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Conserved domains on  [gi|2444544623|ref|NP_001403577|]
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cell division control protein 45 homolog isoform 3 [Mus musculus]

Protein Classification

cell division control 45 family protein( domain architecture ID 10497898)

cell division control 45 (CDC45) family protein similar to Saccharomyces cerevisiae CDC45, which is required for initiation of chromosomal DNA replication, forming a complex with MCM5/CDC46, and plays a role in minichromosome maintenance

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDC45 pfam02724
CDC45-like protein; CDC45 is an essential gene required for initiation of DNA replication in S. ...
 19-560 2.63e-172

CDC45-like protein; CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae, forming a complex with MCM5/CDC46. homologs of CDC45 have been identified in human, mouse and smut fungus among others.


:

Pssm-ID: 460663  Cd Length: 529  Bit Score: 498.22  E-value: 2.63e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623  19 VLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAY--LEHKEQFSYFILINCGANVDLLDILQPDEDSIFF 96
Cdd:pfam02724   1 VLILVALDVDALCACRILTSLLKRDLIPHKIVPVSGYSELERAGeeLVAPGEIRSVILINCGGMVDLEELLGLPPGVTVY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623  97 VCDTHRPVNVVNVY-NDTQIKllikqeddlevpayddIFRDEAEDEDLSDsDGDGSEpsekrtRLEEEIvernrkrrqrr 175
Cdd:pfam02724  81 VIDSHRPWNLDNLFgGSDGII----------------VFDDGDIEEDLQE-EREAYE------ALEELP----------- 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623 176 ewearrkdilfDYEQYEYYGTSSAMVMFDLAWMMSKDLNDMLW-AIVGLTDQWVHDKITQMKYVTDVGILQRHVSRHNHR 254
Cdd:pfam02724 127 -----------YYSQGTSYGESASSLMYSLASELGREDNDLLWlAIVGLTSQYLHGRISRERYDRLRPLLQDEVRRLNPP 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623 255 NEAEENMLSVDCTRISFEYDLCLVLYQHWSLHESLYNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQSMDVS 334
Cdd:pfam02724 196 GVIPTTARSPDDTSIRLSPEYRFMLLRHWSLYDSMYHSSYVASKLGLWSENGRKRLHKLLAKMGISLAQAQQKYTHMDMD 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623 335 LKGNLREMIEESANKFGMKDMRVQTFSIQFGFKHKFLASDVVFATMSLMESP---------------------------- 386
Cdd:pfam02724 276 LKRELREKLEKFAPEYGLDDLVYPSFVRSYGYRGPLSASDVVEALTALLEVGkgvrleveeeggrnasedeeedaaedee 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623 387 EKDGSGTDHFIQALDSLSRSNLDKLYLGLELAKKHLQATQQTIASCLCTNLVTSQGPFLYCSLMEGtPDVTLFSKPASLS 466
Cdd:pfam02724 356 KDEEWWVSNFWEAYDALDPKNIDLLRKGLPLAQSLQRAIVRTGTSLIEKKLIRHLRAFRLAVLKDG-PDLALFTHPLALT 434

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623 467 LLSRHLLKSFVYSTKNRRCKLLPLVMAApLSVEQGTVTVVGIPPETDSSD--RKNFFGRAFEKAAESTSSRTLHNYFDLS 544
Cdd:pfam02724 435 KLALWLMEALREREKEKGAKLLPLVLAS-LDEARGTYLVVGVSGRAPEGGdvRKNRFGLAFQEAAEETGARVRHDSFESS 513

                         570
                  ....*....|....*.
gi 2444544623 545 VIELKAEDRSKFLDAL 560
Cdd:pfam02724 514 VIEVRKEDLGPFLEKL 529
 
Name Accession Description Interval E-value
CDC45 pfam02724
CDC45-like protein; CDC45 is an essential gene required for initiation of DNA replication in S. ...
 19-560 2.63e-172

CDC45-like protein; CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae, forming a complex with MCM5/CDC46. homologs of CDC45 have been identified in human, mouse and smut fungus among others.


Pssm-ID: 460663  Cd Length: 529  Bit Score: 498.22  E-value: 2.63e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623  19 VLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAY--LEHKEQFSYFILINCGANVDLLDILQPDEDSIFF 96
Cdd:pfam02724   1 VLILVALDVDALCACRILTSLLKRDLIPHKIVPVSGYSELERAGeeLVAPGEIRSVILINCGGMVDLEELLGLPPGVTVY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623  97 VCDTHRPVNVVNVY-NDTQIKllikqeddlevpayddIFRDEAEDEDLSDsDGDGSEpsekrtRLEEEIvernrkrrqrr 175
Cdd:pfam02724  81 VIDSHRPWNLDNLFgGSDGII----------------VFDDGDIEEDLQE-EREAYE------ALEELP----------- 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623 176 ewearrkdilfDYEQYEYYGTSSAMVMFDLAWMMSKDLNDMLW-AIVGLTDQWVHDKITQMKYVTDVGILQRHVSRHNHR 254
Cdd:pfam02724 127 -----------YYSQGTSYGESASSLMYSLASELGREDNDLLWlAIVGLTSQYLHGRISRERYDRLRPLLQDEVRRLNPP 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623 255 NEAEENMLSVDCTRISFEYDLCLVLYQHWSLHESLYNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQSMDVS 334
Cdd:pfam02724 196 GVIPTTARSPDDTSIRLSPEYRFMLLRHWSLYDSMYHSSYVASKLGLWSENGRKRLHKLLAKMGISLAQAQQKYTHMDMD 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623 335 LKGNLREMIEESANKFGMKDMRVQTFSIQFGFKHKFLASDVVFATMSLMESP---------------------------- 386
Cdd:pfam02724 276 LKRELREKLEKFAPEYGLDDLVYPSFVRSYGYRGPLSASDVVEALTALLEVGkgvrleveeeggrnasedeeedaaedee 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623 387 EKDGSGTDHFIQALDSLSRSNLDKLYLGLELAKKHLQATQQTIASCLCTNLVTSQGPFLYCSLMEGtPDVTLFSKPASLS 466
Cdd:pfam02724 356 KDEEWWVSNFWEAYDALDPKNIDLLRKGLPLAQSLQRAIVRTGTSLIEKKLIRHLRAFRLAVLKDG-PDLALFTHPLALT 434

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623 467 LLSRHLLKSFVYSTKNRRCKLLPLVMAApLSVEQGTVTVVGIPPETDSSD--RKNFFGRAFEKAAESTSSRTLHNYFDLS 544
Cdd:pfam02724 435 KLALWLMEALREREKEKGAKLLPLVLAS-LDEARGTYLVVGVSGRAPEGGdvRKNRFGLAFQEAAEETGARVRHDSFESS 513

                         570
                  ....*....|....*.
gi 2444544623 545 VIELKAEDRSKFLDAL 560
Cdd:pfam02724 514 VIEVRKEDLGPFLEKL 529
 
Name Accession Description Interval E-value
CDC45 pfam02724
CDC45-like protein; CDC45 is an essential gene required for initiation of DNA replication in S. ...
 19-560 2.63e-172

CDC45-like protein; CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae, forming a complex with MCM5/CDC46. homologs of CDC45 have been identified in human, mouse and smut fungus among others.


Pssm-ID: 460663  Cd Length: 529  Bit Score: 498.22  E-value: 2.63e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623  19 VLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAY--LEHKEQFSYFILINCGANVDLLDILQPDEDSIFF 96
Cdd:pfam02724   1 VLILVALDVDALCACRILTSLLKRDLIPHKIVPVSGYSELERAGeeLVAPGEIRSVILINCGGMVDLEELLGLPPGVTVY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623  97 VCDTHRPVNVVNVY-NDTQIKllikqeddlevpayddIFRDEAEDEDLSDsDGDGSEpsekrtRLEEEIvernrkrrqrr 175
Cdd:pfam02724  81 VIDSHRPWNLDNLFgGSDGII----------------VFDDGDIEEDLQE-EREAYE------ALEELP----------- 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623 176 ewearrkdilfDYEQYEYYGTSSAMVMFDLAWMMSKDLNDMLW-AIVGLTDQWVHDKITQMKYVTDVGILQRHVSRHNHR 254
Cdd:pfam02724 127 -----------YYSQGTSYGESASSLMYSLASELGREDNDLLWlAIVGLTSQYLHGRISRERYDRLRPLLQDEVRRLNPP 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623 255 NEAEENMLSVDCTRISFEYDLCLVLYQHWSLHESLYNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQSMDVS 334
Cdd:pfam02724 196 GVIPTTARSPDDTSIRLSPEYRFMLLRHWSLYDSMYHSSYVASKLGLWSENGRKRLHKLLAKMGISLAQAQQKYTHMDMD 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623 335 LKGNLREMIEESANKFGMKDMRVQTFSIQFGFKHKFLASDVVFATMSLMESP---------------------------- 386
Cdd:pfam02724 276 LKRELREKLEKFAPEYGLDDLVYPSFVRSYGYRGPLSASDVVEALTALLEVGkgvrleveeeggrnasedeeedaaedee 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623 387 EKDGSGTDHFIQALDSLSRSNLDKLYLGLELAKKHLQATQQTIASCLCTNLVTSQGPFLYCSLMEGtPDVTLFSKPASLS 466
Cdd:pfam02724 356 KDEEWWVSNFWEAYDALDPKNIDLLRKGLPLAQSLQRAIVRTGTSLIEKKLIRHLRAFRLAVLKDG-PDLALFTHPLALT 434

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2444544623 467 LLSRHLLKSFVYSTKNRRCKLLPLVMAApLSVEQGTVTVVGIPPETDSSD--RKNFFGRAFEKAAESTSSRTLHNYFDLS 544
Cdd:pfam02724 435 KLALWLMEALREREKEKGAKLLPLVLAS-LDEARGTYLVVGVSGRAPEGGdvRKNRFGLAFQEAAEETGARVRHDSFESS 513

                         570
                  ....*....|....*.
gi 2444544623 545 VIELKAEDRSKFLDAL 560
Cdd:pfam02724 514 VIEVRKEDLGPFLEKL 529
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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