NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|9634886|ref|NP_039179|]
View 

ankyrin repeat protein [Fowlpox virus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 5-286 2.02e-138

ankyrin repeat protein; Provisional


:

Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 392.81  E-value: 2.02e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886     5 SIINNLIDIITLYIRIFYVIYYIAIKSKNQICIANILYTSIKFYYTDIIDAVLKRGIDPNIPFPLSENSYVNPLIYAIEC 84
Cdd:PHA02884   1 MIIINLIDIITLLCRIFYIIFYIAIKKKNKICIANILYSSIKFHYTDIIDAILKLGADPEAPFPLSENSKTNPLIYAIDC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886    85 DNHDAILSLIRYGADVNTYSNYLVITPLYISVLHGCPKCVEILLYYGANINIVTYKMVTPIELASRICYNNLAFMVCDRT 164
Cdd:PHA02884  81 DNDDAAKLLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELALMICNNFLAFMICDNE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886   165 ITNI---PKKITYNFEIMKILVSHFILQASNDRLNNRHNKYFSEGYNKNKMLVSTSIILTYFKKQCIEDIDIMKNIKLGD 241
Cdd:PHA02884 161 ISNFykhPKKILINFDILKILVSHFILQASNDRLNEKHNKNFNAGYNKNKHLIIQSIILKQFKDLCIDDIDIMKNIKLGD 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 9634886   242 D-----SFLDILVERNTMKLSTYISNQDILDIPKTVKVYNTRINMLLDEA 286
Cdd:PHA02884 241 DsndmlSFFDILVENDLIKLLNNIDNIDILDIPKKLKVYNNKIKLFLDEA 290
 
Name Accession Description Interval E-value
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 5-286 2.02e-138

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 392.81  E-value: 2.02e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886     5 SIINNLIDIITLYIRIFYVIYYIAIKSKNQICIANILYTSIKFYYTDIIDAVLKRGIDPNIPFPLSENSYVNPLIYAIEC 84
Cdd:PHA02884   1 MIIINLIDIITLLCRIFYIIFYIAIKKKNKICIANILYSSIKFHYTDIIDAILKLGADPEAPFPLSENSKTNPLIYAIDC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886    85 DNHDAILSLIRYGADVNTYSNYLVITPLYISVLHGCPKCVEILLYYGANINIVTYKMVTPIELASRICYNNLAFMVCDRT 164
Cdd:PHA02884  81 DNDDAAKLLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELALMICNNFLAFMICDNE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886   165 ITNI---PKKITYNFEIMKILVSHFILQASNDRLNNRHNKYFSEGYNKNKMLVSTSIILTYFKKQCIEDIDIMKNIKLGD 241
Cdd:PHA02884 161 ISNFykhPKKILINFDILKILVSHFILQASNDRLNEKHNKNFNAGYNKNKHLIIQSIILKQFKDLCIDDIDIMKNIKLGD 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 9634886   242 D-----SFLDILVERNTMKLSTYISNQDILDIPKTVKVYNTRINMLLDEA 286
Cdd:PHA02884 241 DsndmlSFFDILVENDLIKLLNNIDNIDILDIPKKLKVYNNKIKLFLDEA 290
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
41-202 1.69e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.21  E-value: 1.69e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886   41 LYTSIKFYYTDIIDAVLKRGIDPNIPfplsENSYVNPLIYAIECDNHDAILSLIRYGADVNTYSNYLvITPLYISVLHGC 120
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLEAGADVNAQ----DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDG-ETPLHLAAENGH 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886  121 PKCVEILLYYGANINIVTYKMVTPIELASRICYNNLAFMVCDRTITNIPKKITYNFEIMKILVSHFILQASNDRLNNRHN 200
Cdd:COG0666 199 LEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLL 278


                ..
gi 9634886  201 KY 202
Cdd:COG0666 279 AA 280
Ank_2 pfam12796
Ankyrin repeats (3 copies);
41-136 1.39e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 1.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886     41 LYTSIKFYYTDIIDAVLKRGIDPNIPFPLSENsyvnPLIYAIECDNHDAILSLIRYgADVNTYSNYLviTPLYISVLHGC 120
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRT----ALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR--TALHYAARSGH 73

                          90
                  ....*....|....*.
gi 9634886    121 PKCVEILLYYGANINI 136
Cdd:pfam12796  74 LEIVKLLLEKGADINV 89
 
Name Accession Description Interval E-value
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 5-286 2.02e-138

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 392.81  E-value: 2.02e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886     5 SIINNLIDIITLYIRIFYVIYYIAIKSKNQICIANILYTSIKFYYTDIIDAVLKRGIDPNIPFPLSENSYVNPLIYAIEC 84
Cdd:PHA02884   1 MIIINLIDIITLLCRIFYIIFYIAIKKKNKICIANILYSSIKFHYTDIIDAILKLGADPEAPFPLSENSKTNPLIYAIDC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886    85 DNHDAILSLIRYGADVNTYSNYLVITPLYISVLHGCPKCVEILLYYGANINIVTYKMVTPIELASRICYNNLAFMVCDRT 164
Cdd:PHA02884  81 DNDDAAKLLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELALMICNNFLAFMICDNE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886   165 ITNI---PKKITYNFEIMKILVSHFILQASNDRLNNRHNKYFSEGYNKNKMLVSTSIILTYFKKQCIEDIDIMKNIKLGD 241
Cdd:PHA02884 161 ISNFykhPKKILINFDILKILVSHFILQASNDRLNEKHNKNFNAGYNKNKHLIIQSIILKQFKDLCIDDIDIMKNIKLGD 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 9634886   242 D-----SFLDILVERNTMKLSTYISNQDILDIPKTVKVYNTRINMLLDEA 286
Cdd:PHA02884 241 DsndmlSFFDILVENDLIKLLNNIDNIDILDIPKKLKVYNNKIKLFLDEA 290
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
41-202 1.69e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.21  E-value: 1.69e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886   41 LYTSIKFYYTDIIDAVLKRGIDPNIPfplsENSYVNPLIYAIECDNHDAILSLIRYGADVNTYSNYLvITPLYISVLHGC 120
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLEAGADVNAQ----DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDG-ETPLHLAAENGH 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886  121 PKCVEILLYYGANINIVTYKMVTPIELASRICYNNLAFMVCDRTITNIPKKITYNFEIMKILVSHFILQASNDRLNNRHN 200
Cdd:COG0666 199 LEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLL 278


                ..
gi 9634886  201 KY 202
Cdd:COG0666 279 AA 280
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
41-150 1.09e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.90  E-value: 1.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886   41 LYTSIKFYYTDIIDAVLKRGIDPNIPfplsENSYVNPLIYAIECDNHDAILSLIRYGADVNTYSNYLViTPLYISVLHGC 120
Cdd:COG0666  91 LHAAARNGDLEIVKLLLEAGADVNAR----DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGN-TPLHLAAANGN 165

                        90       100       110
                ....*....|....*....|....*....|
gi 9634886  121 PKCVEILLYYGANINIVTYKMVTPIELASR 150
Cdd:COG0666 166 LEIVKLLLEAGADVNARDNDGETPLHLAAE 195
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 22-269 1.90e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 61.05  E-value: 1.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886    22 YVIYYIAIKSKNQICIANILYTSIKFYYTDIIDAVLKRGIDPNIpfplsENSYVN-PLIYAI-ECDNHDAILSLIRYGAD 99
Cdd:PHA02878 186 LLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA-----RDKCGNtPLHISVgYCKDYDILKLLLEHGVD 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886   100 VNTYSNYLVITPLYISVLHgcPKCVEILLYYGANINIVTYKMVTPIELASricynnlafmvcdrtitnipkKITYNFEIM 179
Cdd:PHA02878 261 VNAKSYILGLTALHSSIKS--ERKLKLLLEYGADINSLNSYKLTPLSSAV---------------------KQYLCINIG 317

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886   180 KILVSHFILQAsndrlnnRHNKYF--SEGYNKNKMLVSTSIILTYFKKQCIEDIDIMKNIKLGDD-SFLDILVERNTMKL 256
Cdd:PHA02878 318 RILISNICLLK-------RIKPDIknSEGFIDNMDCITSNKRLNQIKDKCEDELNRLASIKITNTySFDDFLKCDNSTLL 390

                        250
                 ....*....|...
gi 9634886   257 STYISNQDILDIP 269
Cdd:PHA02878 391 CKLVNNSIIDDIL 403
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
3-150 7.10e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.81  E-value: 7.10e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886    3 ITSIINNLIDIITLYIRIFYVIYYIAIKSKNQICIANILYTSIKFYYTDIIDAVLKRGIDPNIPFPLSENSYVNPLIYAI 82
Cdd:COG0666  16 LLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAA 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9634886   83 ECDNHDAILSLIRYGADVNTYSNYLvITPLYISVLHGCPKCVEILLYYGANINIVTYKMVTPIELASR 150
Cdd:COG0666  96 RNGDLEIVKLLLEAGADVNARDKDG-ETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162
Ank_2 pfam12796
Ankyrin repeats (3 copies);
41-136 1.39e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 1.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886     41 LYTSIKFYYTDIIDAVLKRGIDPNIPFPLSENsyvnPLIYAIECDNHDAILSLIRYgADVNTYSNYLviTPLYISVLHGC 120
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRT----ALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR--TALHYAARSGH 73

                          90
                  ....*....|....*.
gi 9634886    121 PKCVEILLYYGANINI 136
Cdd:pfam12796  74 LEIVKLLLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 85-286 2.17e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 54.67  E-value: 2.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886    85 DNHDAILSLIRYGADVNTYSNYlVITPLYISVLHGCPKCVEILLYYGANINIVTYKMVTPIELASRICynnlafmvcdrt 164
Cdd:PHA03100 170 NAKNRVNYLLSYGVPINIKDVY-GFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNN------------ 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886   165 ITNIPKKITYNFEIMKILVSHFILQASNDRLNNRHNKY----------FSEGYNKNKMLVSTSIILTYFKKQCIEDIDIM 234
Cdd:PHA03100 237 NKEIFKLLLNNGPSIKTIIETLLYFKDKDLNTITKIKMlkksimymflLDPGFYKNRKLIENSKSLKDVINECEKEIERM 316

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 9634886   235 KNIKLGDDSFLDILVERNTMKLSTYISNQDILDIpKTVKVYNTRINMLLDEA 286
Cdd:PHA03100 317 KEIKLNKVTVYDIIFNKNINFLSRYVNNKSVTKY-TTSKIYGKYIKKVINKA 367
PHA03095 PHA03095
ankyrin-like protein; Provisional
 49-280 5.14e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.33  E-value: 5.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886    49 YTDIIDAVLKRGIDPNiPFPLSENSYVNPLIYAIECDNHDaILSLIRYGADVNtYSNYLVITPLYISVLHGCPKCVEILL 128
Cdd:PHA03095 201 RARIVRELIRAGCDPA-ATDMLGNTPLHSMATGSSCKRSL-VLPLLIAGISIN-ARNRYGQTPLHYAAVFNNPRACRRLI 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886   129 YYGANINIVTYKMVTPIelasricynNLAFMVCDRTITNIPKKITYNFEIMKilvshfilqASNDRLNNRHnkyFSEGYN 208
Cdd:PHA03095 278 ALGADINAVSSDGNTPL---------SLMVRNNNGRAVRAALAKNPSAETVA---------ATLNTASVAG---GDIPSD 336

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886   209 KNKMLVST-----------SIILTYFKK---QCIEDIDIMKNIKLGDD-SFLDILVERNTMklSTYISNqDILDIPKTVK 273
Cdd:PHA03095 337 ATRLCVAKvvlrgafsllpEPIRAYHADfirECEAEIAVMRTTRIGTGvSLLDILFARNPD--ILLVSN-ASLRKKARLT 413


                 ....*..
gi 9634886   274 VYNTRIN 280
Cdd:PHA03095 414 VYGKALR 420
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
24-150 2.89e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.86  E-value: 2.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886   24 IYYIAIKSKNQICIANILYTSIKFYYTDIIDAVLKRGIDPNIPFPLSENSYVNPLIYAIECDNHDAILSLIRYGADVNTY 103
Cdd:COG0666   3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 9634886  104 SNYLVITPLYISVLHGCPKCVEILLYYGANINIVTYKMVTPIELASR 150
Cdd:COG0666  83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAY 129
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 41-286 1.51e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.97  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886    41 LYTSIKFYYTDIIDAVLKRGIDPNIPfplsENSYVNPLIYAIECDNHDAILSLIRYGADVNTYSNYlVITPLYISVLHGC 120
Cdd:PHA02875 106 LHLATILKKLDIMKLLIARGADPDIP----NTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCC-GCTPLIIAMAKGD 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886   121 PKCVEILLYYGANINIVTYK-----MVTPIE---------LASRICYNNLAFMVCDR--TITNIPKKITYNFEIMKI--L 182
Cdd:PHA02875 181 IAICKMLLDSGANIDYFGKNgcvaaLCYAIEnnkidivrlFIKRGADCNIMFMIEGEecTILDMICNMCTNLESEAIdaL 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886   183 VSHFILQASNDRLNNrhnkyfSEGYNKNKMLVSTSIILTYFKKQCIEDIDIMKNIKLGDDSFLDI-LVERNTMKLstyis 261
Cdd:PHA02875 261 IADIAIRIHKKTIRR------DEGFKNNMSTIEDKEEFKDVFEKCIIELRRIKSEKIGKKNILDLcILEKNSHNL----- 329

                        250       260
                 ....*....|....*....|....*....
gi 9634886   262 NQDIL--DIPKTVKVYNTRI--NMLLDEA 286
Cdd:PHA02875 330 DENILarHSKKILGLNDEAHfyKYLLKEA 358
PHA03095 PHA03095
ankyrin-like protein; Provisional
 49-145 6.67e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 37.70  E-value: 6.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9634886    49 YTDIIDAVLKRGIDPNIPfplsENSYVNPLIYAIECDNHDAILS-LIRYGADVNtYSNYLVITPL--YISVLHGCPKCVE 125
Cdd:PHA03095  62 VKDIVRLLLEAGADVNAP----ERCGFTPLHLYLYNATTLDVIKlLIKAGADVN-AKDKVGRTPLhvYLSGFNINPKVIR 136

                         90       100
                 ....*....|....*....|
gi 9634886   126 ILLYYGANINIVTYKMVTPI 145
Cdd:PHA03095 137 LLLRKGADVNALDLYGMTPL 156
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 110-138 8.82e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 33.42  E-value: 8.82e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 9634886    110 TPLYISVLH-GCPKCVEILLYYGANINIVT 138
Cdd:pfam00023   4 TPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH