGVVQSIKLITEEASKRIAEFAFEYAR--NNHRSNVTAVHKANIMRMSDGLF-------------------- 211
Cdd:PRK07362 191 elgkRQIPLGSGIGIKPVSKTGSQRHIRRAIEHALrlPGDKRHVTLVHKGNIMKYTEGAFrdwgyelattefrdecvter 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  212 -------LQK----------------------------CREVAENCKDI-------KFNEMYL------DTVCLNMVQDP 243
Cdd:PRK07362 271 eswilsnKEKnpnisiednarmiepgydsltpekkaaiCAEVKEVLDSIwsshgngKWKEKVLvddriaDSIFQQIQTRP 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  244 SQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANgVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDH 323
Cdd:PRK07362 351 QEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDN-AAIFEATHGTAPKHAGLDRINPGSVILSGVMMLEYLGWQEA 429

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 18250284  324 AAKIEAACFATIKDgKSLTKDLG-------GNAKCSDFTEEICRR 361
Cdd:PRK07362 430 ADLITKGLSAAIAN-KQVTYDLArlmeppvDPLSCSEFAEAIISH 473
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 34-362 2.44e-40

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 147.14  E-value: 2.44e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284   34 VTLIPGDGIGPEIsASVMKI------------FDAAKAPIQWEERNVTAIQGPGGKWMippEAKESmDKNKMGLKGPLKT 101
Cdd:PLN02329  49 IALLPGDGIGPEV-ISVAKNvlqkagslegleFDFQEMPVGGAALDLVGVPLPEETFT---AAKQS-DAILLGAIGGYKW 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  102 PIAAGH--PSMNLL-LRKTFDLYANVRPCVSIEGY-------KTPYTDVNIVTIRENTEGEYSGIEHVIV-----DGVVQ 166
Cdd:PLN02329 124 DKNEKHlrPEMALFyLRRDLKVFANLRPATVLPQLvdastlkKEVAEGVDMMIVRELTGGIYFGEPRGITinengEEVGV 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  167 SIKLITEEASKRIAEFAFEYARNnHRSNVTAVHKANIMRMSDgLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQF 246
Cdd:PLN02329 204 STEIYAAHEIDRIARVAFETARK-RRGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQF 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  247 DVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRH-MGLFDHAA 325
Cdd:PLN02329 282 DTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAK 361

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 18250284  326 KIEAACFATIKDGKSlTKDL--GGN--AKCSDFTEEICRRV 362
Cdd:PLN02329 362 RIEDAVVDALNKGFR-TGDIysPGNklVGCKEMGEEVLKSV 401
PLN03065 PLN03065
isocitrate dehydrogenase (NADP+); Provisional
 172-345 3.14e-07

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 178617 [Multi-domain]  Cd Length: 483  Bit Score: 51.81  E-value: 3.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  172 TEEASKRIAEFAFEYARNNhRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEM---YLDTVCLNMVQDPSQFD- 247
Cdd:PLN03065 254 VDESIRAFAESSMAMALQK-KWPLYLSTKNTILKKYDGRFKDIFQEVYEEQWKQKFEEHsiwYEHRLIDDMVAYAVKSEg 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  248 --VLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAI-FESVHGTAPD-----IAGKDMA-NPTALLLSAVMMLRHM 318
Cdd:PLN03065 333 gyVWACKNYDGDVQSDLLAQGFGSLGLMTSVLLSSDGKTLeAEAAHGTVTRhfrlhQKGQETStNSIASIFAWTRGLEHR 412

                        170       180       190
                 ....*....|....*....|....*....|....
gi 18250284  319 G-------LFDHAAKIEAACFATIKDGKsLTKDL 345
Cdd:PLN03065 413 AkldkneeLLDFVHKLESACIETVESGK-MTKDL 445
PLN00103 PLN00103
isocitrate dehydrogenase (NADP+); Provisional
 200-345 1.36e-05

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 177720  Cd Length: 410  Bit Score: 46.75  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  200 KANIMRMSDGLFLQKCREVAENCKDIKFNEM---YLDTVCLNMVQDPSQFD---VLVMPNLYGDILSDLCAGLIGGLGVT 273
Cdd:PLN00103 214 KNTILKKYDGRFKDIFQEVYEAQWKSKFEAAgiwYEHRLIDDMVAYALKSEggyVWACKNYDGDVQSDFLAQGFGSLGLM 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  274 PSGNIGANGVAI-FESVHGTAP------DIAGKDMANPTALLLSAVMMLRHMG-------LFDHAAKIEAACFATIKDGK 339
Cdd:PLN00103 294 TSVLVCPDGKTIeAEAAHGTVTrhyrvhQKGGETSTNSIASIFAWSRGLAHRAkldgnarLLDFTEKLEAACVGTVESGK 373


                 ....*.
gi 18250284  340 sLTKDL 345
Cdd:PLN00103 374 -MTKDL 378
PRK08299 PRK08299
NADP-dependent isocitrate dehydrogenase;
253-345 5.63e-04

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236226  Cd Length: 402  Bit Score: 41.77  E-value: 5.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18250284  253 NLYGDILSDLCAGLIGGLG------VTPSGNigangVAIFESVHGTAPD-----IAGKDMA-NPTALLLSAVMMLRHMGL 320
Cdd:PRK08299 269 NYDGDVQSDTVAQGFGSLGlmtsvlMTPDGK-----TVEAEAAHGTVTRhyrqhQKGEETStNPIASIFAWTRGLAHRGK 343

                         90       100       110
                 ....*....|....*....|....*....|..
gi 18250284  321 FDH-------AAKIEAACFATIKDGKsLTKDL 345
Cdd:PRK08299 344 LDGnpelvkfADTLEKVCIETVESGF-MTKDL 374
PdxA COG1995
4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; ...
 288-317 3.27e-03

4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; 4-hydroxy-L-threonine phosphate dehydrogenase PdxA is part of the Pathway/BioSystem: Pyridoxal phosphate biosynthesis


Pssm-ID: 441598  Cd Length: 330  Bit Score: 38.89  E-value: 3.27e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 18250284 288 SV-HGTAPDIAGKDMANPTAL---LLSAVMMLRH 317
Cdd:COG1995 295 SVdHGTAFDIAGKGIADPGSLiaaIRLAARLARN 328
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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