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Conserved domains on  [gi|2328705292|ref|NP_001400882|]
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cadherin-17 isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 570-663 5.28e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 5.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 570 VFQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGS 645
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdSGENgeVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 2328705292 646 SLSSVSEFHLILMDVNDN 663
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 131-235 1.24e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 131 YEGSVRQNSRPGKPFLYVNATDLDDPatPNGQLYYQIVIQlpmiNNVMYFQINNKTGAISLTRegsqELNPAKNPSYNLV 210
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTAK----PLDREEQSSYTLT 71

                          90       100
                  ....*....|....*....|....*
gi 2328705292 211 ISVKDMGGqseNSFSDTTSVDIIVT 235
Cdd:cd11304    72 VTATDGGG---PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 346-444 1.46e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 346 VFEVQENERLGNSIGTLTAHDRDEENtaNSFLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKqSLKKQDTPQYNLTIEVS 425
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE----DGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|..
gi 2328705292 426 DKD---FKTLCFVQINVIDIND 444
Cdd:cd11304    76 DGGgppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-122 2.78e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 2.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292  33 PMTFSIYEGQEPSQIIFQFKANPP------AVTFELT-GETDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGI 104
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdsgengEVTYSIVsGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 2328705292 105 IVEGPVPITIKVKDINDN 122
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 271-338 3.11e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 3.11e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2328705292  271 YSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPP 338
Cdd:smart00112  15 YSILSGN--DDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-562 6.41e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 6.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 456 NLTLAEDTNIGSTILTIQATDADEPFTGssKILYHIIKGDSEGRLGVDtdphTNTGYVIIKKPLDFETAAVSNIVFKAEN 535
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*..
gi 2328705292 536 PEPLVFgvkynaSSFAKFTLIVTDVNE 562
Cdd:cd11304    77 GGGPPL------SSTATVTITVLDVND 97
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 681-765 1.88e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 38.05  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 681 SAPGSLI--FEATDDDqhlfRGPH--FTFSLGSGSLQNDWEVSKINGTharLSTRHT-EFEER-EYVVLIRINDGGRPPL 754
Cdd:pfam00028   9 APVGTEVltVTATDPD----LGPNgrIFYSILGGGPGGNFRIDPDTGD---ISTTKPlDRESIgEYELTVEATDSGGPPL 81

                          90
                  ....*....|.
gi 2328705292 755 EGIVSLPVTFC 765
Cdd:pfam00028  82 SSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 570-663 5.28e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 5.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 570 VFQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGS 645
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdSGENgeVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 2328705292 646 SLSSVSEFHLILMDVNDN 663
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 131-235 1.24e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 131 YEGSVRQNSRPGKPFLYVNATDLDDPatPNGQLYYQIVIQlpmiNNVMYFQINNKTGAISLTRegsqELNPAKNPSYNLV 210
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTAK----PLDREEQSSYTLT 71

                          90       100
                  ....*....|....*....|....*
gi 2328705292 211 ISVKDMGGqseNSFSDTTSVDIIVT 235
Cdd:cd11304    72 VTATDGGG---PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 346-444 1.46e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 346 VFEVQENERLGNSIGTLTAHDRDEENtaNSFLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKqSLKKQDTPQYNLTIEVS 425
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE----DGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|..
gi 2328705292 426 DKD---FKTLCFVQINVIDIND 444
Cdd:cd11304    76 DGGgppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-122 2.78e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 2.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292  33 PMTFSIYEGQEPSQIIFQFKANPP------AVTFELT-GETDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGI 104
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdsgengEVTYSIVsGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 2328705292 105 IVEGPVPITIKVKDINDN 122
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 271-338 3.11e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 3.11e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2328705292  271 YSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPP 338
Cdd:smart00112  15 YSILSGN--DDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-562 6.41e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 6.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 456 NLTLAEDTNIGSTILTIQATDADEPFTGssKILYHIIKGDSEGRLGVDtdphTNTGYVIIKKPLDFETAAVSNIVFKAEN 535
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*..
gi 2328705292 536 PEPLVFgvkynaSSFAKFTLIVTDVNE 562
Cdd:cd11304    77 GGGPPL------SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 245-336 2.32e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 245 VEMVENSTDPHPIkiTQVRWNDPGA------QYSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYG 317
Cdd:cd11304     4 VSVPENAPPGTVV--LTVSATDPDSgengevTYSIVSGN--EDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 2328705292 318 KPLSYPLEIHVKVKDINDN 336
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 58-124 1.50e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.60  E-value: 1.50e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2328705292   58 VTFELT-GETDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRP 124
Cdd:smart00112  13 VTYSILsGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
571-640 3.01e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 3.01e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2328705292 571 FQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYS-LRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVAT 640
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPdLGPNgrIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-665 5.55e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 5.55e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2328705292  592 DPEGLDISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPP 665
Cdd:smart00112   7 SGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
131-235 1.37e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 131 YEGSVRQNSRPGKPFLYVNATDLDDPatPNGQLYYQIvIQLPMINNvmyFQINNKTGAISLTRegsqELNPAKNPSYNLV 210
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSI-LGGGPGGN---FRIDPDTGDISTTK----PLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|....*
gi 2328705292 211 ISVKDMGGQSEnsfSDTTSVDIIVT 235
Cdd:pfam00028  71 VEATDSGGPPL---SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
346-428 1.59e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 1.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 346 VFEVQENERLGNSIGTLTAHDRDEenTANSFLNYRIVEQtpklPMDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVS 425
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGG----GPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEAT 74


                  ...
gi 2328705292 426 DKD 428
Cdd:pfam00028  75 DSG 77
Cadherin pfam00028
Cadherin domain;
35-116 3.57e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 3.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292  35 TFSIYEGQEPSQIIFQFKANPP-------AVTFELTGETDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIV 106
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPdlgpngrIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                          90
                  ....*....|
gi 2328705292 107 EGPVPITIKV 116
Cdd:pfam00028  82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
284-330 1.80e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.38  E-value: 1.80e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2328705292 284 FSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKV 330
Cdd:pfam00028  44 FRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 149-235 1.88e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 1.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292  149 NATDLDDPatPNGQLYYQIVIQlpmiNNVMYFQINNKTGAISLTREgsqeLNPAKNPSYNLVISVKDMGGQsenSFSDTT 228
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSG----NDDGLFSIDPETGEITTTKP----LDREEQPEYTLTVEATDGGGP---PLSSTA 67


                   ....*..
gi 2328705292  229 SVDIIVT 235
Cdd:smart00112  68 TVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 363-447 2.73e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 2.73e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292  363 TAHDRDEEntANSFLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVSDKDFKTL---CFVQINV 439
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGND----DGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLsstATVTITV 73


                   ....*...
gi 2328705292  440 IDINDQIP 447
Cdd:smart00112  74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 473-564 1.32e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.35  E-value: 1.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292  473 QATDADEPFtgSSKILYHIIKGDSEGRLGVDTdphtNTGYVIIKKPLDFETAAVSNIVFKAENpeplvfGVKYNASSFAK 552
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDP----ETGEITTTKPLDREEQPEYTLTVEATD------GGGPPLSSTAT 68

                           90
                   ....*....|..
gi 2328705292  553 FTLIVTDVNEAP 564
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
458-535 6.72e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 6.72e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2328705292 458 TLAEDTNIGSTILTIQATDADEPftGSSKILYHIIKGDSEGRLGVDTDphtnTGYVIIKKPLDFETAAVSNIVFKAEN 535
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPD----TGDISTTKPLDRESIGEYELTVEATD 75
Cadherin pfam00028
Cadherin domain;
681-765 1.88e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.05  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 681 SAPGSLI--FEATDDDqhlfRGPH--FTFSLGSGSLQNDWEVSKINGTharLSTRHT-EFEER-EYVVLIRINDGGRPPL 754
Cdd:pfam00028   9 APVGTEVltVTATDPD----LGPNgrIFYSILGGGPGGNFRIDPDTGD---ISTTKPlDRESIgEYELTVEATDSGGPPL 81

                          90
                  ....*....|.
gi 2328705292 755 EGIVSLPVTFC 765
Cdd:pfam00028  82 SSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 570-663 5.28e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 5.28e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 570 VFQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGS 645
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdSGENgeVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 2328705292 646 SLSSVSEFHLILMDVNDN 663
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 131-235 1.24e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 131 YEGSVRQNSRPGKPFLYVNATDLDDPatPNGQLYYQIVIQlpmiNNVMYFQINNKTGAISLTRegsqELNPAKNPSYNLV 210
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTAK----PLDREEQSSYTLT 71

                          90       100
                  ....*....|....*....|....*
gi 2328705292 211 ISVKDMGGqseNSFSDTTSVDIIVT 235
Cdd:cd11304    72 VTATDGGG---PPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 346-444 1.46e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 346 VFEVQENERLGNSIGTLTAHDRDEENtaNSFLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKqSLKKQDTPQYNLTIEVS 425
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE----DGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|..
gi 2328705292 426 DKD---FKTLCFVQINVIDIND 444
Cdd:cd11304    76 DGGgppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-122 2.78e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.04  E-value: 2.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292  33 PMTFSIYEGQEPSQIIFQFKANPP------AVTFELT-GETDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGI 104
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPdsgengEVTYSIVsGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 2328705292 105 IVEGPVPITIKVKDINDN 122
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 271-338 3.11e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 3.11e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2328705292  271 YSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDNPP 338
Cdd:smart00112  15 YSILSGN--DDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-562 6.41e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 6.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 456 NLTLAEDTNIGSTILTIQATDADEPFTGssKILYHIIKGDSEGRLGVDtdphTNTGYVIIKKPLDFETAAVSNIVFKAEN 535
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*..
gi 2328705292 536 PEPLVFgvkynaSSFAKFTLIVTDVNE 562
Cdd:cd11304    77 GGGPPL------SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 245-336 2.32e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 245 VEMVENSTDPHPIkiTQVRWNDPGA------QYSLVDKEklPRFPFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYG 317
Cdd:cd11304     4 VSVPENAPPGTVV--LTVSATDPDSgengevTYSIVSGN--EDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 2328705292 318 KPLSYPLEIHVKVKDINDN 336
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 58-124 1.50e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.60  E-value: 1.50e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2328705292   58 VTFELT-GETDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDNRP 124
Cdd:smart00112  13 VTYSILsGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
571-640 3.01e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 3.01e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2328705292 571 FQAKVSEDVAIGTKVGNVTAKDP-EGLD--ISYS-LRGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVAT 640
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPdLGPNgrIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEAT 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-665 5.55e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.06  E-value: 5.55e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2328705292  592 DPEGLDISYSL-RGDTRGWLKIDHVTGEIFSVAPLDREAGSPYRVQVVATEVGGSSLSSVSEFHLILMDVNDNPP 665
Cdd:smart00112   7 SGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
131-235 1.37e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 131 YEGSVRQNSRPGKPFLYVNATDLDDPatPNGQLYYQIvIQLPMINNvmyFQINNKTGAISLTRegsqELNPAKNPSYNLV 210
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSI-LGGGPGGN---FRIDPDTGDISTTK----PLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|....*
gi 2328705292 211 ISVKDMGGQSEnsfSDTTSVDIIVT 235
Cdd:pfam00028  71 VEATDSGGPPL---SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
346-428 1.59e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 1.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 346 VFEVQENERLGNSIGTLTAHDRDEenTANSFLNYRIVEQtpklPMDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVS 425
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGG----GPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEAT 74


                  ...
gi 2328705292 426 DKD 428
Cdd:pfam00028  75 DSG 77
Cadherin pfam00028
Cadherin domain;
35-116 3.57e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 3.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292  35 TFSIYEGQEPSQIIFQFKANPP-------AVTFELTGETDNIFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIV 106
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPdlgpngrIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                          90
                  ....*....|
gi 2328705292 107 EGPVPITIKV 116
Cdd:pfam00028  82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
284-330 1.80e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.38  E-value: 1.80e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2328705292 284 FSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKV 330
Cdd:pfam00028  44 FRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 149-235 1.88e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 1.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292  149 NATDLDDPatPNGQLYYQIVIQlpmiNNVMYFQINNKTGAISLTREgsqeLNPAKNPSYNLVISVKDMGGQsenSFSDTT 228
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSG----NDDGLFSIDPETGEITTTKP----LDREEQPEYTLTVEATDGGGP---PLSSTA 67


                   ....*..
gi 2328705292  229 SVDIIVT 235
Cdd:smart00112  68 TVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 363-447 2.73e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.28  E-value: 2.73e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292  363 TAHDRDEEntANSFLNYRIVEQTPklpmDGLFLIQTYAGMLQLAKQsLKKQDTPQYNLTIEVSDKDFKTL---CFVQINV 439
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGND----DGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLsstATVTITV 73


                   ....*...
gi 2328705292  440 IDINDQIP 447
Cdd:smart00112  74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 473-564 1.32e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 52.35  E-value: 1.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292  473 QATDADEPFtgSSKILYHIIKGDSEGRLGVDTdphtNTGYVIIKKPLDFETAAVSNIVFKAENpeplvfGVKYNASSFAK 552
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDP----ETGEITTTKPLDREEQPEYTLTVEATD------GGGPPLSSTAT 68

                           90
                   ....*....|..
gi 2328705292  553 FTLIVTDVNEAP 564
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
458-535 6.72e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 6.72e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2328705292 458 TLAEDTNIGSTILTIQATDADEPftGSSKILYHIIKGDSEGRLGVDTDphtnTGYVIIKKPLDFETAAVSNIVFKAEN 535
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPD----TGDISTTKPLDRESIGEYELTVEATD 75
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 268-336 1.13e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 44.64  E-value: 1.13e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 268 GAQYSLVDKEKLPRFpFSIDQE-GDIYVTQPLDREEKDAYVFYAVAKDEYGKPLSYPLEIHVKVKDINDN 336
Cdd:cd00031    30 IIKISAAGKEALPSW-LHWEPHsGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 69-122 9.65e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 39.25  E-value: 9.65e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2328705292  69 IFVIERE-GLLYYNRALDRETRSTHNLQVAALDANGIIVEGPVPITIKVKDINDN 122
Cdd:cd00031    44 WLHWEPHsGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
681-765 1.88e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.05  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705292 681 SAPGSLI--FEATDDDqhlfRGPH--FTFSLGSGSLQNDWEVSKINGTharLSTRHT-EFEER-EYVVLIRINDGGRPPL 754
Cdd:pfam00028   9 APVGTEVltVTATDPD----LGPNgrIFYSILGGGPGGNFRIDPDTGD---ISTTKPlDRESIgEYELTVEATDSGGPPL 81

                          90
                  ....*....|.
gi 2328705292 755 EGIVSLPVTFC 765
Cdd:pfam00028  82 SSTATVTITVL 92
Cadherin_3 pfam16184
Cadherin-like;
435-506 5.03e-03

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 37.58  E-value: 5.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2328705292 435 VQINVIDINDQIPIFEKSdyGNLTLAEDtniGSTILT---IQATDADEPftgSSKILYHIIKGDSEGRLGVDTDP 506
Cdd:pfam16184   7 FNITIIPVNDEAPVLTTN--TGLRLWEG---SSRPITpdlLQAEDPDTP---PEDLTYTVVQGPSHGHLALKGAP 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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