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Conserved domains on  [gi|165377232|ref|NP_080065|]
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radial spoke head protein 3 homolog A [Mus musculus]

Protein Classification

radial spoke RSP3 family protein( domain architecture ID 12068743)

radial spoke RSP3 family protein is found in the flagella and cilia of eukaryotic cells, and is a member of the A-kinase anchoring protein (AKAP) family, which anchor protein kinases to specific cellular locations.

Gene Ontology:  GO:2000145|GO:0005929

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Radial_spoke_3 pfam06098
Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) ...
 172-451 1.10e-124

Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organizms from protists to humans. They are centred by precisely organized, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation.


:

Pssm-ID: 461827  Cd Length: 286  Bit Score: 365.81  E-value: 1.10e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165377232  172 YGNIMYDRRVIRGNTYALPTGQVPGQPDPLELQRQQQARRRALARKRAQEQLK---PRTPEPVEGRKHVDIQTELYLEEI 248
Cdd:pfam06098   1 YGNIMYDRRVVRGNTYASHILPTSAQPDPLEAQREAEARRRALARKRAKEQRRrglLGTPPPVEGRKHIDVQTELYLEEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165377232  249 ADRIVEVDMECQTDAFLDRPPTPLFIPAKTGKDVATQILGGELFDFDLEVKPMLEVLVGKTIEQSLLEVMEEEELANLRA 328
Cdd:pfam06098  81 TDRPPEVDVDTQTDAFLDRPPTPLFVPAKTGIDVETQIEEGDLFDFDTEVQPILEVLVGKTLEQALLEVLEEEELANLRE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165377232  329 RQYAYEEIRNVELAEVQRLEEQERRHREEKERRKKQQWEIVHKRNETLQKISALIFARQYLANLLPSVFDKLRNSGFFYD 408
Cdd:pfam06098 161 QQRAFEELRNAELAEVQRLEEQERRLREEKERRIAQQREALKKEKETAEKIAARAFAQGYLSDLLPSVFDSLEDSGYFYD 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 165377232  409 PIERDIEVGFLPWLMNEVEKSMEHSMVGRTVLDMLIRDVVERR 451
Cdd:pfam06098 241 PVERDVETEFLPWLMEEVAKELEKRVAARELLDSIIREVVETR 283
 
Name Accession Description Interval E-value
Radial_spoke_3 pfam06098
Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) ...
 172-451 1.10e-124

Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organizms from protists to humans. They are centred by precisely organized, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation.


Pssm-ID: 461827  Cd Length: 286  Bit Score: 365.81  E-value: 1.10e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165377232  172 YGNIMYDRRVIRGNTYALPTGQVPGQPDPLELQRQQQARRRALARKRAQEQLK---PRTPEPVEGRKHVDIQTELYLEEI 248
Cdd:pfam06098   1 YGNIMYDRRVVRGNTYASHILPTSAQPDPLEAQREAEARRRALARKRAKEQRRrglLGTPPPVEGRKHIDVQTELYLEEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165377232  249 ADRIVEVDMECQTDAFLDRPPTPLFIPAKTGKDVATQILGGELFDFDLEVKPMLEVLVGKTIEQSLLEVMEEEELANLRA 328
Cdd:pfam06098  81 TDRPPEVDVDTQTDAFLDRPPTPLFVPAKTGIDVETQIEEGDLFDFDTEVQPILEVLVGKTLEQALLEVLEEEELANLRE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165377232  329 RQYAYEEIRNVELAEVQRLEEQERRHREEKERRKKQQWEIVHKRNETLQKISALIFARQYLANLLPSVFDKLRNSGFFYD 408
Cdd:pfam06098 161 QQRAFEELRNAELAEVQRLEEQERRLREEKERRIAQQREALKKEKETAEKIAARAFAQGYLSDLLPSVFDSLEDSGYFYD 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 165377232  409 PIERDIEVGFLPWLMNEVEKSMEHSMVGRTVLDMLIRDVVERR 451
Cdd:pfam06098 241 PVERDVETEFLPWLMEEVAKELEKRVAARELLDSIIREVVETR 283
 
Name Accession Description Interval E-value
Radial_spoke_3 pfam06098
Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) ...
 172-451 1.10e-124

Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organizms from protists to humans. They are centred by precisely organized, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation.


Pssm-ID: 461827  Cd Length: 286  Bit Score: 365.81  E-value: 1.10e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165377232  172 YGNIMYDRRVIRGNTYALPTGQVPGQPDPLELQRQQQARRRALARKRAQEQLK---PRTPEPVEGRKHVDIQTELYLEEI 248
Cdd:pfam06098   1 YGNIMYDRRVVRGNTYASHILPTSAQPDPLEAQREAEARRRALARKRAKEQRRrglLGTPPPVEGRKHIDVQTELYLEEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165377232  249 ADRIVEVDMECQTDAFLDRPPTPLFIPAKTGKDVATQILGGELFDFDLEVKPMLEVLVGKTIEQSLLEVMEEEELANLRA 328
Cdd:pfam06098  81 TDRPPEVDVDTQTDAFLDRPPTPLFVPAKTGIDVETQIEEGDLFDFDTEVQPILEVLVGKTLEQALLEVLEEEELANLRE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165377232  329 RQYAYEEIRNVELAEVQRLEEQERRHREEKERRKKQQWEIVHKRNETLQKISALIFARQYLANLLPSVFDKLRNSGFFYD 408
Cdd:pfam06098 161 QQRAFEELRNAELAEVQRLEEQERRLREEKERRIAQQREALKKEKETAEKIAARAFAQGYLSDLLPSVFDSLEDSGYFYD 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 165377232  409 PIERDIEVGFLPWLMNEVEKSMEHSMVGRTVLDMLIRDVVERR 451
Cdd:pfam06098 241 PVERDVETEFLPWLMEEVAKELEKRVAARELLDSIIREVVETR 283
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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