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Conserved domains on  [gi|2430295226|ref|NP_001403147|]
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uncharacterized protein LOC115489547 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
50-258 2.31e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2430295226  50 KAFANESGSQRHQIKHTG-EKQHDCNQCGKAFKRRSDLQIHKRT--HTGE--KPYEC--KQCGKAFSQSSHLRIHKRTHT 122
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2430295226 123 GEKPYECKqcgkafaqsshLQIHKRTHTGEKPYECKQCGKAFAHSSHLHIHERTHTGekpyeckqCGKGFARSGDLQKHK 202
Cdd:COG5048   348 SISPAKEK-----------LLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNS--------CIRNFKRDSNLSLHI 408

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2430295226 203 QTHTGEKPYECK--QCGKAFSRKSVLQIHKRTHTGEKPYECKQCGKAFAQSSHLRIHK 258
Cdd:COG5048   409 ITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
50-258 2.31e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2430295226  50 KAFANESGSQRHQIKHTG-EKQHDCNQCGKAFKRRSDLQIHKRT--HTGE--KPYEC--KQCGKAFSQSSHLRIHKRTHT 122
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2430295226 123 GEKPYECKqcgkafaqsshLQIHKRTHTGEKPYECKQCGKAFAHSSHLHIHERTHTGekpyeckqCGKGFARSGDLQKHK 202
Cdd:COG5048   348 SISPAKEK-----------LLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNS--------CIRNFKRDSNLSLHI 408

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2430295226 203 QTHTGEKPYECK--QCGKAFSRKSVLQIHKRTHTGEKPYECKQCGKAFAQSSHLRIHK 258
Cdd:COG5048   409 ITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
113-138 2.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.10e-04
                          10        20
                  ....*....|....*....|....*.
gi 2430295226 113 HLRIHKRTHTGEKPYECKQCGKAFAQ 138
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
50-258 2.31e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 2.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2430295226  50 KAFANESGSQRHQIKHTG-EKQHDCNQCGKAFKRRSDLQIHKRT--HTGE--KPYEC--KQCGKAFSQSSHLRIHKRTHT 122
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2430295226 123 GEKPYECKqcgkafaqsshLQIHKRTHTGEKPYECKQCGKAFAHSSHLHIHERTHTGekpyeckqCGKGFARSGDLQKHK 202
Cdd:COG5048   348 SISPAKEK-----------LLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNS--------CIRNFKRDSNLSLHI 408

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2430295226 203 QTHTGEKPYECK--QCGKAFSRKSVLQIHKRTHTGEKPYECKQCGKAFAQSSHLRIHK 258
Cdd:COG5048   409 ITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
113-138 2.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.10e-04
                          10        20
                  ....*....|....*....|....*.
gi 2430295226 113 HLRIHKRTHTGEKPYECKQCGKAFAQ 138
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
141-166 2.41e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.41e-04
                          10        20
                  ....*....|....*....|....*.
gi 2430295226 141 HLQIHKRTHTGEKPYECKQCGKAFAH 166
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-270 2.76e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2430295226 138 QSSHLQIHKRTHTGEKPYecKQCGKAFAHSSHLHIHERTHtgekpYECKQCGKGFARSGDLQKHKQTHTG-EKPYECKQC 216
Cdd:COG5048   223 SSSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASES-----PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQC 295

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2430295226 217 GKAFSRKSVLQIHKRT--HTGE--KPYEC--KQCGKAFAQSSHLRIHKRAHTGLKPYECK 270
Cdd:COG5048   296 NISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
85-110 4.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 4.26e-04
                          10        20
                  ....*....|....*....|....*.
gi 2430295226  85 DLQIHKRTHTGEKPYECKQCGKAFSQ 110
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
69-195 4.53e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2430295226  69 KQHDCNQCGKAFKRRSDLQIHKRTHTGEKPYEC--KQCGKAFSQSSHLRIHKRTHTGEKPYEC-KQCGKAFAQSSHLQIH 145
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2430295226 146 KRTHTGEKPYECKQCGKAFAHSSHLHIHERTHTGEKPYECKQCGKGFARS 195
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNT 161
zf-H2C2_2 pfam13465
Zinc-finger double domain;
226-250 4.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 4.84e-04
                          10        20
                  ....*....|....*....|....*
gi 2430295226 226 LQIHKRTHTGEKPYECKQCGKAFAQ 250
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
42-326 4.86e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 4.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2430295226  42 PSEFIHCGKAFANESGSQRHQIKHTGEKQHDCNQ--CGKAFKRRSDLQIHKRTHTGEKPYECKQCGK------------- 106
Cdd:COG5048    33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsnskasssslss 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2430295226 107 ----------AFSQSSHLRIHKRTH---------TGEKPYECKQCGKAFAQSSHLQ-------------------IHKRT 148
Cdd:COG5048   113 sssnsndnnlLSSHSLPPSSRDPQLpdllsisnlRNNPLPGNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSNV 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2430295226 149 HTGEKPYECKQCGKAFAHSSHLHIHERTHTGEKPYECKQCGKGFARSGDLQKHKQTHTGEKPYECKQCG------KAFSR 222
Cdd:COG5048   193 STSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQS 272

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2430295226 223 KSVLQIHKRTHTG-EKPYECKQCGKAFAQSSHLRIHKRA--HTG--LKPYEC--KQCGKAFAGSSGLQCHKRSHTGETPY 295
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPA 352

                         330       340       350
                  ....*....|....*....|....*....|.
gi 2430295226 296 ECNQGGKPFEGSSGLEYNNRTQTAEKPYECN 326
Cdd:COG5048   353 KEKLLNSSSKFSPLLNNEPPQSLQQYKDLKN 383
RPL43A COG1997
Ribosomal protein L37AE/L43A [Translation, ribosomal structure and biogenesis]; Ribosomal ...
 220-280 5.78e-04

Ribosomal protein L37AE/L43A [Translation, ribosomal structure and biogenesis]; Ribosomal protein L37AE/L43A is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 441600  Cd Length: 87  Bit Score: 38.37  E-value: 5.78e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2430295226 220 FSRKSVLQIHKRTHtgeKPYECKQCGkafaqssHLRIhKRAHTGLkpYECKQCGKAFAGSS 280
Cdd:COG1997    21 KLRKRVADIEEKMR---AKHTCPECG-------SKRV-KRVATGI--WECRKCGYKFAGGA 68
zf-H2C2_2 pfam13465
Zinc-finger double domain;
197-222 6.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 6.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 2430295226 197 DLQKHKQTHTGEKPYECKQCGKAFSR 222
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
153-218 7.74e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 7.74e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2430295226 153 KPYECKQCGKAFAHSSHLHIHERTHTGEKPYEC--KQCGKGFARSGDLQKHKQTHTGEKPYECKQCGK 218
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-194 5.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 5.63e-03
                          10        20
                  ....*....|....*....|..
gi 2430295226 173 HERTHTGEKPYECKQCGKGFAR 194
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 99-121 6.84e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 6.84e-03
                          10        20
                  ....*....|....*....|...
gi 2430295226  99 YECKQCGKAFSQSSHLRIHKRTH 121
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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