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Conserved domains on  [gi|49227135|ref|NP_080946|]
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zinc finger MYM-type protein 1 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4371 super family cl46273
Domain of unknown function (DUF4371);
336-562 5.74e-20

Domain of unknown function (DUF4371);


The actual alignment was detected with superfamily member pfam14291:

Pssm-ID: 480613  Cd Length: 236  Bit Score: 89.98  E-value: 5.74e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49227135   336 AFATQGTADWEKMLGN--FRKHEESDVH----LKSLQFWRQYQfldaiPCDNSSVYSKQIEGNKK--YLRLIIENILFLG 407
Cdd:pfam14291   2 AFLSTGFCSWNKADRLdqFVGHQVNSFHniakRKCEDLMRQGQ-----SIKHILHKETDLEKNDYriWLKASIDIIIHLL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49227135   408 KQCLLLKGNDQSVSPMNKGSFLELLELRARDR---GEVFQLMSSHVDfYSSTLVQEEIIEMIKDEMLQDIVSEINaSSAF 484
Cdd:pfam14291  77 HQGLPLRGHDESEESTNKGLFVELLKYTAGQDevvKKVLKNAPKNNT-YTSPPIQNDIVNCFSNEVTRSIIEEMD-NDVF 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 49227135   485 SIICEEIAGSAAERQLSVCVRYPQKTPSavlVKERFLGFVTAEEVTGVHVHGRIKAYLQQVGVDFNKICGQAYDSATN 562
Cdd:pfam14291 155 GILVDETADASDKEQMAIVFRYVDKYGV---PIERFIGVIHVQETSSLSLKSAIDSLLKSLGISLKKLRSQCYDGASN 229
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 870-959 1.08e-12

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


:

Pssm-ID: 399013  Cd Length: 83  Bit Score: 64.20  E-value: 1.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49227135   870 FYRQYAGFNFIAEDgslSFIDLGSLFIQHalHNNIPCITKLLHIALSWPITSANNEKSFSTLshLKTYLLRTMGQEKLSS 949
Cdd:pfam05699   1 ELDQYLSEPVLPRN---EDFDPLEWWKEN--SSRYPNLSKLARDILSIPVSSAASERSFSTL--GKVILESRNRLEPLNV 73

                          90
                  ....*....|
gi 49227135   950 LALIAVEQEL 959
Cdd:pfam05699  74 EALLCIEDWL 83
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 57-96 1.28e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 40.05  E-value: 1.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 49227135    57 KRMCLNCSRDILSLKDMKSVQLEDSScdKNFCSQSCLTSY 96
Cdd:pfam06467   3 KATCWFCKKLIKNKPTVIVLQNDGSV--GQFCSQSCLDSY 40
 
Name Accession Description Interval E-value
DUF4371 pfam14291
Domain of unknown function (DUF4371);
336-562 5.74e-20

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 89.98  E-value: 5.74e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49227135   336 AFATQGTADWEKMLGN--FRKHEESDVH----LKSLQFWRQYQfldaiPCDNSSVYSKQIEGNKK--YLRLIIENILFLG 407
Cdd:pfam14291   2 AFLSTGFCSWNKADRLdqFVGHQVNSFHniakRKCEDLMRQGQ-----SIKHILHKETDLEKNDYriWLKASIDIIIHLL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49227135   408 KQCLLLKGNDQSVSPMNKGSFLELLELRARDR---GEVFQLMSSHVDfYSSTLVQEEIIEMIKDEMLQDIVSEINaSSAF 484
Cdd:pfam14291  77 HQGLPLRGHDESEESTNKGLFVELLKYTAGQDevvKKVLKNAPKNNT-YTSPPIQNDIVNCFSNEVTRSIIEEMD-NDVF 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 49227135   485 SIICEEIAGSAAERQLSVCVRYPQKTPSavlVKERFLGFVTAEEVTGVHVHGRIKAYLQQVGVDFNKICGQAYDSATN 562
Cdd:pfam14291 155 GILVDETADASDKEQMAIVFRYVDKYGV---PIERFIGVIHVQETSSLSLKSAIDSLLKSLGISLKKLRSQCYDGASN 229
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 870-959 1.08e-12

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


Pssm-ID: 399013  Cd Length: 83  Bit Score: 64.20  E-value: 1.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49227135   870 FYRQYAGFNFIAEDgslSFIDLGSLFIQHalHNNIPCITKLLHIALSWPITSANNEKSFSTLshLKTYLLRTMGQEKLSS 949
Cdd:pfam05699   1 ELDQYLSEPVLPRN---EDFDPLEWWKEN--SSRYPNLSKLARDILSIPVSSAASERSFSTL--GKVILESRNRLEPLNV 73

                          90
                  ....*....|
gi 49227135   950 LALIAVEQEL 959
Cdd:pfam05699  74 EALLCIEDWL 83
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 57-96 1.28e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 40.05  E-value: 1.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 49227135    57 KRMCLNCSRDILSLKDMKSVQLEDSScdKNFCSQSCLTSY 96
Cdd:pfam06467   3 KATCWFCKKLIKNKPTVIVLQNDGSV--GQFCSQSCLDSY 40
 
Name Accession Description Interval E-value
DUF4371 pfam14291
Domain of unknown function (DUF4371);
336-562 5.74e-20

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 89.98  E-value: 5.74e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49227135   336 AFATQGTADWEKMLGN--FRKHEESDVH----LKSLQFWRQYQfldaiPCDNSSVYSKQIEGNKK--YLRLIIENILFLG 407
Cdd:pfam14291   2 AFLSTGFCSWNKADRLdqFVGHQVNSFHniakRKCEDLMRQGQ-----SIKHILHKETDLEKNDYriWLKASIDIIIHLL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49227135   408 KQCLLLKGNDQSVSPMNKGSFLELLELRARDR---GEVFQLMSSHVDfYSSTLVQEEIIEMIKDEMLQDIVSEINaSSAF 484
Cdd:pfam14291  77 HQGLPLRGHDESEESTNKGLFVELLKYTAGQDevvKKVLKNAPKNNT-YTSPPIQNDIVNCFSNEVTRSIIEEMD-NDVF 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 49227135   485 SIICEEIAGSAAERQLSVCVRYPQKTPSavlVKERFLGFVTAEEVTGVHVHGRIKAYLQQVGVDFNKICGQAYDSATN 562
Cdd:pfam14291 155 GILVDETADASDKEQMAIVFRYVDKYGV---PIERFIGVIHVQETSSLSLKSAIDSLLKSLGISLKKLRSQCYDGASN 229
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 870-959 1.08e-12

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


Pssm-ID: 399013  Cd Length: 83  Bit Score: 64.20  E-value: 1.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 49227135   870 FYRQYAGFNFIAEDgslSFIDLGSLFIQHalHNNIPCITKLLHIALSWPITSANNEKSFSTLshLKTYLLRTMGQEKLSS 949
Cdd:pfam05699   1 ELDQYLSEPVLPRN---EDFDPLEWWKEN--SSRYPNLSKLARDILSIPVSSAASERSFSTL--GKVILESRNRLEPLNV 73

                          90
                  ....*....|
gi 49227135   950 LALIAVEQEL 959
Cdd:pfam05699  74 EALLCIEDWL 83
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 57-96 1.28e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 40.05  E-value: 1.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 49227135    57 KRMCLNCSRDILSLKDMKSVQLEDSScdKNFCSQSCLTSY 96
Cdd:pfam06467   3 KATCWFCKKLIKNKPTVIVLQNDGSV--GQFCSQSCLDSY 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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