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Conserved domains on  [gi|19923142|ref|NP_002256|]
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importin subunit beta-1 isoform 1 [Homo sapiens]

Protein Classification

importin beta family protein( domain architecture ID 707677)

importin beta family protein may function in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
2-871 0e+00

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 613.87  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142   2 ELITILEKTV-SPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRW 80
Cdd:COG5215   5 EFRCLGKNHVlSPDPNARLRAEAQLLELQSGDFEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHANDPELQKGCSQRW 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142  81 LAIDANARREVKNYVLQTLGTETYR-PSSASQCVAGIACAEIPVNQWPELIPQLVANVTNpNSTEHMKESTLEAIGYICQ 159
Cdd:COG5215  85 LGMRHESKEQVKGMALRALKSPEPRfCTMAAQLLAAIARMELPNSLWPGLMEEMVRNVGD-EQPVSGKCESLGICGYHCE 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 160 DIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQ 239
Cdd:COG5215 164 SEAPEDLIQMSNVILFAIVMGALKNETTSAVRLAALKALMDSLMFVQGNFCYEEERNYFMQVVCEATQGNDEELQHAAFG 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 240 NLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQgrpPEHTSKFyAKGAL 319
Cdd:COG5215 244 CLNKIMMLYYKFMQSYMENALAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEV---PAQNHGF-ARAAV 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 320 QYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEP 399
Cdd:COG5215 320 ADVLPELLSLLEKQGEDYYGDDWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGPCE 399

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 400 SQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAE 479
Cdd:COG5215 400 DCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHLVLEVSASLIGLMDCPFRSINCSWRKENLVD 479

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 480 aayEAADVADDQEEPatycLSSSFELIVQKLLETTDRPDgHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQ 559
Cdd:COG5215 480 ---HIAKAVREVESF----LAKFYLAILNALVKGTELAL-NESNLRVSLFSALGTLILICPDAVSDILAGFYDYTSKKLD 551

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 560 QVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKvQHQDALQISDVVMASLLRMFQSTAgSGGVQEDALMAVSTLVEVL 639
Cdd:COG5215 552 ECISVLGQILATEDQLLVEELQSNYIGVLEAIIRT-RRRDIEDVEDQLMELFIRILESTK-PTTAFGDVYTAISALSTSL 629

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 640 GGEFLKYMEAFKPFLGIGLkNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGD 719
Cdd:COG5215 630 EERFEQYASKFIPYLTRAL-NCTDRFVLNSAVGLVGDLANTLGTDFNIYADVLMSSLVQCLSSEATHRDLKPAILSVFGD 708

                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 720 IALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGlkgdqenVHPDVMLVQPRVEFILS 799
Cdd:COG5215 709 IALAIGANFESYLDMIMMLFQQASELDPHSDEVYVDDYRKNAVQLVNCAYVGIGDS-------SKNRVRSVLPYVISIFH 781

                       810       820       830       840       850       860       870
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19923142 800 FIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKA-KTLATWATKELRK 871
Cdd:COG5215 782 KIGMIAEDPNGSEAHTRAALGLIGDLAGMFPKGELKFGLDEDWVKDFLYGMMKKISSQQtKDSARWAAEQVKR 854
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
2-871 0e+00

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 613.87  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142   2 ELITILEKTV-SPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRW 80
Cdd:COG5215   5 EFRCLGKNHVlSPDPNARLRAEAQLLELQSGDFEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHANDPELQKGCSQRW 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142  81 LAIDANARREVKNYVLQTLGTETYR-PSSASQCVAGIACAEIPVNQWPELIPQLVANVTNpNSTEHMKESTLEAIGYICQ 159
Cdd:COG5215  85 LGMRHESKEQVKGMALRALKSPEPRfCTMAAQLLAAIARMELPNSLWPGLMEEMVRNVGD-EQPVSGKCESLGICGYHCE 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 160 DIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQ 239
Cdd:COG5215 164 SEAPEDLIQMSNVILFAIVMGALKNETTSAVRLAALKALMDSLMFVQGNFCYEEERNYFMQVVCEATQGNDEELQHAAFG 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 240 NLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQgrpPEHTSKFyAKGAL 319
Cdd:COG5215 244 CLNKIMMLYYKFMQSYMENALAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEV---PAQNHGF-ARAAV 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 320 QYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEP 399
Cdd:COG5215 320 ADVLPELLSLLEKQGEDYYGDDWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGPCE 399

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 400 SQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAE 479
Cdd:COG5215 400 DCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHLVLEVSASLIGLMDCPFRSINCSWRKENLVD 479

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 480 aayEAADVADDQEEPatycLSSSFELIVQKLLETTDRPDgHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQ 559
Cdd:COG5215 480 ---HIAKAVREVESF----LAKFYLAILNALVKGTELAL-NESNLRVSLFSALGTLILICPDAVSDILAGFYDYTSKKLD 551

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 560 QVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKvQHQDALQISDVVMASLLRMFQSTAgSGGVQEDALMAVSTLVEVL 639
Cdd:COG5215 552 ECISVLGQILATEDQLLVEELQSNYIGVLEAIIRT-RRRDIEDVEDQLMELFIRILESTK-PTTAFGDVYTAISALSTSL 629

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 640 GGEFLKYMEAFKPFLGIGLkNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGD 719
Cdd:COG5215 630 EERFEQYASKFIPYLTRAL-NCTDRFVLNSAVGLVGDLANTLGTDFNIYADVLMSSLVQCLSSEATHRDLKPAILSVFGD 708

                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 720 IALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGlkgdqenVHPDVMLVQPRVEFILS 799
Cdd:COG5215 709 IALAIGANFESYLDMIMMLFQQASELDPHSDEVYVDDYRKNAVQLVNCAYVGIGDS-------SKNRVRSVLPYVISIFH 781

                       810       820       830       840       850       860       870
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19923142 800 FIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKA-KTLATWATKELRK 871
Cdd:COG5215 782 KIGMIAEDPNGSEAHTRAALGLIGDLAGMFPKGELKFGLDEDWVKDFLYGMMKKISSQQtKDSARWAAEQVKR 854
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 380-435 9.22e-12

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 60.84  E-value: 9.22e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 19923142   380 WRYRDAAVMAFGCILEGpEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRI 435
Cdd:pfam13513   1 WRVREAAALALGSLAEG-GPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 21-101 8.63e-08

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 49.93  E-value: 8.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142     21 AQKFLERAavENLPTFLVELSRVLANPGNSQVaRVAAGLQIKNSLTSkdpdikaqyqqRWLAIDANARREVKNYVLQTLG 100
Cdd:smart00913   1 AEKQLEQF--QKSPGFWLLLLEILANSEDQYV-RQLAAITLKNKITR-----------RWSSLPEEEKEEIKNSLLELLL 66


                   .
gi 19923142    101 T 101
Cdd:smart00913  67 S 67
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
2-871 0e+00

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 613.87  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142   2 ELITILEKTV-SPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRW 80
Cdd:COG5215   5 EFRCLGKNHVlSPDPNARLRAEAQLLELQSGDFEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHANDPELQKGCSQRW 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142  81 LAIDANARREVKNYVLQTLGTETYR-PSSASQCVAGIACAEIPVNQWPELIPQLVANVTNpNSTEHMKESTLEAIGYICQ 159
Cdd:COG5215  85 LGMRHESKEQVKGMALRALKSPEPRfCTMAAQLLAAIARMELPNSLWPGLMEEMVRNVGD-EQPVSGKCESLGICGYHCE 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 160 DIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQ 239
Cdd:COG5215 164 SEAPEDLIQMSNVILFAIVMGALKNETTSAVRLAALKALMDSLMFVQGNFCYEEERNYFMQVVCEATQGNDEELQHAAFG 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 240 NLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQgrpPEHTSKFyAKGAL 319
Cdd:COG5215 244 CLNKIMMLYYKFMQSYMENALAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEV---PAQNHGF-ARAAV 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 320 QYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEP 399
Cdd:COG5215 320 ADVLPELLSLLEKQGEDYYGDDWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGPCE 399

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 400 SQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAE 479
Cdd:COG5215 400 DCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHLVLEVSASLIGLMDCPFRSINCSWRKENLVD 479

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 480 aayEAADVADDQEEPatycLSSSFELIVQKLLETTDRPDgHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQ 559
Cdd:COG5215 480 ---HIAKAVREVESF----LAKFYLAILNALVKGTELAL-NESNLRVSLFSALGTLILICPDAVSDILAGFYDYTSKKLD 551

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 560 QVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKvQHQDALQISDVVMASLLRMFQSTAgSGGVQEDALMAVSTLVEVL 639
Cdd:COG5215 552 ECISVLGQILATEDQLLVEELQSNYIGVLEAIIRT-RRRDIEDVEDQLMELFIRILESTK-PTTAFGDVYTAISALSTSL 629

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 640 GGEFLKYMEAFKPFLGIGLkNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGD 719
Cdd:COG5215 630 EERFEQYASKFIPYLTRAL-NCTDRFVLNSAVGLVGDLANTLGTDFNIYADVLMSSLVQCLSSEATHRDLKPAILSVFGD 708

                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 720 IALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGlkgdqenVHPDVMLVQPRVEFILS 799
Cdd:COG5215 709 IALAIGANFESYLDMIMMLFQQASELDPHSDEVYVDDYRKNAVQLVNCAYVGIGDS-------SKNRVRSVLPYVISIFH 781

                       810       820       830       840       850       860       870
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19923142 800 FIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKA-KTLATWATKELRK 871
Cdd:COG5215 782 KIGMIAEDPNGSEAHTRAALGLIGDLAGMFPKGELKFGLDEDWVKDFLYGMMKKISSQQtKDSARWAAEQVKR 854
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 380-435 9.22e-12

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 60.84  E-value: 9.22e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 19923142   380 WRYRDAAVMAFGCILEGpEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRI 435
Cdd:pfam13513   1 WRVREAAALALGSLAEG-GPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N pfam03810
Importin-beta N-terminal domain;
21-101 3.80e-11

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 59.56  E-value: 3.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142    21 AQKFLERAavENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKaqyqqrwLAIDANARREVKNYVLQTLG 100
Cdd:pfam03810   1 AEKQLEQF--EKSPGFWSKLLQILSNSENPLEVRQLAALYLKNLITRHWEEEK-------NSLPPEEKEQIKNNLLNLLG 71


                  .
gi 19923142   101 T 101
Cdd:pfam03810  72 S 72
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 21-101 8.63e-08

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 49.93  E-value: 8.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142     21 AQKFLERAavENLPTFLVELSRVLANPGNSQVaRVAAGLQIKNSLTSkdpdikaqyqqRWLAIDANARREVKNYVLQTLG 100
Cdd:smart00913   1 AEKQLEQF--QKSPGFWLLLLEILANSEDQYV-RQLAAITLKNKITR-----------RWSSLPEEEKEEIKNSLLELLL 66


                   .
gi 19923142    101 T 101
Cdd:smart00913  67 S 67
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 410-439 2.22e-04

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 39.05  E-value: 2.22e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 19923142   410 MPTLIELMKDPSVVVRDTAAWTVGRICELL 439
Cdd:pfam02985   2 LPLLLKLLNDPSPEVREAAAEALGELAEVL 31
HEAT COG1413
HEAT repeat [General function prediction only];
365-435 6.92e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.77  E-value: 6.92e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19923142 365 PHVLPFIKEHIKNPDWRYRDAAVMAFGCIleGPEPsqlkplviqAMPTLIELMKDPSVVVRDTAAWTVGRI 435
Cdd:COG1413  77 PEAVPALIAALKDEDPEVRRAAAEALGRL--GDPA---------AVPALLEALKDPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
365-478 1.17e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923142 365 PHVLPFIKEHIKNPDWRYRDAAVMAFGCIleGPEpsqlkplviQAMPTLIELMKDPSVVVRDTAAWTVGRICEllpEAAI 444
Cdd:COG1413  46 PRAVPALLEALKDPDPEVRAAAAEALGRI--GDP---------EAVPALIAALKDEDPEVRRAAAEALGRLGD---PAAV 111

                        90       100       110
                ....*....|....*....|....*....|....
gi 19923142 445 NdvYLAPLLQclieglSAEPRVASNVCWAFSSLA 478
Cdd:COG1413 112 P--ALLEALK------DPDWEVRRAAARALGRLG 137
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 424-477 3.29e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.58  E-value: 3.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 19923142   424 VRDTAAWTVGRICELLPEAAINdvYLAPLLQCLIEGL-SAEPRVASNVCWAFSSL 477
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAP--AVPELLPALLPLLnDDSDLVREAAAWALGRL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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