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Conserved domains on  [gi|38490561|ref|NP_033998|]
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cadherin-5 preproprotein [Mus musculus]

Protein Classification

Cadherin_repeat and Cadherin_C domain-containing protein( domain architecture ID 11254411)

Cadherin_repeat and Cadherin_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 153-252 1.75e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 1.75e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561 153 VFNASVPEMSAIGTSVIRVTAVDADDPTvagHATVLYQIVKGNE--YFSID-NSGLIFTKiKNLDREKQAEYKIVVETQD 229
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIVSGNEdgLFSIDpSTGEITTA-KPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|...
gi 38490561 230 AlGLRGESGTATVMIRLEDINDN 252
Cdd:cd11304  77 G-GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
261-363 6.92e-23

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 93.52  E-value: 6.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561   261 YTFSVPEDIRVGKPLGFLTVVDPDEPQNRMTKYSIMQGEYRDTFTIETDPkrneGIIKPTKSLDYEVIQQYTFYIEATDP 340
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 38490561   341 TIRyeYLSSTsgknkAMVTINVL 363
Cdd:pfam00028  77 GGP--PLSST-----ATVTITVL 92
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 716-775 2.05e-21

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 87.98  E-value: 2.05e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561   716 ADNDGGGPPYDTLHIYGYEGAESIAESLSSLSTNSSDSDIDYDFLNDWGPRFKMLAELYG 775
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 376-474 5.01e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 5.01e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561 376 YHFKLPENQKKP-LIGTVVAKDPDKAQRS-IGYSIRKTSDRGqFFRI-TKQGNIYNEKELDRETYAWYNLTVEANEldsR 452
Cdd:cd11304   2 YEVSVPENAPPGtVVLTVSATDPDSGENGeVTYSIVSGNEDG-LFSIdPSTGEITTAKPLDREEQSSYTLTVTATD---G 77

                        90       100
                ....*....|....*....|..
gi 38490561 453 GNPvGKESIVQVYIEVLDENDN 474
Cdd:cd11304  78 GGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 481-576 7.76e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.50  E-value: 7.76e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561 481 PYEPKVCENAAQGKLVVQISATDKDVvPVNPKFKFALK--NEDSNFTLinnHDNTANITVKyGQFNREHAKFHYLPVLIS 558
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVsgNEDGLFSI---DPSTGEITTA-KPLDREEQSSYTLTVTAT 75

                        90
                ....*....|....*...
gi 38490561 559 DNGVPSLTGTSTLTVGVC 576
Cdd:cd11304  76 DGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 77-147 2.76e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.75  E-value: 2.76e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38490561     77 NAKYVLQGEFAGKIFGVDANTGNVLAYERLDREKVSEYFLTALIVDKNTnKNLEQPSSFTVKVHDINDNWP 147
Cdd:smart00112  12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGG-PPLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 153-252 1.75e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 1.75e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561 153 VFNASVPEMSAIGTSVIRVTAVDADDPTvagHATVLYQIVKGNE--YFSID-NSGLIFTKiKNLDREKQAEYKIVVETQD 229
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIVSGNEdgLFSIDpSTGEITTA-KPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|...
gi 38490561 230 AlGLRGESGTATVMIRLEDINDN 252
Cdd:cd11304  77 G-GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
261-363 6.92e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 93.52  E-value: 6.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561   261 YTFSVPEDIRVGKPLGFLTVVDPDEPQNRMTKYSIMQGEYRDTFTIETDPkrneGIIKPTKSLDYEVIQQYTFYIEATDP 340
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 38490561   341 TIRyeYLSSTsgknkAMVTINVL 363
Cdd:pfam00028  77 GGP--PLSST-----ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 260-367 1.10e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 1.10e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561 260 TYTFSVPEDIRVGKPLGFLTVVDPDEPQNRMTKYSIMQGEYRDTFTIEtdpkRNEGIIKPTKSLDYEVIQQYTFYIEATD 339
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....*...
gi 38490561 340 PTIryEYLSSTsgknkAMVTINVLDVDE 367
Cdd:cd11304  77 GGG--PPLSST-----ATVTITVLDVND 97
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 716-775 2.05e-21

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 87.98  E-value: 2.05e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561   716 ADNDGGGPPYDTLHIYGYEGAESIAESLSSLSTNSSDSDIDYDFLNDWGPRFKMLAELYG 775
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 376-474 5.01e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 5.01e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561 376 YHFKLPENQKKP-LIGTVVAKDPDKAQRS-IGYSIRKTSDRGqFFRI-TKQGNIYNEKELDRETYAWYNLTVEANEldsR 452
Cdd:cd11304   2 YEVSVPENAPPGtVVLTVSATDPDSGENGeVTYSIVSGNEDG-LFSIdPSTGEITTAKPLDREEQSSYTLTVTATD---G 77

                        90       100
                ....*....|....*....|..
gi 38490561 453 GNPvGKESIVQVYIEVLDENDN 474
Cdd:cd11304  78 GGP-PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
154-247 5.05e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 5.05e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561   154 FNASVPEMSAIGTSVIRVTAVDADDPTvagHATVLYQIVKGNEY--FSID-NSGLIFTKiKNLDREKQAEYKIVVETQDA 230
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDpDTGDISTT-KPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*..
gi 38490561   231 lGLRGESGTATVMIRLE 247
Cdd:pfam00028  77 -GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 279-369 4.57e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 4.57e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561    279 TVVDPDEPQNRMTKYSIMQGEYRDTFTIETDPkrneGIIKPTKSLDYEVIQQYTFYIEATDPTIRyeYLSSTsgknkAMV 358
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGGGP--PLSST-----ATV 69

                           90
                   ....*....|..
gi 38490561    359 TINVLDV-DEPP 369
Cdd:smart00112  70 TITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
376-469 5.67e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 5.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561   376 YHFKLPENQK-KPLIGTVVAKDPDKAQRS-IGYSIRKTsDRGQFFRITKQ-GNIYNEKELDRETYAWYNLTVEANELDSR 452
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGrIFYSILGG-GPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|....*..
gi 38490561   453 gnpvGKESIVQVYIEVL 469
Cdd:pfam00028  80 ----PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 481-576 7.76e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.50  E-value: 7.76e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561 481 PYEPKVCENAAQGKLVVQISATDKDVvPVNPKFKFALK--NEDSNFTLinnHDNTANITVKyGQFNREHAKFHYLPVLIS 558
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVsgNEDGLFSI---DPSTGEITTA-KPLDREEQSSYTLTVTAT 75

                        90
                ....*....|....*...
gi 38490561 559 DNGVPSLTGTSTLTVGVC 576
Cdd:cd11304  76 DGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 172-254 8.53e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 8.53e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561    172 TAVDADDPTvagHATVLYQIVKGNE--YFSID-NSGLIFTKiKNLDREKQAEYKIVVETQDAlGLRGESGTATVMIRLED 248
Cdd:smart00112   1 SATDADSGE---NGKVTYSILSGNDdgLFSIDpETGEITTT-KPLDREEQPEYTLTVEATDG-GGPPLSSTATVTITVLD 75


                   ....*.
gi 38490561    249 INDNFP 254
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 393-476 3.39e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 3.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561    393 VAKDPDKAQRS-IGYSIrKTSDRGQFFRITKQ-GNIYNEKELDRETYAWYNLTVEANelDSRGNPvgKESIVQVYIEVLD 470
Cdd:smart00112   1 SATDADSGENGkVTYSI-LSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEAT--DGGGPP--LSSTATVTITVLD 75


                   ....*.
gi 38490561    471 ENDNPP 476
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 77-147 2.76e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.75  E-value: 2.76e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38490561     77 NAKYVLQGEFAGKIFGVDANTGNVLAYERLDREKVSEYFLTALIVDKNTnKNLEQPSSFTVKVHDINDNWP 147
Cdd:smart00112  12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGG-PPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 51-145 5.38e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.63  E-value: 5.38e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561  51 QMHIDEekNESLPHYVGKIK-----SNVNrQNAKYVLQGEFAGKIFGVDANTGNVLAYERLDREKVSEYFLTALIVDKNT 125
Cdd:cd11304   3 EVSVPE--NAPPGTVVLTVSatdpdSGEN-GEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90       100
                ....*....|....*....|
gi 38490561 126 NKnLEQPSSFTVKVHDINDN 145
Cdd:cd11304  80 PP-LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
486-576 1.15e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561   486 VCENAAQGKLVVQISATDKDVVP-VNPKFKFALKNEDSNFTLinnHDNTANITVKyGQFNREHAKFHYLPVLISDNGVPS 564
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPnGRIFYSILGGGPGGNFRI---DPDTGDISTT-KPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
gi 38490561   565 LTGTSTLTVGVC 576
Cdd:pfam00028  81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 500-580 1.73e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561    500 SATDKDVvPVNPKFKFALK--NEDSNFTLinnHDNTANITVKyGQFNREHAKFHYLPVLISDNGVPSLTGTSTLTVGVCK 577
Cdd:smart00112   1 SATDADS-GENGKVTYSILsgNDDGLFSI---DPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ...
gi 38490561    578 CNE 580
Cdd:smart00112  76 VND 78
Cadherin pfam00028
Cadherin domain;
76-140 5.46e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 45.37  E-value: 5.46e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38490561    76 QNAKYVLQGEFAGKIFGVDANTGNVLAYERLDREKVSEYFLTALIVDKNTnKNLEQPSSFTVKVH 140
Cdd:pfam00028  29 GRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG-PPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 153-252 1.75e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.85  E-value: 1.75e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561 153 VFNASVPEMSAIGTSVIRVTAVDADDPTvagHATVLYQIVKGNE--YFSID-NSGLIFTKiKNLDREKQAEYKIVVETQD 229
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIVSGNEdgLFSIDpSTGEITTA-KPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|...
gi 38490561 230 AlGLRGESGTATVMIRLEDINDN 252
Cdd:cd11304  77 G-GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
261-363 6.92e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 93.52  E-value: 6.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561   261 YTFSVPEDIRVGKPLGFLTVVDPDEPQNRMTKYSIMQGEYRDTFTIETDPkrneGIIKPTKSLDYEVIQQYTFYIEATDP 340
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 38490561   341 TIRyeYLSSTsgknkAMVTINVL 363
Cdd:pfam00028  77 GGP--PLSST-----ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 260-367 1.10e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 1.10e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561 260 TYTFSVPEDIRVGKPLGFLTVVDPDEPQNRMTKYSIMQGEYRDTFTIEtdpkRNEGIIKPTKSLDYEVIQQYTFYIEATD 339
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|....*...
gi 38490561 340 PTIryEYLSSTsgknkAMVTINVLDVDE 367
Cdd:cd11304  77 GGG--PPLSST-----ATVTITVLDVND 97
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 716-775 2.05e-21

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 87.98  E-value: 2.05e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561   716 ADNDGGGPPYDTLHIYGYEGAESIAESLSSLSTNSSDSDIDYDFLNDWGPRFKMLAELYG 775
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 376-474 5.01e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 5.01e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561 376 YHFKLPENQKKP-LIGTVVAKDPDKAQRS-IGYSIRKTSDRGqFFRI-TKQGNIYNEKELDRETYAWYNLTVEANEldsR 452
Cdd:cd11304   2 YEVSVPENAPPGtVVLTVSATDPDSGENGeVTYSIVSGNEDG-LFSIdPSTGEITTAKPLDREEQSSYTLTVTATD---G 77

                        90       100
                ....*....|....*....|..
gi 38490561 453 GNPvGKESIVQVYIEVLDENDN 474
Cdd:cd11304  78 GGP-PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
154-247 5.05e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 5.05e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561   154 FNASVPEMSAIGTSVIRVTAVDADDPTvagHATVLYQIVKGNEY--FSID-NSGLIFTKiKNLDREKQAEYKIVVETQDA 230
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDpDTGDISTT-KPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*..
gi 38490561   231 lGLRGESGTATVMIRLE 247
Cdd:pfam00028  77 -GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 279-369 4.57e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 4.57e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561    279 TVVDPDEPQNRMTKYSIMQGEYRDTFTIETDPkrneGIIKPTKSLDYEVIQQYTFYIEATDPTIRyeYLSSTsgknkAMV 358
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGGGP--PLSST-----ATV 69

                           90
                   ....*....|..
gi 38490561    359 TINVLDV-DEPP 369
Cdd:smart00112  70 TITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
376-469 5.67e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 5.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561   376 YHFKLPENQK-KPLIGTVVAKDPDKAQRS-IGYSIRKTsDRGQFFRITKQ-GNIYNEKELDRETYAWYNLTVEANELDSR 452
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGrIFYSILGG-GPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|....*..
gi 38490561   453 gnpvGKESIVQVYIEVL 469
Cdd:pfam00028  80 ----PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 481-576 7.76e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.50  E-value: 7.76e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561 481 PYEPKVCENAAQGKLVVQISATDKDVvPVNPKFKFALK--NEDSNFTLinnHDNTANITVKyGQFNREHAKFHYLPVLIS 558
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVsgNEDGLFSI---DPSTGEITTA-KPLDREEQSSYTLTVTAT 75

                        90
                ....*....|....*...
gi 38490561 559 DNGVPSLTGTSTLTVGVC 576
Cdd:cd11304  76 DGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 172-254 8.53e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 8.53e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561    172 TAVDADDPTvagHATVLYQIVKGNE--YFSID-NSGLIFTKiKNLDREKQAEYKIVVETQDAlGLRGESGTATVMIRLED 248
Cdd:smart00112   1 SATDADSGE---NGKVTYSILSGNDdgLFSIDpETGEITTT-KPLDREEQPEYTLTVEATDG-GGPPLSSTATVTITVLD 75


                   ....*.
gi 38490561    249 INDNFP 254
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 393-476 3.39e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 3.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561    393 VAKDPDKAQRS-IGYSIrKTSDRGQFFRITKQ-GNIYNEKELDRETYAWYNLTVEANelDSRGNPvgKESIVQVYIEVLD 470
Cdd:smart00112   1 SATDADSGENGkVTYSI-LSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEAT--DGGGPP--LSSTATVTITVLD 75


                   ....*.
gi 38490561    471 ENDNPP 476
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 77-147 2.76e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.75  E-value: 2.76e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38490561     77 NAKYVLQGEFAGKIFGVDANTGNVLAYERLDREKVSEYFLTALIVDKNTnKNLEQPSSFTVKVHDINDNWP 147
Cdd:smart00112  12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGG-PPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 51-145 5.38e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.63  E-value: 5.38e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561  51 QMHIDEekNESLPHYVGKIK-----SNVNrQNAKYVLQGEFAGKIFGVDANTGNVLAYERLDREKVSEYFLTALIVDKNT 125
Cdd:cd11304   3 EVSVPE--NAPPGTVVLTVSatdpdSGEN-GEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90       100
                ....*....|....*....|
gi 38490561 126 NKnLEQPSSFTVKVHDINDN 145
Cdd:cd11304  80 PP-LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
486-576 1.15e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561   486 VCENAAQGKLVVQISATDKDVVP-VNPKFKFALKNEDSNFTLinnHDNTANITVKyGQFNREHAKFHYLPVLISDNGVPS 564
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPnGRIFYSILGGGPGGNFRI---DPDTGDISTT-KPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
gi 38490561   565 LTGTSTLTVGVC 576
Cdd:pfam00028  81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 500-580 1.73e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561    500 SATDKDVvPVNPKFKFALK--NEDSNFTLinnHDNTANITVKyGQFNREHAKFHYLPVLISDNGVPSLTGTSTLTVGVCK 577
Cdd:smart00112   1 SATDADS-GENGKVTYSILsgNDDGLFSI---DPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ...
gi 38490561    578 CNE 580
Cdd:smart00112  76 VND 78
Cadherin pfam00028
Cadherin domain;
76-140 5.46e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 45.37  E-value: 5.46e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38490561    76 QNAKYVLQGEFAGKIFGVDANTGNVLAYERLDREKVSEYFLTALIVDKNTnKNLEQPSSFTVKVH 140
Cdd:pfam00028  29 GRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG-PPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 59-145 2.02e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.87  E-value: 2.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38490561  59 NESLPHYVGKIKSNVNRQN---AKYVLQG-EFAGKIFGVDANTGNVLAYERLDREKVSEYFLTALIVDKNTNKnLEQPSS 134
Cdd:cd00031   9 GRSRGSFRVSIPTDLIASSgeiIKISAAGkEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANV-PQTSSV 87

                        90
                ....*....|.
gi 38490561 135 FTVKVHDINDN 145
Cdd:cd00031  88 FSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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