|
Name |
Accession |
Description |
Interval |
E-value |
| MAGE |
pfam01454 |
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ... |
475-635 |
3.72e-18 |
|
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis. :
Pssm-ID: 426270 Cd Length: 205 Bit Score: 83.47 E-value: 3.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 475 LVKYLMLKDYTKVPIKRSEMLRDIIREY-TDVYPEIIERACFVLEKKFGIQLKEIDKEEHL------------------- 534
Cdd:pfam01454 1 LVRYALACEYQRTPIRREDISKKVLGENrKRLFKKVFEEAQKILRDVFGMELVELPAKEEKkttvtsqqrraaakssrsk 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 535 -YILIST--PESLAGILGTTKDTPKLGLLLVILGII----------FMNGNRATEAVLWEALRKMGLR---PGVRHPLLG 598
Cdd:pfam01454 81 sYILVSTlpPEYRVPAIIWPSKAPSFVLDQDEATYTgiltvilsliLLSGGSISEQELLRYLRRLGIDtdgTKEIPPLNG 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 9789935 599 DLRKLLTyEFVKQKYLDYRRVPNSNP--PEYEFLWGLRS 635
Cdd:pfam01454 161 NTDDLLK-RLVKQGYLVRTKEGASDDgeEIIEYRVGPRA 198
|
|
| PRK12323 super family |
cl46901 |
DNA polymerase III subunit gamma/tau; |
271-462 |
6.54e-07 |
|
DNA polymerase III subunit gamma/tau; The actual alignment was detected with superfamily member PRK12323:
Pssm-ID: 481241 [Multi-domain] Cd Length: 700 Bit Score: 52.96 E-value: 6.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 271 RSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQNQTARQTPPAArqSPPARQTPSAWQNPVAWQNPVIWPNPViwqnP 350
Cdd:PRK12323 375 ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVA--AAPARRSPAPEALAAARQASARGPGGA----P 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 351 VIWPNPIVWPGPIVwPNPMAWQSTPgwqsPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDwsFPSDWPFPPDWIPADW 430
Cdd:PRK12323 449 APAPAPAAAPAAAA-RPAAAGPRPV----AAAAAAAPARAAPAAAPAPADDDPPPWEELPPE--FASPAPAQPDAAPAGW 521
|
170 180 190
....*....|....*....|....*....|..
gi 9789935 431 PippdwQNLRPSPNLRSSSNSRASQNQGPPQP 462
Cdd:PRK12323 522 V-----AESIPDPATADPDDAFETLAPAPAAA 548
|
|
| PRK07764 super family |
cl35613 |
DNA polymerase III subunits gamma and tau; Validated |
36-477 |
4.80e-06 |
|
DNA polymerase III subunits gamma and tau; Validated The actual alignment was detected with superfamily member PRK07764:
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 50.37 E-value: 4.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 36 ISEAPPTSQATAAASGPNASPQSSQPPTAnekADTEVSAAAARPktgfkaqnATTKGPNDYSQARNAKEMPknqskAAFK 115
Cdd:PRK07764 385 LGVAGGAGAPAAAAPSAAAAAPAAAPAPA---AAAPAAAAAPAP--------AAAPQPAPAPAPAPAPPSP-----AGNA 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 116 SQNGTPKGPHAASDFSQAAPTGKSAKKSEMAFKGQNSTKAGPGTTYNFPQSPSANE--MTNNQPKTakAWNDT-TKVPGA 192
Cdd:PRK07764 449 PAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAgaDDAATLRE--RWPEIlAAVPKR 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 193 daqtqnvNQAKMADVGTSAGISEADG----------AAAQTSADGSQTQNVesRTIIR---GKRTRKVNNLNVEENNSGD 259
Cdd:PRK07764 527 -------SRKTWAILLPEATVLGVRGdtlvlgfstgGLARRFASPGNAEVL--VTALAeelGGDWQVEAVVGPAPGAAGG 597
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 260 QRRASLASGNWRSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQN--QTARQTPPAARQSPPARQTPSAWQNPVAWQN 337
Cdd:PRK07764 598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPApgVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA 677
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 338 PVIWPNPVIWQNPviwPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDwsMPPDWSFPS 417
Cdd:PRK07764 678 PAAPPPAPAPAAP---AAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPP--EPDDPPDPA 752
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 418 DWPFPPDwiPADWPIPPDWQNLRPSPNLRSSSNSRASQNQGPPQPRDVALLQERANKLVK 477
Cdd:PRK07764 753 GAPAQPP--PPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLE 810
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| MAGE |
pfam01454 |
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ... |
475-635 |
3.72e-18 |
|
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.
Pssm-ID: 426270 Cd Length: 205 Bit Score: 83.47 E-value: 3.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 475 LVKYLMLKDYTKVPIKRSEMLRDIIREY-TDVYPEIIERACFVLEKKFGIQLKEIDKEEHL------------------- 534
Cdd:pfam01454 1 LVRYALACEYQRTPIRREDISKKVLGENrKRLFKKVFEEAQKILRDVFGMELVELPAKEEKkttvtsqqrraaakssrsk 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 535 -YILIST--PESLAGILGTTKDTPKLGLLLVILGII----------FMNGNRATEAVLWEALRKMGLR---PGVRHPLLG 598
Cdd:pfam01454 81 sYILVSTlpPEYRVPAIIWPSKAPSFVLDQDEATYTgiltvilsliLLSGGSISEQELLRYLRRLGIDtdgTKEIPPLNG 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 9789935 599 DLRKLLTyEFVKQKYLDYRRVPNSNP--PEYEFLWGLRS 635
Cdd:pfam01454 161 NTDDLLK-RLVKQGYLVRTKEGASDDgeEIIEYRVGPRA 198
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
271-462 |
6.54e-07 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 52.96 E-value: 6.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 271 RSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQNQTARQTPPAArqSPPARQTPSAWQNPVAWQNPVIWPNPViwqnP 350
Cdd:PRK12323 375 ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVA--AAPARRSPAPEALAAARQASARGPGGA----P 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 351 VIWPNPIVWPGPIVwPNPMAWQSTPgwqsPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDwsFPSDWPFPPDWIPADW 430
Cdd:PRK12323 449 APAPAPAAAPAAAA-RPAAAGPRPV----AAAAAAAPARAAPAAAPAPADDDPPPWEELPPE--FASPAPAQPDAAPAGW 521
|
170 180 190
....*....|....*....|....*....|..
gi 9789935 431 PippdwQNLRPSPNLRSSSNSRASQNQGPPQP 462
Cdd:PRK12323 522 V-----AESIPDPATADPDDAFETLAPAPAAA 548
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
36-477 |
4.80e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 50.37 E-value: 4.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 36 ISEAPPTSQATAAASGPNASPQSSQPPTAnekADTEVSAAAARPktgfkaqnATTKGPNDYSQARNAKEMPknqskAAFK 115
Cdd:PRK07764 385 LGVAGGAGAPAAAAPSAAAAAPAAAPAPA---AAAPAAAAAPAP--------AAAPQPAPAPAPAPAPPSP-----AGNA 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 116 SQNGTPKGPHAASDFSQAAPTGKSAKKSEMAFKGQNSTKAGPGTTYNFPQSPSANE--MTNNQPKTakAWNDT-TKVPGA 192
Cdd:PRK07764 449 PAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAgaDDAATLRE--RWPEIlAAVPKR 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 193 daqtqnvNQAKMADVGTSAGISEADG----------AAAQTSADGSQTQNVesRTIIR---GKRTRKVNNLNVEENNSGD 259
Cdd:PRK07764 527 -------SRKTWAILLPEATVLGVRGdtlvlgfstgGLARRFASPGNAEVL--VTALAeelGGDWQVEAVVGPAPGAAGG 597
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 260 QRRASLASGNWRSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQN--QTARQTPPAARQSPPARQTPSAWQNPVAWQN 337
Cdd:PRK07764 598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPApgVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA 677
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 338 PVIWPNPVIWQNPviwPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDwsMPPDWSFPS 417
Cdd:PRK07764 678 PAAPPPAPAPAAP---AAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPP--EPDDPPDPA 752
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 418 DWPFPPDwiPADWPIPPDWQNLRPSPNLRSSSNSRASQNQGPPQPRDVALLQERANKLVK 477
Cdd:PRK07764 753 GAPAQPP--PPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLE 810
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
276-467 |
1.92e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 45.14 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 276 PVTTQQNPPGAPPnvvwqtplawQNPSGWQNQTARQTPPAARQSPPARQTPSAWQNPVAWQNPVIwPNPVIWQNPVIWPN 355
Cdd:pfam03154 172 PVLQAQSGAASPP----------SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAA-PHTLIQQTPTLHPQ 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 356 PIVWPGPIVWPNPmawQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDwsfPSDWPFPPDWIPADWPIPPD 435
Cdd:pfam03154 241 RLPSPHPPLQPMT---QPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVP---PQPFPLTPQSSQSQVPPGPS 314
|
170 180 190
....*....|....*....|....*....|....
gi 9789935 436 WQNLRPSpnlRSSSNSRASQNQGPPQ--PRDVAL 467
Cdd:pfam03154 315 PAAPGQS---QQRIHTPPSQSQLQSQqpPREQPL 345
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| MAGE |
pfam01454 |
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ... |
475-635 |
3.72e-18 |
|
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.
Pssm-ID: 426270 Cd Length: 205 Bit Score: 83.47 E-value: 3.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 475 LVKYLMLKDYTKVPIKRSEMLRDIIREY-TDVYPEIIERACFVLEKKFGIQLKEIDKEEHL------------------- 534
Cdd:pfam01454 1 LVRYALACEYQRTPIRREDISKKVLGENrKRLFKKVFEEAQKILRDVFGMELVELPAKEEKkttvtsqqrraaakssrsk 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 535 -YILIST--PESLAGILGTTKDTPKLGLLLVILGII----------FMNGNRATEAVLWEALRKMGLR---PGVRHPLLG 598
Cdd:pfam01454 81 sYILVSTlpPEYRVPAIIWPSKAPSFVLDQDEATYTgiltvilsliLLSGGSISEQELLRYLRRLGIDtdgTKEIPPLNG 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 9789935 599 DLRKLLTyEFVKQKYLDYRRVPNSNP--PEYEFLWGLRS 635
Cdd:pfam01454 161 NTDDLLK-RLVKQGYLVRTKEGASDDgeEIIEYRVGPRA 198
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
271-462 |
6.54e-07 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 52.96 E-value: 6.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 271 RSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQNQTARQTPPAArqSPPARQTPSAWQNPVAWQNPVIWPNPViwqnP 350
Cdd:PRK12323 375 ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVA--AAPARRSPAPEALAAARQASARGPGGA----P 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 351 VIWPNPIVWPGPIVwPNPMAWQSTPgwqsPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDwsFPSDWPFPPDWIPADW 430
Cdd:PRK12323 449 APAPAPAAAPAAAA-RPAAAGPRPV----AAAAAAAPARAAPAAAPAPADDDPPPWEELPPE--FASPAPAQPDAAPAGW 521
|
170 180 190
....*....|....*....|....*....|..
gi 9789935 431 PippdwQNLRPSPNLRSSSNSRASQNQGPPQP 462
Cdd:PRK12323 522 V-----AESIPDPATADPDDAFETLAPAPAAA 548
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
36-477 |
4.80e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 50.37 E-value: 4.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 36 ISEAPPTSQATAAASGPNASPQSSQPPTAnekADTEVSAAAARPktgfkaqnATTKGPNDYSQARNAKEMPknqskAAFK 115
Cdd:PRK07764 385 LGVAGGAGAPAAAAPSAAAAAPAAAPAPA---AAAPAAAAAPAP--------AAAPQPAPAPAPAPAPPSP-----AGNA 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 116 SQNGTPKGPHAASDFSQAAPTGKSAKKSEMAFKGQNSTKAGPGTTYNFPQSPSANE--MTNNQPKTakAWNDT-TKVPGA 192
Cdd:PRK07764 449 PAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAgaDDAATLRE--RWPEIlAAVPKR 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 193 daqtqnvNQAKMADVGTSAGISEADG----------AAAQTSADGSQTQNVesRTIIR---GKRTRKVNNLNVEENNSGD 259
Cdd:PRK07764 527 -------SRKTWAILLPEATVLGVRGdtlvlgfstgGLARRFASPGNAEVL--VTALAeelGGDWQVEAVVGPAPGAAGG 597
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 260 QRRASLASGNWRSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQN--QTARQTPPAARQSPPARQTPSAWQNPVAWQN 337
Cdd:PRK07764 598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPApgVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA 677
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 338 PVIWPNPVIWQNPviwPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDwsMPPDWSFPS 417
Cdd:PRK07764 678 PAAPPPAPAPAAP---AAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPP--EPDDPPDPA 752
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 418 DWPFPPDwiPADWPIPPDWQNLRPSPNLRSSSNSRASQNQGPPQPRDVALLQERANKLVK 477
Cdd:PRK07764 753 GAPAQPP--PPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLE 810
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
38-462 |
1.27e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.17 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 38 EAPPTSQATAAASGPNASPQSSQPPTANEKADTEV-------SAAAARPKTGFKAQNATTKGPNDYSQARNAKEMPKNQS 110
Cdd:PHA03247 2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPdppppspSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARR 2669
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 111 KAAFKSQNGTPKGPHAASDFSQAAPTGKSAKKSEmafKGQNSTKAGPGTTYNFPQSPSANEMTNNQPKT-----AKAWND 185
Cdd:PHA03247 2670 LGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP---PPPTPEPAPHALVSATPLPPGPAAARQASPALpaapaPPAVPA 2746
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 186 TTKVPGADAQTQNVNQAKMADVGTSAGISEADGAAAQTSADGSQTQnvESRTIIRGKRTRKVNNLNVEENNSGDQRRASL 265
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLS--ESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 266 ASGnwrSAPVPVTTQQNPPGAPPNVVWQTPL-AWQNPSG--WQNQTARQTP--PAARQSPPARQTPSawqnpvawqnpvi 340
Cdd:PHA03247 2825 AGP---LPPPTSAQPTAPPPPPGPPPPSLPLgGSVAPGGdvRRRPPSRSPAakPAAPARPPVRRLAR------------- 2888
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 341 wpnpviwqnpviwpnPIVWPGPIVWPNPmawqstpgwqsPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDWSFPSDWP 420
Cdd:PHA03247 2889 ---------------PAVSRSTESFALP-----------PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 9789935 421 FPPDWIPADWPIP----PDWQNLRPSPNLRSSSNSRASQNQgPPQP 462
Cdd:PHA03247 2943 LAPTTDPAGAGEPsgavPQPWLGALVPGRVAVPRFRVPQPA-PSRE 2987
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
263-416 |
3.25e-05 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 47.77 E-value: 3.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 263 ASLASGNWrSAPVPVTTQQNPPGAPPNVVWQTPLAWQNPSGWQN------QTARQTPPAARQSPPARQTPSAWQNPVAWQ 336
Cdd:PRK10263 326 ATTATQSW-AAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTgepviaPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQ 404
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 337 NPVIWPNPVIWQNPVIWPNPIVWPGPIVWPNPMAWQSTPG--WQSPPS---WQAPPSWQSPQDWQGP---PDWQVPPDWS 408
Cdd:PRK10263 405 QPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGnaWQAEEQqstFAPQSTYQTEQTYQQPaaqEPLYQQPQPV 484
|
....*...
gi 9789935 409 MPPDWSFP 416
Cdd:PRK10263 485 EQQPVVEP 492
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
276-467 |
1.92e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 45.14 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 276 PVTTQQNPPGAPPnvvwqtplawQNPSGWQNQTARQTPPAARQSPPARQTPSAWQNPVAWQNPVIwPNPVIWQNPVIWPN 355
Cdd:pfam03154 172 PVLQAQSGAASPP----------SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAA-PHTLIQQTPTLHPQ 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 356 PIVWPGPIVWPNPmawQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDwsfPSDWPFPPDWIPADWPIPPD 435
Cdd:pfam03154 241 RLPSPHPPLQPMT---QPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVP---PQPFPLTPQSSQSQVPPGPS 314
|
170 180 190
....*....|....*....|....*....|....
gi 9789935 436 WQNLRPSpnlRSSSNSRASQNQGPPQ--PRDVAL 467
Cdd:pfam03154 315 PAAPGQS---QQRIHTPPSQSQLQSQqpPREQPL 345
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
272-447 |
3.99e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.99 E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 272 SAPVPVTTQQNPPGAPPnvVWQTPLAWQNPSGWQN--QTARQTPPAARQSPPARQTPSAWQNPVAWQNPVIWPNPVIWQN 349
Cdd:pfam03154 197 AGPTPSAPSVPPQGSPA--TSQPPNQTQSTAAPHTliQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQ 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 350 PVIWPNPIvWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDWSFPSDWPFPPDWIPAD 429
Cdd:pfam03154 275 MPPMPHSL-QTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMP 353
|
170
....*....|....*...
gi 9789935 430 WPIPPDWQNLRPSPNLRS 447
Cdd:pfam03154 354 HIKPPPTTPIPQLPNPQS 371
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
39-471 |
4.67e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.16 E-value: 4.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 39 APPTSQATAAASGPNASPQSSQPPTANEKADTEVSAAAARPKT--GFKAQNATTKGPNDYSQARNAKEMPKNQSKAAFKS 116
Cdd:PHA03247 2558 AAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRApvDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANE 2637
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 117 QNGTPKGPHAASDFSQAAPTGKSAKKSEMAfkGQNSTKAGPGTTYNFPQSPSAnemtnnqPKTAKAWNDTTKVPGADAQT 196
Cdd:PHA03247 2638 PDPHPPPTVPPPERPRDDPAPGRVSRPRRA--RRLGRAAQASSPPQRPRRRAA-------RPTVGSLTSLADPPPPPPTP 2708
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 197 QNVNQAKMADVGTSAGISEADGAAAQTSADGSQTQNVESRTIIRGKRTRKvnnlnveennsgdqrRASLASGNWRSAPVP 276
Cdd:PHA03247 2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA---------------RPPTTAGPPAPAPPA 2773
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 277 VTTQQNPPGAP-PNVVWQTPLAWQNPSGWQNQTARQTPPAARQSPPARQTPSAWQNPVAWQNPVIWPNPVIWQNPVIWPN 355
Cdd:PHA03247 2774 APAAGPPRRLTrPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG 2853
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 356 PIVWPGPIVWPNPMAWQSTPGWQSPP-----SWQAPPSWQSPQDWQGPPDWQVPPDWSMPPDWSFPsdwpfPPDWIPADW 430
Cdd:PHA03247 2854 GSVAPGGDVRRRPPSRSPAAKPAAPArppvrRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQP-----QPQPPPPPQ 2928
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 9789935 431 PIPPDWQNLRPSPNLRSSSNSRASQNQGP--PQPRDVALLQER 471
Cdd:PHA03247 2929 PQPPPPPPPRPQPPLAPTTDPAGAGEPSGavPQPWLGALVPGR 2971
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
260-400 |
9.68e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.67 E-value: 9.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 260 QRRASLASGNWRSAPVPVTTQQNPPGAPPnvvwqTPLAWQNPSGWQNQTArQTPPAARQSPPARQTPSAWQNPVAWQNPV 339
Cdd:PRK07764 376 ARLERLERRLGVAGGAGAPAAAAPSAAAA-----APAAAPAPAAAAPAAA-AAPAPAAAPQPAPAPAPAPAPPSPAGNAP 449
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9789935 340 IWPNPVIWQNPVIWPNPIVWPGPIVWPNPMAWQSTPGWQSPPSWQAPPSWQSPQdwQGPPD 400
Cdd:PRK07764 450 AGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAP--AGADD 508
|
|
| PRK13808 |
PRK13808 |
adenylate kinase; Provisional |
30-156 |
1.72e-03 |
|
adenylate kinase; Provisional
Pssm-ID: 172341 [Multi-domain] Cd Length: 333 Bit Score: 41.41 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 30 LMEAIQISEAPPTSQATAAASGPNASpqSSQPPTANEKADTEVSAAAARP------------KTGFKAQNATTKGPNDyS 97
Cdd:PRK13808 190 VLAAVGAANAKKAAKTPAAKSGAKKA--SAKAKSAAKKVSKKKAAKTAVSakkaaktaakaaKKAKKTAKKALKKAAK-A 266
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 9789935 98 QARNAKEMPKNQSKAAFKSQNGTPKGPHAASDFSQAAPTGKSAKKSEMAFKGQNSTKAG 156
Cdd:PRK13808 267 VKKAAKKAAKAAAKAAKGAAKATKGKAKAKKKAGKKAAAGSKAKATAKAPKRGAKGKKA 325
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
217-460 |
1.86e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 41.99 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 217 DGAAAQTSADGSQTQNVESRtIIRGKRTRKVNNLNVEENNSGDQRRASLASGNWRSAPVPVTTQQNPPGAPPNVVW---- 292
Cdd:PRK10263 219 DDEEYEDENHGKQHESRRAR-ILRGALARRKRLAEKFINPMGRQTDAALFSGKRMDDDEEITYTARGVAADPDDVLfsgn 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 293 -QTPLAWQNPSGWQNQTARQTP-PAARQSPPARQTPSAWQNPVAWQNPVIWPNPVIWQNPVIW---PNPIVwPGPIVWPN 367
Cdd:PRK10263 298 rATQPEYDEYDPLLNGAPITEPvAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWqpvPGPQT-GEPVIAPA 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 368 PMAWQSTPGWQSPPS-----WQAPPSWQSPQDWQGPPDWQVPPDWSMPPDWSFPSDWPFPPDWIPAD---WPIPPDWQNL 439
Cdd:PRK10263 377 PEGYPQQSQYAQPAVqynepLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAgnaWQAEEQQSTF 456
|
250 260
....*....|....*....|.
gi 9789935 440 RPSPNLRSSSNSRASQNQGPP 460
Cdd:PRK10263 457 APQSTYQTEQTYQQPAAQEPL 477
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
39-321 |
2.54e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 41.37 E-value: 2.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 39 APPTSQATAAASGPNASPQSSQPPTANEKADTEVSAAAARPKTGFKAQNATTKGPNDYS---QARNAKEMPKNQSKAAFK 115
Cdd:PRK07003 372 VPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPappATADRGDDAADGDAPVPA 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 116 SQNgTPKGPHAASDFSQAAPTGKSAKKSEMAFKGQNSTKAGPGTTYNFPQSPSANEMTNNQPKTAKAWNDTTKVPGADAQ 195
Cdd:PRK07003 452 KAN-ARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAP 530
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 196 tqnvnQAKMADVGTSAGISEADGAAAqtsadgsqtqnveSRTIIRGKRTRkvnnlnveenNSGDQRRASLASGNWRSAPV 275
Cdd:PRK07003 531 -----EARPPTPAAAAPAARAGGAAA-------------ALDVLRNAGMR----------VSSDRGARAAAAAKPAAAPA 582
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 9789935 276 PVTTqqnPPGAPPNVVWQTPLAWQNPSGWQNQTARQTPPAA--RQSPP 321
Cdd:PRK07003 583 AAPK---PAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAesRGAPP 627
|
|
| dnaA |
PRK14086 |
chromosomal replication initiator protein DnaA; |
275-471 |
7.56e-03 |
|
chromosomal replication initiator protein DnaA;
Pssm-ID: 237605 [Multi-domain] Cd Length: 617 Bit Score: 39.81 E-value: 7.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 275 VPVTTQQNPPGAPPnvvwQTPLAWQNPsgwqnqtarQTPPAARQSPPARQTPSAWQNPVAW----QNPVIWPNPVIWQNP 350
Cdd:PRK14086 86 ITVDPSAGEPAPPP----PHARRTSEP---------ELPRPGRRPYEGYGGPRADDRPPGLprqdQLPTARPAYPAYQQR 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789935 351 viwPNPIVWPGPivwPNPMAWQSTPGWQSPPSWQAPPSwqspQDWQGPPDWQVPPDWSMPpdwSFPSDWPfPPDWIPADW 430
Cdd:PRK14086 153 ---PEPGAWPRA---ADDYGWQQQRLGFPPRAPYASPA----SYAPEQERDREPYDAGRP---EYDQRRR-DYDHPRPDW 218
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 9789935 431 PIPPDWQNLRPSPNLRSSSNSRASqnQGPPQPRDVALLQER 471
Cdd:PRK14086 219 DRPRRDRTDRPEPPPGAGHVHRGG--PGPPERDDAPVVPIR 257
|
|
|